{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:50:48Z","timestamp":1791982248763,"version":"4.4.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T00:00:00Z","timestamp":1597622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81774252"],"award-info":[{"award-number":["81774252"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy Nucleic Acids"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.omtn.2020.08.014","type":"journal-article","created":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T12:59:24Z","timestamp":1597841964000},"page":"114-123","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["ROS\/NF-\u03baB Signaling Pathway-Mediated Transcriptional Activation of TRIM37 Promotes HBV-Associated Hepatic Fibrosis"],"prefix":"10.1016","volume":"22","author":[{"given":"Haina","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenye","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghao","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omtn.2020.08.014_bib1","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.cld.2008.07.007","article-title":"The global impact of hepatic fibrosis and end-stage liver disease","volume":"12","author":"Lim","year":"2008","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.omtn.2020.08.014_bib2","doi-asserted-by":"crossref","first-page":"11033","DOI":"10.3748\/wjg.v20.i32.11033","article-title":"Chronic hepatitis C and liver fibrosis","volume":"20","author":"Sebastiani","year":"2014","journal-title":"World J. Gastroenterol."},{"issue":"1, Suppl","key":"10.1016\/j.omtn.2020.08.014_bib3","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1016\/j.jhep.2015.02.039","article-title":"Hepatic fibrosis: Concept to treatment","volume":"62","author":"Trautwein","year":"2015","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.omtn.2020.08.014_bib4","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev-pathol-011110-130246","article-title":"Pathogenesis of liver fibrosis","volume":"6","author":"Hernandez-Gea","year":"2011","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.omtn.2020.08.014_bib5","doi-asserted-by":"crossref","first-page":"10512","DOI":"10.3748\/wjg.v22.i48.10512","article-title":"Liver fibrosis and hepatic stellate cells: etiology, pathological hallmarks and therapeutic targets","volume":"22","author":"Zhang","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.omtn.2020.08.014_bib6","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.3892\/ijmm.2012.1148","article-title":"HBV promotes the proliferation of hepatic stellate cells via the PDGF-B\/PDGFR-\u03b2 signaling pathway in\u00a0vitro","volume":"30","author":"Bai","year":"2012","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.omtn.2020.08.014_bib7","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev.iy.13.040195.000333","article-title":"Hepatitis B virus immunopathogenesis","volume":"13","author":"Chisari","year":"1995","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.omtn.2020.08.014_bib8","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev.pathol.1.110304.100230","article-title":"Immunobiology and pathogenesis of viral hepatitis","volume":"1","author":"Guidotti","year":"2006","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.omtn.2020.08.014_bib9","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nri2413","article-title":"TRIM family proteins and their emerging roles in innate immunity","volume":"8","author":"Ozato","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.omtn.2020.08.014_bib10","doi-asserted-by":"crossref","first-page":"jc2","DOI":"10.1126\/scisignal.3118jc2","article-title":"TRIM proteins: another class of viral victims","volume":"3","author":"Munir","year":"2010","journal-title":"Sci. Signal."},{"key":"10.1016\/j.omtn.2020.08.014_bib11","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.coi.2010.10.021","article-title":"Tripartite-motif proteins and innate immune regulation","volume":"23","author":"McNab","year":"2011","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.omtn.2020.08.014_bib12","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1128\/JVI.02445-07","article-title":"Primer binding site-dependent restriction of murine leukemia virus requires HP1 binding by TRIM28","volume":"82","author":"Wolf","year":"2008","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.omtn.2020.08.014_bib13","doi-asserted-by":"crossref","first-page":"11827","DOI":"10.1073\/pnas.0403364101","article-title":"TRIM5\u03b1 mediates the postentry block to N-tropic murine leukemia viruses in human cells","volume":"101","author":"Perron","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtn.2020.08.014_bib14","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nature02343","article-title":"The cytoplasmic body component TRIM5\u03b1 restricts HIV-1 infection in Old World monkeys","volume":"427","author":"Stremlau","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.omtn.2020.08.014_bib15","doi-asserted-by":"crossref","first-page":"e70001","DOI":"10.1371\/journal.pone.0070001","article-title":"Identification and characterization of multiple TRIM proteins that inhibit hepatitis B virus transcription","volume":"8","author":"Zhang","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtn.2020.08.014_bib16","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1136\/jmg.2003.014118","article-title":"Mulibrey nanism: clinical features and diagnostic criteria","volume":"41","author":"Karlberg","year":"2004","journal-title":"J.\u00a0Med. Genet."},{"key":"10.1016\/j.omtn.2020.08.014_bib17","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/humu.9233","article-title":"Novel mutations in the TRIM37 gene in Mulibrey nanism","volume":"23","author":"H\u00e4m\u00e4l\u00e4inen","year":"2004","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.omtn.2020.08.014_bib18","doi-asserted-by":"crossref","first-page":"7935","DOI":"10.2147\/OTT.S183303","article-title":"TRIM37 targets AKT in the growth of lung cancer cells","volume":"11","author":"Dong","year":"2018","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.omtn.2020.08.014_bib19","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/path.5144","article-title":"Tripartite motif-containing 37 (TRIM37) promotes the aggressiveness of non-small-cell lung cancer cells by activating the NF-\u03baB pathway","volume":"246","author":"Li","year":"2018","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.omtn.2020.08.014_bib20","first-page":"502","article-title":"Tripartite motif-containing protein 37 is overexpressed in human glioma and its downregulation inhibits human glioma cell growth in\u00a0vitro","volume":"11","author":"Chang","year":"2018","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.omtn.2020.08.014_bib21","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.biopha.2018.01.054","article-title":"Knockdown of TRIM37 suppresses the proliferation, migration and invasion of glioma cells through the inactivation of PI3K\/Akt signaling pathway","volume":"99","author":"Tang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.omtn.2020.08.014_bib22","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3727\/096504016X14732772150181","article-title":"Knockdown of tripartite motif-containing protein 37 (TRIM37) inhibits the proliferation and tumorigenesis in colorectal cancer cells","volume":"25","author":"Zhao","year":"2017","journal-title":"Oncol. Res."},{"key":"10.1016\/j.omtn.2020.08.014_bib23","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1007\/s13277-015-4078-7","article-title":"TRIM37 promoted the growth and migration of the pancreatic cancer cells","volume":"37","author":"Jiang","year":"2016","journal-title":"Tumour Biol."},{"key":"10.1016\/j.omtn.2020.08.014_bib24","doi-asserted-by":"crossref","first-page":"8803","DOI":"10.2147\/OTT.S178446","article-title":"TRIM37 promotes cell invasion and metastasis by regulating SIP1-mediated epithelial-mesenchymal transition in gastric cancer","volume":"11","author":"Chen","year":"2018","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.omtn.2020.08.014_bib25","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.bbrc.2015.07.089","article-title":"Over-expression of TRIM37 promotes cell migration and metastasis in hepatocellular carcinoma by activating Wnt\/\u03b2-catenin signaling","volume":"464","author":"Jiang","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.omtn.2020.08.014_bib26","first-page":"2261","article-title":"Semiquantitative evaluation of hepatic fibrosis by measuring tissue hydroxyproline","volume":"45","author":"Toyoki","year":"1998","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.omtn.2020.08.014_bib27","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1002\/hep.22109","article-title":"Serum activity of alanine aminotransferase (ALT) as an indicator of health and disease","volume":"47","author":"Kim","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.omtn.2020.08.014_bib28","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.18632\/oncotarget.13904","article-title":"Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis","volume":"8","author":"Ivanov","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.omtn.2020.08.014_bib29","doi-asserted-by":"crossref","first-page":"e22453","DOI":"10.1371\/journal.pone.0022453","article-title":"Low-level laser therapy activates NF-kB via generation of reactive oxygen species in mouse embryonic fibroblasts","volume":"6","author":"Chen","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtn.2020.08.014_bib30","doi-asserted-by":"crossref","first-page":"D102","DOI":"10.1093\/nar\/gkm955","article-title":"JASPAR, the open access database of transcription factor-binding profiles: new content and tools in the 2008 update","volume":"36","author":"Bryne","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.omtn.2020.08.014_bib31","doi-asserted-by":"crossref","first-page":"4488","DOI":"10.1128\/MCB.01636-06","article-title":"Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation","volume":"27","author":"Zhang","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.omtn.2020.08.014_bib32","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.redox.2016.12.011","article-title":"Oxidative stress in cancer and fibrosis: opportunity for therapeutic intervention with antioxidant compounds, enzymes, and nanoparticles","volume":"11","author":"Morry","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.omtn.2020.08.014_bib33","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0016-5085(03)00666-8","article-title":"Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats","volume":"125","author":"Dooley","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.omtn.2020.08.014_bib34","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s00441-016-2445-3","article-title":"Reactive oxygen species and fibrosis: further evidence of a significant liaison","volume":"365","author":"Richter","year":"2016","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.omtn.2020.08.014_bib35","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.trsl.2017.09.005","article-title":"Reactive oxygen species as signaling molecules in the development of lung fibrosis","volume":"190","author":"Gonzalez-Gonzalez","year":"2017","journal-title":"Transl. Res."},{"key":"10.1016\/j.omtn.2020.08.014_bib36","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/cbin.11206","article-title":"Tripartite motif protein 52 (TRIM52) promoted fibrosis in LX-2 cells through PPM1A-mediated Smad2\/3 pathway","volume":"44","author":"Zhou","year":"2020","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.omtn.2020.08.014_bib37","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00109-009-0563-z","article-title":"HBx targeting to mitochondria and ROS generation are necessary but insufficient for HBV-induced cyclooxygenase-2 expression","volume":"88","author":"Lim","year":"2010","journal-title":"J.\u00a0Mol. Med. (Berl.)"},{"key":"10.1016\/j.omtn.2020.08.014_bib38","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.gene.2019.01.004","article-title":"ARHGAP17 suppresses tumor progression and up-regulates P21 and P27 expression via inhibiting PI3K\/AKT signaling pathway in cervical cancer","volume":"692","author":"Guo","year":"2019","journal-title":"Gene"}],"container-title":["Molecular Therapy Nucleic Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253120302432?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253120302432?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T12:13:41Z","timestamp":1784808821000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2162253120302432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":38,"alternative-id":["S2162253120302432"],"URL":"https:\/\/doi.org\/10.1016\/j.omtn.2020.08.014","relation":{},"ISSN":["2162-2531"],"issn-type":[{"value":"2162-2531","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ROS\/NF-\u03baB Signaling Pathway-Mediated Transcriptional Activation of TRIM37 Promotes HBV-Associated Hepatic Fibrosis","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy Nucleic Acids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omtn.2020.08.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors.","name":"copyright","label":"Copyright"}]}}