{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:45:17Z","timestamp":1793835917088,"version":"4.6.1"},"reference-count":58,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T00:00:00Z","timestamp":1753488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006439","name":"Faculty of Tropical Medicine, Mahidol University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006439","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010203","name":"Walter Reed Army Institute of Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010203","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"National Institute of Allergy and Infectious Diseases Division of Intramural Research","doi-asserted-by":"publisher","award":["1U01AI155361"],"award-info":[{"award-number":["1U01AI155361"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"National Institute of Allergy and Infectious Diseases Division of Intramural Research","doi-asserted-by":"publisher","award":["R01AI146101"],"award-info":[{"award-number":["R01AI146101"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI153064"],"award-info":[{"award-number":["R01AI153064"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy Nucleic Acids"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.omtn.2025.102645","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:16:59Z","timestamp":1753888619000},"page":"102645","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["mRNA-LNP vaccine encoding the Plasmodium vivax circumsporozoite protein is highly immunogenic and confers protection in mice"],"prefix":"10.1016","volume":"36","author":[{"given":"Amporn","family":"Limsalakpetch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utaiwan","family":"Kum-Arb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosol","family":"Yongvanitchit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rawiwan","family":"Im-Erbsin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratawan","family":"Ubalee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman","family":"Waters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A.","family":"Vesely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Muramatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drew","family":"Weissman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying K.","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeto","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Yadava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Pardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9149-3351","authenticated-orcid":false,"given":"Sathit","family":"Pichyangkul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omtn.2025.102645_bib1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12936-024-04851-z","article-title":"Progress towards malaria elimination in the Greater Mekong Subregion: perspectives from the World Health Organization","volume":"23","author":"Manzoni","year":"2024","journal-title":"Malar. J."},{"key":"10.1016\/j.omtn.2025.102645_bib2","series-title":"World Malaria Report 2023","year":"2023"},{"key":"10.1016\/j.omtn.2025.102645_bib3","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2017.50","article-title":"Malaria","volume":"3","author":"Phillips","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.omtn.2025.102645_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-397900-1.00001-3","article-title":"The global public health significance of Plasmodium vivax","volume":"80","author":"Battle","year":"2012","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.omtn.2025.102645_bib5","series-title":"StatPearls","article-title":"Plasmodium vivax Malaria","author":"Menkin-Smith","year":"2024"},{"key":"10.1016\/j.omtn.2025.102645_bib6","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4269\/ajtmh.16-0141","article-title":"Global Epidemiology of Plasmodium vivax","volume":"95","author":"Howes","year":"2016","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.omtn.2025.102645_bib7","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s10739-010-9239-3","article-title":"Malaria: origin of the term \"hypnozoite\"","volume":"44","author":"Markus","year":"2011","journal-title":"J. Hist. Biol."},{"key":"10.1016\/j.omtn.2025.102645_bib8","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1179\/2047773215Y.0000000016","article-title":"Origins and implications of neglect of G6PD deficiency and primaquine toxicity in Plasmodium vivax malaria","volume":"109","author":"Baird","year":"2015","journal-title":"Pathog. Glob. Health"},{"key":"10.1016\/j.omtn.2025.102645_bib9","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.bcmd.2008.12.005","article-title":"The global prevalence of glucose-6-phosphate dehydrogenase deficiency: a systematic review and meta-analysis","volume":"42","author":"Nkhoma","year":"2009","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.omtn.2025.102645_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0006440","article-title":"Implications of current therapeutic restrictions for primaquine and tafenoquine in the radical cure of vivax malaria","volume":"12","author":"Watson","year":"2018","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.omtn.2025.102645_bib11","doi-asserted-by":"crossref","DOI":"10.1172\/JCI156588","article-title":"RTS,S: the first malaria vaccine","volume":"132","author":"Zavala","year":"2022","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.omtn.2025.102645_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004423","article-title":"Phase 1\/2a Trial of Plasmodium vivax Malaria Vaccine Candidate VMP001\/AS01B in Malaria-Naive Adults: Safety, Immunogenicity, and Efficacy","volume":"10","author":"Bennett","year":"2016","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.omtn.2025.102645_bib14","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1038\/s41467-022-29226-3","article-title":"Randomized clinical trial to assess the protective efficacy of a Plasmodium vivax CS synthetic vaccine","volume":"13","author":"Arevalo-Herrera","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtn.2025.102645_bib15","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1056\/NEJMoa2035389","article-title":"Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine","volume":"384","author":"Baden","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.omtn.2025.102645_bib16","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1056\/NEJMoa2034577","article-title":"Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine","volume":"383","author":"Polack","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.omtn.2025.102645_bib17","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1146\/annurev-med-042420-112725","article-title":"mRNA Vaccines in the COVID-19 Pandemic and Beyond","volume":"73","author":"Hogan","year":"2022","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.omtn.2025.102645_bib18","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/283157a0","article-title":"Genetic variance of laboratory outbred Swiss mice","volume":"283","author":"Rice","year":"1980","journal-title":"Nature"},{"key":"10.1016\/j.omtn.2025.102645_bib19","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.3389\/fimmu.2017.01527","article-title":"Revealing the Complexity in CD8 T Cell Responses to Infection in Inbred C57B\/6 versus Outbred Swiss Mice","volume":"8","author":"Martin","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.omtn.2025.102645_bib20","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1586\/14760584.2014.883285","article-title":"Influence of parenteral administration routes and additional factors on vaccine safety and immunogenicity: a review of recent literature","volume":"13","author":"Herzog","year":"2014","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.omtn.2025.102645_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.645210","article-title":"Vaccine Inoculation Route Modulates Early Immunity and Consequently Antigen-Specific Immune Response","volume":"12","author":"Rosenbaum","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.omtn.2025.102645_bib22","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/s41541-021-00345-0","article-title":"Messenger RNA expressing PfCSP induces functional, protective immune responses against malaria in mice","volume":"6","author":"Mallory","year":"2021","journal-title":"NPJ Vaccines"},{"key":"10.1016\/j.omtn.2025.102645_bib23","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1126\/science.1704150","article-title":"Inability of malaria vaccine to induce antibodies to a protective epitope within its sequence","volume":"251","author":"Charoenvit","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.omtn.2025.102645_bib24","doi-asserted-by":"crossref","first-page":"837","DOI":"10.4269\/ajtmh.1992.47.837","article-title":"Low immunogenicity of a Plasmodium vivax circumsporozoite protein epitope bound by a protective monoclonal antibody","volume":"47","author":"Jones","year":"1992","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.omtn.2025.102645_bib25","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/s41541-022-00577-8","article-title":"mRNA-LNP expressing PfCSP and Pfs25 vaccine candidates targeting infection and transmission of Plasmodium falciparum","volume":"7","author":"Hayashi","year":"2022","journal-title":"NPJ Vaccines"},{"key":"10.1016\/j.omtn.2025.102645_bib26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41541-023-00783-y","article-title":"mRNA vaccines expressing malaria transmission-blocking antigens Pfs25 and Pfs230D1 induce a functional immune response","volume":"9","author":"Scaria","year":"2024","journal-title":"NPJ Vaccines"},{"key":"10.1016\/j.omtn.2025.102645_bib27","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/s41541-023-00786-9","article-title":"A Pvs25 mRNA vaccine induces complete and durable transmission-blocking immunity to Plasmodium vivax","volume":"8","author":"Kunkeaw","year":"2023","journal-title":"NPJ Vaccines"},{"key":"10.1016\/j.omtn.2025.102645_bib28","article-title":"Plasmodium vivax vaccine: What is the best way to go?","volume":"13","author":"da Veiga","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.omtn.2025.102645_bib29","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1194\/jlr.R062885","article-title":"GPI-anchored protein organization and dynamics at the cell surface","volume":"57","author":"Saha","year":"2016","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.omtn.2025.102645_bib30","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev.immunol.20.100301.064828","article-title":"Antigen presentation and T cell stimulation by dendritic cells","volume":"20","author":"Guermonprez","year":"2002","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.omtn.2025.102645_bib31","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.immuni.2005.09.013","article-title":"Cell surface recycling of internalized antigen permits dendritic cell priming of B cells","volume":"23","author":"Bergtold","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.omtn.2025.102645_bib32","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1126\/science.1125703","article-title":"Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells","volume":"312","author":"Qi","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.omtn.2025.102645_bib33","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/eji.202149658","article-title":"The unexpected contribution of conventional type 1 dendritic cells in driving antibody responses","volume":"52","author":"Steiner","year":"2022","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.omtn.2025.102645_bib34","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/35078099","article-title":"B cells acquire antigen from target cells after synapse formation","volume":"411","author":"Batista","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.omtn.2025.102645_bib35","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/sj.emboj.7600944","article-title":"B-cell activation by membrane-bound antigens is facilitated by the interaction of VLA-4 with VCAM-1","volume":"25","author":"Carrasco","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.omtn.2025.102645_bib36","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.coi.2019.04.003","article-title":"Antigen presentation by dendritic cells for B cell activation","volume":"58","author":"Heath","year":"2019","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.omtn.2025.102645_bib37","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1586\/erv.10.134","article-title":"Intanza((R)): a new intradermal vaccine for seasonal influenza","volume":"9","author":"Atmar","year":"2010","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.omtn.2025.102645_bib38","first-page":"113","article-title":"Targeting skin dendritic cells to improve intradermal vaccination","volume":"351","author":"Romani","year":"2012","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.omtn.2025.102645_bib39","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1021\/acscentsci.1c00361","article-title":"An mRNA SARS-CoV-2 Vaccine Employing Charge-Altering Releasable Transporters with a TLR-9 Agonist Induces Neutralizing Antibodies and T Cell Memory","volume":"7","author":"Haabeth","year":"2021","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.omtn.2025.102645_bib40","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1038\/s41590-023-01562-6","article-title":"mRNA vaccine against malaria tailored for liver-resident memory T cells","volume":"24","author":"Ganley","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.omtn.2025.102645_bib41","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1056\/NEJMc2113468","article-title":"SARS-CoV-2 Neutralization with BNT162b2 Vaccine Dose 3","volume":"385","author":"Falsey","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.omtn.2025.102645_bib42","doi-asserted-by":"crossref","first-page":"7394","DOI":"10.1016\/j.vaccine.2021.11.001","article-title":"Variant SARS-CoV-2 mRNA vaccines confer broad neutralization as primary or booster series in mice","volume":"39","author":"Wu","year":"2021","journal-title":"Vaccine"},{"key":"10.1016\/j.omtn.2025.102645_bib43","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1056\/NEJMc2119912","article-title":"SARS-CoV-2 Omicron Variant Neutralization after mRNA-1273 Booster Vaccination","volume":"386","author":"Pajon","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.omtn.2025.102645_bib44","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adf1782","article-title":"Vaccination with Plasmodium vivax Duffy-binding protein inhibits parasite growth during controlled human malaria infection","volume":"15","author":"Hou","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.omtn.2025.102645_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003268","article-title":"Protective efficacy of a Plasmodium vivax circumsporozoite protein-based vaccine in Aotus nancymaae is associated with antibodies to the repeat region","volume":"8","author":"Yadava","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.omtn.2025.102645_bib46","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.178801","article-title":"Identification of RTS,S\/AS01 vaccine-induced humoral biomarkers predictive of protection against controlled human malaria infection","volume":"9","author":"Spreng","year":"2024","journal-title":"JCI Insight"},{"key":"10.1016\/j.omtn.2025.102645_bib47","doi-asserted-by":"crossref","first-page":"4346","DOI":"10.1016\/j.vaccine.2020.03.063","article-title":"Protective efficacy of peptides from Plasmodium vivax circumsporozoite protein","volume":"38","author":"Atcheson","year":"2020","journal-title":"Vaccine"},{"key":"10.1016\/j.omtn.2025.102645_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109956","article-title":"Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria","volume":"37","author":"Lefebvre","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.omtn.2025.102645_bib49","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1128\/IAI.00566-07","article-title":"Class II-restricted protective immunity induced by malaria sporozoites","volume":"76","author":"Oliveira","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.omtn.2025.102645_bib50","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.4049\/jimmunol.150.4.1471","article-title":"Effector functions of circumsporozoite peptide-primed CD4+ T cell clones against Plasmodium yoelii liver stages","volume":"150","author":"Renia","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/j.omtn.2025.102645_bib51","doi-asserted-by":"crossref","first-page":"5604","DOI":"10.1128\/IAI.67.11.5604-5614.1999","article-title":"CD4(+) T-cell- and gamma interferon-dependent protection against murine malaria by immunization with linear synthetic peptides from a Plasmodium yoelii 17-kilodalton hepatocyte erythrocyte protein","volume":"67","author":"Charoenvit","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.omtn.2025.102645_bib52","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1128\/iai.62.9.4043-4046.1994","article-title":"Nitric oxide-mediated antiplasmodial activity in human and murine hepatocytes induced by gamma interferon and the parasite itself: enhancement by exogenous tetrahydrobiopterin","volume":"62","author":"Mellouk","year":"1994","journal-title":"Infect. Immun."},{"key":"10.1016\/j.omtn.2025.102645_bib53","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1038\/s41467-024-46270-3","article-title":"Malaria blood stage infection suppresses liver stage infection via host-induced interferons but not hepcidin","volume":"15","author":"Patel","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtn.2025.102645_bib54","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.4049\/jimmunol.146.5.1674","article-title":"T cell epitopes of the circumsporozoite protein of Plasmodium vivax. Recognition by lymphocytes of a sporozoite-immunized chimpanzee","volume":"146","author":"Nardin","year":"1991","journal-title":"J. Immunol."},{"key":"10.1016\/j.omtn.2025.102645_bib55","doi-asserted-by":"crossref","first-page":"3986","DOI":"10.4049\/jimmunol.148.12.3986","article-title":"Human recognition of T cell epitopes on the Plasmodium vivax circumsporozoite protein","volume":"148","author":"Herrera","year":"1992","journal-title":"J. Immunol."},{"key":"10.1016\/j.omtn.2025.102645_bib56","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1128\/IAI.05257-11","article-title":"Evaluation of the safety and immunogenicity in rhesus monkeys of a recombinant malaria vaccine for Plasmodium vivax with a synthetic Toll-like receptor 4 agonist formulated in an emulsion","volume":"79","author":"Lumsden","year":"2011","journal-title":"Infect. Immun."},{"key":"10.1016\/j.omtn.2025.102645_bib57","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/978-1-0716-3770-8_7","article-title":"Production and Evaluation of Nucleoside-Modified mRNA Vaccines for Infectious Diseases","volume":"2786","author":"Vadovics","year":"2024","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.omtn.2025.102645_bib58","article-title":"Generation and Identification of GM-CSF Derived Alveolar-like Macrophages and Dendritic Cells From Mouse Bone Marrow","volume":"112","author":"Dong","year":"2016","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.omtn.2025.102645_bib59","doi-asserted-by":"crossref","first-page":"4348","DOI":"10.1128\/IAI.02040-14","article-title":"Baculovirus-vectored multistage Plasmodium vivax vaccine induces both protective and transmission-blocking immunities against transgenic rodent malaria parasites","volume":"82","author":"Mizutani","year":"2014","journal-title":"Infect. Immun."}],"container-title":["Molecular Therapy Nucleic Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253125001994?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253125001994?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T20:24:39Z","timestamp":1777321479000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2162253125001994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":58,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S2162253125001994"],"URL":"https:\/\/doi.org\/10.1016\/j.omtn.2025.102645","relation":{},"ISSN":["2162-2531"],"issn-type":[{"value":"2162-2531","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"mRNA-LNP vaccine encoding the Plasmodium vivax circumsporozoite protein is highly immunogenic and confers protection in mice","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy Nucleic Acids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omtn.2025.102645","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc. on behalf of The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}],"article-number":"102645"}}