{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:24:53Z","timestamp":1778739893565,"version":"3.51.4"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873819"],"award-info":[{"award-number":["81873819"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ20H040010"],"award-info":[{"award-number":["LQ20H040010"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1003201"],"award-info":[{"award-number":["2018YFC1003201"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy - Nucleic Acids"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.omtn.2021.06.012","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T08:54:53Z","timestamp":1624524893000},"page":"1433-1445","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["circRNA-DURSA regulates trophoblast apoptosis via miR-760-HIST1H2BE axis in unexplained recurrent spontaneous abortion"],"prefix":"10.1016","volume":"26","author":[{"given":"Minyue","family":"Tang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeqing","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiali","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoling","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yimin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.omtn.2021.06.012_bib1","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.fertnstert.2012.06.048","article-title":"Evaluation and treatment of recurrent pregnancy loss: a committee opinion","volume":"98","year":"2012","journal-title":"Fertil. Steril"},{"key":"10.1016\/j.omtn.2021.06.012_bib2","first-page":"hoy004","article-title":"ESHRE guideline: Recurrent pregnancy loss","volume":"Open 2","author":"Bender Atik","year":"2018","journal-title":"Hum. Reprod"},{"key":"10.1016\/j.omtn.2021.06.012_bib3","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1093\/humrep\/17.2.446","article-title":"Cytogenetic analysis of miscarriages from couples with recurrent miscarriage: A case-control study","volume":"17","author":"Stephenson","year":"2002","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.omtn.2021.06.012_bib4","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1097\/OGX.0b013e31828aca19","article-title":"Current concepts and new trends in the diagnosis and management of recurrent miscarriage","volume":"68","author":"Alijotas-Reig","year":"2013","journal-title":"Obstet. Gynecol. Surv."},{"key":"10.1016\/j.omtn.2021.06.012_bib5","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1111\/j.1600-0897.2010.00847.x","article-title":"Immunological modes of pregnancy loss. Am","volume":"63","author":"Kwak-Kim","year":"2010","journal-title":"J.\u00a0Reprod. Immunol"},{"key":"10.1016\/j.omtn.2021.06.012_bib6","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1600-0897.2010.00837.x","article-title":"Placental apoptosis in health and disease","volume":"64","author":"Sharp","year":"2010","journal-title":"Am. J. Reprod. Immunol"},{"key":"10.1016\/j.omtn.2021.06.012_bib7","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ajog.2005.07.039","article-title":"Apoptosis and its role in the trophoblast","volume":"195","author":"Huppertz","year":"2006","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"Suppl","key":"10.1016\/j.omtn.2021.06.012_bib8","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1016\/j.placenta.2005.02.002","article-title":"Extravillous trophoblast apoptosis\u2014A workshop report","volume":"26","author":"Huppertz","year":"2005","journal-title":"Placenta"},{"key":"10.1016\/j.omtn.2021.06.012_bib9","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1007\/s00335-008-9136-7","article-title":"Noncoding RNA in development","volume":"19","author":"Amaral","year":"2008","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.omtn.2021.06.012_bib10","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1101\/gad.1800909","article-title":"Long noncoding RNAs: Functional surprises from the RNA world","volume":"23","author":"Wilusz","year":"2009","journal-title":"Genes Dev."},{"key":"10.1016\/j.omtn.2021.06.012_bib11","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.canlet.2015.06.003","article-title":"Circular RNA: A new star of noncoding RNAs","volume":"365","author":"Qu","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.omtn.2021.06.012_bib12","doi-asserted-by":"crossref","first-page":"8834","DOI":"10.7150\/thno.45158","article-title":"LXR activation potentiates sorafenib sensitivity in HCC by activating microRNA-378a transcription","volume":"10","author":"Lin","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.omtn.2021.06.012_bib13","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: Target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"issue":"4, Suppl","key":"10.1016\/j.omtn.2021.06.012_bib14","doi-asserted-by":"crossref","first-page":"S163","DOI":"10.1016\/j.ajog.2015.05.057","article-title":"MicroRNAs in placental health and disease","volume":"213","author":"Mouillet","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.omtn.2021.06.012_bib15","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/jhh.2014.35","article-title":"miR-101 regulates apoptosis of trophoblast HTR-8\/SVneo cells by targeting endoplasmic reticulum (ER) protein 44 during preeclampsia","volume":"28","author":"Zou","year":"2014","journal-title":"J.\u00a0Hum. Hypertens."},{"key":"10.1016\/j.omtn.2021.06.012_bib16","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41419-019-1443-2","article-title":"MicroRNA-184 promotes apoptosis of trophoblast cells via targeting WIG1 and induces early spontaneous abortion","volume":"10","author":"Zhang","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.omtn.2021.06.012_bib17","doi-asserted-by":"crossref","first-page":"FSO314","DOI":"10.4155\/fsoa-2018-0036","article-title":"Circular RNAs as novel biomarkers with regulatory potency in human diseases","volume":"4","author":"Fang","year":"2018","journal-title":"Future Sci. OA"},{"key":"10.1016\/j.omtn.2021.06.012_bib18","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.canlet.2018.10.040","article-title":"A novel circular RNA, circFAT1(e2), inhibits gastric cancer progression by targeting miR-548g in the cytoplasm and interacting with YBX1 in the nucleus","volume":"442","author":"Fang","year":"2019","journal-title":"Cancer Lett."},{"key":"10.1016\/j.omtn.2021.06.012_bib19","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12943-018-0933-7","article-title":"The circRNA circAGFG1 acts as a sponge of miR-195-5p to promote triple-negative breast cancer progression through regulating CCNE1 expression","volume":"18","author":"Yang","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.omtn.2021.06.012_bib20","doi-asserted-by":"crossref","first-page":"3842","DOI":"10.7150\/thno.19764","article-title":"A circular RNA binds to and activates AKT phosphorylation and nuclear localization reducing apoptosis and enhancing cardiac repair","volume":"7","author":"Zeng","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/j.omtn.2021.06.012_bib21","doi-asserted-by":"crossref","first-page":"e1003777","DOI":"10.1371\/journal.pgen.1003777","article-title":"Cell-type specific features of circular RNA expression","volume":"9","author":"Salzman","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.omtn.2021.06.012_bib22","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/cr.2015.82","article-title":"Circular RNA is enriched and stable in exosomes: A promising biomarker for cancer diagnosis","volume":"25","author":"Li","year":"2015","journal-title":"Cell Res."},{"key":"10.1016\/j.omtn.2021.06.012_bib23","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3389\/fgene.2013.00307","article-title":"Circular RNA (circRNA) in Alzheimer\u2019s disease (AD)","volume":"4","author":"Lukiw","year":"2013","journal-title":"Front. Genet."},{"key":"10.1016\/j.omtn.2021.06.012_bib24","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s12943-017-0663-2","article-title":"CircRNA: Functions and properties of a novel potential biomarker for cancer","volume":"16","author":"Meng","year":"2017","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.omtn.2021.06.012_bib25","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s13059-016-0991-3","article-title":"Tracing the expression of circular RNAs in human pre-implantation embryos","volume":"17","author":"Dang","year":"2016","journal-title":"Genome Biol."},{"key":"10.1016\/j.omtn.2021.06.012_bib26","first-page":"2576","article-title":"circRNA-0004904, circRNA-0001855, and PAPP-A: Potential novel biomarkers for the prediction of preeclampsia. Cell","volume":"46","author":"Jiang","year":"2018","journal-title":"Physiol. Biochem."},{"key":"10.1016\/j.omtn.2021.06.012_bib27","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1159\/000484887","article-title":"Altered circular RNA expression in patients with repeated implantation failure","volume":"44","author":"Liu","year":"2017","journal-title":"Cell. Physiol. Biochem"},{"key":"10.1016\/j.omtn.2021.06.012_bib28","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.cell.2011.07.014","article-title":"A ceRNA hypothesis: The Rosetta Stone of a hidden RNA language?","volume":"146","author":"Salmena","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.omtn.2021.06.012_bib29","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nature12986","article-title":"The multilayered complexity of ceRNA crosstalk and competition","volume":"505","author":"Tay","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.omtn.2021.06.012_bib30","doi-asserted-by":"crossref","first-page":"287.e1","DOI":"10.1016\/j.ajog.2016.12.029","article-title":"Failure of physiologic transformation of spiral arteries, endothelial and trophoblast cell activation, and acute atherosis in the basal plate of the placenta","volume":"216","author":"Labarrere","year":"2017","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.omtn.2021.06.012_bib31","doi-asserted-by":"crossref","first-page":"e2908","DOI":"10.1038\/cddis.2017.301","article-title":"Role of peroxiredoxin2 downregulation in recurrent miscarriage through regulation of trophoblast proliferation and apoptosis","volume":"8","author":"Wu","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.omtn.2021.06.012_bib32","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1177\/1933719117725816","article-title":"Impact of galectin-1 on trophoblast stem cell differentiation and invasion in in\u00a0vitro implantation model","volume":"25","author":"Tang","year":"2018","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.omtn.2021.06.012_bib33","doi-asserted-by":"crossref","first-page":"249.e1","DOI":"10.1016\/j.ajog.2017.11.568","article-title":"MicroRNA-30a-3p is overexpressed in the placentas of patients with preeclampsia and affects trophoblast invasion and apoptosis by its effects on IGF-1","volume":"218","author":"Niu","year":"2018","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.omtn.2021.06.012_bib34","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jri.2011.12.004","article-title":"Association of FAS \u22121377 G>A and FAS \u2212670 A>G functional polymorphisms of FAS gene of cell death pathway with recurrent early pregnancy loss risk","volume":"93","author":"Nair","year":"2012","journal-title":"J.\u00a0Reprod. Immunol."},{"key":"10.1016\/j.omtn.2021.06.012_bib35","first-page":"2376","article-title":"FasL on decidual macrophages mediates trophoblast apoptosis: A potential cause of recurrent miscarriage","volume":"43","author":"Ding","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.omtn.2021.06.012_bib36","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1080\/09513590.2016.1266476","article-title":"miR-520 promotes DNA-damage-induced trophoblast cell apoptosis by targeting PARP1 in recurrent spontaneous abortion (RSA)","volume":"33","author":"Dong","year":"2017","journal-title":"Gynecol. Endocrinol"},{"key":"10.1016\/j.omtn.2021.06.012_bib37","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature11993","article-title":"Natural RNA circles function as efficient microRNA sponges","volume":"495","author":"Hansen","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.omtn.2021.06.012_bib38","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1002\/hep.29270","article-title":"Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression","volume":"66","author":"Han","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.omtn.2021.06.012_bib39","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1038\/cdd.2017.61","article-title":"Circular RNA mediates cardiomyocyte death via miRNA-dependent upregulation of MTP18 expression","volume":"24","author":"Wang","year":"2017","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.omtn.2021.06.012_bib40","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.jgg.2018.08.004","article-title":"The present and future of whole-exome sequencing in studying and treating human reproductive disorders","volume":"45","author":"Guo","year":"2018","journal-title":"J.\u00a0Genet. Genomics"},{"key":"10.1016\/j.omtn.2021.06.012_bib41","doi-asserted-by":"crossref","first-page":"7090767","DOI":"10.1155\/2019\/7090767","article-title":"Noncoding RNAs in unexplained recurrent spontaneous abortions and their diagnostic potential","volume":"2019","author":"Jia","year":"2019","journal-title":"Dis. Markers"},{"key":"10.1016\/j.omtn.2021.06.012_bib42","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.dnarep.2015.09.012","article-title":"Nucleosome positioning, nucleotide excision repair and photoreactivation in Saccharomyces cerevisiae","volume":"36","author":"Guintini","year":"2015","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.omtn.2021.06.012_bib43","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.dnarep.2015.04.021","article-title":"Accessing DNA damage in chromatin: Preparing the chromatin landscape for base excision repair","volume":"32","author":"Rodriguez","year":"2015","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.omtn.2021.06.012_bib44","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s12672-015-0230-5","article-title":"A role for histone H2B variants in endocrine-resistant breast cancer","volume":"6","author":"Nayak","year":"2015","journal-title":"Horm. Cancer"},{"key":"10.1016\/j.omtn.2021.06.012_bib45","doi-asserted-by":"crossref","first-page":"6438","DOI":"10.1158\/1078-0432.CCR-12-3186","article-title":"Contrasting expression patterns of histone mRNA and microRNA 760 in patients with gastric cancer","volume":"19","author":"Iwaya","year":"2013","journal-title":"Clin. Cancer Res"},{"key":"10.1016\/j.omtn.2021.06.012_bib46","doi-asserted-by":"crossref","first-page":"18385","DOI":"10.1007\/s11356-017-1138-0","article-title":"miR-760 suppresses non-small cell lung cancer proliferation and metastasis by targeting ROS1","volume":"25","author":"Yan","year":"2018","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.omtn.2021.06.012_bib47","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13046-018-0757-8","article-title":"miR-760 suppresses human colorectal cancer growth by targeting BATF3\/AP-1\/cyclinD1 signaling","volume":"37","author":"Cao","year":"2018","journal-title":"J.\u00a0Exp. Clin. Cancer Res."},{"key":"10.1016\/j.omtn.2021.06.012_bib48","doi-asserted-by":"crossref","first-page":"e44398","DOI":"10.1371\/journal.pone.0044398","article-title":"Plasma miR-601 and miR-760 are novel biomarkers for the early detection of colorectal cancer","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtn.2021.06.012_bib49","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1038\/cdd.2017.86","article-title":"A circular RNA promotes tumorigenesis by inducing c-myc nuclear translocation","volume":"24","author":"Yang","year":"2017","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.omtn.2021.06.012_bib50","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/cr.2017.31","article-title":"Extensive translation of circular RNAs driven by N6-methyladenosine","volume":"27","author":"Yang","year":"2017","journal-title":"Cell Res."},{"key":"10.1016\/j.omtn.2021.06.012_bib51","doi-asserted-by":"crossref","first-page":"E2216","DOI":"10.1210\/jc.2014-2118","article-title":"Activin A, B, and AB increase human trophoblast cell invasion by up-regulating N-cadherin","volume":"99","author":"Li","year":"2014","journal-title":"J.\u00a0Clin. Endocrinol. Metab."}],"container-title":["Molecular Therapy - Nucleic Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253121001530?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253121001530?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T01:38:17Z","timestamp":1761874697000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2162253121001530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":51,"alternative-id":["S2162253121001530"],"URL":"https:\/\/doi.org\/10.1016\/j.omtn.2021.06.012","relation":{},"ISSN":["2162-2531"],"issn-type":[{"value":"2162-2531","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"circRNA-DURSA regulates trophoblast apoptosis via miR-760-HIST1H2BE axis in unexplained recurrent spontaneous abortion","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy - Nucleic Acids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omtn.2021.06.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors.","name":"copyright","label":"Copyright"}]}}