{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T12:38:17Z","timestamp":1793363897405,"version":"4.5.0"},"reference-count":303,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:00:00Z","timestamp":1644451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["9980"],"award-info":[{"award-number":["9980"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["16695"],"award-info":[{"award-number":["16695"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["2016\/17"],"award-info":[{"award-number":["2016\/17"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["2010\/15"],"award-info":[{"award-number":["2010\/15"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy Nucleic Acids"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.omtn.2022.02.005","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T20:39:16Z","timestamp":1644525556000},"page":"1191-1224","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":147,"special_numbering":"C","title":["miR-221\/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review"],"prefix":"10.1016","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8205-2706","authenticated-orcid":false,"given":"Maria Teresa","family":"Di Martino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariamena","family":"Arbitrio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Caracciolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Cordua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onofrio","family":"Cuomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Grillone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7983-5099","authenticated-orcid":false,"given":"Caterina","family":"Riillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Carid\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8149-7957","authenticated-orcid":false,"given":"Francesca","family":"Scionti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Labanca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Romeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Anna","family":"Siciliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"D'Apolito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Napoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Montesano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Farenza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Uppolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Tafuni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Falcone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"D'Aquino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natale Daniele","family":"Calandruccio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Luciano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Licia","family":"Pensabene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierosandro","family":"Tagliaferri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8298-6787","authenticated-orcid":false,"given":"Pierfrancesco","family":"Tassone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omtn.2022.02.005_bib1","first-page":"1","article-title":"MicroRNAs and cancer: a long story for short RNAs","volume":"135","author":"Drusco","year":"2017","journal-title":"Adv. Cancer Res."},{"key":"10.1016\/j.omtn.2022.02.005_bib2","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.canlet.2016.03.043","article-title":"MicroRNAs as novel targets and tools in cancer therapy","volume":"387","author":"Abba","year":"2017","journal-title":"Cancer Lett."},{"key":"10.1016\/j.omtn.2022.02.005_bib3","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/nrd3625","article-title":"RNA therapeutics: beyond RNA interference and antisense oligonucleotides","volume":"11","author":"Kole","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.omtn.2022.02.005_bib4","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s10637-016-0407-y","article-title":"Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors","volume":"35","author":"Beg","year":"2017","journal-title":"Invest. New Drugs"},{"key":"10.1016\/j.omtn.2022.02.005_bib5","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/bjh.15547","article-title":"Cobomarsen, an oligonucleotide inhibitor of miR-155, co-ordinately regulates multiple survival pathways to reduce cellular proliferation and survival in cutaneous T-cell lymphoma","volume":"183","author":"Seto","year":"2018","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.omtn.2022.02.005_bib6","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0140-6736(16)31715-9","article-title":"Safety, tolerability, and antiviral effect of RG-101 in patients with chronic hepatitis C: a phase 1B, double-blind, randomised controlled trial","volume":"389","author":"van der Ree","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.omtn.2022.02.005_bib7","doi-asserted-by":"crossref","first-page":"7223","DOI":"10.3390\/ijms21197223","article-title":"Dicing the disease with dicer: the implications of dicer ribonuclease in human pathologies","volume":"21","author":"Theotoki","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.omtn.2022.02.005_bib8","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3389\/fendo.2018.00402","article-title":"Overview of MicroRNA biogenesis, mechanisms of actions, and circulation","volume":"9","author":"O'Brien","year":"2018","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.omtn.2022.02.005_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1261\/rna.068692.118","article-title":"Post-transcriptional control of miRNA biogenesis","volume":"25","author":"Michlewski","year":"2019","journal-title":"RNA"},{"key":"10.1016\/j.omtn.2022.02.005_bib10","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41580-018-0059-1","article-title":"Regulation of microRNA biogenesis and its crosstalk with other cellular pathways","volume":"20","author":"Treiber","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.omtn.2022.02.005_bib11","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.molcel.2016.09.004","article-title":"Pairing beyond the seed supports MicroRNA targeting specificity","volume":"64","author":"Broughton","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.omtn.2022.02.005_bib12","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nrm3838","article-title":"Regulation of microRNA biogenesis","volume":"15","author":"Ha","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1016\/j.omtn.2022.02.005_bib13","first-page":"3094","article-title":"MicroRNA-221: biogenesis, function and signatures in human cancers","volume":"22","author":"Abak","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.omtn.2022.02.005_bib14","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1093\/jnci\/djq102","article-title":"MicroRNA cluster 221-222 and estrogen receptor alpha interactions in breast cancer","volume":"102","author":"Di Leva","year":"2010","journal-title":"J.\u00a0Natl. Cancer Inst."},{"key":"10.1016\/j.omtn.2022.02.005_bib15","doi-asserted-by":"crossref","first-page":"15672","DOI":"10.1074\/jbc.M111.322669","article-title":"Small RNA sequencing reveals microRNAs that modulate angiotensin II effects in vascular smooth muscle cells","volume":"287","author":"Jin","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.omtn.2022.02.005_bib16","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.3390\/cells9081767","article-title":"MicroRNA-221: a fine tuner and potential biomarker of chronic liver injury","volume":"9","author":"Markovic","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.omtn.2022.02.005_bib17","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s13046-020-01622-x","article-title":"Non-coding RNAs in cancer: platforms and strategies for investigating the genomic \u201cdark matter\u201d","volume":"39","author":"Grillone","year":"2020","journal-title":"J.\u00a0Exp. Clin. Cancer Res."},{"key":"10.1016\/j.omtn.2022.02.005_bib18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3390\/ht7040033","article-title":"From single level analysis to multi-omics integrative approaches: a powerful strategy towards the precision oncology","volume":"7","author":"Gallo Cantafio","year":"2018","journal-title":"High Throughput"},{"key":"10.1016\/j.omtn.2022.02.005_bib19","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1007\/s00204-016-1815-7","article-title":"MicroRNA epigenetic signatures in human disease","volume":"90","author":"Piletic","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.omtn.2022.02.005_bib20","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/labmed\/lmz002","article-title":"MicroRNA-221 and MicroRNA-222 in common human cancers: expression, function, and triggering of tumor progression as a key modulator","volume":"50","author":"Amini","year":"2019","journal-title":"Lab. Med."},{"key":"10.1016\/j.omtn.2022.02.005_bib21","doi-asserted-by":"crossref","first-page":"950","DOI":"10.3389\/fgene.2019.00950","article-title":"Epigenetic biomarkers in cardiovascular diseases","volume":"10","author":"Soler-Botija","year":"2019","journal-title":"Front. Genet."},{"key":"10.1016\/j.omtn.2022.02.005_bib22","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.ijcard.2017.07.045","article-title":"Profiling of cardiovascular and cerebrovascular disease associated microRNA expression in umbilical cord blood in gestational hypertension, preeclampsia and fetal growth restriction","volume":"249","author":"Hromadnikova","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.omtn.2022.02.005_bib23","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.ijcard.2020.11.004","article-title":"A systematic review of microRNAs in patients with hypertrophic cardiomyopathy","volume":"327","author":"Scolari","year":"2021","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.omtn.2022.02.005_bib24","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/s41586-018-0253-5","article-title":"Induction of innate immune memory via microRNA targeting of chromatin remodelling factors","volume":"559","author":"Seeley","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.omtn.2022.02.005_bib25","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.parkreldis.2016.09.028","article-title":"Parkinson's disease: SNCA-, PARK2-, and LRRK2- targeting microRNAs elevated in cingulate gyrus","volume":"33","author":"Tatura","year":"2016","journal-title":"Parkinson. Relat. Disord."},{"key":"10.1016\/j.omtn.2022.02.005_bib26","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.tiv.2016.06.001","article-title":"Polychlorinated biphenyl exposure alters the expression profile of microRNAs associated with vascular diseases","volume":"35","author":"Wahlang","year":"2016","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.omtn.2022.02.005_bib27","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ijcard.2019.05.036","article-title":"Postpartum profiling of microRNAs involved in pathogenesis of cardiovascular\/cerebrovascular diseases in women exposed to pregnancy-related complications","volume":"291","author":"Hromadnikova","year":"2019","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.omtn.2022.02.005_bib28","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.thromres.2015.11.032","article-title":"Gestational hypertension, preeclampsia and intrauterine growth restriction induce dysregulation of cardiovascular and cerebrovascular disease associated microRNAs in maternal whole peripheral blood","volume":"137","author":"Hromadnikova","year":"2016","journal-title":"Thromb. Res."},{"key":"10.1016\/j.omtn.2022.02.005_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0138383","article-title":"Cardiovascular and cerebrovascular disease associated microRNAs are dysregulated in placental tissues affected with gestational hypertension, preeclampsia and intrauterine growth restriction","volume":"10","author":"Hromadnikova","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtn.2022.02.005_bib30","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3390\/ijms21020430","article-title":"Evaluation of vascular endothelial function in young and middle-aged women with respect to a history of pregnancy, pregnancy-related complications, classical cardiovascular risk factors, and epigenetics","volume":"21","author":"Hromadnikova","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.omtn.2022.02.005_bib31","doi-asserted-by":"crossref","first-page":"101442","DOI":"10.1016\/j.mcp.2019.101442","article-title":"Differential expression of miRNAs regulating NF-kappaB and STAT3 crosstalk during colitis-associated tumorigenesis","volume":"47","author":"El-Daly","year":"2019","journal-title":"Mol. Cell Probes"},{"key":"10.1016\/j.omtn.2022.02.005_bib32","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1080\/15592294.2019.1595997","article-title":"The rs17084733 variant in the KIT 3' UTR disrupts a miR-221\/222 binding site in gastrointestinal stromal tumour: a sponge-like mechanism conferring disease susceptibility","volume":"14","author":"Ravegnini","year":"2019","journal-title":"Epigenetics"},{"key":"10.1016\/j.omtn.2022.02.005_bib33","doi-asserted-by":"crossref","first-page":"3709","DOI":"10.18632\/oncotarget.2888","article-title":"Role of microRNA221 in regulating normal mammary epithelial hierarchy and breast cancer stem-like cells","volume":"6","author":"Ke","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.omtn.2022.02.005_bib34","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1038\/onc.2015.295","article-title":"Comprehensive proteomic profiling identifies the androgen receptor axis and other signaling pathways as targets of microRNAs suppressed in metastatic prostate cancer","volume":"35","author":"Coarfa","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.omtn.2022.02.005_bib35","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3233\/CBM-171011","article-title":"Prognostic and predictive value of long non-coding RNA GAS5 and mircoRNA-221 in colorectal cancer and their effects on colorectal cancer cell proliferation, migration and invasion","volume":"22","author":"Liu","year":"2018","journal-title":"Cancer Biomark."},{"key":"10.1016\/j.omtn.2022.02.005_bib36","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.omtn.2018.09.026","article-title":"lncRNA GAS5 reverses EMT and tumor stem cell-mediated gemcitabine resistance and metastasis by targeting miR-221\/SOCS3 in pancreatic cancer","volume":"13","author":"Liu","year":"2018","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.omtn.2022.02.005_bib37","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.omtn.2020.01.030","article-title":"The lncRNA-GAS5\/miR-221-3p\/DKK2 Axis modulates ABCB1-mediated adriamycin resistance of breast cancer via the Wnt\/beta-catenin signaling pathway","volume":"19","author":"Chen","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.omtn.2022.02.005_bib38","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1159\/000513338","article-title":"Long noncoding RNA GAS5 targeting miR-221-3p\/cyclin-dependent kinase inhibitor 2B Axis regulates follicular thyroid carcinoma cell cycle and proliferation","volume":"88","author":"Liu","year":"2021","journal-title":"Pathobiology"},{"key":"10.1016\/j.omtn.2022.02.005_bib39","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13000-021-01108-0","article-title":"LncRNA GAS5 modulates the progression of non-small cell lung cancer through repressing miR-221-3p and up-regulating IRF2","volume":"16","author":"Ma","year":"2021","journal-title":"Diagn. Pathol."},{"key":"10.1016\/j.omtn.2022.02.005_bib40","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.3892\/ol.2020.11821","article-title":"Long non-coding RNA-ZNF281 upregulates PTEN expression via downregulation of microRNA-221 in non-small cell lung cancer","volume":"20","author":"Lu","year":"2020","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.omtn.2022.02.005_bib41","first-page":"4226","article-title":"Effects of miR-221 on the apoptosis of non-small cell lung cancer cells by lncRNA HOTAIR","volume":"23","author":"Sun","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.omtn.2022.02.005_bib42","doi-asserted-by":"crossref","first-page":"7553","DOI":"10.18632\/aging.102271","article-title":"Long non-coding RNA TUG1 enhances chemosensitivity in non-small cell lung cancer by impairing microRNA-221-dependent PTEN inhibition","volume":"11","author":"Guo","year":"2019","journal-title":"Aging"},{"key":"10.1016\/j.omtn.2022.02.005_bib43","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3233\/CH-200906","article-title":"Silencing of long noncoding RNA TUG1 inhibits viability and promotes apoptosis of acute myeloid leukemia cells by targeting microRNA-221-3p\/KIT axis","volume":"76","author":"Zhang","year":"2020","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"10.1016\/j.omtn.2022.02.005_bib44","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.7150\/jca.32552","article-title":"Long non-coding RNA TCL6 enhances preferential toxicity of paclitaxel to renal cell carcinoma cells","volume":"11","author":"Chen","year":"2020","journal-title":"J.\u00a0Cancer"},{"key":"10.1016\/j.omtn.2022.02.005_bib45","first-page":"7524","article-title":"LINC00671 inhibits renal cell cancer progression via regulating miR-221-5p\/SOCS1 axis","volume":"13","author":"Jin","year":"2021","journal-title":"Am. J. Transl Res."},{"key":"10.1016\/j.omtn.2022.02.005_bib46","doi-asserted-by":"crossref","first-page":"5237","DOI":"10.3390\/ijms21155237","article-title":"The biological and clinical role of the long non-coding RNA LOC642852 in ovarian carcinoma","volume":"21","author":"Filippov-Levy","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.omtn.2022.02.005_bib47","doi-asserted-by":"crossref","first-page":"8725","DOI":"10.2147\/OTT.S219900","article-title":"LncRNA CASC15 functions as an unfavorable predictor of ovarian cancer prognosis and inhibits tumor progression through regulation of miR-221\/ARID1A Axis","volume":"12","author":"Shi","year":"2019","journal-title":"Onco Targets Ther."},{"key":"10.1016\/j.omtn.2022.02.005_bib48","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s11010-019-03569-w","article-title":"Potential of C1QTNF1-AS1 regulation in human hepatocellular carcinoma","volume":"460","author":"Han","year":"2019","journal-title":"Mol. Cell Biochem."},{"key":"10.1016\/j.omtn.2022.02.005_bib49","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s12072-019-09944-5","article-title":"C1QTNF1-AS1 regulates the occurrence and development of hepatocellular carcinoma by regulating miR-221-3p\/SOCS3","volume":"13","author":"Li","year":"2019","journal-title":"Hepatol. Int."},{"key":"10.1016\/j.omtn.2022.02.005_bib50","doi-asserted-by":"crossref","first-page":"118928","DOI":"10.1016\/j.lfs.2020.118928","article-title":"RNF185-AS1 promotes hepatocellular carcinoma progression through targeting miR-221-5p\/integrin beta5 axis","volume":"267","author":"Huang","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.omtn.2022.02.005_bib51","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1089\/nat.2014.0506","article-title":"Phosphorothioates, essential components of therapeutic oligonucleotides","volume":"24","author":"Eckstein","year":"2014","journal-title":"Nucleic Acid Ther."},{"key":"10.1016\/j.omtn.2022.02.005_bib52","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1002\/hep.25747","article-title":"Liver tumorigenicity promoted by microRNA-221 in a mouse transgenic model","volume":"56","author":"Callegari","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.omtn.2022.02.005_bib53","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1093\/nar\/23.11.2019","article-title":"Characterization of fully 2'-modified oligoribonucleotide hetero- and homoduplex hybridization and nuclease sensitivity","volume":"23","author":"Cummins","year":"1995","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.omtn.2022.02.005_bib54","doi-asserted-by":"crossref","first-page":"7608","DOI":"10.1158\/0008-5472.CAN-11-1144","article-title":"miR-221 silencing blocks hepatocellular carcinoma and promotes survival","volume":"71","author":"Park","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.omtn.2022.02.005_bib55","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1517\/13543776.2014.863874","article-title":"Peptide nucleic acids: a review on recent patents and technology transfer","volume":"24","author":"Gambari","year":"2014","journal-title":"Expert Opin. Ther. Pat"},{"key":"10.1016\/j.omtn.2022.02.005_bib56","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/978-1-0716-0943-9_10","article-title":"Delivery of peptide nucleic acids using an argininocalix[4]arene as vector","volume":"2211","author":"Finotti","year":"2021","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.omtn.2022.02.005_bib57","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1126\/science.1962210","article-title":"Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide","volume":"254","author":"Nielsen","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.omtn.2022.02.005_bib58","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/0006-2952(94)90171-6","article-title":"Stability of peptide nucleic acids in human serum and cellular extracts","volume":"48","author":"Demidov","year":"1994","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.omtn.2022.02.005_bib59","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/365490a0","article-title":"Nucleic acid recognition. Marriage of convenience","volume":"365","author":"Patel","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.omtn.2022.02.005_bib60","doi-asserted-by":"crossref","first-page":"5401","DOI":"10.1016\/S0040-4039(98)01084-3","article-title":"Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2 '-O,4 '-C-methyleneribonucleosides","volume":"39","author":"Obika","year":"1998","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.omtn.2022.02.005_bib61","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jconrel.2021.03.018","article-title":"Nano-ghosts: novel biomimetic nano-vesicles for the delivery of antisense oligonucleotides","volume":"333","author":"Oieni","year":"2021","journal-title":"J.\u00a0Control Release"},{"key":"10.1016\/j.omtn.2022.02.005_bib62","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0089659","article-title":"In\u00a0vitro and in\u00a0vivo activity of a novel locked nucleic acid (LNA)-inhibitor-miR-221 against multiple myeloma cells","volume":"9","author":"Di Martino","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtn.2022.02.005_bib63","doi-asserted-by":"crossref","DOI":"10.1038\/mtna.2016.36","article-title":"Pharmacokinetics and pharmacodynamics of a 13-mer LNA-inhibitor-miR-221 in mice and non-human primates","volume":"5","author":"Gallo Cantafio","year":"2016","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.omtn.2022.02.005_bib64","doi-asserted-by":"crossref","first-page":"5618","DOI":"10.1039\/c3cc40340h","article-title":"Locked nucleic acid: tighter is different","volume":"49","author":"Watts","year":"2013","journal-title":"Chem. Commun."},{"key":"10.1016\/j.omtn.2022.02.005_bib65","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/978-1-4939-2727-2_9","article-title":"Design and selection of antisense oligonucleotides targeting transforming growth factor beta (TGF-beta) isoform mRNAs for the treatment of solid tumors","volume":"1317","author":"Jaschinski","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.omtn.2022.02.005_bib66","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1101\/gad.1941310","article-title":"Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model","volume":"24","author":"Hua","year":"2010","journal-title":"Genes Dev."},{"key":"10.1016\/j.omtn.2022.02.005_bib67","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1517\/14728222.2016.1164693","article-title":"Mir-221\/222 are promising targets for innovative anticancer therapy","volume":"20","author":"Di Martino","year":"2016","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.omtn.2022.02.005_bib68","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1158\/1078-0432.CCR-15-0489","article-title":"A 13 mer LNA-i-miR-221 inhibitor restores drug sensitivity in melphalan-refractory multiple myeloma cells","volume":"22","author":"Gulla","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.omtn.2022.02.005_bib69","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.omtn.2020.01.036","article-title":"Dose-finding study and pharmacokinetics profile of the novel 13-mer antisense miR-221 inhibitor in sprague-dawley rats","volume":"20","author":"Di Martino","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.omtn.2022.02.005_bib70","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3390\/cancers12010027","article-title":"Allometric scaling approaches for predicting human pharmacokinetic of a locked nucleic acid oligonucleotide targeting cancer-associated miR-221","volume":"12","author":"Di Martino","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.omtn.2022.02.005_bib71","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jpba.2017.12.027","article-title":"Development and validation of a bioanalytical method for quantification of LNA-i-miR-221, a 13-mer oligonucleotide, in rat plasma using LC-MS\/MS","volume":"150","author":"Franzoni","year":"2018","journal-title":"J.\u00a0Pharm. Biomed. Anal."},{"key":"10.1016\/j.omtn.2022.02.005_bib72","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s00403-017-1784-6","article-title":"Resveratrol suppresses melanoma by inhibiting NF-kappaB\/miR-221 and inducing TFG expression","volume":"309","author":"Wu","year":"2017","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.omtn.2022.02.005_bib73","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0125779","article-title":"Metformin causes G1-phase Arrest via down-regulation of MiR-221 and enhances TRAIL sensitivity through DR5 up-regulation in pancreatic cancer cells","volume":"10","author":"Tanaka","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtn.2022.02.005_bib74","doi-asserted-by":"crossref","first-page":"105783","DOI":"10.1016\/j.intimp.2019.105783","article-title":"Myrothecine A modulates the proliferation of HCC cells and the maturation of dendritic cells through downregulating miR-221","volume":"75","author":"Fu","year":"2019","journal-title":"Int. Immunopharmacol"},{"key":"10.1016\/j.omtn.2022.02.005_bib75","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.3390\/v11121111","article-title":"Virucidal activity of gold nanoparticles synthesized by green chemistry using garlic extract","volume":"11","author":"Melendez-Villanueva","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.omtn.2022.02.005_bib76","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.2174\/1389201019666181112103204","article-title":"Effect of Vinca alkaloids on the expression levels of microRNAs targeting apoptosis-related genes in breast cancer cell lines","volume":"19","author":"Mavrogiannis","year":"2018","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.omtn.2022.02.005_bib77","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.bbamcr.2014.10.017","article-title":"Indole-3-carbinol inhibits tumorigenicity of hepatocellular carcinoma cells via suppression of microRNA-21 and upregulation of phosphatase and tensin homolog","volume":"1853","author":"Wang","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.omtn.2022.02.005_bib78","doi-asserted-by":"crossref","first-page":"173509","DOI":"10.1016\/j.ejphar.2020.173509","article-title":"The effect of oleuropein on apoptotic pathway regulators in breast cancer cells","volume":"886","author":"Asgharzade","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.omtn.2022.02.005_bib79","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.2174\/1381612823666170109144818","article-title":"Curcumin and lung cancer: the role of microRNAs","volume":"23","author":"Lelli","year":"2017","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.omtn.2022.02.005_bib80","doi-asserted-by":"crossref","first-page":"541","DOI":"10.3892\/ol.2013.1697","article-title":"5-FU and ixabepilone modify the microRNA expression profiles in MDA-MB-453 triple-negative breast cancer cells","volume":"7","author":"Yao","year":"2014","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.omtn.2022.02.005_bib81","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20180980","article-title":"Alpha-pinene regulates miR-221 and induces G2\/M phase cell cycle arrest in human hepatocellular carcinoma cells","volume":"38","author":"Xu","year":"2018","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.omtn.2022.02.005_bib82","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1055\/s-0042-119647","article-title":"Chrysin alters microRNAs expression levels in gastric cancer cells: possible molecular mechanism","volume":"67","author":"Mohammadian","year":"2017","journal-title":"Drug Res."},{"key":"10.1016\/j.omtn.2022.02.005_bib83","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.tox.2015.04.002","article-title":"Effects of treatment with androgen receptor ligands on microRNA expression of prostate cancer cells","volume":"333","author":"Segal","year":"2015","journal-title":"Toxicology"},{"key":"10.1016\/j.omtn.2022.02.005_bib84","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.ejphar.2019.03.040","article-title":"Ginsenoside Rg3 inhibits growth and epithelial-mesenchymal transition of human oral squamous carcinoma cells by down-regulating miR-221Zhou","author":"Cheng","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.omtn.2022.02.005_bib85","article-title":"Treatment of 13-cis retinoic acid and 1,25-dihydroxyvitamin D3 inhibits TNF-alpha-mediated expression of MMP-9 protein and cell invasion through the suppression of JNK pathway and microRNA 221 in human pancreatic adenocarcinoma cancer cells","volume":"0247550","author":"Cheng","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.omtn.2022.02.005_bib86","doi-asserted-by":"crossref","first-page":"6260","DOI":"10.1158\/1078-0432.CCR-12-1708","article-title":"Synthetic miR-34a mimics as a novel therapeutic agent for multiple myeloma: in\u00a0vitro and in\u00a0vivo evidence","volume":"18","author":"Di Martino","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.omtn.2022.02.005_bib87","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0090005","article-title":"In\u00a0vivo activity of miR-34a mimics delivered by stable nucleic acid lipid particles (SNALPs) against multiple myeloma","volume":"9","author":"Di Martino","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtn.2022.02.005_bib88","doi-asserted-by":"crossref","first-page":"217365","DOI":"10.1155\/2014\/217365","article-title":"Transferrin-conjugated SNALPs encapsulating 2'-O-methylated miR-34a for the treatment of multiple myeloma","volume":"2014","author":"Scognamiglio","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.omtn.2022.02.005_bib89","doi-asserted-by":"crossref","first-page":"S125","DOI":"10.1517\/14712598.2013.796356","article-title":"Non-coding RNA: a novel opportunity for the personalized treatment of multiple myeloma","volume":"13","author":"Amodio","year":"2013","journal-title":"Expert Opin. Biol. Ther."},{"key":"10.1016\/j.omtn.2022.02.005_bib90","doi-asserted-by":"crossref","first-page":"459","DOI":"10.2174\/1389201015666140519104743","article-title":"MicroRNA and multiple myeloma: from laboratory findings to translational therapeutic approaches","volume":"15","author":"Rossi","year":"2014","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.omtn.2022.02.005_bib91","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/7651_2015_250","article-title":"Functional analysis of microRNA in multiple myeloma","volume":"1375","author":"Di Martino","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.omtn.2022.02.005_bib92","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1158\/1078-0432.CCR-12-3325","article-title":"Targeting miR-21 inhibits in\u00a0vitro and in\u00a0vivo multiple myeloma cell growth","volume":"19","author":"Leone","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.omtn.2022.02.005_bib93","doi-asserted-by":"crossref","first-page":"242","DOI":"10.18632\/oncotarget.820","article-title":"In\u00a0vitro and in\u00a0vivo anti-tumor activity of miR-221\/222 inhibitors in multiple myeloma","volume":"4","author":"Di Martino","year":"2013","journal-title":"Oncotarget"},{"key":"10.1016\/j.omtn.2022.02.005_bib94","doi-asserted-by":"crossref","first-page":"4384","DOI":"10.1158\/0008-5472.CAN-15-0457","article-title":"Targeting the miR-221-222\/PUMA\/BAK\/BAX pathway abrogates dexamethasone resistance in multiple myeloma","volume":"75","author":"Zhao","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.omtn.2022.02.005_bib95","doi-asserted-by":"crossref","first-page":"e406","DOI":"10.1038\/bcj.2016.10","article-title":"miR-203 and miR-221 regulate SOCS1 and SOCS3 in essential thrombocythemia","volume":"6","author":"Navarro","year":"2016","journal-title":"Blood Cancer J."},{"key":"10.1016\/j.omtn.2022.02.005_bib96","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1182\/blood-2011-02-339556","article-title":"Nodal marginal zone lymphoma: gene expression and miRNA profiling identify diagnostic markers and potential therapeutic targets","volume":"119","author":"Arribas","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.omtn.2022.02.005_bib97","doi-asserted-by":"crossref","first-page":"19136","DOI":"10.18632\/oncotarget.24927","article-title":"Assessment of micro RNAs expression in leukemic cells as prognostic markers in chronic lymphocytic leukemia: micro RNAs can predict survival in a course of the disease","volume":"9","author":"Szymczyk","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.omtn.2022.02.005_bib98","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/S0140-6736(13)62120-0","article-title":"Chronic myeloid leukaemia","volume":"385","author":"Apperley","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.omtn.2022.02.005_bib99","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1476-4598-10-41","article-title":"Expression patterns of microRNAs associated with CML phases and their disease related targets","volume":"10","author":"Machova Polakova","year":"2011","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.omtn.2022.02.005_bib100","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1080\/10428194.2018.1543875","article-title":"MicroRNA-221 sensitizes chronic myeloid leukemia cells to imatinib by targeting STAT5","volume":"60","author":"Jiang","year":"2019","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.omtn.2022.02.005_bib101","article-title":"Therapeutic afucosylated monoclonal antibody and bispecific T-cell engagers for T-cell acute lymphoblastic leukemia","volume":"9","author":"Caracciolo","year":"2021","journal-title":"J.\u00a0Immunother. Cancer"},{"key":"10.1016\/j.omtn.2022.02.005_bib102","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/2162-3619-2-10","article-title":"Increased expression of miR-221 is associated with shorter overall survival in T-cell acute lymphoid leukemia","volume":"2","author":"Gimenes-Teixeira","year":"2013","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.omtn.2022.02.005_bib103","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.leukres.2013.02.019","article-title":"MicroRNA profiling reveals aberrant microRNA expression in adult ETP-ALL and functional studies implicate a role for miR-222 in acute leukemia","volume":"37","author":"Coskun","year":"2013","journal-title":"Leuk. Res."},{"key":"10.1016\/j.omtn.2022.02.005_bib104","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1158\/1541-7786.MCR-15-0474","article-title":"Bone marrow microenvironment niche regulates miR-221\/222 in acute lymphoblastic leukemia","volume":"14","author":"Moses","year":"2016","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.omtn.2022.02.005_bib105","doi-asserted-by":"crossref","first-page":"85783","DOI":"10.18632\/oncotarget.21266","article-title":"MiR-221-regulated KIT level by wild type or leukemia mutant RUNX1: a determinant of single myeloblast fate decisions that - collectively - drives or hinders granulopoiesis","volume":"8","author":"Rossetti","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.omtn.2022.02.005_bib106","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1158\/1078-0432.CCR-12-3657","article-title":"MicroRNA profiling can classify acute leukemias of ambiguous lineage as either acute myeloid leukemia or acute lymphoid leukemia","volume":"19","author":"de Leeuw","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.omtn.2022.02.005_bib107","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.2147\/OTT.S222734","article-title":"Long noncoding RNA SOCS2-AS promotes leukemogenesis in FLT3-ITD+ acute myeloid leukemia through miRNA-221","volume":"13","author":"Zhang","year":"2020","journal-title":"Onco Targets Ther."},{"key":"10.1016\/j.omtn.2022.02.005_bib108","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.biomaterials.2018.03.013","article-title":"Targeting epigenetic pathway with gold nanoparticles for acute myeloid leukemia therapy","volume":"167","author":"Deng","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.omtn.2022.02.005_bib109","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/gcc.22032","article-title":"Cell-free microRNAs as diagnostic, prognostic, and predictive biomarkers for lung cancer","volume":"52","author":"Zandberga","year":"2013","journal-title":"Gene Chromosomes Cancer"},{"key":"10.1016\/j.omtn.2022.02.005_bib110","doi-asserted-by":"crossref","first-page":"6513","DOI":"10.18632\/oncotarget.14311","article-title":"A six-microRNA panel in plasma was identified as a potential biomarker for lung adenocarcinoma diagnosis","volume":"8","author":"Zhou","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.omtn.2022.02.005_bib111","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.lungcan.2017.10.002","article-title":"Identification of a serum microRNA expression signature for detection of lung cancer, involving miR-23b, miR-221, miR-148b and miR-423-3p","volume":"114","author":"Zhu","year":"2017","journal-title":"Lung Cancer"},{"key":"10.1016\/j.omtn.2022.02.005_bib112","doi-asserted-by":"crossref","first-page":"48","DOI":"10.7150\/jca.16644","article-title":"Identification of A Panel of serum microRNAs as biomarkers for early detection of lung adenocarcinoma","volume":"8","author":"Lv","year":"2017","journal-title":"J.\u00a0Cancer"},{"key":"10.1016\/j.omtn.2022.02.005_bib113","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1007\/s00432-012-1240-0","article-title":"miRNAs expression profiling to distinguish lung squamous-cell carcinoma from adenocarcinoma subtypes","volume":"138","author":"Zhang","year":"2012","journal-title":"J.\u00a0Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.omtn.2022.02.005_bib114","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.ccr.2009.10.014","article-title":"miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation","volume":"16","author":"Garofalo","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.omtn.2022.02.005_bib115","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/onc.2011.260","article-title":"miR-130a targets MET and induces TRAIL-sensitivity in NSCLC by downregulating miR-221 and 222","volume":"31","author":"Acunzo","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.omtn.2022.02.005_bib116","first-page":"7908950","article-title":"Negative regulation of PTEN by MicroRNA-221 and its association with drug resistance and cellular senescence in lung cancer cells","volume":"2018","author":"Wang","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.omtn.2022.02.005_bib117","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/s41467-017-00842-8","article-title":"Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism","volume":"8","author":"Antoniali","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtn.2022.02.005_bib118","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41417-020-00249-6","article-title":"Extracellular vesicle-associated microRNA-221-3p secreted by drug-resistant lung cancer cells targets HMBOX1 to promote the progression of lung cancer","volume":"28","author":"Li","year":"2021","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.omtn.2022.02.005_bib119","doi-asserted-by":"crossref","first-page":"3845","DOI":"10.2147\/CMAR.S246422","article-title":"lncRNA LEF1-AS1 promotes proliferation and induces apoptosis of non-small-cell lung cancer cells by regulating miR-221\/PTEN signaling","volume":"12","author":"Xiang","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.omtn.2022.02.005_bib120","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.gene.2017.04.007","article-title":"miRNA-221 acts as an oncogenic role by directly targeting TIMP2 in non-small-cell lung carcinoma","volume":"620","author":"Yin","year":"2017","journal-title":"Gene"},{"key":"10.1016\/j.omtn.2022.02.005_bib121","first-page":"604","article-title":"miR2213p promotes the cell growth of nonsmall cell lung cancer by targeting p27","volume":"20","author":"Yin","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.omtn.2022.02.005_bib122","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1158\/1535-7163.MCT-15-0089","article-title":"Targeting adenine nucleotide translocase-2 (ANT2) to overcome resistance to epidermal growth factor receptor tyrosine kinase inhibitor in non-small cell lung cancer","volume":"15","author":"Jang","year":"2016","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.omtn.2022.02.005_bib123","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.radonc.2014.11.006","article-title":"Serum inflammatory miRNAs predict radiation esophagitis in patients receiving definitive radiochemotherapy for non-small cell lung cancer","volume":"113","author":"Xu","year":"2014","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.omtn.2022.02.005_bib124","doi-asserted-by":"crossref","first-page":"13681","DOI":"10.1074\/jbc.RA119.008619","article-title":"Triple-negative breast cancer-derived microvesicles transfer microRNA221 to the recipient cells and thereby promote epithelial-to-mesenchymal transition","volume":"294","author":"Das","year":"2019","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.omtn.2022.02.005_bib125","first-page":"6983","article-title":"MiRNA-221-5p promotes breast cancer progression by regulating E-cadherin expression","volume":"23","author":"Niu","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.omtn.2022.02.005_bib126","doi-asserted-by":"crossref","first-page":"8103","DOI":"10.18632\/oncotarget.3516","article-title":"Secreted uPAR isoform 2 (uPAR7b) is a novel direct target of miR-221","volume":"6","author":"Falkenberg","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.omtn.2022.02.005_bib127","doi-asserted-by":"crossref","first-page":"4509","DOI":"10.1007\/s13277-015-4267-4","article-title":"Knockdown of miR-221 promotes the cisplatin-inducing apoptosis by targeting the BIM-Bax\/Bak axis in breast cancer","volume":"37","author":"Ye","year":"2016","journal-title":"Tumour Biol."},{"key":"10.1016\/j.omtn.2022.02.005_bib128","doi-asserted-by":"crossref","first-page":"7122","DOI":"10.3390\/molecules19067122","article-title":"miR-221\/222 promotes S-phase entry and cellular migration in control of basal-like breast cancer","volume":"19","author":"Li","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.omtn.2022.02.005_bib129","article-title":"miR-221\/222 targets adiponectin receptor 1 to promote the epithelial-to-mesenchymal transition in breast cancer","volume":"8","author":"Hwang","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtn.2022.02.005_bib130","doi-asserted-by":"crossref","first-page":"268","DOI":"10.5483\/BMBRep.2014.47.5.165","article-title":"MiR-221 promotes trastuzumab-resistance and metastasis in HER2-positive breast cancers by targeting PTEN","volume":"47","author":"Ye","year":"2014","journal-title":"BMB Rep."},{"key":"10.1016\/j.omtn.2022.02.005_bib131","article-title":"Trail resistance induces epithelial-mesenchymal transition and enhances invasiveness by suppressing PTEN via miR-221 in breast cancer","volume":"9","author":"Wang","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtn.2022.02.005_bib132","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1002\/cam4.2817","article-title":"MicroRNA-221 promotes breast cancer resistance to adriamycin via modulation of PTEN\/Akt\/mTOR signaling","volume":"9","author":"Yin","year":"2020","journal-title":"Cancer Med."},{"key":"10.1016\/j.omtn.2022.02.005_bib133","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1080\/15384101.2015.1006048","article-title":"ZEB1: at the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance","volume":"14","author":"Zhang","year":"2015","journal-title":"Cell Cycle"},{"key":"10.1016\/j.omtn.2022.02.005_bib134","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.3390\/cancers12123760","article-title":"MEK1 inhibitor combined with irradiation reduces migration of breast cancer cells including miR-221 and ZEB1 EMT marker expression","volume":"12","author":"Anastasov","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.omtn.2022.02.005_bib135","doi-asserted-by":"crossref","first-page":"704","DOI":"10.3390\/cancers12030704","article-title":"MicroRNAs in cancer treatment-induced cardiotoxicity","volume":"12","author":"Pellegrini","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.omtn.2022.02.005_bib136","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/cgt.2014.29","article-title":"Downregulation of miR-221\/222 enhances sensitivity of breast cancer cells to tamoxifen through upregulation of TIMP3","volume":"21","author":"Gan","year":"2014","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.omtn.2022.02.005_bib137","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1158\/0008-5472.CAN-16-2129","article-title":"Evolution of cancer stem-like cells in endocrine-resistant metastatic breast cancers is mediated by stromal microvesicles","volume":"77","author":"Sansone","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.omtn.2022.02.005_bib138","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1158\/0008-5472.CAN-13-2016","article-title":"14-3-3zeta orchestrates mammary tumor onset and progression via miR-221-mediated cell proliferation","volume":"74","author":"Rehman","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.omtn.2022.02.005_bib139","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.4161\/cc.28758","article-title":"miR-221\/222 control luminal breast cancer tumor progression by regulating different targets","volume":"13","author":"Dentelli","year":"2014","journal-title":"Cell Cycle"},{"key":"10.1016\/j.omtn.2022.02.005_bib140","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1093\/annonc\/mdt190","article-title":"Prognostic value of the trichorhinophalangeal syndrome-1 (TRPS-1), a GATA family transcription factor, in early-stage breast cancer","volume":"24","author":"Chen","year":"2013","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.omtn.2022.02.005_bib141","doi-asserted-by":"crossref","first-page":"ra41","DOI":"10.1126\/scisignal.2001538","article-title":"TRPS1 targeting by miR-221\/222 promotes the epithelial-to-mesenchymal transition in breast cancer","volume":"4","author":"Stinson","year":"2011","journal-title":"Sci. Signal."},{"key":"10.1016\/j.omtn.2022.02.005_bib142","first-page":"1091","article-title":"Alteration of miRNA expression correlates with lifestyle, social and environmental determinants in esophageal carcinoma","volume":"35","author":"Stanitz","year":"2015","journal-title":"Anticancer Res."},{"key":"10.1016\/j.omtn.2022.02.005_bib143","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/bjc.2011.198","article-title":"Circulating microRNAs in plasma of patients with oesophageal squamous cell carcinoma","volume":"105","author":"Komatsu","year":"2011","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.omtn.2022.02.005_bib144","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.3892\/ol.2013.1251","article-title":"Differential expression of miRNAs in esophageal cancer tissue","volume":"5","author":"Liu","year":"2013","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.omtn.2022.02.005_bib145","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1053\/j.gastro.2013.08.008","article-title":"Bile acids increase levels of microRNAs 221 and 222, leading to degradation of CDX2 during esophageal carcinogenesis","volume":"145","author":"Matsuzaki","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.omtn.2022.02.005_bib146","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.3390\/jcm4081566","article-title":"Role of MicroRNAs-221\/222 in digestive systems","volume":"4","author":"Matsuzaki","year":"2015","journal-title":"J.\u00a0Clin. Med."},{"key":"10.1016\/j.omtn.2022.02.005_bib147","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1097\/SLA.0000000000001928","article-title":"miR-221 mediates chemoresistance of esophageal adenocarcinoma by direct targeting of DKK2 expression","volume":"264","author":"Wang","year":"2016","journal-title":"Ann. Surg."},{"key":"10.1016\/j.omtn.2022.02.005_bib148","first-page":"1439","article-title":"MicroRNAs and the PTEN\/PI3K\/Akt pathway in gastric cancer (Review)","volume":"41","author":"Hu","year":"2019","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.omtn.2022.02.005_bib149","first-page":"467","article-title":"Increased Expression of MicroRNA-221 in gastric cancer and its clinical significance","volume":"40","author":"Liu","year":"2012","journal-title":"J.\u00a0Int. Med. Res."},{"key":"10.1016\/j.omtn.2022.02.005_bib150","first-page":"1273","article-title":"MicroRNA dysregulation in gastric cancer","volume":"19","author":"Pan","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.omtn.2022.02.005_bib151","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1186\/1471-2407-10-367","article-title":"MicroRNA-221 and microRNA-222 regulate gastric carcinoma cell proliferation and radioresistance by targeting PTEN","volume":"10","author":"Chun-Zhi","year":"2010","journal-title":"BMC Cancer"},{"key":"10.1016\/j.omtn.2022.02.005_bib152","doi-asserted-by":"crossref","DOI":"10.1177\/1010428317701636","article-title":"miR-221 and miR-222 synergistically regulate hepatocyte growth factor activator inhibitor type 1 to promote cell proliferation and migration in gastric cancer","volume":"39","author":"Ning","year":"2017","journal-title":"Tumour Biol."},{"key":"10.1016\/j.omtn.2022.02.005_bib153","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.12659\/MSM.894324","article-title":"miR-221 and miR-222 simultaneously target RECK and regulate growth and invasion of gastric cancer cells","volume":"21","author":"Liu","year":"2015","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.omtn.2022.02.005_bib154","doi-asserted-by":"crossref","first-page":"ra63","DOI":"10.1126\/scisignal.2005231","article-title":"Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells","volume":"7","author":"Ono","year":"2014","journal-title":"Sci. Signal."},{"key":"10.1016\/j.omtn.2022.02.005_bib155","doi-asserted-by":"crossref","first-page":"5473","DOI":"10.18632\/oncotarget.16681","article-title":"miRNA dysregulation and the risk of metastasis and invasion in papillary thyroid cancer: a systematic review and meta-analysis","volume":"9","author":"Wang","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.omtn.2022.02.005_bib156","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1038\/onc.2015.189","article-title":"Induction of miRNA-181a by genotoxic treatments promotes chemotherapeutic resistance and metastasis in breast cancer","volume":"35","author":"Niu","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.omtn.2022.02.005_bib157","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.ccell.2014.09.005","article-title":"Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis","volume":"26","author":"Melo","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.omtn.2022.02.005_bib158","doi-asserted-by":"crossref","first-page":"4161","DOI":"10.2147\/OTT.S143315","article-title":"miRNA-221 of exosomes originating from bone marrow mesenchymal stem cells promotes oncogenic activity in gastric cancer","volume":"10","author":"Ma","year":"2017","journal-title":"Onco Targets Ther."},{"key":"10.1016\/j.omtn.2022.02.005_bib159","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/bjc.2014.14","article-title":"Deregulated microRNAs in gastric cancer tissue-derived mesenchymal stem cells: novel biomarkers and a mechanism for gastric cancer","volume":"110","author":"Wang","year":"2014","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.omtn.2022.02.005_bib160","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1007\/s12032-012-0452-0","article-title":"Plasma microRNAs serve as novel potential biomarkers for early detection of gastric cancer","volume":"30","author":"Cai","year":"2013","journal-title":"Med. Oncol."},{"key":"10.1016\/j.omtn.2022.02.005_bib161","first-page":"188","article-title":"Expression analysis of mir-21 and mir-221 in cancerous tissues from Iranian patients with gastric cancer","volume":"19","author":"Effatpanah","year":"2015","journal-title":"Iran Biomed. J."},{"key":"10.1016\/j.omtn.2022.02.005_bib162","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/jso.23271","article-title":"Prognostic implications for high expression of oncogenic microRNAs in advanced gastric carcinoma","volume":"107","author":"Kim","year":"2013","journal-title":"J.\u00a0Surg. Oncol."},{"key":"10.1016\/j.omtn.2022.02.005_bib163","doi-asserted-by":"crossref","first-page":"14153","DOI":"10.18632\/oncotarget.3686","article-title":"miR-221\/222 induces pancreatic cancer progression through the regulation of matrix metalloproteinases","volume":"6","author":"Xu","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.omtn.2022.02.005_bib164","first-page":"465","article-title":"Down-regulation of miR-221 inhibits proliferation of pancreatic cancer cells through up-regulation of PTEN, p27(kip1), p57(kip2), and PUMA","volume":"3","author":"Sarkar","year":"2013","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.omtn.2022.02.005_bib165","doi-asserted-by":"crossref","DOI":"10.1007\/s13277-016-5445-8","article-title":"MiRNA-221-3p desensitizes pancreatic cancer cells to 5-fluorouracil by targeting RB1","author":"Zhao","year":"2016","journal-title":"Tumour Biol."},{"key":"10.1016\/j.omtn.2022.02.005_bib166","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.omtn.2022.02.005_bib167","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1056\/NEJMoa1915745","article-title":"Atezolizumab plus bevacizumab in Unresectable hepatocellular carcinoma","volume":"382","author":"Finn","year":"2020","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.omtn.2022.02.005_bib168","first-page":"4764","article-title":"miR-221 promotes growth and invasion of hepatocellular carcinoma cells by constitutive activation of NFkappaB","volume":"8","author":"Liu","year":"2016","journal-title":"Am. J. Transl Res."},{"key":"10.1016\/j.omtn.2022.02.005_bib169","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.1002\/jcp.26863","article-title":"In\u00a0vivo and in\u00a0vitro effects of microRNA-221 on hepatocellular carcinoma development and progression through the JAK-STAT3 signaling pathway by targeting SOCS3","volume":"234","author":"Huang","year":"2019","journal-title":"J.\u00a0Cell Physiol."},{"key":"10.1016\/j.omtn.2022.02.005_bib170","doi-asserted-by":"crossref","first-page":"5651","DOI":"10.1038\/onc.2008.178","article-title":"MiR-221 controls CDKN1C\/p57 and CDKN1B\/p27 expression in human hepatocellular carcinoma","volume":"27","author":"Fornari","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.omtn.2022.02.005_bib171","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/j.humpath.2010.12.010","article-title":"Deregulated expression of microRNA-221 with the potential for prognostic biomarkers in surgically resected hepatocellular carcinoma","volume":"42","author":"Yoon","year":"2011","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.omtn.2022.02.005_bib172","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.meegid.2017.03.030","article-title":"miRNA-101-1 and miRNA-221 expressions and their polymorphisms as biomarkers for early diagnosis of hepatocellular carcinoma","volume":"51","author":"Shaker","year":"2017","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.omtn.2022.02.005_bib173","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3233\/CBM-161671","article-title":"Clinical potential of miRNA-221 as a novel prognostic biomarker for hepatocellular carcinoma","volume":"18","author":"Chen","year":"2017","journal-title":"Cancer Biomark."},{"key":"10.1016\/j.omtn.2022.02.005_bib174","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/mc.21864","article-title":"Expression of microRNAs, miR-21, miR-31, miR-122, miR-145, miR-146a, miR-200c, miR-221, miR-222, and miR-223 in patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma and its prognostic significance","volume":"52","author":"Karakatsanis","year":"2013","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.omtn.2022.02.005_bib175","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.bbrc.2011.01.111","article-title":"Expression of serum miR-221 in human hepatocellular carcinoma and its prognostic significance","volume":"406","author":"Li","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.omtn.2022.02.005_bib176","doi-asserted-by":"crossref","first-page":"12273","DOI":"10.1007\/s13277-016-5097-8","article-title":"Serum microRNA panels as potential biomarkers for early detection of hepatocellular carcinoma on top of HCV infection","volume":"37","author":"Zekri","year":"2016","journal-title":"Tumour Biol."},{"key":"10.1016\/j.omtn.2022.02.005_bib177","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.1002\/ijc.33111","article-title":"The exosome encapsulated microRNAs as circulating diagnostic marker for hepatocellular carcinoma with low alpha-fetoprotein","volume":"147","author":"Ghosh","year":"2020","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.omtn.2022.02.005_bib178","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.2147\/IJN.S157805","article-title":"miR-221 suppression through nanoparticle-based miRNA delivery system for hepatocellular carcinoma therapy and its diagnosis as a potential biomarker","volume":"13","author":"Li","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.omtn.2022.02.005_bib179","doi-asserted-by":"crossref","first-page":"3953","DOI":"10.1158\/1078-0432.CCR-16-1464","article-title":"In hepatocellular carcinoma miR-221 modulates sorafenib resistance through inhibition of caspase-3-mediated apoptosis","volume":"23","author":"Fornari","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.omtn.2022.02.005_bib180","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.omtn.2022.02.005_bib181","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.critrevonc.2016.11.012","article-title":"Cholangiocarcinoma","volume":"116","author":"Squadroni","year":"2017","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.omtn.2022.02.005_bib182","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.2217\/pgs-2017-0010","article-title":"miRNA profiling for diagnosis, prognosis and stratification of cancer treatment in cholangiocarcinoma","volume":"18","author":"Puik","year":"2017","journal-title":"Pharmacogenomics"},{"key":"10.1016\/j.omtn.2022.02.005_bib183","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0163699","article-title":"Circulating plasma levels of MicroRNA-21 and MicroRNA-221 are potential diagnostic markers for primary intrahepatic cholangiocarcinoma","volume":"11","author":"Correa-Gallego","year":"2016","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtn.2022.02.005_bib184","article-title":"miR-221 promotes epithelial-mesenchymal transition through targeting PTEN and forms a positive feedback loop with beta-catenin\/c-Jun signaling pathway in extra-hepatic cholangiocarcinoma","volume":"10","author":"Li","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtn.2022.02.005_bib185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0077623","article-title":"miR-29b, miR-205 and miR-221 enhance chemosensitivity to gemcitabine in HuH28 human cholangiocarcinoma cells","volume":"8","author":"Okamoto","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtn.2022.02.005_bib186","first-page":"15","article-title":"Epidemiology of bladder cancer","volume":"8","author":"Saginala","year":"2020","journal-title":"Med. Sci."},{"key":"10.1016\/j.omtn.2022.02.005_bib187","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/gcc.22516","article-title":"miR-221\/222 cluster expression improves clinical stratification of non-muscle invasive bladder cancer (TaT1) patients' risk for short-term relapse and progression","volume":"57","author":"Tsikrika","year":"2018","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.omtn.2022.02.005_bib188","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s12943-019-1036-9","article-title":"METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221\/222 maturation in m6A-dependent manner","volume":"18","author":"Han","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.omtn.2022.02.005_bib189","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3389\/fonc.2020.00589","article-title":"Downregulation of HMGA1 mediates autophagy and inhibits migration and invasion in bladder cancer via miRNA-221\/TP53INP1\/p-ERK Axis","volume":"10","author":"Liu","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.omtn.2022.02.005_bib190","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12894-015-0028-3","article-title":"miR-221 facilitates the TGFbeta1-induced epithelial-mesenchymal transition in human bladder cancer cells by targeting STMN1","volume":"15","author":"Liu","year":"2015","journal-title":"BMC Urol."},{"key":"10.1016\/j.omtn.2022.02.005_bib191","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.bbrc.2018.12.046","article-title":"Circular RNA circMTO1 suppresses bladder cancer metastasis by sponging miR-221 and inhibiting epithelial-to-mesenchymal transition","volume":"508","author":"Li","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.omtn.2022.02.005_bib192","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.3892\/ijo.2015.2837","article-title":"MiR-221-induced PUMA silencing mediates immune evasion of bladder cancer cells","volume":"46","author":"Fu","year":"2015","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.omtn.2022.02.005_bib193","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0140862","article-title":"Integrated analysis reveals together miR-182, miR-200c and miR-221 can help in the diagnosis of prostate cancer","volume":"10","author":"Gu","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtn.2022.02.005_bib194","doi-asserted-by":"crossref","DOI":"10.1111\/and.13384","article-title":"Diagnostic significance of miR-21, miR-141, miR-18a and miR-221 as novel biomarkers in prostate cancer among Egyptian patients","volume":"51","author":"Ibrahim","year":"2019","journal-title":"Andrologia"},{"key":"10.1016\/j.omtn.2022.02.005_bib195","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1002\/ijc.27973","article-title":"miQ--a novel microRNA based diagnostic and prognostic tool for prostate cancer","volume":"132","author":"Larne","year":"2013","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.omtn.2022.02.005_bib196","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/s41598-019-57101-7","article-title":"Circulating miR-141 and miR-375 are associated with treatment outcome in metastatic castration resistant prostate cancer","volume":"10","author":"Zedan","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omtn.2022.02.005_bib197","doi-asserted-by":"crossref","first-page":"4106","DOI":"10.7150\/jca.37842","article-title":"microRNA expression profiling in young prostate cancer patients","volume":"11","author":"Valera","year":"2020","journal-title":"J.\u00a0Cancer"},{"key":"10.1016\/j.omtn.2022.02.005_bib198","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.gene.2015.07.017","article-title":"Effects of microRNA-221\/222 on cell proliferation and apoptosis in prostate cancer cells","volume":"572","author":"Wang","year":"2015","journal-title":"Gene"},{"key":"10.1016\/j.omtn.2022.02.005_bib199","doi-asserted-by":"crossref","first-page":"5311","DOI":"10.21873\/anticanres.13724","article-title":"MiR-221 is specifically elevated in PC3 cells and its deletion reduces adhesion, motility and growth","volume":"39","author":"Dart","year":"2019","journal-title":"Anticancer Res."},{"key":"10.1016\/j.omtn.2022.02.005_bib200","article-title":"Down-regulation of mir-221 and mir-222 restrain prostate cancer cell proliferation and migration that is partly mediated by activation of SIRT1","volume":"9","author":"Yang","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtn.2022.02.005_bib201","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1158\/0008-5472.CAN-13-1606","article-title":"Survival in patients with high-risk prostate cancer is predicted by miR-221, which regulates proliferation, apoptosis, and invasion of prostate cancer cells by inhibiting IRF2 and SOCS3","volume":"74","author":"Kneitz","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.omtn.2022.02.005_bib202","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/ijc.24715","article-title":"Expression of microRNA-221 is progressively reduced in aggressive prostate cancer and metastasis and predicts clinical recurrence","volume":"127","author":"Spahn","year":"2010","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.omtn.2022.02.005_bib203","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1134\/S0006297915030037","article-title":"Downregulation of miR-221, -30d, and -15a contributes to pathogenesis of prostate cancer by targeting Bmi-1","volume":"80","author":"Xuan","year":"2015","journal-title":"Biochemistry (Mosc)"},{"key":"10.1016\/j.omtn.2022.02.005_bib204","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/bjc.2015.300","article-title":"MicroRNA expression signature of castration-resistant prostate cancer: the microRNA-221\/222 cluster functions as a tumour suppressor and disease progression marker","volume":"113","author":"Goto","year":"2015","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.omtn.2022.02.005_bib205","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/6392748","article-title":"miR-221 augments TRAIL-mediated apoptosis in prostate cancer cells by inducing endogenous TRAIL expression and targeting the functional repressors SOCS3 and PIK3R1","volume":"2019","author":"Krebs","year":"2019","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.omtn.2022.02.005_bib206","doi-asserted-by":"crossref","first-page":"670","DOI":"10.3390\/jcm9030670","article-title":"miR-221-3p regulates VEGFR2 expression in high-risk prostate cancer and represents an escape mechanism from sunitinib in\u00a0vitro","volume":"9","author":"Krebs","year":"2020","journal-title":"J.\u00a0Clin. Med."},{"key":"10.1016\/j.omtn.2022.02.005_bib207","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1186\/s12885-019-5819-6","article-title":"miR-221-5p regulates proliferation and migration in human prostate cancer cells and reduces tumor growth in\u00a0vivo","volume":"19","author":"Kiener","year":"2019","journal-title":"BMC Cancer"},{"key":"10.1016\/j.omtn.2022.02.005_bib208","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12894-018-0325-8","article-title":"miR-221-5p enhances cell proliferation and metastasis through post-transcriptional regulation of SOCS1 in human prostate cancer","volume":"18","author":"Shao","year":"2018","journal-title":"BMC Urol."},{"key":"10.1016\/j.omtn.2022.02.005_bib209","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s12920-020-00788-9","article-title":"miRNAs expression signature potentially associated with lymphatic dissemination in locally advanced prostate cancer","volume":"13","author":"Pudova","year":"2020","journal-title":"BMC Med. Genomics"},{"key":"10.1016\/j.omtn.2022.02.005_bib210","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1002\/pros.23825","article-title":"The association of let-7c, miR-21, miR-145, miR-182, and miR-221 with clinicopathologic parameters of prostate cancer in patients diagnosed with low-risk disease","volume":"79","author":"Kurul","year":"2019","journal-title":"Prostate"},{"key":"10.1016\/j.omtn.2022.02.005_bib211","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0184166","article-title":"Androgen receptor-mediated downregulation of microRNA-221 and -222 in castration-resistant prostate cancer","volume":"12","author":"Gui","year":"2017","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtn.2022.02.005_bib212","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.1038\/onc.2013.230","article-title":"MiR-221 promotes the development of androgen independence in prostate cancer cells via downregulation of HECTD2 and RAB1A","volume":"33","author":"Sun","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.omtn.2022.02.005_bib213","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s12032-011-9934-8","article-title":"MiR-221 expression affects invasion potential of human prostate carcinoma cell lines by targeting DVL2","volume":"29","author":"Zheng","year":"2012","journal-title":"Med. Oncol."},{"key":"10.1016\/j.omtn.2022.02.005_bib214","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrurol.2014.194","article-title":"Landmarks in the diagnosis and treatment of renal cell carcinoma","volume":"11","author":"Bhatt","year":"2014","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.omtn.2022.02.005_bib215","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.ctrv.2005.07.009","article-title":"Renal cell carcinoma: current status and future prospects","volume":"31","author":"Drucker","year":"2005","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.omtn.2022.02.005_bib216","doi-asserted-by":"crossref","first-page":"543817","DOI":"10.3389\/fonc.2020.543817","article-title":"Systematic analysis of microRNA biomarkers for diagnosis, prognosis, and therapy in patients with clear cell renal cell carcinoma","volume":"10","author":"Cheng","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.omtn.2022.02.005_bib217","doi-asserted-by":"crossref","first-page":"533.e521","DOI":"10.1016\/j.urolonc.2016.06.011","article-title":"Expression of miRNA-21 and miRNA-221 in clear cell renal cell carcinoma (ccRCC) and their possible role in the development of ccRCC","volume":"34","author":"Szabo","year":"2016","journal-title":"Urol. Oncol."},{"key":"10.1016\/j.omtn.2022.02.005_bib218","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1007\/s13277-013-1531-3","article-title":"Higher circulating expression levels of miR-221 associated with poor overall survival in renal cell carcinoma patients","volume":"35","author":"Teixeira","year":"2014","journal-title":"Tumour Biol."},{"key":"10.1016\/j.omtn.2022.02.005_bib219","article-title":"Combined influence of EGF+61G>A and TGFB+869T>C functional polymorphisms in renal cell carcinoma progression and overall survival: the link to plasma circulating MiR-7 and MiR-221\/222 expression","volume":"10","author":"Teixeira","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtn.2022.02.005_bib220","first-page":"5224","article-title":"miRNA-221 promotes proliferation, migration and invasion by targeting TIMP2 in renal cell carcinoma","volume":"8","author":"Lu","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.omtn.2022.02.005_bib221","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1038\/mt.2015.129","article-title":"miR-221\/222 are involved in response to sunitinib treatment in metastatic renal cell carcinoma","volume":"23","author":"Khella","year":"2015","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omtn.2022.02.005_bib222","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.86051","article-title":"Deep sequencing reveals microRNAs predictive of antiangiogenic drug response","volume":"1","author":"Garcia-Donas","year":"2016","journal-title":"JCI Insight"},{"key":"10.1016\/j.omtn.2022.02.005_bib223","first-page":"2961","article-title":"Candidate MicroRNA biomarkers of therapeutic response to sunitinib in metastatic renal cell carcinoma: a validation study in patients with extremely good and poor response","volume":"38","author":"Kovacova","year":"2018","journal-title":"Anticancer Res."},{"key":"10.1016\/j.omtn.2022.02.005_bib224","doi-asserted-by":"crossref","first-page":"109406","DOI":"10.1016\/j.biopha.2019.109406","article-title":"miR-221-5p acts as an oncogene and predicts worse survival in patients of renal cell cancer","volume":"119","author":"Liu","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.omtn.2022.02.005_bib225","doi-asserted-by":"crossref","first-page":"103315","DOI":"10.18632\/oncotarget.21733","article-title":"Plasmatic miR-210, miR-221 and miR-1233 profile: potential liquid biopsies candidates for renal cell carcinoma","volume":"8","author":"Dias","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.omtn.2022.02.005_bib226","first-page":"6697","article-title":"miR-221 regulates proliferation and apoptosis of ovarian cancer cells by targeting BMF","volume":"16","author":"Xie","year":"2018","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.omtn.2022.02.005_bib227","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.3892\/ijo.2017.3898","article-title":"Overexpression of miRNA-221 promotes cell proliferation by targeting the apoptotic protease activating factor-1 and indicates a poor prognosis in ovarian cancer","volume":"50","author":"Li","year":"2017","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.omtn.2022.02.005_bib228","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/gcc.20768","article-title":"MiR-221 and MiR-222 alterations in sporadic ovarian carcinoma: relationship to CDKN1B, CDKNIC and overall survival","volume":"49","author":"Wurz","year":"2010","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.omtn.2022.02.005_bib229","first-page":"64","article-title":"Prognostic significance of serum microRNA-221 expression in human epithelial ovarian cancer","volume":"41","author":"Hong","year":"2013","journal-title":"J.\u00a0Int. Med. Res."},{"key":"10.1016\/j.omtn.2022.02.005_bib230","first-page":"7252013","article-title":"Role of miR-221\/222 in tumor development and the underlying mechanism","volume":"2019","author":"Song","year":"2019","journal-title":"J.\u00a0Oncol."},{"key":"10.1016\/j.omtn.2022.02.005_bib231","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s10616-017-0134-z","article-title":"MiR-221\/222 promote chemoresistance to cisplatin in ovarian cancer cells by targeting PTEN\/PI3K\/AKT signaling pathway","volume":"70","author":"Amini-Farsani","year":"2018","journal-title":"Cytotechnology"},{"key":"10.1016\/j.omtn.2022.02.005_bib232","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.bbrc.2017.01.002","article-title":"MiR-221-3p targets ARF4 and inhibits the proliferation and migration of epithelial ovarian cancer cells","volume":"497","author":"Wu","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.omtn.2022.02.005_bib233","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1056\/NEJMcp1210379","article-title":"Clinical practice. Cervical-cancer screening with human papillomavirus and cytologic cotesting","volume":"369","author":"Schiffman","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.omtn.2022.02.005_bib234","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0140-6736(13)60022-7","article-title":"Human papillomavirus and cervical cancer","volume":"382","author":"Crosbie","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.omtn.2022.02.005_bib235","first-page":"1518","article-title":"MicroRNA-221 inhibits human papillomavirus 16 E1-E2 mediated DNA replication through activating SOCS1\/Type I IFN signaling pathway","volume":"12","author":"Lu","year":"2019","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.omtn.2022.02.005_bib236","doi-asserted-by":"crossref","first-page":"3220","DOI":"10.1038\/s41419-017-0077-5","article-title":"MicroRNA-221-3p, a TWIST2 target, promotes cervical cancer metastasis by directly targeting THBS2","volume":"8","author":"Wei","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.omtn.2022.02.005_bib237","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1038\/s41388-018-0511-x","article-title":"Cervical squamous cell carcinoma-secreted exosomal miR-221-3p promotes lymphangiogenesis and lymphatic metastasis by targeting VASH1","volume":"38","author":"Zhou","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.omtn.2022.02.005_bib238","first-page":"3645","article-title":"Upregulated exosomal miR-221\/222 promotes cervical cancer via repressing methyl-CpG-binding domain protein 2","volume":"23","author":"Pan","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.omtn.2022.02.005_bib239","first-page":"1509","article-title":"MiR-221 and miR-222 simultaneously target ARID1A and enhance proliferation and invasion of cervical cancer cells","volume":"20","author":"Yang","year":"2016","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.omtn.2022.02.005_bib240","doi-asserted-by":"crossref","DOI":"10.3390\/cancers10110408","article-title":"The emerging role of the microenvironment in endometrial cancer","volume":"10","author":"Sahoo","year":"2018","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.omtn.2022.02.005_bib241","doi-asserted-by":"crossref","first-page":"143938","DOI":"10.1016\/j.gene.2019.06.028","article-title":"SLUG\/HIF1-alpha\/miR-221 regulatory circuit in endometrial cancer","volume":"711","author":"Penolazzi","year":"2019","journal-title":"Gene"},{"key":"10.1016\/j.omtn.2022.02.005_bib242","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.12659\/MSM.891327","article-title":"Circulating miR-221 expression level and prognosis of cutaneous malignant melanoma","volume":"20","author":"Li","year":"2014","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.omtn.2022.02.005_bib243","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1002\/ijc.28097","article-title":"The abrogation of the HOXB7\/PBX2 complex induces apoptosis in melanoma through the miR-221&222-c-FOS pathway","volume":"133","author":"Errico","year":"2013","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.omtn.2022.02.005_bib244","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.biopha.2015.07.018","article-title":"Serum microRNA-221 functions as a potential diagnostic and prognostic marker for patients with osteosarcoma","volume":"75","author":"Yang","year":"2015","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.omtn.2022.02.005_bib245","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1177\/1724600819843537","article-title":"Clinical significance of tumor miR-21, miR-221, miR-143, and miR-106a as biomarkers in patients with osteosarcoma","volume":"34","author":"Zhao","year":"2019","journal-title":"Int. J. Biol. Markers"},{"key":"10.1016\/j.omtn.2022.02.005_bib246","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000011100","article-title":"MiRNA-221 from tissue may predict the prognosis of patients with osteosarcoma","volume":"97","author":"Gong","year":"2018","journal-title":"Medicine"},{"key":"10.1016\/j.omtn.2022.02.005_bib247","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/1878-0261.12154","article-title":"miRNA profiling identifies deregulated miRNAs associated with osteosarcoma development and time to metastasis in two large cohorts","volume":"12","author":"Andersen","year":"2018","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.omtn.2022.02.005_bib248","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.3892\/ijmm.2015.2352","article-title":"MiR-221 increases osteosarcoma cell proliferation, invasion and migration partly through the downregulation of PTEN","volume":"36","author":"Zhu","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.omtn.2022.02.005_bib249","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.arcmed.2020.10.017","article-title":"MicroRNA-221 promotes cell proliferation and inhibits apoptosis in osteosarcoma cells by directly targeting FBXW11 and regulating Wnt signaling","volume":"52","author":"Zhang","year":"2021","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.omtn.2022.02.005_bib250","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20190198","article-title":"MicroRNA-221 promotes cisplatin resistance in osteosarcoma cells by targeting PPP2R2A","volume":"39","author":"Yu","year":"2019","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.omtn.2022.02.005_bib251","article-title":"MicroRNA-221 induces cell survival and cisplatin resistance through PI3K\/Akt pathway in human osteosarcoma","volume":"8","author":"Zhao","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtn.2022.02.005_bib252","doi-asserted-by":"crossref","first-page":"4665","DOI":"10.1002\/jcb.27755","article-title":"MicroRNA-221 regulates osteosarcoma cell proliferation, apoptosis, migration, and invasion by targeting CDKN1B\/p27","volume":"120","author":"Hu","year":"2019","journal-title":"J.\u00a0Cell Biochem."},{"key":"10.1016\/j.omtn.2022.02.005_bib253","doi-asserted-by":"crossref","first-page":"4772","DOI":"10.1002\/jcb.26145","article-title":"Long noncoding RNA GAS5 suppresses cell growth and epithelial-mesenchymal transition in osteosarcoma by regulating the miR-221\/ARHI pathway","volume":"118","author":"Ye","year":"2017","journal-title":"J.\u00a0Cell Biochem."},{"key":"10.1016\/j.omtn.2022.02.005_bib254","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1038\/s41388-017-0081-3","article-title":"PAX3-FOXO1 drives miR-486-5p and represses miR-221 contributing to pathogenesis of alveolar rhabdomyosarcoma","volume":"37","author":"Hanna","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.omtn.2022.02.005_bib255","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/j.molonc.2015.03.013","article-title":"miRNA-221 and miRNA-222 induce apoptosis via the KIT\/AKT signalling pathway in gastrointestinal stromal tumours","volume":"9","author":"Ihle","year":"2015","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.omtn.2022.02.005_bib256","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12918-015-0242-3","article-title":"c-Myc and viral cofactor Kaposin B co-operate to elicit angiogenesis through modulating miRNome traits of endothelial cells","volume":"10","author":"Chang","year":"2016","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.omtn.2022.02.005_bib257","doi-asserted-by":"crossref","DOI":"10.1093\/annonc\/mdu050","article-title":"High-grade glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"25","author":"Stupp","year":"2014","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.omtn.2022.02.005_bib258","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.molonc.2013.12.010","article-title":"Expression of 19 microRNAs in glioblastoma and comparison with other brain neoplasia of grades I-III","volume":"8","author":"Visani","year":"2014","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.omtn.2022.02.005_bib259","doi-asserted-by":"crossref","DOI":"10.1177\/1010428317726842","article-title":"MicroRNA-target cross-talks: key players in glioblastoma multiforme","volume":"39","author":"Toraih","year":"2017","journal-title":"Tumour Biol."},{"key":"10.1016\/j.omtn.2022.02.005_bib260","doi-asserted-by":"crossref","first-page":"264","DOI":"10.4149\/neo_2010_03_264","article-title":"MicroRNA-181 family predicts response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients","volume":"57","author":"Slaby","year":"2010","journal-title":"Neoplasma"},{"key":"10.1016\/j.omtn.2022.02.005_bib261","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1111\/j.1349-7006.2011.02092.x","article-title":"MiR-195, miR-196b, miR-181c, miR-21 expression levels and O-6-methylguanine-DNA methyltransferase methylation status are associated with clinical outcome in glioblastoma patients","volume":"102","author":"Lakomy","year":"2011","journal-title":"Cancer Sci."},{"key":"10.1016\/j.omtn.2022.02.005_bib262","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s11060-013-1078-6","article-title":"Comparison of microRNA expression levels between initial and recurrent glioblastoma specimens","volume":"112","author":"Ilhan-Mutlu","year":"2013","journal-title":"J.\u00a0Neurooncol."},{"key":"10.1016\/j.omtn.2022.02.005_bib263","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/ajcp\/aqy008","article-title":"Upregulation of miR-125b, miR-181d, and miR-221 predicts poor prognosis in MGMT promoter-unmethylated glioblastoma patients","volume":"149","author":"Chen","year":"2018","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.omtn.2022.02.005_bib264","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s11060-019-03256-2","article-title":"Clinical impact of circulating oncogenic MiRNA-221 and MiRNA-222 in glioblastoma multiform","volume":"144","author":"Swellam","year":"2019","journal-title":"J.\u00a0Neurooncol."},{"key":"10.1016\/j.omtn.2022.02.005_bib265","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.21873\/anticanres.14308","article-title":"Investigation of the effects of MicroRNA-221 expression levels in glioblastoma multiforme tumors","volume":"40","author":"Ozdogan","year":"2020","journal-title":"Anticancer Res."},{"key":"10.1016\/j.omtn.2022.02.005_bib266","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1007\/s12031-020-01706-5","article-title":"Emerging role of miRNAs as liquid biopsy markers for prediction of glioblastoma multiforme prognosis","volume":"71","author":"Swellam","year":"2021","journal-title":"J.\u00a0Mol. Neurosci."},{"key":"10.1016\/j.omtn.2022.02.005_bib267","first-page":"1504","article-title":"miR-221\/222 is the regulator of Cx43 expression in human glioblastoma cells","volume":"27","author":"Hao","year":"2012","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.omtn.2022.02.005_bib268","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/onc.2011.280","article-title":"miR-221\/222 overexpession in human glioblastoma increases invasiveness by targeting the protein phosphate PTPmu","volume":"31","author":"Quintavalle","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.omtn.2022.02.005_bib269","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/neup.12129","article-title":"MicroRNA-221 targeting PI3-K\/Akt signaling axis induces cell proliferation and BCNU resistance in human glioblastoma","volume":"34","author":"Xie","year":"2014","journal-title":"Neuropathology"},{"key":"10.1016\/j.omtn.2022.02.005_bib270","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.3892\/ol.2015.3594","article-title":"Reduced PTEN expression and overexpression of miR-17-5p, -19a-3p, -19b-3p, -21-5p, -130b-3p, -221-3p and -222-3p by glioblastoma stem-like cells following irradiation","volume":"10","author":"Tokudome","year":"2015","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.omtn.2022.02.005_bib271","doi-asserted-by":"crossref","first-page":"22272","DOI":"10.1002\/jcp.28794","article-title":"Silencing microRNA-221\/222 cluster suppresses glioblastoma angiogenesis by suppressor of cytokine signaling-3-dependent JAK\/STAT pathway","volume":"234","author":"Xu","year":"2019","journal-title":"J.\u00a0Cell Physiol."},{"key":"10.1016\/j.omtn.2022.02.005_bib272","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2174\/1566524013666131203103147","article-title":"miR-221\/222 confers radioresistance in glioblastoma cells through activating Akt independent of PTEN status","volume":"14","author":"Li","year":"2014","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.omtn.2022.02.005_bib273","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s11060-016-2308-5","article-title":"Exosomal miR-221 targets DNM3 to induce tumor progression and temozolomide resistance in glioma","volume":"131","author":"Yang","year":"2017","journal-title":"J.\u00a0Neurooncol."},{"key":"10.1016\/j.omtn.2022.02.005_bib274","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0074466","article-title":"MiR-221\/222 target the DNA methyltransferase MGMT in glioma cells","volume":"8","author":"Quintavalle","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtn.2022.02.005_bib275","doi-asserted-by":"crossref","first-page":"17768","DOI":"10.1038\/s41598-020-74746-x","article-title":"Reduced EGFR and increased miR-221 is associated with increased resistance to temozolomide and radiotherapy in glioblastoma","volume":"10","author":"Areeb","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omtn.2022.02.005_bib276","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2015.05.001","article-title":"An overview of microRNAs","volume":"87","author":"Hammond","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.omtn.2022.02.005_bib277","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.jhep.2011.10.027","article-title":"Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace","volume":"56","author":"Baffy","year":"2012","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.omtn.2022.02.005_bib278","doi-asserted-by":"crossref","first-page":"846","DOI":"10.4254\/wjh.v7.i6.846","article-title":"Non-alcoholic fatty liver disease: the diagnosis and management","volume":"7","author":"Abd El-Kader","year":"2015","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.omtn.2022.02.005_bib279","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1007\/s10620-015-4025-x","article-title":"Function of autophagy in nonalcoholic fatty liver disease","volume":"61","author":"Czaja","year":"2016","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.omtn.2022.02.005_bib280","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1055\/s-0034-1397345","article-title":"MicroRNAs in fatty liver disease","volume":"35","author":"Sobolewski","year":"2015","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.omtn.2022.02.005_bib281","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.mad.2016.07.001","article-title":"Endoplasmic reticulum stress related molecular mechanisms in nonalcoholic steatohepatitis","volume":"157","author":"Bozaykut","year":"2016","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.omtn.2022.02.005_bib282","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.taap.2012.04.018","article-title":"Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet","volume":"262","author":"Tryndyak","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.omtn.2022.02.005_bib283","doi-asserted-by":"crossref","first-page":"9360","DOI":"10.3390\/ijms15069360","article-title":"MicroRNA function in the profibrogenic interplay upon chronic liver disease","volume":"15","author":"Huang","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.omtn.2022.02.005_bib284","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ebiom.2018.09.051","article-title":"Targeting hepatic miR-221\/222 for therapeutic intervention of nonalcoholic steatohepatitis in mice","volume":"37","author":"Jiang","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.omtn.2022.02.005_bib285","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1089\/ars.2012.4803","article-title":"Regulation of SIRT1 by oxidative stress-responsive miRNAs and a systematic approach to identify its role in the endothelium","volume":"19","author":"Chen","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.omtn.2022.02.005_bib286","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1007\/s00125-013-2950-9","article-title":"Human adipose microRNA-221 is upregulated in obesity and affects fat metabolism downstream of leptin and TNF-alpha","volume":"56","author":"Meerson","year":"2013","journal-title":"Diabetologia"},{"key":"10.1016\/j.omtn.2022.02.005_bib287","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/hep.25984","article-title":"MicroRNA-221 overexpression accelerates hepatocyte proliferation during liver regeneration","volume":"57","author":"Yuan","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.omtn.2022.02.005_bib288","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ebiom.2018.10.040","article-title":"MicroRNA 221\/222 cluster kicks out Timp-3 to inflame the liver","volume":"37","author":"Menghini","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.omtn.2022.02.005_bib289","doi-asserted-by":"crossref","first-page":"476","DOI":"10.3389\/fncel.2015.00476","article-title":"Neuroinflammation and depression: microglia activation, extracellular microvesicles and microRNA dysregulation","volume":"9","author":"Brites","year":"2015","journal-title":"Front. Cell Neurosci"},{"key":"10.1016\/j.omtn.2022.02.005_bib290","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.neuroscience.2018.03.019","article-title":"miR-221-3p inhibits Schwann cell myelination","volume":"379","author":"Zhao","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.omtn.2022.02.005_bib291","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1007\/s00701-020-04238-4","article-title":"Tumor miRNA expression profile is related to vestibular schwannoma growth rate","volume":"162","author":"Sass","year":"2020","journal-title":"Acta Neurochir."},{"key":"10.1016\/j.omtn.2022.02.005_bib292","first-page":"2675","article-title":"miR-221 and miR-222 promote Schwann cell proliferation and migration by targeting LASS2 after sciatic nerve injury","volume":"125","author":"Yu","year":"2012","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.omtn.2022.02.005_bib293","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0065868","article-title":"Global profiling in vestibular schwannomas shows critical deregulation of microRNAs and upregulation in those included in chromosomal region 14q32","volume":"8","author":"Torres-Martin","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtn.2022.02.005_bib294","first-page":"16","article-title":"Intratumoral heterogeneity of expression of 16 miRNA in luminal cancer of the mammary gland","volume":"6","author":"Veryaskina","year":"2020","journal-title":"Noncoding RNA"},{"key":"10.1016\/j.omtn.2022.02.005_bib295","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1038\/s41416-020-0802-1","article-title":"Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours","volume":"122","author":"Hong","year":"2020","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.omtn.2022.02.005_bib296","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJMoa1209026","article-title":"Treatment of HCV infection by targeting microRNA","volume":"368","author":"Janssen","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.omtn.2022.02.005_bib297","article-title":"Guideline on strategies to identify and mitigate risks for first-in-human and early clinical trials with investigational medicinal products","volume":"1","year":"2017"},{"key":"10.1016\/j.omtn.2022.02.005_bib298","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.addr.2015.01.008","article-title":"Pharmacokinetics, biodistribution and cell uptake of antisense oligonucleotides","volume":"87","author":"Geary","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.omtn.2022.02.005_bib299","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1517\/17425250902877680","article-title":"Antisense oligonucleotide pharmacokinetics and metabolism","volume":"5","author":"Geary","year":"2009","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.omtn.2022.02.005_bib300","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.4155\/bio-2019-0194","article-title":"Bioanalysis considerations on the pharmacokinetic evaluation of antisense therapeutics","volume":"11","author":"Norris","year":"2019","journal-title":"Bioanalysis"},{"key":"10.1016\/j.omtn.2022.02.005_bib301","first-page":"114","article-title":"How close are miRNAs from clinical practice? A perspective on the diagnostic and therapeutic market","volume":"30","author":"Bonneau","year":"2019","journal-title":"EJIFCC"},{"key":"10.1016\/j.omtn.2022.02.005_bib302","first-page":"695","article-title":"The emerging role of microRNAs in drug responses","volume":"12","author":"Zhang","year":"2010","journal-title":"Curr. Opin. Mol. Ther."},{"key":"10.1016\/j.omtn.2022.02.005_bib303","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.2217\/pgs-2019-0089","article-title":"miRNAs in drug response variability: potential utility as biomarkers for personalized medicine","volume":"20","author":"Latini","year":"2019","journal-title":"Pharmacogenomics"}],"container-title":["Molecular Therapy Nucleic Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253122000336?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253122000336?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T09:54:29Z","timestamp":1778838869000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2162253122000336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":303,"alternative-id":["S2162253122000336"],"URL":"https:\/\/doi.org\/10.1016\/j.omtn.2022.02.005","relation":{},"ISSN":["2162-2531"],"issn-type":[{"value":"2162-2531","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"miR-221\/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy Nucleic Acids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omtn.2022.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors.","name":"copyright","label":"Copyright"}]}}