{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T11:16:58Z","timestamp":1784805418722,"version":"3.55.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T00:00:00Z","timestamp":1609200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-148704"],"award-info":[{"award-number":["PJT-148704"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy Nucleic Acids"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.omtn.2020.12.022","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T22:55:35Z","timestamp":1609455335000},"page":"1020-1034","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Efficacy, accumulation, and transcriptional profile of anti-HIV shRNAs expressed from human U6, 7SK, and H1 promoters"],"prefix":"10.1016","volume":"23","author":[{"given":"Ryan P.","family":"Goguen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Del Corpo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisier","family":"Malard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A\u00efcha","family":"Daher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio P.","family":"Alpuche-Lazcano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle J.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7724-2441","authenticated-orcid":false,"given":"Robert J.","family":"Scarborough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Gatignol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omtn.2020.12.022_bib1","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.coph.2010.04.011","article-title":"Antiretroviral drugs","volume":"10","author":"De Clercq","year":"2010","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.omtn.2020.12.022_bib2","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1093\/jac\/dkr599","article-title":"Achieving a cure for HIV infection: do we have reasons to be optimistic?","volume":"67","author":"Le Douce","year":"2012","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.omtn.2020.12.022_bib3","doi-asserted-by":"crossref","first-page":"13110","DOI":"10.1073\/pnas.0705474104","article-title":"Stable reduction of CCR5 by RNAi through hematopoietic stem cell transplant in non-human primates","volume":"104","author":"An","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtn.2020.12.022_bib4","doi-asserted-by":"crossref","first-page":"36ra43","DOI":"10.1126\/scitranslmed.3000931","article-title":"RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphoma","volume":"2","author":"DiGiusto","year":"2010","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.omtn.2020.12.022_bib5","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/S1525-0016(03)00165-5","article-title":"Inhibition of HIV-1 infection by lentiviral vectors expressing Pol III-promoted anti-HIV RNAs","volume":"8","author":"Li","year":"2003","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omtn.2020.12.022_bib6","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.ymthe.2005.07.524","article-title":"Long-term inhibition of HIV-1 infection in primary hematopoietic cells by lentiviral vector delivery of a triple combination of anti-HIV shRNA, anti-CCR5 ribozyme, and a nucleolar-localizing TAR decoy","volume":"12","author":"Li","year":"2005","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omtn.2020.12.022_bib7","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1182\/blood.V94.1.368.413a47_368_371","article-title":"A clinical trial of retroviral-mediated transfer of a rev-responsive element decoy gene into CD34(+) cells from the bone marrow of human immunodeficiency virus-1-infected children","volume":"94","author":"Kohn","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.omtn.2020.12.022_bib8","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1056\/NEJMoa0802905","article-title":"Long-term control of HIV by CCR5 Delta32\/Delta32 stem-cell transplantation","volume":"360","author":"H\u00fctter","year":"2009","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.omtn.2020.12.022_bib9","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/s41586-019-1027-4","article-title":"HIV-1 remission following CCR5\u039432\/\u039432 haematopoietic stem-cell transplantation","volume":"568","author":"Gupta","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.omtn.2020.12.022_bib10","first-page":"1","article-title":"A second patient cured of HIV infection: hopes and limitations","volume":"23","author":"Scarborough","year":"2019","journal-title":"Virologie (Montrouge)"},{"key":"10.1016\/j.omtn.2020.12.022_bib11","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1038\/nbt1367","article-title":"Genetic therapies against HIV","volume":"25","author":"Rossi","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.omtn.2020.12.022_bib12","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.chembiol.2011.12.008","article-title":"RNA-based therapeutics: current progress and future prospects","volume":"19","author":"Burnett","year":"2012","journal-title":"Chem. Biol."},{"key":"10.1016\/j.omtn.2020.12.022_bib13","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/jgm.705","article-title":"Long-term survival and concomitant gene expression of ribozyme-transduced CD4+ T-lymphocytes in HIV-infected patients","volume":"7","author":"Macpherson","year":"2005","journal-title":"J.\u00a0Gene Med."},{"key":"10.1016\/j.omtn.2020.12.022_bib14","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nm.1932","article-title":"Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD34+ cells","volume":"15","author":"Mitsuyasu","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.omtn.2020.12.022_bib15","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.coviro.2019.04.003","article-title":"Small RNAs to treat human immunodeficiency virus type 1 infection by gene therapy","volume":"38","author":"Goguen","year":"2019","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.omtn.2020.12.022_bib16","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3390\/v10010008","article-title":"RNA Interference Therapies for an HIV-1 Functional Cure","volume":"10","author":"Scarborough","year":"2017","journal-title":"Viruses"},{"key":"10.1016\/j.omtn.2020.12.022_bib17","doi-asserted-by":"crossref","first-page":"e178","DOI":"10.1038\/mtna.2014.31","article-title":"A Conserved Target Site in HIV-1 Gag RNA is Accessible to Inhibition by Both an HDV Ribozyme and a Short Hairpin RNA","volume":"3","author":"Scarborough","year":"2014","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.omtn.2020.12.022_bib18","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1093\/nar\/gkx980","article-title":"Incorporation of aptamers in the terminal loop of shRNAs yields an effective and novel combinatorial targeting strategy","volume":"46","author":"Pang","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.omtn.2020.12.022_bib19","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1089\/oli.2008.0150","article-title":"Identification and characterization of a highly efficient anti-HIV pol hammerhead ribozyme","volume":"19","author":"M\u00fcller-Kuller","year":"2009","journal-title":"Oligonucleotides"},{"key":"10.1016\/j.omtn.2020.12.022_bib20","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.omtn.2019.10.011","article-title":"A U1i RNA that Enhances HIV-1 RNA Splicing with an Elongated Recognition Domain Is an Optimal Candidate for Combination HIV-1 Gene Therapy","volume":"18","author":"Del Corpo","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.omtn.2020.12.022_bib21","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1146\/annurev.biophys.37.032807.130008","article-title":"Structure of eukaryotic RNA polymerases","volume":"37","author":"Cramer","year":"2008","journal-title":"Annu. Rev. Biophys."},{"key":"10.1016\/j.omtn.2020.12.022_bib22","doi-asserted-by":"crossref","first-page":"e27639","DOI":"10.4161\/trns.27369","article-title":"Comparative overview of RNA polymerase II and III transcription cycles, with focus on RNA polymerase III termination and reinitiation","volume":"5","author":"Arimbasseri","year":"2014","journal-title":"Transcription"},{"key":"10.1016\/j.omtn.2020.12.022_bib23","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1101\/gad.1018902","article-title":"Recruitment of RNA polymerase III to its target promoters","volume":"16","author":"Schramm","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.omtn.2020.12.022_bib24","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.omtn.2017.11.006","article-title":"Delineation of the Exact Transcription Termination Signal for Type 3 Polymerase III","volume":"10","author":"Gao","year":"2018","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.omtn.2020.12.022_bib25","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.ymthe.2006.05.015","article-title":"Optimization and functional effects of stable short hairpin RNA expression in primary human lymphocytes via lentiviral vectors","volume":"14","author":"An","year":"2006","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omtn.2020.12.022_bib26","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1089\/hum.2012.239","article-title":"Studies of efficacy and liver toxicity related to adeno-associated virus-mediated RNA interference","volume":"24","author":"Sun","year":"2013","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.omtn.2020.12.022_bib27","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/jgm.860","article-title":"Stable RNA interference: comparison of U6 and H1 promoters in endothelial cells and in mouse brain","volume":"8","author":"M\u00e4kinen","year":"2006","journal-title":"J.\u00a0Gene Med."},{"key":"10.1016\/j.omtn.2020.12.022_bib28","doi-asserted-by":"crossref","first-page":"e312","DOI":"10.1038\/mtna.2016.24","article-title":"Development of Lentiviral Vectors Simultaneously Expressing Multiple siRNAs Against CCR5, vif and tat\/rev Genes for an HIV-1 Gene Therapy Approach","volume":"5","author":"Spanevello","year":"2016","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.omtn.2020.12.022_bib29","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/sj.mt.6300382","article-title":"Lentiviral Vector Design for Multiple shRNA Expression and Durable HIV-1 Inhibition","volume":"16","author":"Brake","year":"2008","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omtn.2020.12.022_bib30","doi-asserted-by":"crossref","first-page":"e161","DOI":"10.1038\/mtna.2014.12","article-title":"Pol III Promoters to Express Small RNAs: Delineation of Transcription Initiation","volume":"3","author":"Ma","year":"2014","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.omtn.2020.12.022_bib31","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1080\/21541264.2017.1322170","article-title":"Mutation of nucleotides around the\u00a0+1 position of type 3 polymerase III promoters: The effect on transcriptional activity and start site usage","volume":"8","author":"Gao","year":"2017","journal-title":"Transcription"},{"key":"10.1016\/j.omtn.2020.12.022_bib32","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nature10198","article-title":"Dicer recognizes the 5\u2032 end of RNA for efficient and accurate processing","volume":"475","author":"Park","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.omtn.2020.12.022_bib33","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1126\/science.1121638","article-title":"Structural basis for double-stranded RNA processing by Dicer","volume":"311","author":"Macrae","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.omtn.2020.12.022_bib34","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nrd3141","article-title":"Aptamers as therapeutics","volume":"9","author":"Keefe","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.omtn.2020.12.022_bib35","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1080\/15476286.2018.1551703","article-title":"Improvement of the CRISPR-Cpf1 system with ribozyme-processed crRNA","volume":"15","author":"Gao","year":"2018","journal-title":"RNA Biol."},{"key":"10.1016\/j.omtn.2020.12.022_bib36","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/nbt0502-500","article-title":"Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells","volume":"20","author":"Lee","year":"2002","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.omtn.2020.12.022_bib37","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1006\/mthe.2002.0558","article-title":"Design of HIV vectors for efficient gene delivery into human hematopoietic cells","volume":"5","author":"Yam","year":"2002","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omtn.2020.12.022_bib38","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/gt.2011.191","article-title":"A competitive cell growth assay for the detection of subtle effects of gene transduction on cell proliferation","volume":"19","author":"Eekels","year":"2012","journal-title":"Gene Ther."},{"key":"10.1016\/j.omtn.2020.12.022_bib39","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1073\/pnas.232688199","article-title":"Inhibiting HIV-1 infection in human T\u00a0cells by lentiviral-mediated delivery of small interfering RNA against CCR5","volume":"100","author":"Qin","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtn.2020.12.022_bib40","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1479-0556-7-8","article-title":"Characterization of a potent non-cytotoxic shRNA directed to the HIV-1 co-receptor CCR5","volume":"7","author":"Shimizu","year":"2009","journal-title":"Genet. Vaccines Ther."},{"key":"10.1016\/j.omtn.2020.12.022_bib41","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1089\/hum.2012.011","article-title":"Endogenous MCM7 microRNA cluster as a novel platform to multiplex small interfering and nucleolar RNAs for combinational HIV-1 gene therapy","volume":"23","author":"Chung","year":"2012","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.omtn.2020.12.022_bib42","doi-asserted-by":"crossref","first-page":"e236","DOI":"10.1038\/mtna.2015.10","article-title":"Engineering Cellular Resistance to HIV-1 Infection In\u00a0Vivo Using a Dual Therapeutic Lentiviral Vector","volume":"4","author":"Burke","year":"2015","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.omtn.2020.12.022_bib43","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1471-2199-5-9","article-title":"Short-term cytotoxic effects and long-term instability of RNAi delivered using lentiviral vectors","volume":"5","author":"Fish","year":"2004","journal-title":"BMC Mol. Biol."},{"key":"10.1016\/j.omtn.2020.12.022_bib44","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/ng1173","article-title":"Induction of an interferon response by RNAi vectors in mammalian cells","volume":"34","author":"Bridge","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.omtn.2020.12.022_bib45","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.bbagrm.2015.11.005","article-title":"Sequence-non-specific effects generated by various types of RNA interference triggers","volume":"1859","author":"Olejniczak","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.omtn.2020.12.022_bib46","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/nbt831","article-title":"Expression profiling reveals off-target gene regulation by RNAi","volume":"21","author":"Jackson","year":"2003","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.omtn.2020.12.022_bib47","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1073\/pnas.0308698100","article-title":"Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells","volume":"101","author":"Scacheri","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtn.2020.12.022_bib48","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nature04791","article-title":"Fatality in mice due to oversaturation of cellular microRNA\/short hairpin RNA pathways","volume":"441","author":"Grimm","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.omtn.2020.12.022_bib49","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.omtm.2019.02.006","article-title":"Safety of CD34+ Hematopoietic Stem Cells and CD4+ T Lymphocytes Transduced with LVsh5\/C46 in HIV-1 Infected Patients with High-Risk Lymphoma","volume":"13","author":"Delville","year":"2019","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.omtn.2020.12.022_bib50","doi-asserted-by":"crossref","first-page":"5297","DOI":"10.1128\/AAC.00949-15","article-title":"Effective inhibition of HIV-1 production by short hairpin RNAs and small interfering RNAs targeting a highly conserved site in HIV-1 Gag RNA is optimized by evaluating alternative length formats","volume":"59","author":"Scarborough","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.omtn.2020.12.022_bib51","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/978-1-62703-730-3_3","article-title":"Design and evaluation of clinically relevant SOFA-HDV ribozymes targeting HIV RNA","volume":"1103","author":"Scarborough","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.omtn.2020.12.022_bib52","first-page":"e54486","article-title":"Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy","volume":"115","author":"Scarborough","year":"2016","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.omtn.2020.12.022_bib53","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3390\/v10020053","article-title":"Higher Cytopathic Effects of a Zika Virus Brazilian Isolate from Bahia Compared to a Canadian-Imported Thai Strain","volume":"10","author":"Alpuche-Lazcano","year":"2018","journal-title":"Viruses"},{"key":"10.1016\/j.omtn.2020.12.022_bib54","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/978-1-0716-0716-9_14","article-title":"Cloning and Detection of Aptamer-Ribozyme Conjugations","volume":"2167","author":"Goguen","year":"2021","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.omtn.2020.12.022_bib55","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"}],"container-title":["Molecular Therapy Nucleic Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253120304030?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253120304030?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:31:01Z","timestamp":1777624261000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2162253120304030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":55,"alternative-id":["S2162253120304030"],"URL":"https:\/\/doi.org\/10.1016\/j.omtn.2020.12.022","relation":{},"ISSN":["2162-2531"],"issn-type":[{"value":"2162-2531","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy, accumulation, and transcriptional profile of anti-HIV shRNAs expressed from human U6, 7SK, and H1 promoters","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy Nucleic Acids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omtn.2020.12.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors.","name":"copyright","label":"Copyright"}]}}