{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:22:58Z","timestamp":1792686178530,"version":"4.5.0"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI21C1353020021"],"award-info":[{"award-number":["HI21C1353020021"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003569","name":"Ministry of Food and Drug Safety","doi-asserted-by":"publisher","award":["NRF-2021M3E5E5096420"],"award-info":[{"award-number":["NRF-2021M3E5E5096420"]}],"id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["- 2020R1A6A3A01100338"],"award-info":[{"award-number":["- 2020R1A6A3A01100338"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["NRF-2020R1A2C2005012"],"award-info":[{"award-number":["NRF-2020R1A2C2005012"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["NRF-2020R1A6A3A01100338"],"award-info":[{"award-number":["NRF-2020R1A6A3A01100338"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["NRF-2022M3A9E4016936"],"award-info":[{"award-number":["NRF-2022M3A9E4016936"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003052","name":"Ministry of Trade, Industry and Energy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["- 2019R1A6A1A03032888"],"award-info":[{"award-number":["- 2019R1A6A1A03032888"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF-2021R1A2C4001776"],"award-info":[{"award-number":["NRF-2021R1A2C4001776"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007886","name":"Dana-Farber Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007886","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy - Nucleic Acids"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.omtn.2022.11.018","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T20:34:27Z","timestamp":1669062867000},"page":"663-676","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Liposome-mediated small RNA delivery to convert the macrophage polarity: A novel therapeutic approach to treat inflammatory uterine disease"],"prefix":"10.1016","volume":"30","author":[{"given":"Mira","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeon-Ji","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieun","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok-Ho","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wooram","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5027-7310","authenticated-orcid":false,"given":"Haengseok","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omtn.2022.11.018_bib1","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature07201","article-title":"Origin and physiological roles of inflammation","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.omtn.2022.11.018_bib2","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/nature01320","article-title":"Points of control in inflammation","volume":"420","author":"Nathan","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.omtn.2022.11.018_bib3","doi-asserted-by":"crossref","first-page":"6506","DOI":"10.1073\/pnas.1303377110","article-title":"Development and in\u00a0vivo efficacy of targeted polymeric inflammation-resolving nanoparticles","volume":"110","author":"Kamaly","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtn.2022.11.018_bib4","doi-asserted-by":"crossref","first-page":"6296","DOI":"10.1038\/s41467-020-20141-z","article-title":"Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques","volume":"11","author":"Baardman","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtn.2022.11.018_bib5","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/mi.2010.75","article-title":"Immunoregulatory mechanisms of macrophage PPAR-\u03b3 in mice with experimental inflammatory bowel disease","volume":"4","author":"Hontecillas","year":"2011","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.omtn.2022.11.018_bib6","doi-asserted-by":"crossref","first-page":"120865","DOI":"10.1016\/j.biomaterials.2021.120865","article-title":"Artificial M2 macrophages for disease-modifying osteoarthritis therapeutics","volume":"274","author":"Ma","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.omtn.2022.11.018_bib7","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.omtm.2017.01.001","article-title":"CXCL12 promotes stem cell recruitment and uterine repair after injury in Asherman's syndrome","volume":"4","author":"Sahin Ersoy","year":"2017","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.omtn.2022.11.018_bib8","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s11154-012-9221-9","article-title":"Endometrial regeneration and endometrial stem\/progenitor cells","volume":"13","author":"Gargett","year":"2012","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.omtn.2022.11.018_bib9","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/1477-7827-11-118","article-title":"The management of Asherman syndrome: a review of literature","volume":"11","author":"Conforti","year":"2013","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.omtn.2022.11.018_bib10","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1016\/j.ymthe.2020.05.015","article-title":"Perivascular stem cell-derived cyclophilin A improves uterine environment with Asherman's syndrome via HIF1alpha-dependent angiogenesis","volume":"28","author":"Park","year":"2020","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omtn.2022.11.018_bib11","doi-asserted-by":"crossref","first-page":"681171","DOI":"10.3389\/fcell.2021.681171","article-title":"Mesenchymal stem cell-macrophage crosstalk and maintenance of inflammatory microenvironment homeostasis","volume":"9","author":"Lu","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.omtn.2022.11.018_bib12","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.7150\/thno.50683","article-title":"The twin cytokines interleukin-34 and CSF-1: masterful conductors of macrophage homeostasis","volume":"11","author":"Mu\u00f1oz-Garcia","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.omtn.2022.11.018_bib13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.12703\/P6-13","article-title":"The M1 and M2 paradigm of macrophage activation: time for reassessment","volume":"6","author":"Martinez","year":"2014","journal-title":"F1000Prime Rep."},{"key":"10.1016\/j.omtn.2022.11.018_bib14","first-page":"3044","article-title":"Macrophage functional phenotype can be consecutively and reversibly shifted to adapt to microenvironmental changes","volume":"8","author":"Liu","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.omtn.2022.11.018_bib15","doi-asserted-by":"crossref","first-page":"173090","DOI":"10.1016\/j.ejphar.2020.173090","article-title":"Macrophage M1\/M2 polarization","volume":"877","author":"Yunna","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.omtn.2022.11.018_bib16","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"Murray","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.omtn.2022.11.018_bib17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41584-018-0109-2","article-title":"Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis","volume":"15","author":"Chen","year":"2019","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.omtn.2022.11.018_bib18","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/j.1476-5381.2009.00206.x","article-title":"Current status and challenges of cytokine pharmacology","volume":"157","author":"Z\u00eddek","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.omtn.2022.11.018_bib19","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41580-018-0045-7","article-title":"Regulation of microRNA function in animals","volume":"20","author":"Gebert","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.omtn.2022.11.018_bib20","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.3389\/fimmu.2018.01377","article-title":"Anti-inflammatory microRNAs and their potential for inflammatory diseases treatment","volume":"9","author":"Tahamtan","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.omtn.2022.11.018_bib21","doi-asserted-by":"crossref","first-page":"6542","DOI":"10.4049\/jimmunol.1202496","article-title":"MicroRNA let-7c regulates macrophage polarization","volume":"190","author":"Banerjee","year":"2013","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.omtn.2022.11.018_bib22","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jconrel.2019.10.007","article-title":"MicroRNA delivery through nanoparticles","volume":"313","author":"Lee","year":"2019","journal-title":"J.\u00a0Contr. Release"},{"key":"10.1016\/j.omtn.2022.11.018_bib23","doi-asserted-by":"crossref","first-page":"336","DOI":"10.3390\/ijms18020336","article-title":"The current state of nanoparticle-induced macrophage polarization and reprogramming research","volume":"18","author":"Miao","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.omtn.2022.11.018_bib24","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1021\/acs.nanolett.6b04130","article-title":"Extra-large pore mesoporous silica nanoparticles for directing in\u00a0vivo M2 macrophage polarization by delivering IL-4","volume":"17","author":"Kwon","year":"2017","journal-title":"Nano Lett."},{"key":"10.1016\/j.omtn.2022.11.018_bib25","doi-asserted-by":"crossref","first-page":"19436","DOI":"10.1021\/acsami.8b04718","article-title":"Modulation of macrophage phenotype by biodegradable polyurethane nanoparticles: possible relation between macrophage polarization and immune response of nanoparticles","volume":"10","author":"Huang","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.omtn.2022.11.018_bib26","first-page":"1","article-title":"Manipulation of macrophage polarization by peptide-coated gold nanoparticles and its protective effects on acute lung injury","volume":"18","author":"Wang","year":"2020","journal-title":"J.\u00a0Nanobiotechnol."},{"key":"10.1016\/j.omtn.2022.11.018_bib27","doi-asserted-by":"crossref","first-page":"10648","DOI":"10.1073\/pnas.1806908115","article-title":"Functional muscle recovery with nanoparticle-directed M2 macrophage polarization in mice","volume":"115","author":"Raimondo","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtn.2022.11.018_bib28","doi-asserted-by":"crossref","first-page":"6491","DOI":"10.1021\/acsnano.8b09679","article-title":"Delivery of microRNAs by chitosan nanoparticles to functionally alter macrophage cholesterol efflux in\u00a0vitro and in\u00a0vivo","volume":"13","author":"Nguyen","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.omtn.2022.11.018_bib29","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1007\/s00018-009-0053-z","article-title":"Nanocarriers\u2019 entry into the cell: relevance to drug delivery","volume":"66","author":"Hillaireau","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.omtn.2022.11.018_bib30","doi-asserted-by":"crossref","first-page":"4946","DOI":"10.1021\/acs.chemrev.7b00668","article-title":"Surface-enhanced Raman spectroscopy for bioanalysis: reliability and challenges","volume":"118","author":"Zong","year":"2018","journal-title":"Chem. Rev."},{"key":"10.1016\/j.omtn.2022.11.018_bib31","series-title":"Liposomes","first-page":"189","article-title":"Liposomes for specific depletion of macrophages from organs and tissues","author":"van Rooijen","year":"2010"},{"key":"10.1016\/j.omtn.2022.11.018_bib32","series-title":"Macrophages","first-page":"259","article-title":"Depleting macrophages in\u00a0vivo with clodronate-liposomes","author":"Moreno","year":"2018"},{"key":"10.1016\/j.omtn.2022.11.018_bib33","first-page":"263","article-title":"Expression profiling and functional characterization of MicroRNAs in apical periodontitis","volume":"47","author":"Shen","year":"2021","journal-title":"J.\u00a0Endod."},{"key":"10.1016\/j.omtn.2022.11.018_bib34","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jconrel.2019.08.020","article-title":"Optimization of the method for analyzing endocytosis of fluorescently tagged molecules: impact of incubation in the cell culture medium and cell surface wash with glycine-hydrochloric acid buffer","volume":"310","author":"Kamei","year":"2019","journal-title":"J.\u00a0Contr. Release"},{"key":"10.1016\/j.omtn.2022.11.018_bib35","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.molmet.2019.08.015","article-title":"MicroRNA-10a-5p regulates macrophage polarization and promotes therapeutic adipose tissue remodeling","volume":"29","author":"Cho","year":"2019","journal-title":"Mol. Metabol."},{"key":"10.1016\/j.omtn.2022.11.018_bib36","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.3390\/ijms19061756","article-title":"Macrophage microRNAs as therapeutic targets for atherosclerosis, metabolic syndrome, and cancer","volume":"19","author":"Wei","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.omtn.2022.11.018_bib37","series-title":"Macrophages","first-page":"119","article-title":"Polarizing macrophages in\u00a0vitro","author":"Huang","year":"2018"},{"key":"10.1016\/j.omtn.2022.11.018_bib38","doi-asserted-by":"crossref","first-page":"520","DOI":"10.7150\/ijbs.8879","article-title":"Macrophage polarization in inflammatory diseases","volume":"10","author":"Liu","year":"2014","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.omtn.2022.11.018_bib39","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1016\/j.ymthe.2020.05.015","article-title":"Perivascular stem cell-derived Cyclophilin A improves uterine environment with Asherman\u2019s syndrome via HIF1\u03b1-dependent angiogenesis","volume":"28","author":"Park","year":"2020","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omtn.2022.11.018_bib40","doi-asserted-by":"crossref","first-page":"2100924","DOI":"10.1002\/adfm.202100924","article-title":"Engineering bioactive M2 macrophage-polarized anti-inflammatory, antioxidant, and antibacterial scaffolds for rapid angiogenesis and diabetic wound repair","volume":"31","author":"Tu","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.omtn.2022.11.018_bib41","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1021\/acsnano.7b09107","article-title":"Dual roles of graphene oxide to attenuate inflammation and elicit timely polarization of macrophage phenotypes for cardiac repair","volume":"12","author":"Han","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.omtn.2022.11.018_bib42","doi-asserted-by":"crossref","first-page":"14463","DOI":"10.1021\/acsami.8b02073","article-title":"Design of mannose-functionalized curdlan nanoparticles for macrophage-targeted siRNA delivery","volume":"10","author":"Ganbold","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.omtn.2022.11.018_bib43","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ejps.2017.12.006","article-title":"Mannose-functionalized solid lipid nanoparticles are effective in targeting alveolar macrophages","volume":"114","author":"Costa","year":"2018","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.omtn.2022.11.018_bib44","doi-asserted-by":"crossref","first-page":"4335","DOI":"10.1021\/acsabm.0c00368","article-title":"Targeted Imaging of CD206 expressing tumor-associated M2-like macrophages using mannose-conjugated antibiofouling magnetic iron oxide nanoparticles","volume":"3","author":"Li","year":"2020","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.omtn.2022.11.018_bib45","doi-asserted-by":"crossref","first-page":"120677","DOI":"10.1016\/j.biomaterials.2021.120677","article-title":"Targeting and clearance of senescent foamy macrophages and senescent endothelial cells by antibody-functionalized mesoporous silica nanoparticles for alleviating aorta atherosclerosis","volume":"269","author":"Pham","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.omtn.2022.11.018_bib46","doi-asserted-by":"crossref","first-page":"e39039","DOI":"10.1371\/journal.pone.0039039","article-title":"Antigen delivery to macrophages using liposomal nanoparticles targeting sialoadhesin\/CD169","volume":"7","author":"Chen","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.omtn.2022.11.018_bib47","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.trsl.2017.10.008","article-title":"Development of mannose functionalized dendrimeric nanoparticles for targeted delivery to macrophages: use of this platform to modulate atherosclerosis","volume":"193","author":"He","year":"2018","journal-title":"Transl. Res."},{"key":"10.1016\/j.omtn.2022.11.018_bib48","doi-asserted-by":"crossref","first-page":"13450","DOI":"10.1073\/pnas.1002120107","article-title":"MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in\u00a0vivo and in\u00a0vitro","volume":"107","author":"Fang","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtn.2022.11.018_bib49","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1182\/blood-2014-11-611046","article-title":"Endothelial cells suppress monocyte activation through secretion of extracellular vesicles containing antiinflammatory microRNAs","volume":"125","author":"Njock","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.omtn.2022.11.018_bib50","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/emmm.201202318","article-title":"Micro RNA-146 represses endothelial activation by inhibiting pro-inflammatory pathways","volume":"5","author":"Cheng","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.omtn.2022.11.018_bib51","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0168-3659(02)00129-3","article-title":"Intracellular route and transcriptional competence of polyethylenimine\u2013DNA complexes","volume":"82","author":"Bieber","year":"2002","journal-title":"J.\u00a0Contr. Release"},{"key":"10.1016\/j.omtn.2022.11.018_bib52","doi-asserted-by":"crossref","first-page":"9912","DOI":"10.1016\/j.biomaterials.2014.08.029","article-title":"A self-assembled polymeric micellar immunomodulator for cancer treatment based on cationic amphiphilic polymers","volume":"35","author":"Yim","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.omtn.2022.11.018_bib53","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/j.ymthe.2017.01.024","article-title":"Polyplex evolution: understanding biology, optimizing performance","volume":"25","author":"Hall","year":"2017","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omtn.2022.11.018_bib54","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0092-8674(01)00449-4","article-title":"Dendritic cells: specialized and regulated antigen processing machines","volume":"106","author":"Mellman","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.omtn.2022.11.018_bib55","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.3389\/fimmu.2018.03176","article-title":"Human dendritic cells: their heterogeneity and clinical application potential in cancer immunotherapy","volume":"9","author":"Patente","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.omtn.2022.11.018_bib56","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/imm.12056","article-title":"Chemokine programming dendritic cell antigen response: part I - select chemokine programming of antigen uptake even after maturation","volume":"139","author":"Park","year":"2013","journal-title":"Immunology"},{"key":"10.1016\/j.omtn.2022.11.018_bib57","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.jconrel.2014.04.021","article-title":"Macrophage-targeted delivery systems for nucleic acid therapy of inflammatory diseases","volume":"190","author":"Singh","year":"2014","journal-title":"J.\u00a0Contr. Release"},{"key":"10.1016\/j.omtn.2022.11.018_bib58","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nm.2807","article-title":"Mechanisms of fibrosis: therapeutic translation for fibrotic disease","volume":"18","author":"Wynn","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.omtn.2022.11.018_bib59","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1152\/physiol.00046.2014","article-title":"Macrophages in kidney injury, inflammation, and fibrosis","volume":"30","author":"Cao","year":"2015","journal-title":"Physiology"},{"key":"10.1016\/j.omtn.2022.11.018_bib60","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/nrneph.2011.149","article-title":"Cellular and molecular mechanisms of renal fibrosis","volume":"7","author":"Liu","year":"2011","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.omtn.2022.11.018_bib61","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.semnephrol.2010.03.003","article-title":"Macrophages and immunologic inflammation of the kidney","volume":"30","author":"Duffield","year":"2010","journal-title":"Semin. Nephrol."},{"key":"10.1016\/j.omtn.2022.11.018_bib62","doi-asserted-by":"crossref","first-page":"602","DOI":"10.3389\/fimmu.2015.00602","article-title":"Macrophages during the fibrotic process: M2 as friend and foe","volume":"6","author":"Braga","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.omtn.2022.11.018_bib63","doi-asserted-by":"crossref","first-page":"e12034","DOI":"10.15252\/emmm.202012034","article-title":"Reprogramming of profibrotic macrophages for treatment of bleomycin-induced pulmonary fibrosis","volume":"12","author":"Zhang","year":"2020","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.omtn.2022.11.018_bib64","doi-asserted-by":"crossref","first-page":"678457","DOI":"10.3389\/fimmu.2021.678457","article-title":"Roles of macrophage polarization and macrophage-derived miRNAs in pulmonary fibrosis","volume":"12","author":"Kishore","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.omtn.2022.11.018_bib65","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1189\/jlb.0712327","article-title":"The importance of the macrophage within the human endometrium","volume":"93","author":"Thiruchelvam","year":"2013","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.omtn.2022.11.018_bib66","doi-asserted-by":"crossref","first-page":"e13191","DOI":"10.1111\/aji.13191","article-title":"CSF1-associated decrease in endometrial macrophages may contribute to Asherman's syndrome","volume":"83","author":"Liu","year":"2020","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.omtn.2022.11.018_bib67","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1111\/jcmm.15005","article-title":"Peritoneal M2 macrophage transplantation as a potential cell therapy for enhancing renal repair in acute kidney injury","volume":"24","author":"Mao","year":"2020","journal-title":"J.\u00a0Cell Mol. Med."},{"key":"10.1016\/j.omtn.2022.11.018_bib68","first-page":"101136","article-title":"Application of immunotherapy based on dendritic cells stimulated by tumor cell-derived exosomes in a syngeneic breast tumor mouse model","volume":"28","author":"Piao","year":"2021","journal-title":"Biochem. Biophys. Rep."},{"key":"10.1016\/j.omtn.2022.11.018_bib69","doi-asserted-by":"crossref","first-page":"154797","DOI":"10.1016\/j.metabol.2021.154797","article-title":"A new mechanism of obeticholic acid on NASH treatment by inhibiting NLRP3 inflammasome activation in macrophage","volume":"120","author":"Huang","year":"2021","journal-title":"Metabolism"}],"container-title":["Molecular Therapy - Nucleic Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253122003109?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253122003109?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T09:55:02Z","timestamp":1778838902000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2162253122003109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":69,"alternative-id":["S2162253122003109"],"URL":"https:\/\/doi.org\/10.1016\/j.omtn.2022.11.018","relation":{},"ISSN":["2162-2531"],"issn-type":[{"value":"2162-2531","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Liposome-mediated small RNA delivery to convert the macrophage polarity: A novel therapeutic approach to treat inflammatory uterine disease","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy - Nucleic Acids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omtn.2022.11.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s).","name":"copyright","label":"Copyright"}]}}