{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T13:42:44Z","timestamp":1784900564465,"version":"3.55.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770701"],"award-info":[{"award-number":["81770701"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970619"],"award-info":[{"award-number":["81970619"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100764"],"award-info":[{"award-number":["82100764"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC0904103"],"award-info":[{"award-number":["2016YFC0904103"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1312705"],"award-info":[{"award-number":["2018YFC1312705"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013058","name":"Jiangsu Provincial Key Research and Development Program","doi-asserted-by":"publisher","award":["BE2020698"],"award-info":[{"award-number":["BE2020698"]}],"id":[{"id":"10.13039\/501100013058","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy - Nucleic Acids"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.omtn.2021.09.005","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T01:14:15Z","timestamp":1632100455000},"page":"749-759","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["A novel approach to identify the mechanism of miR-145-5p toxicity to podocytes based on the essential genes targeting analysis"],"prefix":"10.1016","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2929-743X","authenticated-orcid":false,"given":"Sipan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0624-2057","authenticated-orcid":false,"given":"Junnan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoli","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunbei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3402-0002","authenticated-orcid":false,"given":"Jiong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2297-6496","authenticated-orcid":false,"given":"Shaolin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omtn.2021.09.005_bib1","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nature03702","article-title":"MicroRNA expression profiles classify human cancers","volume":"435","author":"Lu","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.omtn.2021.09.005_bib2","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.cell.2005.01.014","article-title":"RAS is regulated by the let-7 microRNA family","volume":"120","author":"Johnson","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.omtn.2021.09.005_bib3","doi-asserted-by":"crossref","first-page":"15472","DOI":"10.1073\/pnas.0707351104","article-title":"Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells","volume":"104","author":"Tazawa","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtn.2021.09.005_bib4","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.cell.2009.02.038","article-title":"MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells","volume":"137","author":"Xu","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.omtn.2021.09.005_bib5","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.molcel.2007.05.010","article-title":"Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis","volume":"26","author":"Chang","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1016\/j.omtn.2021.09.005_bib6","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/hep.23922","article-title":"Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis","volume":"53","author":"Roderburg","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.omtn.2021.09.005_bib7","doi-asserted-by":"crossref","first-page":"759","DOI":"10.4161\/cc.7.6.5834","article-title":"The let-7 microRNA reduces tumor growth in mouse models of lung cancer","volume":"7","author":"Esquela-Kerscher","year":"2008","journal-title":"Cell Cycle"},{"key":"10.1016\/j.omtn.2021.09.005_bib8","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.cell.2009.04.021","article-title":"Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model","volume":"137","author":"Kota","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.omtn.2021.09.005_bib48","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nm.2284","article-title":"The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44","volume":"17","author":"Liu","year":"2011","journal-title":"Nat Med"},{"key":"10.1016\/j.omtn.2021.09.005_bib10","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/S1470-2045(17)30621-6","article-title":"Safety and activity of microRNA-loaded minicells in patients with recurrent malignant pleural mesothelioma: a first-in-man, phase 1, open-label, dose-escalation study","volume":"18","author":"van Zandwijk","year":"2017","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.omtn.2021.09.005_bib11","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1002\/hep.23380","article-title":"Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma","volume":"51","author":"Xiong","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.omtn.2021.09.005_bib12","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1038\/s41467-018-05023-9","article-title":"miR-130a and miR-145 reprogram Gr-1+CD11b+ myeloid cells and inhibit tumor metastasis through improved host immunity","volume":"9","author":"Ishii","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtn.2021.09.005_bib13","doi-asserted-by":"crossref","first-page":"3184","DOI":"10.1038\/s41467-019-11068-1","article-title":"Multifunctional cationic nanosystems for nucleic acid therapy of thoracic aortic dissection","volume":"10","author":"Xu","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtn.2021.09.005_bib14","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s10637-016-0407-y","article-title":"Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors","volume":"35","author":"Beg","year":"2017","journal-title":"Invest. New Drugs"},{"key":"10.1016\/j.omtn.2021.09.005_bib15","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1038\/s41467-018-04791-8","article-title":"Efficient RNA drug delivery using red blood cell extracellular vesicles","volume":"9","author":"Usman","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtn.2021.09.005_bib16","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.drudis.2016.10.014","article-title":"miRNA nanotherapeutics for cancer","volume":"22","author":"Ganju","year":"2017","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.omtn.2021.09.005_bib17","first-page":"3478","article-title":"LncRNA MALAT1 facilities high glucose induced endothelial to mesenchymal transition and fibrosis via targeting miR-145\/ZEB2 axis","volume":"23","author":"Liu","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.omtn.2021.09.005_bib18","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/s41419-021-03466-5","article-title":"c-MYC-induced long noncoding RNA MEG3 aggravates kidney ischemia-reperfusion injury through activating mitophagy by upregulation of RTKN to trigger the Wnt\/\u03b2-catenin pathway","volume":"12","author":"Liu","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.omtn.2021.09.005_bib19","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.kint.2017.04.022","article-title":"Genome-wide identification of genes essential for podocyte cytoskeletons based on single-cell RNA sequencing","volume":"92","author":"Lu","year":"2017","journal-title":"Kidney Int."},{"key":"10.1016\/j.omtn.2021.09.005_bib20","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1101\/gr.161034.113","article-title":"From single-cell to cell-pool transcriptomes: stochasticity in gene expression and RNA splicing","volume":"24","author":"Marinov","year":"2014","journal-title":"Genome Res."},{"key":"10.1016\/j.omtn.2021.09.005_bib21","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1126\/science.1105891","article-title":"Noise in gene expression: origins, consequences, and control","volume":"309","author":"Raser","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.omtn.2021.09.005_bib22","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1126\/science.aab0917","article-title":"RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance","volume":"349","author":"Miyamoto","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.omtn.2021.09.005_bib23","doi-asserted-by":"crossref","first-page":"4755","DOI":"10.1128\/MCB.00730-13","article-title":"Rac1 activation in podocytes induces rapid foot process effacement and proteinuria","volume":"33","author":"Yu","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.omtn.2021.09.005_bib24","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/ncb1400","article-title":"Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling","volume":"8","author":"Asanuma","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.omtn.2021.09.005_bib25","doi-asserted-by":"crossref","first-page":"415","DOI":"10.2353\/ajpath.2007.070075","article-title":"Synaptopodin protects against proteinuria by disrupting Cdc42:IRSp53:Mena signaling complexes in kidney podocytes","volume":"171","author":"Yanagida-Asanuma","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.omtn.2021.09.005_bib26","doi-asserted-by":"crossref","first-page":"26316","DOI":"10.3402\/jev.v4.26316","article-title":"Extracellular vesicle in\u00a0vivo biodistribution is determined by cell source, route of administration and targeting","volume":"4","author":"Wiklander","year":"2015","journal-title":"J.\u00a0Extracell. Vesicles"},{"key":"10.1016\/j.omtn.2021.09.005_bib27","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1021\/nn404945r","article-title":"Dynamic biodistribution of extracellular vesicles in\u00a0vivo using a multimodal imaging reporter","volume":"8","author":"Lai","year":"2014","journal-title":"ACS Nano"},{"key":"10.1016\/j.omtn.2021.09.005_bib28","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/ki.2012.105","article-title":"Microvesicles derived from endothelial progenitor cells protect the kidney from ischemia-reperfusion injury by microRNA-dependent reprogramming of resident renal cells","volume":"82","author":"Cantaluppi","year":"2012","journal-title":"Kidney Int."},{"key":"10.1016\/j.omtn.2021.09.005_bib29","doi-asserted-by":"crossref","first-page":"e1004619","DOI":"10.1371\/journal.ppat.1004619","article-title":"A novel mechanism of bacterial toxin transfer within host blood cell-derived microvesicles","volume":"11","author":"St\u00e5hl","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.omtn.2021.09.005_bib30","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1053\/j.gastro.2017.09.045","article-title":"MicroRNAs 15A and 16-1 Activate Signaling Pathways That Mediate Chemotaxis of Immune Regulatory B cells to Colorectal Tumors","volume":"154","author":"Liu","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.omtn.2021.09.005_bib31","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1126\/science.aac7041","article-title":"Identification and characterization of essential genes in the human genome","volume":"350","author":"Wang","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.omtn.2021.09.005_bib32","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.celrep.2019.02.041","article-title":"Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies","volume":"27","author":"Mair","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.omtn.2021.09.005_bib33","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s13059-019-1713-4","article-title":"Single-cell transcriptomics unveils gene regulatory network plasticity","volume":"20","author":"Iacono","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.omtn.2021.09.005_bib34","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1038\/nm.1879","article-title":"Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease","volume":"14","author":"Shibata","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.omtn.2021.09.005_bib35","doi-asserted-by":"crossref","first-page":"4127","DOI":"10.1172\/JCI46458","article-title":"Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis","volume":"121","author":"Akilesh","year":"2011","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.omtn.2021.09.005_bib36","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1681\/ASN.2020081126","article-title":"SRGAP1 Controls Small Rho GTPases To Regulate Podocyte Foot Process Maintenance","volume":"32","author":"Rogg","year":"2021","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.omtn.2021.09.005_bib37","doi-asserted-by":"crossref","first-page":"e80328","DOI":"10.1371\/journal.pone.0080328","article-title":"Activation of Rac-1 and RhoA contributes to podocyte injury in chronic kidney disease","volume":"8","author":"Babelova","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtn.2021.09.005_bib38","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1172\/JCI58552","article-title":"CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival","volume":"121","author":"Yaddanapudi","year":"2011","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.omtn.2021.09.005_bib39","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1093\/ndt\/gft532","article-title":"Podocyte-associated gene mutation screening in a heterogeneous cohort of patients with sporadic focal segmental glomerulosclerosis","volume":"29","author":"Laurin","year":"2014","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.omtn.2021.09.005_bib40","doi-asserted-by":"crossref","first-page":"E4621","DOI":"10.1073\/pnas.1617004114","article-title":"The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier","volume":"114","author":"Schell","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtn.2021.09.005_bib41","doi-asserted-by":"crossref","first-page":"9419","DOI":"10.1038\/s41598-020-64907-3","article-title":"Distinct Functional Requirements for Podocalyxin in Immature and Mature Podocytes Reveal Mechanisms of Human Kidney Disease","volume":"10","author":"Refaeli","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omtn.2021.09.005_bib42","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1172\/JCI84424","article-title":"Targeting noncoding RNAs in disease","volume":"127","author":"Adams","year":"2017","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.omtn.2021.09.005_bib43","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1681\/ASN.V133630","article-title":"A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression","volume":"13","author":"Saleem","year":"2002","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.omtn.2021.09.005_bib44","doi-asserted-by":"crossref","DOI":"10.1002\/0471143030.cb0322s30","article-title":"Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids","author":"Th\u00e9ry","year":"2006","journal-title":"Curr. Protoc. Cell. Biol"},{"key":"10.1016\/j.omtn.2021.09.005_bib45","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1038\/nprot.2012.065","article-title":"Fluorescent labeling of nano-sized vesicles released by cells and subsequent quantitative and qualitative analysis by high-resolution flow cytometry","volume":"7","author":"van der Vlist","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.omtn.2021.09.005_bib46","doi-asserted-by":"crossref","first-page":"24436","DOI":"10.1038\/srep24436","article-title":"Lymphatic transport of exosomes as a rapid route of information dissemination to the lymph node","volume":"6","author":"Srinivasan","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omtn.2021.09.005_bib47","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1111\/j.1523-1755.2004.00964.x","article-title":"Podocyte foot process effacement is not correlated with the level of proteinuria in human glomerulopathies","volume":"66","author":"van den Berg","year":"2004","journal-title":"Kidney Int"}],"container-title":["Molecular Therapy - Nucleic Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253121002341?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253121002341?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T01:38:05Z","timestamp":1761874685000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2162253121002341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":47,"alternative-id":["S2162253121002341"],"URL":"https:\/\/doi.org\/10.1016\/j.omtn.2021.09.005","relation":{},"ISSN":["2162-2531"],"issn-type":[{"value":"2162-2531","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel approach to identify the mechanism of miR-145-5p toxicity to podocytes based on the essential genes targeting analysis","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy - Nucleic Acids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omtn.2021.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s).","name":"copyright","label":"Copyright"}]}}