{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:40:31Z","timestamp":1792428031089,"version":"4.5.0"},"reference-count":69,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022298","name":"Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation","doi-asserted-by":"publisher","award":["TCRD 110-27"],"award-info":[{"award-number":["TCRD 110-27"]}],"id":[{"id":"10.13039\/501100022298","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005925","name":"Buddhist Tzu Chi Medical Foundation","doi-asserted-by":"publisher","award":["114-2320-B-259-002-MY3"],"award-info":[{"award-number":["114-2320-B-259-002-MY3"]}],"id":[{"id":"10.13039\/501100005925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005925","name":"Buddhist Tzu Chi Medical Foundation","doi-asserted-by":"publisher","award":["NSTC 110-2320-B-259-002-MY3"],"award-info":[{"award-number":["NSTC 110-2320-B-259-002-MY3"]}],"id":[{"id":"10.13039\/501100005925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005925","name":"Buddhist Tzu Chi Medical Foundation","doi-asserted-by":"publisher","award":["112-2314-B-259-002-MY3"],"award-info":[{"award-number":["112-2314-B-259-002-MY3"]}],"id":[{"id":"10.13039\/501100005925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005925","name":"Buddhist Tzu Chi Medical Foundation","doi-asserted-by":"publisher","award":["114T2560-09"],"award-info":[{"award-number":["114T2560-09"]}],"id":[{"id":"10.13039\/501100005925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005925","name":"Buddhist Tzu Chi Medical Foundation","doi-asserted-by":"publisher","award":["113T2560-07"],"award-info":[{"award-number":["113T2560-07"]}],"id":[{"id":"10.13039\/501100005925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015576","name":"National Dong Hwa University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015576","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSTC 114-2314-B-303-014"],"award-info":[{"award-number":["NSTC 114-2314-B-303-014"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["111-2314-B-303-033"],"award-info":[{"award-number":["111-2314-B-303-033"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy Nucleic Acids"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.omtn.2025.102783","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T17:04:13Z","timestamp":1764003853000},"page":"102783","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["HLA-DQB1-mediated B cell-epithelial crosstalk drives EBV-associated inflammation in Hunner-type interstitial cystitis"],"prefix":"10.1016","volume":"36","author":[{"given":"Shaik Ismail Mohammed","family":"Thangameeran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Fong","family":"Jhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Hong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hann-Chorng","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1985-018X","authenticated-orcid":false,"given":"Chih-Wen","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omtn.2025.102783_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143316","article-title":"Hunner-Type (Classic) Interstitial Cystitis: A Distinct Inflammatory Disorder Characterized by Pancystitis, with Frequent Expansion of Clonal B-Cells and Epithelial Denudation","volume":"10","author":"Maeda","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.omtn.2025.102783_bib2","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/path.6040","article-title":"EBV infection mediated BDNF expression is associated with bladder inflammation in interstitial cystitis\/bladder pain syndrome with Hunner's lesion","volume":"259","author":"Jhang","year":"2023","journal-title":"J. Pathol."},{"key":"10.1016\/j.omtn.2025.102783_bib3","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.juro.2018.03.133","article-title":"Epstein-Barr Virus as a Potential Etiology of Persistent Bladder Inflammation in Human Interstitial Cystitis\/Bladder Pain Syndrome","volume":"200","author":"Jhang","year":"2018","journal-title":"J. Urol."},{"key":"10.1016\/j.omtn.2025.102783_bib4","doi-asserted-by":"crossref","first-page":"3652","DOI":"10.1016\/j.cell.2022.08.026","article-title":"Epstein-Barr virus: Biology and clinical disease","volume":"185","author":"Damania","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.omtn.2025.102783_bib5","article-title":"Genome-wide association study identifies risk loci within the major histocompatibility complex region for Hunner-type interstitial cystitis","volume":"4","author":"Akiyama","year":"2023","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.omtn.2025.102783_bib6","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202106063","article-title":"Multimodal Single-Cell Analyses Outline the Immune Microenvironment and Therapeutic Effectors of Interstitial Cystitis\/Bladder Pain Syndrome","volume":"9","author":"Su","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.omtn.2025.102783_bib7","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1007\/s12026-014-8496-1","article-title":"The interplay between Epstein-Barr virus and B lymphocytes: implications for infection, immunity, and disease","volume":"58","author":"Hatton","year":"2014","journal-title":"Immunol. Res."},{"key":"10.1016\/j.omtn.2025.102783_bib8","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/cei\/uxad007","article-title":"The ups and downs of STAT3 function: too much, too little and human immune dysregulation","volume":"212","author":"Mackie","year":"2023","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.omtn.2025.102783_bib9","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41392-024-01757-9","article-title":"NF-kappaB in biology and targeted therapy: new insights and translational implications","volume":"9","author":"Guo","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.omtn.2025.102783_bib10","doi-asserted-by":"crossref","first-page":"5692","DOI":"10.1038\/s41467-021-25960-2","article-title":"Confronting false discoveries in single-cell differential expression","volume":"12","author":"Squair","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtn.2025.102783_bib11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s12967-022-03236-7","article-title":"Immune cell profiles of patients with interstitial cystitis\/bladder pain syndrome","volume":"20","author":"Moldwin","year":"2022","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.omtn.2025.102783_bib12","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3892\/etm.2020.9225","article-title":"Evaluation of immune-biomarker expression in high-grade soft-tissue sarcoma: HLA-DQA1 expression as a prognostic marker","volume":"20","author":"Bae","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.omtn.2025.102783_bib13","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.85687","article-title":"HLA-DQ beta1 alleles associated with Epstein-Barr virus (EBV) infectivity and EBV gp42 binding to cells","volume":"2","author":"Li","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.omtn.2025.102783_bib14","doi-asserted-by":"crossref","first-page":"12812","DOI":"10.18632\/oncotarget.14559","article-title":"High TMPRSS11D protein expression predicts poor overall survival in non-small cell lung cancer","volume":"8","author":"Cao","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.omtn.2025.102783_bib15","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1158\/0008-5472.CAN-11-0669","article-title":"S100A7 enhances mammary tumorigenesis through upregulation of inflammatory pathways","volume":"72","author":"Nasser","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.omtn.2025.102783_bib16","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1165\/rcmb.2004-0269OC","article-title":"Expression and regulation of small proline-rich protein 2 in allergic inflammation","volume":"32","author":"Zimmermann","year":"2005","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.omtn.2025.102783_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1297994","article-title":"Epstein-Barr virus: the mastermind of immune chaos","volume":"15","author":"Silva","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.omtn.2025.102783_bib18","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and analysis of cell-cell communication using CellChat","volume":"12","author":"Jin","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtn.2025.102783_bib19","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/s41577-022-00694-4","article-title":"Immunomodulation by endothelial cells - partnering up with the immune system?","volume":"22","author":"Amersfoort","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.omtn.2025.102783_bib20","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.bbamcr.2016.03.026","article-title":"The multifaceted roles of the invariant chain CD74--More than just a chaperone","volume":"1863","author":"Schroder","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.omtn.2025.102783_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111572","article-title":"CD74 as a regulator of transcription in normal B cells","volume":"41","author":"David","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.omtn.2025.102783_bib22","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jcmgh.2020.01.009","article-title":"CD74 Signaling Links Inflammation to Intestinal Epithelial Cell Regeneration and Promotes Mucosal Healing","volume":"10","author":"Farr","year":"2020","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.omtn.2025.102783_bib23","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41592-019-0667-5","article-title":"NicheNet: modeling intercellular communication by linking ligands to target genes","volume":"17","author":"Browaeys","year":"2020","journal-title":"Nat. Methods"},{"key":"10.1016\/j.omtn.2025.102783_bib24","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/nmeth.4463","article-title":"SCENIC: single-cell regulatory network inference and clustering","volume":"14","author":"Aibar","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.omtn.2025.102783_bib25","series-title":"Genome Modeling and Design across All Domains of Life with Evo 2","author":"Brixi","year":"2025"},{"key":"10.1016\/j.omtn.2025.102783_bib26","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.it.2024.11.011","article-title":"Epstein-Barr virus hijacks B cell metabolism to establish persistent infection and drive pathogenesis","volume":"46","author":"Muller-Durovic","year":"2025","journal-title":"Trends Immunol."},{"key":"10.1016\/j.omtn.2025.102783_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2042-4280-2-1","article-title":"Innate immune modulation in EBV infection","volume":"2","author":"Ning","year":"2011","journal-title":"Herpesviridae"},{"key":"10.1016\/j.omtn.2025.102783_bib28","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1038\/s41467-024-46347-z","article-title":"Evidence for immune activation in pathogenesis of the HLA class II associated disease, podoconiosis","volume":"15","author":"Negash","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtn.2025.102783_bib29","doi-asserted-by":"crossref","DOI":"10.1172\/JCI162190","article-title":"Intestinal epithelial HDAC3 and MHC class II coordinate microbiota-specific immunity","volume":"133","author":"Eshleman","year":"2023","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.omtn.2025.102783_bib30","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1084\/jem.190.4.567","article-title":"Epstein-barr virus-infected resting memory B cells, not proliferating lymphoblasts, accumulate in the peripheral blood of immunosuppressed patients","volume":"190","author":"Babcock","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.omtn.2025.102783_bib31","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jhep.2007.09.019","article-title":"Small proline-rich proteins (SPRR) function as SH3 domain ligands, increase resistance to injury and are associated with epithelial-mesenchymal transition (EMT) in cholangiocytes","volume":"48","author":"Demetris","year":"2008","journal-title":"J. Hepatol."},{"key":"10.1016\/j.omtn.2025.102783_bib32","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1471-2199-13-20","article-title":"SPRR2A enhances p53 deacetylation through HDAC1 and down regulates p21 promoter activity","volume":"13","author":"Mizuguchi","year":"2012","journal-title":"BMC Mol. Biol."},{"key":"10.1016\/j.omtn.2025.102783_bib33","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s11596-021-2431-1","article-title":"S100A7 Co-localization and Up-regulation of Filaggrin in Human Sinonasal Epithelial Cells","volume":"41","author":"Nakamura","year":"2021","journal-title":"Curr. Med. Sci."},{"key":"10.1016\/j.omtn.2025.102783_bib34","doi-asserted-by":"crossref","first-page":"4351","DOI":"10.1038\/s41467-025-59677-3","article-title":"Structural basis of TMPRSS11D specificity and autocleavage activation","volume":"16","author":"Fraser","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtn.2025.102783_bib35","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1146\/annurev-immunol-030409-101212","article-title":"Differentiation of effector CD4 T cell populations (\u2217)","volume":"28","author":"Zhu","year":"2010","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.omtn.2025.102783_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/v9100303","article-title":"The Th17 Lineage: From Barrier Surfaces Homeostasis to Autoimmunity, Cancer, and HIV-1 Pathogenesis","volume":"9","author":"Wacleche","year":"2017","journal-title":"Viruses"},{"key":"10.1016\/j.omtn.2025.102783_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.108262","article-title":"Th1\/17 polarization and potential treatment by an anti-interferon-gamma DNA aptamer in Hunner-type interstitial cystitis","volume":"26","author":"Akiyama","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.omtn.2025.102783_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107581","article-title":"Chemokines in chronic pain: cellular and molecular mechanisms and therapeutic potential","volume":"212","author":"Jiang","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.omtn.2025.102783_bib39","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s41392-021-00658-5","article-title":"Inflammation and tumor progression: signaling pathways and targeted intervention","volume":"6","author":"Zhao","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.omtn.2025.102783_bib40","article-title":"NF-kappaB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.omtn.2025.102783_bib41","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s43556-023-00151-1","article-title":"JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions","volume":"4","author":"Sarapultsev","year":"2023","journal-title":"Mol. Biomed."},{"key":"10.1016\/j.omtn.2025.102783_bib42","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41392-021-00791-1","article-title":"The JAK\/STAT signaling pathway: from bench to clinic","volume":"6","author":"Hu","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.omtn.2025.102783_bib43","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/s00018-024-05338-5","article-title":"CD74 is a functional MIF receptor on activated CD4(+) T cells","volume":"81","author":"Zhang","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.omtn.2025.102783_bib44","doi-asserted-by":"crossref","DOI":"10.1155\/2009\/535348","article-title":"Substance P increases cell-surface expression of CD74 (receptor for macrophage migration inhibitory factor): in vivo biotinylation of urothelial cell-surface proteins","volume":"2009","author":"Meyer-Siegler","year":"2009","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.omtn.2025.102783_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0255975","article-title":"Intravesical CD74 and CXCR4, macrophage migration inhibitory factor (MIF) receptors, mediate bladder pain","volume":"16","author":"Ye","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.omtn.2025.102783_bib46","article-title":"APP-CD74 axis mediates endothelial cell-macrophage communication to promote kidney injury and fibrosis","volume":"15","author":"Liu","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.omtn.2025.102783_bib47","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.3748\/wjg.v16.i26.3258","article-title":"CD74 is a survival receptor on colon epithelial cells","volume":"16","author":"Maharshak","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.omtn.2025.102783_bib48","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1128\/IAI.74.2.1148-1155.2006","article-title":"The Helicobacter pylori urease B subunit binds to CD74 on gastric epithelial cells and induces NF-kappaB activation and interleukin-8 production","volume":"74","author":"Beswick","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.omtn.2025.102783_bib49","doi-asserted-by":"crossref","DOI":"10.3390\/cells13060489","article-title":"CD74 promotes cyst growth and renal fibrosis in autosomal dominant polycystic kidney disease","volume":"13","author":"Zhou","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.omtn.2025.102783_bib50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0119534","article-title":"Amyloid precursor protein mediated changes in intestinal epithelial phenotype in vitro","volume":"10","author":"Puig","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.omtn.2025.102783_bib51","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1186\/s12935-021-01982-0","article-title":"Identification of collagen genes related to immune infiltration and epithelial-mesenchymal transition in glioma","volume":"21","author":"Yin","year":"2021","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.omtn.2025.102783_bib52","doi-asserted-by":"crossref","first-page":"358","DOI":"10.3389\/fonc.2020.00358","article-title":"NAMPT and NAPRT: Two Metabolic Enzymes With Key Roles in Inflammation","volume":"10","author":"Audrito","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.omtn.2025.102783_bib53","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.coviro.2015.09.007","article-title":"Epstein-Barr virus latency: current and future perspectives","volume":"14","author":"Kempkes","year":"2015","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.omtn.2025.102783_bib54","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1136\/gut.52.9.1250","article-title":"Interleukin 1beta induces gastric epithelial cell matrix metalloproteinase secretion and activation during Helicobacter pylori infection","volume":"52","author":"Gooz","year":"2003","journal-title":"Gut"},{"key":"10.1016\/j.omtn.2025.102783_bib55","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1161\/01.RES.86.12.1259","article-title":"Interleukin-1beta and tumor necrosis factor-alpha decrease collagen synthesis and increase matrix metalloproteinase activity in cardiac fibroblasts in vitro","volume":"86","author":"Siwik","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.omtn.2025.102783_bib56","doi-asserted-by":"crossref","DOI":"10.3390\/cells8101130","article-title":"The Interactivity between TGFbeta and BMP Signaling in Organogenesis, Fibrosis, and Cancer","volume":"8","author":"Dituri","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.omtn.2025.102783_bib57","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006868","article-title":"Interferon regulatory factor 8 regulates caspase-1 expression to facilitate Epstein-Barr virus reactivation in response to B cell receptor stimulation and chemical induction","volume":"14","author":"Lv","year":"2018","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.omtn.2025.102783_bib58","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.virol.2019.11.011","article-title":"Protein inhibitor of activated STAT1 (PIAS1) inhibits IRF8 activation of Epstein-Barr virus lytic gene expression","volume":"540","author":"Zhang","year":"2020","journal-title":"Virology"},{"key":"10.1016\/j.omtn.2025.102783_bib59","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031521","article-title":"Role of the Transcription Factor FOSL1 in Organ Development and Tumorigenesis","volume":"23","author":"Sobolev","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.omtn.2025.102783_bib60","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0152385","article-title":"Interferon Regulatory Factor 6 Has a Protective Role in the Host Response to Endotoxic Shock","volume":"11","author":"Joly","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.omtn.2025.102783_bib61","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1186\/s12864-017-3785-4","article-title":"Transversions have larger regulatory effects than transitions","volume":"18","author":"Guo","year":"2017","journal-title":"BMC Genom."},{"key":"10.1016\/j.omtn.2025.102783_bib62","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/ncpuro0874","article-title":"Interstitial cystitis and systemic autoimmune diseases","volume":"4","author":"van de Merwe","year":"2007","journal-title":"Nat. Clin. Pract. Urol."},{"key":"10.1016\/j.omtn.2025.102783_bib63","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.imlet.2017.07.016","article-title":"Influences of HLA DRB1, DQA1 and DQB1 on T-cell recognition of epitopes and of larger regions of the botulinum neurotoxin molecule","volume":"190","author":"Deitiker","year":"2017","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.omtn.2025.102783_bib64","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/path.6353","article-title":"APRIL\/BAFF upregulation is associated with clonal B-cell expansion in Hunner-type interstitial cystitis","volume":"264","author":"Horie","year":"2024","journal-title":"J. Pathol."},{"key":"10.1016\/j.omtn.2025.102783_bib65","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/iju.13969","article-title":"Phenotyping of interstitial cystitis\/bladder pain syndrome","volume":"26","author":"Akiyama","year":"2019","journal-title":"Int. J. Urol."},{"key":"10.1016\/j.omtn.2025.102783_bib66","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.eururo.2007.09.019","article-title":"Diagnostic criteria, classification, and nomenclature for painful bladder syndrome\/interstitial cystitis: an ESSIC proposal","volume":"53","author":"van de Merwe","year":"2008","journal-title":"Eur. Urol."},{"key":"10.1016\/j.omtn.2025.102783_bib67","doi-asserted-by":"crossref","first-page":"W83","DOI":"10.1093\/nar\/gkae410","article-title":"The Galaxy platform for accessible, reproducible, and collaborative data analyses: 2024 update","volume":"52","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.omtn.2025.102783_bib68","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41587-019-0114-2","article-title":"Determining cell type abundance and expression from bulk tissues with digital cytometry","volume":"37","author":"Newman","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.omtn.2025.102783_bib69","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41590-018-0276-y","article-title":"Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage","volume":"20","author":"Aran","year":"2019","journal-title":"Nat. Immunol."}],"container-title":["Molecular Therapy Nucleic Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253125003373?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253125003373?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T20:39:28Z","timestamp":1773866368000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2162253125003373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":69,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S2162253125003373"],"URL":"https:\/\/doi.org\/10.1016\/j.omtn.2025.102783","relation":{},"ISSN":["2162-2531"],"issn-type":[{"value":"2162-2531","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HLA-DQB1-mediated B cell-epithelial crosstalk drives EBV-associated inflammation in Hunner-type interstitial cystitis","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy Nucleic Acids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omtn.2025.102783","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}],"article-number":"102783"}}