{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T22:26:29Z","timestamp":1794435989397,"version":"4.9.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01-EY029739"],"award-info":[{"award-number":["R01-EY029739"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy Nucleic Acids"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.omtn.2026.102922","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T08:01:01Z","timestamp":1775030461000},"page":"102922","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vacuolar ATPase subunit Atp6v0c transgene promotes neuroprotection and long-distance axon regeneration in injured retinal ganglion neurons"],"prefix":"10.1016","volume":"37","author":[{"given":"Anja","family":"Kearney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Lukomska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Brady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashiti","family":"Damania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahit","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2844-4191","authenticated-orcid":false,"given":"Ephraim F.","family":"Trakhtenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omtn.2026.102922_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-398309-1.00002-0","article-title":"Optic nerve disease and axon pathophysiology","volume":"105","author":"Ghaffarieh","year":"2012","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.omtn.2026.102922_bib2","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1093\/brain\/awq105","article-title":"Superoxide is an associated signal for apoptosis in axonal injury","volume":"133","author":"Kanamori","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.omtn.2026.102922_bib3","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nrneurol.2017.99","article-title":"ER stress and the unfolded protein response in neurodegeneration","volume":"13","author":"Hetz","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.omtn.2026.102922_bib4","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1152\/physrev.00038.2021","article-title":"ER-phagy: mechanisms, regulation, and diseases connected to the lysosomal clearance of the endoplasmic reticulum","volume":"102","author":"Reggiori","year":"2022","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.omtn.2026.102922_bib5","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/s41419-022-04830-9","article-title":"Restoration of ER proteostasis attenuates remote apoptotic cell death after spinal cord injury by reducing autophagosome overload","volume":"13","author":"Bisicchia","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.omtn.2026.102922_bib6","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.celrep.2019.06.013","article-title":"Neuronal Soma-Derived Degradative Lysosomes Are Continuously Delivered to Distal Axons to Maintain Local Degradation Capacity","volume":"28","author":"Farfel-Becker","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.omtn.2026.102922_bib7","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202111077","article-title":"Neuronal endolysosomal transport and lysosomal functionality in maintaining axonostasis","volume":"221","author":"Roney","year":"2022","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.omtn.2026.102922_bib8","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.brainres.2016.03.047","article-title":"Mechanisms of neuronal homeostasis: Autophagy in the axon","volume":"1649","author":"Maday","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.omtn.2026.102922_bib9","doi-asserted-by":"crossref","first-page":"11324","DOI":"10.1073\/pnas.1611282113","article-title":"Autophagy induction stabilizes microtubules and promotes axon regeneration after spinal cord injury","volume":"113","author":"He","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtn.2026.102922_bib10","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1080\/15548627.2020.1713645","article-title":"Age-dependent autophagy induction after injury promotes axon regeneration by limiting NOTCH","volume":"16","author":"Ko","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.omtn.2026.102922_bib11","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1016\/j.devcel.2023.10.007","article-title":"V-ATPase recruitment to ER exit sites switches COPII-mediated transport to lysosomal degradation","volume":"58","author":"Sun","year":"2023","journal-title":"Dev. Cell"},{"key":"10.1016\/j.omtn.2026.102922_bib12","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrm2272","article-title":"Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology","volume":"8","author":"Forgac","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.omtn.2026.102922_bib13","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nature14365","article-title":"Electron cryomicroscopy observation of rotational states in a eukaryotic V-ATPase","volume":"521","author":"Zhao","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.omtn.2026.102922_bib14","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.cell.2010.05.008","article-title":"Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations","volume":"141","author":"Lee","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.omtn.2026.102922_bib15","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.molcel.2020.09.029","article-title":"Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly","volume":"80","author":"Wang","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.omtn.2026.102922_bib16","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1038\/s41467-021-22389-5","article-title":"ATP6V0A1 encoding the a1-subunit of the V0 domain of vacuolar H","volume":"12","author":"Aoto","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtn.2026.102922_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0093257","article-title":"ATP6V0C knockdown in neuroblastoma cells alters autophagy-lysosome pathway function and metabolism of proteins that accumulate in neurodegenerative disease","volume":"9","author":"Mangieri","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.omtn.2026.102922_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-64131-3","article-title":"High frequency electrical stimulation reduces \u03b1-synuclein levels and \u03b1-synuclein-mediated autophagy dysfunction","volume":"14","author":"George","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omtn.2026.102922_bib19","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1750-1326-3-4","article-title":"A novel brain-enriched E3 ubiquitin ligase RNF182 is up regulated in the brains of Alzheimer's patients and targets ATP6V0C for degradation","volume":"3","author":"Liu","year":"2008","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.omtn.2026.102922_bib20","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1080\/15548627.2023.2181614","article-title":"Endolysosomal impairment by binding of amyloid beta or MAPT\/Tau to V-ATPase and rescue via the HYAL-CD44 axis in Alzheimer disease","volume":"19","author":"Kim","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.omtn.2026.102922_bib21","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1126\/science.aaz2924","article-title":"Structure of V-ATPase from the mammalian brain","volume":"367","author":"Abbas","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.omtn.2026.102922_bib22","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1093\/brain\/awac330","article-title":"ATP6V0C variants impair V-ATPase function causing a neurodevelopmental disorder often associated with epilepsy","volume":"146","author":"Mattison","year":"2023","journal-title":"Brain"},{"key":"10.1016\/j.omtn.2026.102922_bib23","first-page":"3582","article-title":"Mitochondrial Uncoupling Protein 2 Knock-out Promotes Mitophagy to Decrease Retinal Ganglion Cell Death in a Mouse Model of Glaucoma","volume":"39","author":"Hass","year":"2019","journal-title":"J. Neurosci."},{"key":"10.1016\/j.omtn.2026.102922_bib24","doi-asserted-by":"crossref","DOI":"10.1242\/dev.201644","article-title":"Pten inhibition dedifferentiates long-distance axon-regenerating intrinsically photosensitive retinal ganglion cells and upregulates mitochondria-associated Dynlt1a and Lars2","volume":"150","author":"Rheaume","year":"2023","journal-title":"Development"},{"key":"10.1016\/j.omtn.2026.102922_bib25","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.gene.2007.01.020","article-title":"Molecular cloning and characterization of a novel form of the human vacuolar H+-ATPase e-subunit: an essential proton pump component","volume":"393","author":"Blake-Palmer","year":"2007","journal-title":"Gene"},{"key":"10.1016\/j.omtn.2026.102922_bib26","doi-asserted-by":"crossref","first-page":"7743","DOI":"10.1038\/s41467-024-52049-3","article-title":"The V-ATPase complex component RNAseK is required for lysosomal hydrolase delivery and autophagosome degradation","volume":"15","author":"Makar","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtn.2026.102922_bib27","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1126\/science.1161566","article-title":"Promoting axon regeneration in the adult CNS by modulation of the PTEN\/mTOR pathway","volume":"322","author":"Park","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.omtn.2026.102922_bib28","doi-asserted-by":"crossref","first-page":"9632","DOI":"10.1523\/JNEUROSCI.0643-16.2017","article-title":"KLF9 and JNK3 Interact to Suppress Axon Regeneration in the Adult CNS","volume":"37","author":"Apara","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.omtn.2026.102922_bib29","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.exer.2016.08.006","article-title":"Evaluating retinal ganglion cell loss and dysfunction","volume":"151","author":"Mead","year":"2016","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.omtn.2026.102922_bib30","doi-asserted-by":"crossref","first-page":"9149","DOI":"10.1073\/pnas.1119449109","article-title":"Full-length axon regeneration in the adult mouse optic nerve and partial recovery of simple visual behaviors","volume":"109","author":"de Lima","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtn.2026.102922_bib31","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/nn.4340","article-title":"Neural activity promotes long-distance, target-specific regeneration of adult retinal axons","volume":"19","author":"Lim","year":"2016","journal-title":"Nat. Neurosci."}],"container-title":["Molecular Therapy Nucleic Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253126000934?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253126000934?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T21:33:45Z","timestamp":1794432825000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2162253126000934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S2162253126000934"],"URL":"https:\/\/doi.org\/10.1016\/j.omtn.2026.102922","relation":{},"ISSN":["2162-2531"],"issn-type":[{"value":"2162-2531","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vacuolar ATPase subunit Atp6v0c transgene promotes neuroprotection and long-distance axon regeneration in injured retinal ganglion neurons","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy Nucleic Acids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omtn.2026.102922","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}],"article-number":"102922"}}