{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T17:37:52Z","timestamp":1779385072653,"version":"3.53.1"},"reference-count":54,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M744060"],"award-info":[{"award-number":["2023M744060"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018634","name":"State Key Laboratory of Ophthalmology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018634","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271093"],"award-info":[{"award-number":["82271093"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070972"],"award-info":[{"award-number":["82070972"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515110138"],"award-info":[{"award-number":["2023A1515110138"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy Nucleic Acids"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.omtn.2024.102445","type":"journal-article","created":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T08:01:42Z","timestamp":1735804902000},"page":"102445","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["MSCs act as biopatches for blood-retinal barrier preservation to enhance functional recovery after retinal I\/R"],"prefix":"10.1016","volume":"36","author":[{"given":"Xiaoyue","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyiqi","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinmu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Ru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunbei","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuangling","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebiya","family":"Tuxun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zitong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy Peng","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8064-871X","authenticated-orcid":false,"given":"Tao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omtn.2024.102445_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105757","article-title":"Ethyl pyruvate: A newly discovered compound against ischemia-reperfusion injury in multiple organs","volume":"171","author":"Lu","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.omtn.2024.102445_bib2","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1001\/archopht.1975.01010020934002","article-title":"Retinal ischemia in diabetic retinopathy","volume":"93","author":"Bresnick","year":"1975","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.omtn.2024.102445_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22168446","article-title":"Autophagic Upregulation Is Cytoprotective in Ischemia\/Reperfusion-Injured Retina and Retinal Progenitor Cells","volume":"22","author":"Tang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.omtn.2024.102445_bib4","doi-asserted-by":"crossref","first-page":"e489","DOI":"10.1016\/S2214-109X(20)30488-5","article-title":"The Lancet Global Health Commission on Global Eye Health: vision beyond 2020","volume":"9","author":"Burton","year":"2021","journal-title":"Lancet Global Health"},{"key":"10.1016\/j.omtn.2024.102445_bib5","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1001\/jama.2020.22829","article-title":"Anti-VEGF Therapy or Vitrectomy Surgery for Vitreous Hemorrhage From Proliferative Diabetic Retinopathy","volume":"324","author":"Tan","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.omtn.2024.102445_bib6","doi-asserted-by":"crossref","first-page":"444","DOI":"10.3389\/fimmu.2016.00444","article-title":"Cellular Stress Response and Immune Signaling in Retinal Ischemia-Reperfusion Injury","volume":"7","author":"Minhas","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.omtn.2024.102445_bib7","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.preteyeres.2003.12.001","article-title":"Retinal ischemia: mechanisms of damage and potential therapeutic strategies","volume":"23","author":"Osborne","year":"2004","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.omtn.2024.102445_bib8","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/nri2395","article-title":"Mesenchymal stem cells in health and disease","volume":"8","author":"Uccelli","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.omtn.2024.102445_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2021.100967","article-title":"Mesenchymal stromal cells for the treatment of ocular autoimmune diseases","volume":"85","author":"Oh","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.omtn.2024.102445_bib10","doi-asserted-by":"crossref","first-page":"5036","DOI":"10.1002\/jcp.30213","article-title":"Adipose mesenchymal stem cells-secreted extracellular vesicles containing microRNA-192 delays diabetic retinopathy by targeting ITGA1","volume":"236","author":"Gu","year":"2021","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.omtn.2024.102445_bib11","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.biomaterials.2019.01.016","article-title":"Mesenchymal stem cell-derived extracellular vesicles and retinal ischemia-reperfusion","volume":"197","author":"Mathew","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.omtn.2024.102445_bib12","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nature09262","article-title":"Mesenchymal and haematopoietic stem cells form a unique bone marrow niche","volume":"466","author":"M\u00e9ndez-Ferrer","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.omtn.2024.102445_bib13","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.stem.2012.02.003","article-title":"Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration","volume":"10","author":"Park","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.omtn.2024.102445_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121210","article-title":"Human bone marrow-derived mesenchymal stem cells play a role as a vascular pericyte in the reconstruction of human BBB on the angiogenesis microfluidic chip","volume":"279","author":"Kim","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.omtn.2024.102445_bib15","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s00018-020-03600-0","article-title":"Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses","volume":"78","author":"Costa","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.omtn.2024.102445_bib16","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.7150\/thno.30487","article-title":"Characterization and Therapeutic Application of Mesenchymal Stem Cells with Neuromesodermal Origin from Human Pluripotent Stem Cells","volume":"9","author":"Wang","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.omtn.2024.102445_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.scr.2019.101401","article-title":"Cymerus\u2122 iPSC-MSCs significantly prolong survival in a pre-clinical, humanized mouse model of Graft-vs-host disease","volume":"35","author":"Ozay","year":"2019","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.omtn.2024.102445_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.717772","article-title":"Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Acquire Rejuvenation and Reduced Heterogeneity","volume":"9","author":"Wruck","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.omtn.2024.102445_bib19","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13045-021-01037-x","article-title":"Challenges and advances in clinical applications of mesenchymal stromal cells","volume":"14","author":"Zhou","year":"2021","journal-title":"J.\u00a0Hematol. Oncol."},{"key":"10.1016\/j.omtn.2024.102445_bib20","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.omtn.2023.01.017","article-title":"Increased PRL-1 in BM-derived MSCs triggers anaerobic metabolism via mitochondria in a cholestatic rat model","volume":"31","author":"Kim","year":"2023","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.omtn.2024.102445_bib21","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1038\/eye.2008.376","article-title":"Transplantation prospects for the inner retina","volume":"23","author":"Johnson","year":"2009","journal-title":"Eye"},{"key":"10.1016\/j.omtn.2024.102445_bib22","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.bbrc.2006.03.231","article-title":"Effects of bone marrow stromal cell injection in an experimental glaucoma model","volume":"344","author":"Yu","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.omtn.2024.102445_bib23","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.ymthe.2020.02.014","article-title":"Cxcr6-Based Mesenchymal Stem Cell Gene Therapy Potentiates Skin Regeneration in Murine Diabetic Wounds","volume":"28","author":"Dhoke","year":"2020","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omtn.2024.102445_bib24","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s12013-013-9632-6","article-title":"Overexpression of the mesenchymal stem cell Cxcr4 gene in irradiated mice increases the homing capacity of these cells","volume":"67","author":"Chen","year":"2013","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.omtn.2024.102445_bib25","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1182\/blood-2004-02-0526","article-title":"A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow","volume":"104","author":"Wynn","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.omtn.2024.102445_bib26","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1038\/leu.2011.43","article-title":"A novel role for CCL3 (MIP-1\u03b1) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function","volume":"25","author":"Vallet","year":"2011","journal-title":"Leukemia"},{"key":"10.1016\/j.omtn.2024.102445_bib27","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/jcbfm.2013.230","article-title":"Ischemia-reperfusion injury induces occludin phosphorylation\/ubiquitination and retinal vascular permeability in a VEGFR-2-dependent manner","volume":"34","author":"Muthusamy","year":"2014","journal-title":"J.\u00a0Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.omtn.2024.102445_bib28","article-title":"Compound 49b Restores Retinal Thickness and Reduces Degenerate Capillaries in the Rat Retina following Ischemia\/Reperfusion","volume":"11","author":"Liu","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.omtn.2024.102445_bib29","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202101098R","article-title":"Uveitis-mediated immune cell invasion through the extracellular matrix of the lens capsule","volume":"36","author":"DeDreu","year":"2022","journal-title":"Faseb. J."},{"key":"10.1016\/j.omtn.2024.102445_bib30","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1159\/000489241","article-title":"Current Mechanistic Concepts in Ischemia and Reperfusion Injury","volume":"46","author":"Wu","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.omtn.2024.102445_bib31","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/B978-0-12-394309-5.00006-7","article-title":"Cell biology of ischemia\/reperfusion injury","volume":"298","author":"Kalogeris","year":"2012","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"10.1016\/j.omtn.2024.102445_bib32","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aap8492","article-title":"Repopulating retinal microglia restore endogenous organization and function under CX3CL1-CX3CR1 regulation","volume":"4","author":"Zhang","year":"2018","journal-title":"Sci. Adv."},{"key":"10.1016\/j.omtn.2024.102445_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.564077","article-title":"Microglia and Inflammatory Responses in Diabetic Retinopathy","volume":"11","author":"Kinuthia","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.omtn.2024.102445_bib34","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.ymthe.2020.10.026","article-title":"The Chemokine Receptors Ccr5 and Cxcr6 Enhance Migration of Mesenchymal Stem Cells into the Degenerating Retina","volume":"29","author":"Pesaresi","year":"2021","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omtn.2024.102445_bib35","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.omtn.2020.09.026","article-title":"MSC-Derived Exosomes Protect Vertebral Endplate Chondrocytes against Apoptosis and Calcification via the miR-31-5p\/ATF6 Axis","volume":"22","author":"Xie","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.omtn.2024.102445_bib36","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/s41420-022-00909-6","article-title":"Mesenchymal stem cell-derived exosomal microRNA-182-5p alleviates myocardial ischemia\/reperfusion injury by targeting GSDMD in mice","volume":"8","author":"Yue","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.omtn.2024.102445_bib37","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.healun.2019.07.006","article-title":"Mesenchymal stromal cell therapy during ex\u00a0vivo lung perfusion ameliorates ischemia-reperfusion injury in lung transplantation","volume":"38","author":"Nakajima","year":"2019","journal-title":"J.\u00a0Heart Lung Transplant."},{"key":"10.1016\/j.omtn.2024.102445_bib38","doi-asserted-by":"crossref","first-page":"4014","DOI":"10.1021\/acsnano.9b08207","article-title":"In\u00a0Vivo Tracking of Mesenchymal Stem Cell-Derived Extracellular Vesicles Improving Mitochondrial Function in Renal Ischemia-Reperfusion Injury","volume":"14","author":"Cao","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.omtn.2024.102445_bib39","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.actbio.2022.10.022","article-title":"Mesenchymal stem cell-derived extracellular vesicles attenuate tPA-induced blood-brain barrier disruption in murine ischemic stroke models","volume":"154","author":"Qiu","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.omtn.2024.102445_bib40","first-page":"339","article-title":"Blood-neural barrier: intercellular communication at glio-vascular interface","volume":"39","author":"Kim","year":"2006","journal-title":"J.\u00a0Biochem. Mol. Biol."},{"key":"10.1016\/j.omtn.2024.102445_bib41","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.cell.2015.10.067","article-title":"Establishment and Dysfunction of the Blood-Brain Barrier","volume":"163","author":"Zhao","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.omtn.2024.102445_bib42","article-title":"Immune Privilege: The Microbiome and Uveitis","volume":"11","author":"M\u00f6lzer","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.omtn.2024.102445_bib43","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/nri.2017.100","article-title":"Organ-specific protection mediated by cooperation between vascular and epithelial barriers","volume":"17","author":"Spadoni","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.omtn.2024.102445_bib44","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12987-018-0109-2","article-title":"The role of plasmalemma vesicle-associated protein in pathological breakdown of blood-brain and blood-retinal barriers: potential novel therapeutic target for cerebral edema and diabetic macular edema","volume":"15","author":"Bosma","year":"2018","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.omtn.2024.102445_bib45","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.stem.2018.05.004","article-title":"Mesenchymal Stromal Cells: Clinical Challenges and Therapeutic Opportunities","volume":"22","author":"Galipeau","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.omtn.2024.102445_bib46","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11010-012-1396-6","article-title":"miR-210 activates notch signaling pathway in angiogenesis induced by cerebral ischemia","volume":"370","author":"Lou","year":"2012","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.omtn.2024.102445_bib47","first-page":"3611","article-title":"Vascular Endothelial Growth Factor Isoform-B Stimulates Neurovascular Repair After Ischemic Stroke by Promoting the Function of Pericytes via Vascular Endothelial Growth Factor Receptor-1","volume":"55","author":"Jean LeBlanc","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.omtn.2024.102445_bib48","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s13287-015-0180-4","article-title":"Mesenchymal stem cells stabilize the blood-brain barrier through regulation of astrocytes","volume":"6","author":"Park","year":"2015","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.omtn.2024.102445_bib49","first-page":"111","article-title":"Carotid artery occlusion and collateral circulation in C57Black\/6J mice detected by synchrotron radiation microangiography","volume":"52","author":"Tamaki","year":"2006","journal-title":"Kobe J. Med. Sci."},{"key":"10.1016\/j.omtn.2024.102445_bib50","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/mp.2016.191","article-title":"Characterization and transplantation of enteric neural crest cells from human induced pluripotent stem cells","volume":"23","author":"Li","year":"2018","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.omtn.2024.102445_bib51","article-title":"Overexpression of Heme Oxygenase-1 in Mesenchymal Stem Cells Augments Their Protection on Retinal Cells In\u00a0Vitro and Attenuates Retinal Ischemia\/Reperfusion Injury In\u00a0Vivo against Oxidative Stress","volume":"2017","author":"Li","year":"2017","journal-title":"Stem Cell. Int."},{"key":"10.1016\/j.omtn.2024.102445_bib52","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1084\/jem.20091046","article-title":"Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow","volume":"206","author":"Morikawa","year":"2009","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.omtn.2024.102445_bib53","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.7150\/thno.29422","article-title":"Donation of mitochondria by iPSC-derived mesenchymal stem cells protects retinal ganglion cells against mitochondrial complex I defect-induced degeneration","volume":"9","author":"Jiang","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.omtn.2024.102445_bib54","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1002\/stem.1682","article-title":"Islet-1 overexpression in human mesenchymal stem cells promotes vascularization through monocyte chemoattractant protein-3","volume":"32","author":"Liu","year":"2014","journal-title":"Stem Cell."}],"container-title":["Molecular Therapy Nucleic Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253124003329?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253124003329?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T01:41:59Z","timestamp":1744508519000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2162253124003329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S2162253124003329"],"URL":"https:\/\/doi.org\/10.1016\/j.omtn.2024.102445","relation":{},"ISSN":["2162-2531"],"issn-type":[{"value":"2162-2531","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MSCs act as biopatches for blood-retinal barrier preservation to enhance functional recovery after retinal I\/R","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy Nucleic Acids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omtn.2024.102445","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}],"article-number":"102445"}}