{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:18:21Z","timestamp":1788542301027,"version":"build-2803163510"},"reference-count":152,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T00:00:00Z","timestamp":1617667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874079"],"award-info":[{"award-number":["81874079"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073193"],"award-info":[{"award-number":["82073193"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2017A030308001"],"award-info":[{"award-number":["2017A030308001"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy Nucleic Acids"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.omtn.2021.04.002","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T22:55:01Z","timestamp":1617922501000},"page":"768-779","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":70,"special_numbering":"C","title":["The role of M6A modification in the regulation of tumor-related lncRNAs"],"prefix":"10.1016","volume":"24","author":[{"given":"Yufei","family":"Lan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3671-0445","authenticated-orcid":false,"given":"Boyang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omtn.2021.04.002_bib1","first-page":"236","article-title":"A comprehensive overview of lncRNA annotation resources","volume":"18","author":"Xu","year":"2017","journal-title":"Brief. Bioinform."},{"key":"10.1016\/j.omtn.2021.04.002_bib2","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.2217\/epi-2019-0003","article-title":"lncRNA expression predicts mRNA abundance","volume":"11","author":"Pacholewska","year":"2019","journal-title":"Epigenomics"},{"key":"10.1016\/j.omtn.2021.04.002_bib3","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1186\/s12967-019-2049-2","article-title":"Integration analysis for novel lncRNA markers predicting tumor recurrence in human colon adenocarcinoma","volume":"17","author":"Chen","year":"2019","journal-title":"J.\u00a0Transl. Med."},{"key":"10.1016\/j.omtn.2021.04.002_bib4","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s12943-019-1106-z","article-title":"KIAA1429 contributes to liver cancer progression through N6-methyladenosine-dependent post-transcriptional modification of GATA3","volume":"18","author":"Lan","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.omtn.2021.04.002_bib5","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1080\/21691401.2019.1647225","article-title":"Identification of lncRNA biomarkers in lung squamous cell carcinoma using comprehensive analysis of lncRNA mediated ceRNA network","volume":"47","author":"Li","year":"2019","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.omtn.2021.04.002_bib6","doi-asserted-by":"crossref","first-page":"19518","DOI":"10.1002\/jcb.29259","article-title":"Genome-wide identification of lncRNAs as novel prognosis biomarkers of glioma","volume":"120","author":"Song","year":"2019","journal-title":"J.\u00a0Cell. Biochem."},{"key":"10.1016\/j.omtn.2021.04.002_bib7","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.3390\/cells8111399","article-title":"Emerging roles of long non-coding RNAs as drivers of brain evolution","volume":"8","author":"Zimmer-Bensch","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.omtn.2021.04.002_bib8","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/eji.201444558","article-title":"Emerging role of long noncoding RNAs as regulators of innate immune cell development and inflammatory gene expression","volume":"46","author":"Elling","year":"2016","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.omtn.2021.04.002_bib9","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1186\/s12885-019-6032-3","article-title":"Survival analysis of immune-related lncRNA in low-grade glioma","volume":"19","author":"Li","year":"2019","journal-title":"BMC Cancer"},{"key":"10.1016\/j.omtn.2021.04.002_bib10","doi-asserted-by":"crossref","first-page":"194419","DOI":"10.1016\/j.bbagrm.2019.194419","article-title":"The how and why of lncRNA function: An innate immune perspective","volume":"1863","author":"Robinson","year":"2020","journal-title":"Biochim. Biophys. Acta Gene Regul. Mech."},{"key":"10.1016\/j.omtn.2021.04.002_bib11","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.devcel.2019.07.013","article-title":"The lncRNA locus Handsdown regulates cardiac gene programs and is essential for early mouse development","volume":"50","author":"Ritter","year":"2019","journal-title":"Dev. Cell"},{"key":"10.1016\/j.omtn.2021.04.002_bib12","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s13578-019-0330-y","article-title":"The role of mRNA m6A methylation in the nervous system","volume":"9","author":"Li","year":"2019","journal-title":"Cell Biosci."},{"key":"10.1016\/j.omtn.2021.04.002_bib13","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12943-020-01224-3","article-title":"The role of N6-methyladenosine (m6A) modification in the regulation of circRNAs","volume":"19","author":"Zhang","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.omtn.2021.04.002_bib14","doi-asserted-by":"crossref","first-page":"387","DOI":"10.21037\/atm.2020.03.98","article-title":"Identification of m6A-related genes and m6A RNA methylation regulators in pancreatic cancer and their association with survival","volume":"8","author":"Geng","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.omtn.2021.04.002_bib15","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.bbrc.2019.06.128","article-title":"The m6A methyltransferase METTL3 promotes osteosarcoma progression by regulating the m6A level of LEF1","volume":"516","author":"Miao","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.omtn.2021.04.002_bib16","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s12943-019-1079-y","article-title":"Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively regulated by the m6A reader YTHDF3","volume":"18","author":"Ni","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.omtn.2021.04.002_bib17","doi-asserted-by":"crossref","first-page":"152666","DOI":"10.1016\/j.prp.2019.152666","article-title":"The RNA m6A methyltransferase METTL3 promotes pancreatic cancer cell proliferation and invasion","volume":"215","author":"Xia","year":"2019","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.omtn.2021.04.002_bib18","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/ejhf.1672","article-title":"Changes in m6A RNA methylation contribute to heart failure progression by modulating translation","volume":"22","author":"Berulava","year":"2020","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.omtn.2021.04.002_bib19","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3389\/fnins.2020.00098","article-title":"Abnormality of m6A mRNA methylation is involved in Alzheimer\u2019s disease","volume":"14","author":"Han","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.omtn.2021.04.002_bib20","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1002\/jcp.29005","article-title":"In silico genome-wide identification of m6A-associated SNPs as potential functional variants for periodontitis","volume":"235","author":"Lin","year":"2020","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.omtn.2021.04.002_bib21","doi-asserted-by":"crossref","first-page":"797","DOI":"10.21037\/atm.2019.12.65","article-title":"Increased m6A methylation level is associated with the progression of human abdominal aortic aneurysm","volume":"7","author":"He","year":"2019","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.omtn.2021.04.002_bib22","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00432-018-2796-0","article-title":"Novel positioning from obesity to cancer: FTO, an m6A RNA demethylase, regulates tumour progression","volume":"145","author":"Chen","year":"2019","journal-title":"J.\u00a0Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.omtn.2021.04.002_bib23","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1093\/nar\/gkz1206","article-title":"Integrative network analysis identifies cell-specific trans regulators of m6A","volume":"48","author":"An","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.omtn.2021.04.002_bib24","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/s41422-018-0040-8","article-title":"Dynamic transcriptomic m6A decoration: Writers, erasers, readers and functions in RNA metabolism","volume":"28","author":"Yang","year":"2018","journal-title":"Cell Res."},{"key":"10.1016\/j.omtn.2021.04.002_bib25","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1093\/jmcb\/mjz085","article-title":"Marking RNA: m6A writers, readers, and functions in Arabidopsis","volume":"11","author":"Reichel","year":"2019","journal-title":"J.\u00a0Mol. Cell Biol."},{"key":"10.1016\/j.omtn.2021.04.002_bib26","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.molcel.2019.04.025","article-title":"Where, when, and how: Context-dependent functions of RNA methylation writers, readers, and erasers","volume":"74","author":"Shi","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.omtn.2021.04.002_bib27","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.cell.2017.05.003","article-title":"The U6 snRNA m6A methyltransferase METTL16 regulates SAM synthetase intron retention","volume":"169","author":"Pendleton","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.omtn.2021.04.002_bib28","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.15252\/embr.201744940","article-title":"Human METTL16 is a N6-methyladenosine (m6A) methyltransferase that targets pre-mRNAs and various non-coding RNAs","volume":"18","author":"Warda","year":"2017","journal-title":"EMBO Rep."},{"key":"10.1016\/j.omtn.2021.04.002_bib29","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.3389\/fonc.2019.01403","article-title":"Multiple functions and mechanisms underlying the role of METTL3 in human cancers","volume":"9","author":"Zheng","year":"2019","journal-title":"Front. Oncol."},{"key":"10.1016\/j.omtn.2021.04.002_bib30","doi-asserted-by":"crossref","first-page":"3120391","DOI":"10.1155\/2019\/3120391","article-title":"METTL3 attenuates LPS-induced inflammatory response in macrophages via NF-\u03baB signaling pathway","volume":"2019","author":"Wang","year":"2019","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.omtn.2021.04.002_bib31","doi-asserted-by":"crossref","first-page":"160003","DOI":"10.1098\/rsob.160003","article-title":"Recent advances in dynamic m6A RNA modification","volume":"6","author":"Cao","year":"2016","journal-title":"Open Biol."},{"key":"10.1016\/j.omtn.2021.04.002_bib32","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.stem.2015.01.016","article-title":"m6A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency","volume":"16","author":"Chen","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.omtn.2021.04.002_bib33","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1146\/annurev-cellbio-100616-060758","article-title":"Rethinking m6A readers, writers, and erasers","volume":"33","author":"Meyer","year":"2017","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.omtn.2021.04.002_bib34","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nchembio.1432","article-title":"A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation","volume":"10","author":"Liu","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.omtn.2021.04.002_bib35","doi-asserted-by":"crossref","first-page":"e12573","DOI":"10.1111\/cpr.12573","article-title":"lncRNA Riken-201 and Riken-203 modulates neural development by regulating the Sox6 through sequestering miRNAs","volume":"52","author":"Zhang","year":"2019","journal-title":"Cell Prolif."},{"key":"10.1016\/j.omtn.2021.04.002_bib36","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12943-020-1146-4","article-title":"METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST","volume":"19","author":"Yang","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.omtn.2021.04.002_bib37","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s12943-020-01207-4","article-title":"Interaction between N6-methyladenosine\u00a0(m6A) modification and noncoding RNAs in cancer","volume":"19","author":"Chen","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.omtn.2021.04.002_bib38","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/cr.2014.3","article-title":"Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase","volume":"24","author":"Ping","year":"2014","journal-title":"Cell Res."},{"key":"10.1016\/j.omtn.2021.04.002_bib39","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1038\/s41418-020-0516-1","article-title":"Oocyte competence is maintained by m6A methyltransferase KIAA1429-mediated RNA metabolism during mouse follicular development","volume":"27","author":"Hu","year":"2020","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.omtn.2021.04.002_bib40","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1101\/gad.309146.117","article-title":"Zc3h13\/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15\/Spenito to the m6A machinery component Wtap\/Fl(2)d","volume":"32","author":"Knuckles","year":"2018","journal-title":"Genes Dev."},{"key":"10.1016\/j.omtn.2021.04.002_bib41","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3390\/cancers12010215","article-title":"Heat shock protein 90 chaperone regulates the E3 ubiquitin-ligase Hakai protein stability","volume":"12","author":"D\u00edaz-D\u00edaz","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.omtn.2021.04.002_bib42","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/nph.14586","article-title":"Identification of factors required for m6 A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI","volume":"215","author":"R\u016f\u017ei\u010dka","year":"2017","journal-title":"New Phytol."},{"key":"10.1016\/j.omtn.2021.04.002_bib43","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/nature19342","article-title":"m6A RNA methylation promotes XIST-mediated transcriptional repression","volume":"537","author":"Patil","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.omtn.2021.04.002_bib44","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1126\/science.aau1646","article-title":"RNA modifications modulate gene expression during development","volume":"361","author":"Frye","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.omtn.2021.04.002_bib45","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.cell.2015.05.014","article-title":"N6-methyladenosine modulates messenger RNA translation efficiency","volume":"161","author":"Wang","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.omtn.2021.04.002_bib46","doi-asserted-by":"crossref","first-page":"3816","DOI":"10.1093\/nar\/gkaa048","article-title":"The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation","volume":"48","author":"Liu","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.omtn.2021.04.002_bib47","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/s12943-019-1082-3","article-title":"YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma","volume":"18","author":"Hou","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.omtn.2021.04.002_bib48","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/cr.2017.15","article-title":"YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA","volume":"27","author":"Shi","year":"2017","journal-title":"Cell Res."},{"key":"10.1016\/j.omtn.2021.04.002_bib49","doi-asserted-by":"crossref","first-page":"e1008305","DOI":"10.1371\/journal.ppat.1008305","article-title":"HIV protease cleaves the antiviral m6A reader protein YTHDF3 in the viral particle","volume":"16","author":"Jurczyszak","year":"2020","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.omtn.2021.04.002_bib50","doi-asserted-by":"crossref","first-page":"e1007412","DOI":"10.1371\/journal.pgen.1007412","article-title":"Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development","volume":"14","author":"Kasowitz","year":"2018","journal-title":"PLoS Genet."},{"key":"10.1016\/j.omtn.2021.04.002_bib51","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.3390\/cancers11091233","article-title":"The oncogene metadherin interacts with the known splicing proteins YTHDC1, Sam68 and T-STAR and plays a novel role in alternative mRNA splicing","volume":"11","author":"Luxton","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.omtn.2021.04.002_bib52","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/s41556-018-0045-z","article-title":"Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation","volume":"20","author":"Huang","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.omtn.2021.04.002_bib53","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/s41417-020-0160-4","article-title":"RNA N6-methyladenosine modification in solid tumors: New therapeutic frontiers","volume":"27","author":"Melstrom","year":"2020","journal-title":"Cancer Gene Ther"},{"key":"10.1016\/j.omtn.2021.04.002_bib54","doi-asserted-by":"crossref","first-page":"536","DOI":"10.15252\/embr.201643139","article-title":"Nuclear retention of the lncRNA SNHG1 by doxorubicin attenuates hnRNPC-p53 protein interactions","volume":"18","author":"Shen","year":"2017","journal-title":"EMBO Rep."},{"key":"10.1016\/j.omtn.2021.04.002_bib55","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.molcel.2019.07.005","article-title":"Regulation of co-transcriptional pre-mRNA splicing by m6A through the low-complexity protein hnRNPG","volume":"76","author":"Zhou","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.omtn.2021.04.002_bib56","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/s41467-017-02770-z","article-title":"Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2\/B1","volume":"9","author":"Wu","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtn.2021.04.002_bib57","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.cell.2015.10.012","article-title":"5\u2032 UTR m6A promotes cap-independent translation","volume":"163","author":"Meyer","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.omtn.2021.04.002_bib58","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/s41580-019-0168-5","article-title":"Reading, writing and erasing mRNA methylation","volume":"20","author":"Zaccara","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.omtn.2021.04.002_bib59","doi-asserted-by":"crossref","first-page":"19889","DOI":"10.1074\/jbc.AC119.010078","article-title":"The RNA-binding protein FMRP facilitates the nuclear export of N6-methyladenosine-containing mRNAs","volume":"294","author":"Hsu","year":"2019","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.omtn.2021.04.002_bib60","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41422-018-0113-8","article-title":"A novel m6A reader Prrc2a controls oligodendroglial specification and myelination","volume":"29","author":"Wu","year":"2019","journal-title":"Cell Res."},{"key":"10.1016\/j.omtn.2021.04.002_bib61","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.molcel.2016.03.021","article-title":"The m6A methyltransferase METTL3 promotes translation in human cancer cells","volume":"62","author":"Lin","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.omtn.2021.04.002_bib62","doi-asserted-by":"crossref","first-page":"17249","DOI":"10.1021\/jacs.7b09213","article-title":"RNA chemical proteomics reveals the N6-methyladenosine (m6A)-regulated protein-RNA interactome","volume":"139","author":"Arguello","year":"2017","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.omtn.2021.04.002_bib63","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nchembio.687","article-title":"N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO","volume":"7","author":"Jia","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.omtn.2021.04.002_bib64","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1038\/s41467-019-10669-0","article-title":"m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade","volume":"10","author":"Yang","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtn.2021.04.002_bib65","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1080\/15476286.2019.1621120","article-title":"The dynamics of FTO binding and demethylation from the m6A motifs","volume":"16","author":"Li","year":"2019","journal-title":"RNA Biol."},{"key":"10.1016\/j.omtn.2021.04.002_bib66","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.molcel.2012.10.015","article-title":"ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility","volume":"49","author":"Zheng","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.omtn.2021.04.002_bib67","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12935-020-1105-6","article-title":"ALKBH5-mediated m6A demethylation of lncRNA PVT1 plays an oncogenic role in osteosarcoma","volume":"20","author":"Chen","year":"2020","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.omtn.2021.04.002_bib68","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12943-019-1128-6","article-title":"m(6)A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling","volume":"19","author":"Tang","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.omtn.2021.04.002_bib69","doi-asserted-by":"crossref","first-page":"E325","DOI":"10.1073\/pnas.1717794115","article-title":"ALKBH5-dependent m6A demethylation controls splicing and stability of long 3\u2032-UTR mRNAs in male germ cells","volume":"115","author":"Tang","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtn.2021.04.002_bib70","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s12943-019-1099-7","article-title":"N6-methyladenosine (m6A) RNA modification in gastrointestinal tract cancers: roles, mechanisms, and applications","volume":"18","author":"Hu","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.omtn.2021.04.002_bib71","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1105\/tpc.16.00912","article-title":"ALKBH10B is an RNA N6-methyladenosine demethylase affecting arabidopsis floral transition","volume":"29","author":"Duan","year":"2017","journal-title":"Plant Cell"},{"key":"10.1016\/j.omtn.2021.04.002_bib72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-981-10-5203-3_1","article-title":"History, discovery, and classification of lncRNAs","volume":"1008","author":"Jarroux","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.omtn.2021.04.002_bib73","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1101\/gad.1800909","article-title":"Long noncoding RNAs: Functional surprises from the RNA world","volume":"23","author":"Wilusz","year":"2009","journal-title":"Genes Dev."},{"key":"10.1016\/j.omtn.2021.04.002_bib74","doi-asserted-by":"crossref","first-page":"e1376","DOI":"10.1002\/wrna.1376","article-title":"Evolutionary clues in lncRNAs","volume":"8","author":"Nitsche","year":"2017","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"10.1016\/j.omtn.2021.04.002_bib75","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nature07672","article-title":"Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals","volume":"458","author":"Guttman","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.omtn.2021.04.002_bib76","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/nature12943","article-title":"The evolution of lncRNA repertoires and expression patterns in tetrapods","volume":"505","author":"Necsulea","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.omtn.2021.04.002_bib77","doi-asserted-by":"crossref","first-page":"9029351","DOI":"10.1155\/2019\/9029351","article-title":"Portrait of tissue-specific coexpression networks of noncoding RNAs (miRNA and lncRNA) and mRNAs in normal tissues","volume":"2019","author":"Cava","year":"2019","journal-title":"Comput. Math. Methods Med."},{"key":"10.1016\/j.omtn.2021.04.002_bib78","doi-asserted-by":"crossref","first-page":"6768","DOI":"10.1002\/cam4.1302","article-title":"lncRNA HOTAIR promotes gastric cancer proliferation and metastasis via targeting miR-126 to active CXCR4 and RhoA signaling pathway","volume":"8","author":"Xiao","year":"2019","journal-title":"Cancer Med"},{"key":"10.1016\/j.omtn.2021.04.002_bib79","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s12935-018-0674-0","article-title":"Research progresses in roles of lncRNA and its relationships with breast cancer","volume":"18","author":"Bin","year":"2018","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.omtn.2021.04.002_bib80","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41392-019-0080-7","article-title":"The roles of exosomal miRNAs and lncRNAs in lung diseases","volume":"4","author":"Li","year":"2019","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.omtn.2021.04.002_bib81","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.3390\/ijms21103580","article-title":"Exosomal long non-coding RNAs in lung diseases","volume":"21","author":"Poulet","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.omtn.2021.04.002_bib82","doi-asserted-by":"crossref","first-page":"20721","DOI":"10.1002\/jcp.28678","article-title":"Tumor-derived exosomal lncRNA GAS5 as a biomarker for early-stage non-small-cell lung cancer diagnosis","volume":"234","author":"Li","year":"2019","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.omtn.2021.04.002_bib83","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1089\/dna.2017.3857","article-title":"Transcription factor YY1 modulates lung cancer progression by activating lncRNA-PVT1","volume":"36","author":"Huang","year":"2017","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.omtn.2021.04.002_bib84","first-page":"387","article-title":"Long noncoding RNA HOTAIR contributes to progression in hepatocellular carcinoma by sponging miR-217-5p","volume":"35","author":"Gong","year":"2020","journal-title":"Cancer Biother. Radiopharm."},{"key":"10.1016\/j.omtn.2021.04.002_bib85","first-page":"348","article-title":"Serum long noncoding RNA urothelial carcinoma-associated 1: A novel biomarker for diagnosis and prognosis of hepatocellular carcinoma","volume":"46","author":"Zheng","year":"2018","journal-title":"J.\u00a0Int. Med. Res."},{"key":"10.1016\/j.omtn.2021.04.002_bib86","doi-asserted-by":"crossref","first-page":"104848","DOI":"10.1016\/j.phrs.2020.104848","article-title":"Long non-coding RNAs in hepatocellular carcinoma: Ordering of the complicated lncRNA regulatory network and novel strategies for HCC clinical diagnosis and treatment","volume":"158","author":"Li","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.omtn.2021.04.002_bib87","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.bbrc.2019.11.016","article-title":"lncRNA LINC00470 promotes the degradation of PTEN mRNA to facilitate malignant behavior in gastric cancer cells","volume":"521","author":"Yan","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.omtn.2021.04.002_bib88","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12943-019-1032-0","article-title":"The lncRNA UCA1 promotes proliferation, migration, immune escape and inhibits apoptosis in gastric cancer by sponging anti-tumor miRNAs","volume":"18","author":"Wang","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.omtn.2021.04.002_bib89","doi-asserted-by":"crossref","first-page":"11516","DOI":"10.1038\/srep11516","article-title":"Identification of the long non-coding RNA H19 in plasma as a novel biomarker for diagnosis of gastric cancer","volume":"5","author":"Zhou","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omtn.2021.04.002_bib90","doi-asserted-by":"crossref","first-page":"14467","DOI":"10.1111\/jcmm.16069","article-title":"Correlation between lncRNA-LINC00659 and clinical prognosis in gastric cancer and study on its biological mechanism","volume":"24","author":"Sheng","year":"2020","journal-title":"J.\u00a0Cell. Mol. Med."},{"key":"10.1016\/j.omtn.2021.04.002_bib91","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s10020-020-00156-4","article-title":"Long non-coding RNA H19, a novel therapeutic target for pancreatic cancer","volume":"26","author":"Wang","year":"2020","journal-title":"Mol. Med."},{"key":"10.1016\/j.omtn.2021.04.002_bib92","doi-asserted-by":"crossref","first-page":"5811","DOI":"10.1038\/s41388-018-0382-1","article-title":"Hypoxia-induced lncRNA-BX111 promotes metastasis and progression of pancreatic cancer through regulating ZEB1 transcription","volume":"37","author":"Deng","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.omtn.2021.04.002_bib93","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1158\/0008-5472.CAN-18-0419","article-title":"Nutrient stress-dysregulated antisense lncRNA GLS-AS impairs GLS-mediated metabolism and represses pancreatic cancer progression","volume":"79","author":"Deng","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.omtn.2021.04.002_bib94","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.omtn.2019.12.009","article-title":"Circulating lncRNA UCA1 promotes malignancy of colorectal cancer via the miR-143\/MYO6 axis","volume":"19","author":"Luan","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.omtn.2021.04.002_bib95","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1002\/mc.22868","article-title":"MALAT1 promotes the colorectal cancer malignancy by increasing DCP1A expression and miR203 downregulation","volume":"57","author":"Wu","year":"2018","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.omtn.2021.04.002_bib96","doi-asserted-by":"crossref","first-page":"e12398","DOI":"10.1111\/cpr.12398","article-title":"Long non-coding RNA PVT1: Emerging biomarker in digestive system cancer","volume":"50","author":"Zhou","year":"2017","journal-title":"Cell Prolif."},{"key":"10.1016\/j.omtn.2021.04.002_bib97","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12943-017-0583-1","article-title":"The lncRNA CRNDE promotes colorectal cancer cell proliferation and chemoresistance via miR-181a-5p-mediated regulation of Wnt\/\u03b2-catenin signaling","volume":"16","author":"Han","year":"2017","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.omtn.2021.04.002_bib98","doi-asserted-by":"crossref","first-page":"473","DOI":"10.3390\/ijms18020473","article-title":"Current insights into long non-coding RNAs (lncRNAs) in prostate cancer","volume":"18","author":"Smolle","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.omtn.2021.04.002_bib99","first-page":"2278","article-title":"Long noncoding RNA MALAT-1 is a new potential therapeutic target for castration resistant prostate cancer","volume":"190","author":"Ren","year":"2013","journal-title":"J.\u00a0Urol."},{"key":"10.1016\/j.omtn.2021.04.002_bib100","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.cca.2017.12.009","article-title":"mRNA, microRNA and lncRNA as novel bladder tumor markers","volume":"477","author":"Wieczorek","year":"2018","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.omtn.2021.04.002_bib101","doi-asserted-by":"crossref","first-page":"6415","DOI":"10.2147\/OTT.S167853","article-title":"lncRNA as a diagnostic and prognostic biomarker in bladder cancer: A systematic review and meta-analysis","volume":"11","author":"Quan","year":"2018","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.omtn.2021.04.002_bib102","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.canlet.2016.01.039","article-title":"A novel cell cycle-associated lncRNA, HOXA11-AS, is transcribed from the 5-prime end of the HOXA transcript and is a biomarker of progression in glioma","volume":"373","author":"Wang","year":"2016","journal-title":"Cancer Lett."},{"key":"10.1016\/j.omtn.2021.04.002_bib103","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/cns.13152","article-title":"lncRNA FOXD1-AS1 acts as a potential oncogenic biomarker in glioma","volume":"26","author":"Gao","year":"2020","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.omtn.2021.04.002_bib104","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1186\/s13046-019-1361-2","article-title":"Inhibition of COX-2, mPGES-1 and CYP4A by isoliquiritigenin blocks the angiogenic Akt signaling in glioma through ceRNA effect of miR-194-5p and lncRNA NEAT1","volume":"38","author":"Wang","year":"2019","journal-title":"J.\u00a0Exp. Clin. Cancer Res."},{"key":"10.1016\/j.omtn.2021.04.002_bib105","article-title":"lncRNA ANCR promotes glioma cells invasion, migration, proliferation and inhibits apoptosis via interacting with EZH2 and repressing PTEN expression","author":"Cheng","year":"2020","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.omtn.2021.04.002_bib106","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1002\/jcb.29417","article-title":"lncRNA PCED1B-AS1 activates the proliferation and restricts the apoptosis of glioma through cooperating with miR-194-5p\/PCED1B axis","volume":"121","author":"Yang","year":"2020","journal-title":"J.\u00a0Cell. Biochem."},{"key":"10.1016\/j.omtn.2021.04.002_bib107","first-page":"613","article-title":"Re: The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI\/SNF complex","volume":"192","author":"Atala","year":"2014","journal-title":"J.\u00a0Urol."},{"key":"10.1016\/j.omtn.2021.04.002_bib108","doi-asserted-by":"crossref","first-page":"a018382","DOI":"10.1101\/cshperspect.a018382","article-title":"Genomic imprinting in mammals","volume":"6","author":"Barlow","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.omtn.2021.04.002_bib109","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.bbagrm.2018.12.002","article-title":"m6A modification of non-coding RNA and the control of mammalian gene expression","volume":"1862","author":"Coker","year":"2019","journal-title":"Biochim. Biophys. Acta. Gene Regul. Mech."},{"key":"10.1016\/j.omtn.2021.04.002_bib110","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/s13046-020-01748-y","article-title":"Long noncoding RNA UPK1A-AS1 indicates poor prognosis of hepatocellular carcinoma and promotes cell proliferation through interaction with EZH2","volume":"39","author":"Zhang","year":"2020","journal-title":"J.\u00a0Exp. Clin. Cancer Res."},{"key":"10.1016\/j.omtn.2021.04.002_bib111","doi-asserted-by":"crossref","first-page":"e97174","DOI":"10.15252\/embj.201797174","article-title":"LncKdm2b controls self-renewal of embryonic stem cells via activating expression of transcription factor Zbtb3","volume":"37","author":"Ye","year":"2018","journal-title":"EMBO J."},{"key":"10.1016\/j.omtn.2021.04.002_bib112","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/ni.3712","article-title":"Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression","volume":"18","author":"Liu","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.omtn.2021.04.002_bib113","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.cell.2010.09.001","article-title":"Long noncoding RNAs with enhancer-like function in human cells","volume":"143","author":"\u00d8rom","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.omtn.2021.04.002_bib114","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.jacc.2015.12.051","article-title":"Long Noncoding RNAs: From Clinical Genetics to Therapeutic Targets?","volume":"67","author":"Boon","year":"2016","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.omtn.2021.04.002_bib115","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/jcsm.12281","article-title":"A newly identified lncRNA MAR1 acts as a miR-487b sponge to promote skeletal muscle differentiation and regeneration","volume":"9","author":"Zhang","year":"2018","journal-title":"J.\u00a0Cachexia Sarcopenia Muscle"},{"issue":"Pt A","key":"10.1016\/j.omtn.2021.04.002_bib116","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.yjmcc.2015.09.016","article-title":"CARMEN, a human super enhancer-associated long noncoding RNA controlling cardiac specification, differentiation and homeostasis","volume":"89","author":"Ounzain","year":"2015","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.omtn.2021.04.002_bib117","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s13045-019-0805-7","article-title":"The interplay between m6A RNA methylation and noncoding RNA in cancer","volume":"12","author":"Ma","year":"2019","journal-title":"J.\u00a0Hematol. Oncol."},{"key":"10.1016\/j.omtn.2021.04.002_bib118","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/s41586-020-1974-9","article-title":"SPEN integrates transcriptional and epigenetic control of X-inactivation","volume":"578","author":"Dossin","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.omtn.2021.04.002_bib119","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.bbagrm.2018.10.014","article-title":"Mechanistic insights into m6A RNA enzymes","volume":"1862","author":"Lence","year":"2019","journal-title":"Biochim. Biophys. Acta. Gene Regul. Mech."},{"key":"10.1016\/j.omtn.2021.04.002_bib120","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1002\/jcp.30023","article-title":"m6A transferase METTL3-induced lncRNA ABHD11-AS1 promotes the Warburg effect of non-small-cell lung cancer","volume":"236","author":"Xue","year":"2021","journal-title":"J Cell. Physiol"},{"key":"10.1016\/j.omtn.2021.04.002_bib121","doi-asserted-by":"crossref","first-page":"771","DOI":"10.3390\/cancers12040771","article-title":"VIRMA-dependent N6-methyladenosine modifications regulate the expression of long non-coding RNAs CCAT1 and CCAT2 in prostate cancer","volume":"12","author":"Barros-Silva","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.omtn.2021.04.002_bib122","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/nature14234","article-title":"N6-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions","volume":"518","author":"Liu","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.omtn.2021.04.002_bib123","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1158\/0008-5472.CAN-20-1619","article-title":"DMDRMR-mediated regulation of m6A-modified CDK4 by m6A reader IGF2BP3 drives ccRCC progression","volume":"81","author":"Gu","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.omtn.2021.04.002_bib124","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.gpb.2017.03.002","article-title":"The RNA modification N6-methyladenosine and its implications in human disease","volume":"15","author":"Batista","year":"2017","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"10.1016\/j.omtn.2021.04.002_bib125","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1038\/s41418-019-0461-z","article-title":"IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader","volume":"27","author":"Hu","year":"2020","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.omtn.2021.04.002_bib126","doi-asserted-by":"crossref","first-page":"5626","DOI":"10.1074\/jbc.RA119.011556","article-title":"Long noncoding RNA pncRNA-D reduces cyclin D1 gene expression and arrests cell cycle through RNA m6A modification","volume":"295","author":"Yoneda","year":"2020","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.omtn.2021.04.002_bib127","first-page":"2346","article-title":"Epigenetic regulation of alternative splicing","volume":"8","author":"Zhu","year":"2018","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.omtn.2021.04.002_bib128","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1158\/2326-6066.CIR-18-0443","article-title":"The pseudogene Olfr29-ps1 promotes the suppressive function and differentiation of monocytic MDSCs","volume":"7","author":"Shang","year":"2019","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.omtn.2021.04.002_bib129","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1038\/s41467-020-15403-9","article-title":"An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis","volume":"11","author":"Zhu","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtn.2021.04.002_bib130","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1158\/0008-5472.CAN-20-0961","article-title":"When the smoke clears m6A from a Y chromosome-linked lncRNA, men get an increased risk of cancer","volume":"80","author":"Banday","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.omtn.2021.04.002_bib131","first-page":"9250512","article-title":"Dexmedetomidine postconditioning alleviates hypoxia\/reoxygenation injury in senescent myocardial cells by regulating lncRNA H19 and m6A modification","volume":"2020","author":"Zhang","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.omtn.2021.04.002_bib132","doi-asserted-by":"crossref","first-page":"629947","DOI":"10.3389\/fonc.2021.629947","article-title":"m6A-mediated upregulation of LINC00857 promotes pancreatic cancer tumorigenesis by regulating the miR-150-5p\/E2F3 axis","volume":"11","author":"Meng","year":"2021","journal-title":"Front. Oncol"},{"key":"10.1016\/j.omtn.2021.04.002_bib133","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.3390\/ijms18112387","article-title":"The dark side of the epitranscriptome: Chemical modifications in long non-coding RNAs","volume":"18","author":"Jacob","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.omtn.2021.04.002_bib134","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1261\/rna.041178.113","article-title":"Probing N6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA","volume":"19","author":"Liu","year":"2013","journal-title":"RNA"},{"key":"10.1016\/j.omtn.2021.04.002_bib135","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/s41419-020-02795-1","article-title":"Nuclear export of chimeric mRNAs depends on an lncRNA-triggered autoregulatory loop in blood malignancies","volume":"11","author":"Chen","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.omtn.2021.04.002_bib136","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.devcel.2021.01.015","article-title":"N6-methyladenosine modification of MALAT1 promotes metastasis via reshaping nuclear speckles","volume":"56","author":"Wang","year":"2021","journal-title":"Dev. Cell"},{"key":"10.1016\/j.omtn.2021.04.002_bib137","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/j.cell.2012.05.003","article-title":"Comprehensive analysis of mRNA methylation reveals enrichment in 3\u2032 UTRs and near stop codons","volume":"149","author":"Meyer","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.omtn.2021.04.002_bib138","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nature11112","article-title":"Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq","volume":"485","author":"Dominissini","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.omtn.2021.04.002_bib139","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ab.2019.05.005","article-title":"Role of identified RNA N6-methyladenosine methylation in liver","volume":"578","author":"Xu","year":"2019","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.omtn.2021.04.002_bib140","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.1158\/0008-5472.CAN-19-3440","article-title":"A novel micropeptide encoded by Y-linked LINC00278 links cigarette smoking and AR signaling in male esophageal squamous cell carcinoma","volume":"80","author":"Wu","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.omtn.2021.04.002_bib141","doi-asserted-by":"crossref","first-page":"5358","DOI":"10.1038\/s41388-020-1338-9","article-title":"LNC942 promoting METTL14-mediated m6A methylation in breast cancer cell proliferation and progression","volume":"39","author":"Sun","year":"2020","journal-title":"Oncogene"},{"key":"10.1016\/j.omtn.2021.04.002_bib142","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s12943-019-1014-2","article-title":"m6A-induced lncRNA RP11 triggers the dissemination of colorectal cancer cells via upregulation of Zeb1","volume":"18","author":"Wu","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.omtn.2021.04.002_bib143","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1038\/s41388-020-01638-9","article-title":"A novel hypoxic long noncoding RNA KB-1980E6.3 maintains breast cancer stem cell stemness via interacting with IGF2BP1 to facilitate c-Myc mRNA stability","volume":"40","author":"Zhu","year":"2021","journal-title":"Oncogene"},{"key":"10.1016\/j.omtn.2021.04.002_bib144","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13046-021-01857-2","article-title":"LINC00460\/DHX9\/IGF2BP2 complex promotes colorectal cancer proliferation and metastasis by mediating HMGA1 mRNA stability depending on m6A modification","volume":"40","author":"Hou","year":"2021","journal-title":"J.\u00a0Exp. Clin. Cancer Res."},{"key":"10.1016\/j.omtn.2021.04.002_bib145","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41420-020-00382-z","article-title":"m6A-induced LINC00958 promotes breast cancer tumorigenesis via the miR-378a-3p\/YY1 axis","volume":"7","author":"Rong","year":"2021","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.omtn.2021.04.002_bib146","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1159\/000491915","article-title":"ALKBH5 inhibits pancreatic cancer motility by decreasing long non-coding RNA KCNK15-AS1 methylation","volume":"48","author":"He","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.omtn.2021.04.002_bib147","doi-asserted-by":"crossref","first-page":"4612","DOI":"10.1158\/0008-5472.CAN-19-0799","article-title":"Long noncoding RNA FAM225A promotes nasopharyngeal carcinoma tumorigenesis and metastasis by acting as ceRNA to sponge miR-590-3p\/miR-1275 and upregulate ITGB3","volume":"79","author":"Zheng","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.omtn.2021.04.002_bib148","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1002\/1878-0261.12676","article-title":"LNCAROD is stabilized by m6A methylation and promotes cancer progression via forming a ternary complex with HSPA1A and YBX1 in head and neck squamous cell carcinoma","volume":"14","author":"Ban","year":"2020","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.omtn.2021.04.002_bib149","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/s12943-020-01293-4","article-title":"Long non-coding RNA NEAT1 promotes bone metastasis of prostate cancer through N6-methyladenosine","volume":"19","author":"Wen","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.omtn.2021.04.002_bib150","doi-asserted-by":"crossref","first-page":"4558","DOI":"10.18632\/aging.102911","article-title":"Long non-coding RNA RHPN1-AS1 promotes tumorigenesis and metastasis of ovarian cancer by acting as a ceRNA against miR-596 and upregulating LETM1","volume":"12","author":"Wang","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.omtn.2021.04.002_bib151","doi-asserted-by":"crossref","DOI":"10.1038\/s41374-021-00543-3","article-title":"). N-methyladenosine reader YTHDF2-mediated long noncoding RNA FENDRR degradation promotes cell proliferation in endometrioid endometrial carcinoma","author":"Shen","year":"2021","journal-title":"Lab. Invest"},{"key":"10.1016\/j.omtn.2021.04.002_bib152","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1111\/febs.13614","article-title":"N6-methyladenosine modification in mRNA: Machinery, function and implications for health and diseases","volume":"283","author":"Maity","year":"2016","journal-title":"FEBS J."}],"container-title":["Molecular Therapy Nucleic Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253121000962?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253121000962?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T16:50:09Z","timestamp":1788540609000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2162253121000962"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":152,"alternative-id":["S2162253121000962"],"URL":"https:\/\/doi.org\/10.1016\/j.omtn.2021.04.002","relation":{},"ISSN":["2162-2531"],"issn-type":[{"value":"2162-2531","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of M6A modification in the regulation of tumor-related lncRNAs","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy Nucleic Acids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omtn.2021.04.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors.","name":"copyright","label":"Copyright"}]}}