{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:04:15Z","timestamp":1791932655354,"version":"4.3.4"},"reference-count":18,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy Nucleic Acids"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.omtn.2026.102865","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:33:11Z","timestamp":1770856391000},"page":"102865","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["GalNAc-conjugated siRNA targeting C\/EBP\u03b2 reverses metabolic dysfunction and restores liver homeostasis in a murine MASLD model"],"prefix":"10.1016","volume":"37","author":[{"given":"Shirin Elizabeth","family":"Khorsandi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Vasconcelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Nicholas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikash","family":"Reebye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Nicholls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Sodergren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Rowell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Dehkordi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagy","family":"Habib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Swiderski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Wen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omtn.2026.102865_bib1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1042\/bj20020508","article-title":"CCAAT\/enhancer-binding proteins: structure, function and regulation","volume":"365","author":"Ramji","year":"2002","journal-title":"Biochem. J."},{"key":"10.1016\/j.omtn.2026.102865_bib2","doi-asserted-by":"crossref","first-page":"15717","DOI":"10.1074\/jbc.M701329200","article-title":"CCAAT\/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db\/db) mice","volume":"282","author":"Schroeder-Gloeckler","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.omtn.2026.102865_bib3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1242\/dev.103168","article-title":"CCAAT\/enhancer binding protein-mediated regulation of TGFbeta receptor 2 expression determines the hepatoblast fate decision","volume":"141","author":"Takayama","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.omtn.2026.102865_bib4","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/0092-8674(91)90531-3","article-title":"A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA","volume":"67","author":"Descombes","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.omtn.2026.102865_bib5","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1172\/JCI3135","article-title":"CCAAT enhancer- binding protein beta is required for normal hepatocyte proliferation in mice after partial hepatectomy","volume":"102","author":"Greenbaum","year":"1998","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.omtn.2026.102865_bib6","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.jhep.2023.04.036","article-title":"Changing epidemiology, global trends and implications for outcomes of NAFLD","volume":"79","author":"Wong","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.omtn.2026.102865_bib7","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1056\/NEJMoa2028395","article-title":"A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis","volume":"384","author":"Newsome","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.omtn.2026.102865_bib8","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1056\/NEJMoa2309000","article-title":"A Phase 3, Randomized, Controlled Trial of Resmetirom in NASH with Liver Fibrosis","volume":"390","author":"Harrison","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.omtn.2026.102865_bib9","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41572-020-00240-3","article-title":"Hepatocellular carcinoma","volume":"7","author":"Llovet","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.omtn.2026.102865_bib10","doi-asserted-by":"crossref","first-page":"16958","DOI":"10.1021\/ja505986a","article-title":"Multivalent N-acetylgalactosamine-conjugated siRNA in hepatocytes and elicits robust RNAi-mediated gene silencing","volume":"136","author":"Nair","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.omtn.2026.102865_bib11","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ymthe.2017.08.019","article-title":"Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression","volume":"26","author":"Willoughby","year":"2018","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omtn.2026.102865_bib12","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1200\/JCO.2014.57.9151","article-title":"Assessment of liver function in patients with hepatocellular carcinoma: a new evidence-based approach-the ALBI grade","volume":"33","author":"Johnson","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.omtn.2026.102865_bib13","doi-asserted-by":"crossref","first-page":"497","DOI":"10.14309\/ajg.0000000000002472","article-title":"Cost of Care for Patients With Cirrhosis","volume":"119","author":"Kanwal","year":"2024","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.omtn.2026.102865_bib14","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1016\/j.ymthe.2020.06.015","article-title":"Delivery of Oligonucleotides to the Liver with GalNAc: From Research to Registered Therapeutic Drug","volume":"28","author":"Debacker","year":"2020","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omtn.2026.102865_bib15","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41573-019-0017-4","article-title":"The current state and future directions of RNAi-based therapeutics","volume":"18","author":"Setten","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.omtn.2026.102865_bib16","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.1038\/s41388-018-0665-6","article-title":"Mechanisms involved in the activation of C\/EBPalpha by small activating RNA in hepatocellular carcinoma","volume":"38","author":"Zhao","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.omtn.2026.102865_bib17","doi-asserted-by":"crossref","DOI":"10.1155\/jna\/1461574","article-title":"Design and Evaluation of RNA Aptamer-Mediated Delivery of C\/EBPbeta siRNA for Oncological Therapy","volume":"2025","author":"Vasconcelos","year":"2025","journal-title":"J. Nucleic Acids"},{"key":"10.1016\/j.omtn.2026.102865_bib18","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ymthe.2016.10.019","article-title":"Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate","volume":"25","author":"Zimmermann","year":"2017","journal-title":"Mol. Ther."}],"container-title":["Molecular Therapy Nucleic Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253126000363?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253126000363?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:15:27Z","timestamp":1780103727000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2162253126000363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S2162253126000363"],"URL":"https:\/\/doi.org\/10.1016\/j.omtn.2026.102865","relation":{},"ISSN":["2162-2531"],"issn-type":[{"value":"2162-2531","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GalNAc-conjugated siRNA targeting C\/EBP\u03b2 reverses metabolic dysfunction and restores liver homeostasis in a murine MASLD model","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy Nucleic Acids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omtn.2026.102865","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}],"article-number":"102865"}}