{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:23:53Z","timestamp":1792175033391,"version":"4.4.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004329","name":"Slovenian Research and Innovation Agency","doi-asserted-by":"publisher","award":["P1-0242"],"award-info":[{"award-number":["P1-0242"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009553","name":"Agentura Pro Zdravotnick\u00fd V\u00fdzkum \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["NU23-10-00550"],"award-info":[{"award-number":["NU23-10-00550"]}],"id":[{"id":"10.13039\/501100009553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010653","name":"Masaryk University","doi-asserted-by":"publisher","award":["MUNI\/G\/1771\/2020"],"award-info":[{"award-number":["MUNI\/G\/1771\/2020"]}],"id":[{"id":"10.13039\/501100010653","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020931","name":"Central European Research Infrastructure Consortium","doi-asserted-by":"publisher","award":["20242221"],"award-info":[{"award-number":["20242221"]}],"id":[{"id":"10.13039\/100020931","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011659","name":"L\u00e9ka\u0159sk\u00e1 fakulta, Masarykova univerzita","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","award":["LM2023042"],"award-info":[{"award-number":["LM2023042"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","award":["LUAUS23295"],"award-info":[{"award-number":["LUAUS23295"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","award":["LX22NPO5102"],"award-info":[{"award-number":["LX22NPO5102"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001824","name":"Czech Science Foundation","doi-asserted-by":"publisher","award":["GF21-26400K"],"award-info":[{"award-number":["GF21-26400K"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy Nucleic Acids"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.omtn.2024.102405","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T16:13:52Z","timestamp":1732810432000},"page":"102405","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Specific inhibition of fibroblast growth factor receptor 1 signaling by a DNA aptamer"],"prefix":"10.1016","volume":"36","author":[{"given":"Vladimira","family":"Zlinska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana","family":"Feketova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Czyrek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Chudzian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina Lenarcic","family":"Zivkovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vlad-Constantin","family":"Ursachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Dudeja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bohumil","family":"Fafilek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Rynes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Rico-Llanos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolf","family":"Koudelka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanaya","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martyna","family":"Biadun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vendula","family":"Raskova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina","family":"Svozilova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Stroblova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateusz","family":"Krzyscik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalina","family":"Hristova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Krowarsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvie","family":"Foldynova-Trantirkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Zakrzewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5948-4837","authenticated-orcid":false,"given":"Lukas","family":"Trantirek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0618-9134","authenticated-orcid":false,"given":"Pavel","family":"Krejci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omtn.2024.102405_bib1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/jb\/mvq121","article-title":"Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease","volume":"149","author":"Itoh","year":"2011","journal-title":"J.\u00a0Biochem."},{"key":"10.1016\/j.omtn.2024.102405_bib2","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1002\/jcp.24649","article-title":"Isoforms of Receptors of Fibroblast Growth Factors","volume":"229","author":"Gong","year":"2014","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.omtn.2024.102405_bib3","doi-asserted-by":"crossref","first-page":"15292","DOI":"10.1074\/jbc.271.25.15292","article-title":"Receptor Specificity of the Fibroblast Growth Factor Family","volume":"271","author":"Ornitz","year":"1996","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.omtn.2024.102405_bib4","doi-asserted-by":"crossref","first-page":"15694","DOI":"10.1074\/jbc.M601252200","article-title":"Receptor Specificity of the Fibroblast Growth Factor Family","volume":"281","author":"Zhang","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.omtn.2024.102405_bib5","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0959-437X(95)90053-J","article-title":"Fibroblast growth factors in mammalian development","volume":"5","author":"Yamaguchi","year":"1995","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.omtn.2024.102405_bib6","doi-asserted-by":"crossref","first-page":"d781","DOI":"10.2741\/A321","article-title":"FGF signaling in skeletal development","volume":"3","author":"Ornitz","year":"1998","journal-title":"Front. Biosci."},{"key":"10.1016\/j.omtn.2024.102405_bib7","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.cytogfr.2015.03.003","article-title":"Functions of Fibroblast Growth Factor Receptors in cancer defined by novel translocations and mutations","volume":"26","author":"Gallo","year":"2015","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.omtn.2024.102405_bib8","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1002\/cmdc.201800719","article-title":"TAS-120 Cancer Target Binding: Defining Reactivity and Revealing the First Fibroblast Growth Factor Receptor 1 (FGFR1) Irreversible Structure","volume":"14","author":"Kalyukina","year":"2019","journal-title":"ChemMedChem"},{"key":"10.1016\/j.omtn.2024.102405_bib9","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1158\/2159-8290.CD-23-0475","article-title":"RLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across FGFR2 Alterations and Resistance Mutations","volume":"13","author":"Subbiah","year":"2023","journal-title":"Cancer Discov."},{"key":"10.1016\/j.omtn.2024.102405_bib10","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.omtn.2019.06.020","article-title":"Development of a Monomeric Inhibitory RNA Aptamer Specific for FGFR3 that Acts as an Activator When Dimerized","volume":"17","author":"Kamatkar","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.omtn.2024.102405_bib11","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1021\/jacsau.0c00121","article-title":"A DNA Aptamer That Inhibits the Aberrant Signaling of Fibroblast Growth Factor Receptor in Cancer Cells","volume":"1","author":"Eguchi","year":"2021","journal-title":"JACS Au"},{"key":"10.1016\/j.omtn.2024.102405_bib12","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aba4226","article-title":"An RNA aptamer restores defective bone growth in FGFR3-related skeletal dysplasia in mice","volume":"13","author":"Kimura","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.omtn.2024.102405_bib13","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.3390\/cells10071617","article-title":"Multiple Therapeutic Applications of RBM-007, an Anti-FGF2 Aptamer","volume":"10","author":"Nakamura","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.omtn.2024.102405_bib14","doi-asserted-by":"crossref","first-page":"29347","DOI":"10.1074\/jbc.M101859200","article-title":"Fibroblast Growth Factor Inhibits Chondrocytic Growth through Induction of p21 and Subsequent Inactivation of Cyclin E-Cdk2","volume":"276","author":"Aikawa","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.omtn.2024.102405_bib15","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.bone.2010.03.021","article-title":"FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence","volume":"47","author":"Krejci","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.omtn.2024.102405_bib16","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1083\/jcb.200302075","article-title":"A network of transcriptional and signaling events is activated by FGF to induce chondrocyte growth arrest and differentiation","volume":"161","author":"Dailey","year":"2003","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.omtn.2024.102405_bib17","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.pep.2014.03.012","article-title":"Efficient production and purification of extracellular domain of human FGFR-Fc fusion proteins from Chinese hamster ovary cells","volume":"99","author":"Sokolowska-Wedzina","year":"2014","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.omtn.2024.102405_bib18","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1158\/1541-7786.MCR-16-0136","article-title":"High-Affinity Internalizing Human scFv-Fc Antibody for Targeting FGFR1-Overexpressing Lung Cancer","volume":"15","author":"Sokolowska-Wedzina","year":"2017","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.omtn.2024.102405_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10262","article-title":"Mechanism of FGF receptor dimerization and activation","volume":"7","author":"Sarabipour","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtn.2024.102405_bib20","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aap8608","article-title":"The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases","volume":"11","author":"Fafilek","year":"2018","journal-title":"Sci. Signal."},{"key":"10.1016\/j.omtn.2024.102405_bib21","doi-asserted-by":"crossref","first-page":"8578","DOI":"10.1073\/pnas.161259898","article-title":"Critical role for the docking-protein FRS2\u03b1 in FGF receptor-mediated signal transduction pathways","volume":"98","author":"Hadari","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtn.2024.102405_bib22","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/wdev.176","article-title":"The Fibroblast Growth Factor signaling pathway","volume":"4","author":"Ornitz","year":"2015","journal-title":"WIREs Dev. Biol."},{"key":"10.1016\/j.omtn.2024.102405_bib23","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.21536","article-title":"One reporter for in-cell activity profiling of majority of protein kinase oncogenes","volume":"6","author":"Gudernova","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.omtn.2024.102405_bib24","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0092-8674(00)80051-3","article-title":"Structural Basis for FGF Receptor Dimerization and Activation","volume":"98","author":"Plotnikov","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.omtn.2024.102405_bib25","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1110\/ps.062206106","article-title":"Elucidation of the mechanism of the regulatory function of the Ig1 module of the fibroblast growth factor receptor 1","volume":"15","author":"Kiselyov","year":"2006","journal-title":"Protein Sci."},{"key":"10.1016\/j.omtn.2024.102405_bib26","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1159\/000090758","article-title":"Recording Notch Signaling in Real Time","volume":"28","author":"Hansson","year":"2006","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.omtn.2024.102405_bib27","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s00018-024-05396-9","article-title":"Uncovering key steps in FGF12 cellular release reveals a common mechanism for unconventional FGF protein secretion","volume":"81","author":"Biadun","year":"2024","journal-title":"Cell. Mol. Life Sci."}],"container-title":["Molecular Therapy Nucleic Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253124002920?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253124002920?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T09:57:43Z","timestamp":1778839063000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2162253124002920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S2162253124002920"],"URL":"https:\/\/doi.org\/10.1016\/j.omtn.2024.102405","relation":{},"ISSN":["2162-2531"],"issn-type":[{"value":"2162-2531","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Specific inhibition of fibroblast growth factor receptor 1 signaling by a DNA aptamer","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy Nucleic Acids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omtn.2024.102405","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc. on behalf of The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}],"article-number":"102405"}}