{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T01:25:37Z","timestamp":1794273937688,"version":"4.9.0"},"reference-count":82,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007059","name":"Northwestern University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007059","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R35CA197450"],"award-info":[{"award-number":["R35CA197450"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R42CA291346"],"award-info":[{"award-number":["R42CA291346"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy Nucleic Acids"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.omtn.2026.102963","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T16:20:02Z","timestamp":1779726002000},"page":"102963","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Developing a pan cancer therapy based on DISE-inducing short RNAs"],"prefix":"10.1016","volume":"37","author":[{"given":"Andrea E.","family":"Murmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrnoosh","family":"Ebadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monal","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Ewe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Barajas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Jun","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanghee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bidur","family":"Paudel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth T.","family":"Bartom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masha","family":"Kocherginsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achim","family":"Aigner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3216-036X","authenticated-orcid":false,"given":"Marcus E.","family":"Peter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omtn.2026.102963_bib1","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0092-8674(03)01018-3","article-title":"Prediction of mammalian microRNA targets","volume":"115","author":"Lewis","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.omtn.2026.102963_bib2","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/ng865","article-title":"Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation","volume":"30","author":"Lai","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.omtn.2026.102963_bib3","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nsmb.1405","article-title":"GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay","volume":"15","author":"Eulalio","year":"2008","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.omtn.2026.102963_bib4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nature07315","article-title":"Structure of the guide-strand-containing argonaute silencing complex","volume":"456","author":"Wang","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.omtn.2026.102963_bib5","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1101\/gad.1399806","article-title":"Control of translation and mRNA degradation by miRNAs and siRNAs","volume":"20","author":"Valencia-Sanchez","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.omtn.2026.102963_bib6","doi-asserted-by":"crossref","first-page":"4504","DOI":"10.1038\/s41467-018-06526-1","article-title":"6mer seed toxicity in tumor suppressive miRNAs","volume":"9","author":"Gao","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtn.2026.102963_bib7","doi-asserted-by":"crossref","first-page":"5130","DOI":"10.1038\/s41598-022-09051-w","article-title":"Identification of the toxic 6mer seed consensus in human cancer cells","volume":"12","author":"Patel","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omtn.2026.102963_bib8","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.celrep.2014.02.035","article-title":"Death induced by CD95 or CD95 ligand elimination","volume":"7","author":"Hadji","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.omtn.2026.102963_bib9","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.29702","article-title":"Many si\/shRNAs can kill cancer cells by targeting multiple survival genes through an off-target mechanism","volume":"6","author":"Putzbach","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.omtn.2026.102963_bib10","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.1158\/0008-5472.CAN-21-0953","article-title":"The ratio of toxic-to-nontoxic microRNAs predicts platinum sensitivity in ovarian cancer","volume":"81","author":"Patel","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.omtn.2026.102963_bib11","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00652-23","article-title":"Analysis of the contribution of 6mer seed toxicity to HIV-1 induced cytopathicity","volume":"97","author":"Vaidyanathan","year":"2023","journal-title":"J. Virol."},{"key":"10.1016\/j.omtn.2026.102963_bib12","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/s41467-023-44465-8","article-title":"Death Induced by Survival gene Elimination (DISE) is correlated with neurotoxicity in Alzheimer's disease and aging","volume":"15","author":"Paudel","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtn.2026.102963_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2019.11.031","article-title":"6mer seed toxicity in viral microRNAs","volume":"23","author":"Murmann","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.omtn.2026.102963_bib14","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.omtn.2021.03.002","article-title":"Seed-mediated RNA interference of androgen signaling and survival networks induces cell death in prostate cancer cells","volume":"24","author":"Corbin","year":"2021","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.omtn.2026.102963_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002481","article-title":"A pathogenic mechanism in Huntington's disease involves small CAG-repeated RNAs with neurotoxic activity","volume":"8","author":"Ba\u00f1ez-Coronel","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.omtn.2026.102963_bib16","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201745336","article-title":"Small interfering RNAs based on huntingtin trinucleotide repeats are highly toxic to cancer cells","volume":"19","author":"Murmann","year":"2018","journal-title":"EMBO Rep."},{"key":"10.1016\/j.omtn.2026.102963_bib17","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1038\/s41419-022-05494-1","article-title":"The length of uninterrupted CAG repeats in stem regions of repeat disease associated hairpins determines the amount of short CAG oligonucleotides that are toxic to cells through RNA interference","volume":"13","author":"Murmann","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.omtn.2026.102963_bib18","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.trecan.2018.08.004","article-title":"Trinucleotide repeat expansion diseases, RNAi and cancer","volume":"4","author":"Murmann","year":"2018","journal-title":"Trends Cancer"},{"key":"10.1016\/j.omtn.2026.102963_bib19","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1186\/s13046-021-02177-1","article-title":"DISE\/6mer Seed Toxicity - A powerful anti-cancer mechanism with implications for other diseases","volume":"40","author":"Haluck-Kangas","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.omtn.2026.102963_bib20","doi-asserted-by":"crossref","first-page":"84643","DOI":"10.18632\/oncotarget.21471","article-title":"Induction of DISE in ovarian cancer cells in vivo","volume":"8","author":"Murmann","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.omtn.2026.102963_bib21","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jconrel.2006.02.009","article-title":"A low molecular weight fraction of polyethylenimine (PEI) displays increased transfection efficiency of DNA and siRNA in fresh or lyophilized complexes","volume":"112","author":"Werth","year":"2006","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.omtn.2026.102963_bib22","first-page":"345","article-title":"Nonviral in vivo delivery of therapeutic small interfering RNAs","volume":"9","author":"Aigner","year":"2007","journal-title":"Curr. Opin. Mol. Ther."},{"key":"10.1016\/j.omtn.2026.102963_bib23","article-title":"Tyrosine-modified linear PEIs for highly efficacious and biocompatible siRNA delivery in vitro and in vivo","volume":"36","author":"Karimov","year":"2021","journal-title":"Nanomedicine."},{"key":"10.1016\/j.omtn.2026.102963_bib24","doi-asserted-by":"crossref","first-page":"600","DOI":"10.3390\/pharmaceutics11110600","article-title":"Polymeric Nanoparticles Based on Tyrosine-Modified, Low Molecular Weight Polyethylenimines for siRNA Delivery","volume":"11","author":"Ewe","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.omtn.2026.102963_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/nano10091809","article-title":"Tyrosine-Modification of Polypropylenimine (PPI) and Polyethylenimine (PEI) Strongly Improves Efficacy of siRNA-Mediated Gene Knockdown","volume":"10","author":"Noske","year":"2020","journal-title":"Nanomaterials (Basel)"},{"key":"10.1016\/j.omtn.2026.102963_bib26","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.canlet.2021.01.018","article-title":"miR24-3p activity after delivery into pancreatic carcinoma cell lines exerts profound tumor-inhibitory effects through distinct pathways of apoptosis and autophagy induction","volume":"503","author":"Borchardt","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.omtn.2026.102963_bib27","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.nano.2016.08.005","article-title":"Liposome-polyethylenimine complexes (DPPC-PEI lipopolyplexes) for therapeutic siRNA delivery in vivo","volume":"13","author":"Ewe","year":"2017","journal-title":"Nanomedicine."},{"key":"10.1016\/j.omtn.2026.102963_bib28","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/978-1-60761-588-0_18","article-title":"Polyethylenimine (PEI)\/siRNA-mediated gene knockdown in vitro and in vivo","volume":"623","author":"Hobel","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.omtn.2026.102963_bib29","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/jgm.1431","article-title":"Polyethylenimine\/small interfering RNA-mediated knockdown of vascular endothelial growth factor in vivo exerts anti-tumor effects synergistically with Bevacizumab","volume":"12","author":"H\u00f6bel","year":"2010","journal-title":"J. Gene Med."},{"key":"10.1016\/j.omtn.2026.102963_bib30","doi-asserted-by":"crossref","first-page":"5214","DOI":"10.1158\/0008-5472.CAN-10-4645","article-title":"MicroRNA Replacement Therapy for miR-145 and miR-33a Is Efficacious in a Model of Colon Carcinoma","volume":"71","author":"Ibrahim","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.omtn.2026.102963_bib31","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3390\/cancers11030333","article-title":"Therapeutic Targeting of Stat3 Using Lipopolyplex Nanoparticle-Formulated siRNA in a Syngeneic Orthotopic Mouse Glioma Model","volume":"11","author":"Linder","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.omtn.2026.102963_bib32","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1097\/PAS.0b013e318216c112","article-title":"A comprehensive analysis of PAX8 expression in human epithelial tumors","volume":"35","author":"Laury","year":"2011","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.omtn.2026.102963_bib33","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1038\/onc.2016.455","article-title":"PAX2 function, regulation and targeting in fallopian tube-derived high-grade serous ovarian cancer","volume":"36","author":"Modi","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.omtn.2026.102963_bib34","doi-asserted-by":"crossref","first-page":"788","DOI":"10.4161\/cbt.10.8.12913","article-title":"Overexpression of EZH2 contributes to acquired cisplatin resistance in ovarian cancer cells in vitro and in vivo","volume":"10","author":"Hu","year":"2010","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.omtn.2026.102963_bib35","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1126\/science.281.5383.1677","article-title":"Activation of the ATM kinase by ionizing radiation and phosphorylation of p53","volume":"281","author":"Canman","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.omtn.2026.102963_bib36","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1126\/science.1215691","article-title":"miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay","volume":"336","author":"Djuranovic","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.omtn.2026.102963_bib37","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1212\/WNL.18.7.671","article-title":"Progressive proximal spinal and bulbar muscular atrophy of late onset. A sex-linked recessive trait","volume":"18","author":"Kennedy","year":"1968","journal-title":"Neurology"},{"key":"10.1016\/j.omtn.2026.102963_bib38","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/sj.ejhg.5200656","article-title":"Multiple founder effects in spinal and bulbar muscular atrophy (SBMA, Kennedy disease) around the world","volume":"9","author":"Lund","year":"2001","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.omtn.2026.102963_bib39","first-page":"4400","article-title":"Androgen receptor CAG repeat lengths in prostate cancer: correlation with age of onset","volume":"81","author":"Hardy","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.omtn.2026.102963_bib40","article-title":"Association between polymorphic CAG repeat lengths in the androgen receptor gene and susceptibility to prostate cancer: A systematic review and meta-analysis","volume":"96","author":"Qin","year":"2017","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.omtn.2026.102963_bib41","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/jnci\/89.2.166","article-title":"Association of prostate cancer risk with genetic polymorphisms in vitamin D receptor and androgen receptor","volume":"89","author":"Ingles","year":"1997","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.omtn.2026.102963_bib42","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1073\/pnas.94.7.3320","article-title":"The CAG repeat within the androgen receptor gene and its relationship to prostate cancer","volume":"94","author":"Giovannucci","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtn.2026.102963_bib43","first-page":"379","article-title":"The androgen receptor gene GGN microsatellite and prostate cancer risk","volume":"7","author":"Platz","year":"1998","journal-title":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology"},{"key":"10.1016\/j.omtn.2026.102963_bib44","first-page":"1937","article-title":"The CAG and GGC microsatellites of the androgen receptor gene are in linkage disequilibrium in men with prostate cancer","volume":"55","author":"Irvine","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/j.omtn.2026.102963_bib45","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1007\/s11033-011-1014-9","article-title":"The CAG repeat polymorphism of androgen receptor gene and prostate cancer: a meta-analysis","volume":"39","author":"Gu","year":"2012","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.omtn.2026.102963_bib46","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/pros.10333","article-title":"In situ shortening of CAG repeat length within the androgen receptor gene in prostatic cancer and its possible precursors","volume":"58","author":"Tsujimoto","year":"2004","journal-title":"Prostate"},{"key":"10.1016\/j.omtn.2026.102963_bib47","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jconrel.2016.03.034","article-title":"A novel tyrosine-modified low molecular weight polyethylenimine (P10Y) for efficient siRNA delivery in vitro and in vivo","volume":"230","author":"Ewe","year":"2016","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.omtn.2026.102963_bib48","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nature10166","article-title":"Integrated genomic analyses of ovarian carcinoma","volume":"474","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.omtn.2026.102963_bib49","doi-asserted-by":"crossref","DOI":"10.1172\/JCI174013","article-title":"Biology-driven therapy advances in high-grade serous ovarian cancer","volume":"134","author":"Wang","year":"2024","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.omtn.2026.102963_bib50","doi-asserted-by":"crossref","first-page":"6118","DOI":"10.1158\/0008-5472.CAN-16-1272","article-title":"CRISPR\/Cas9-Mediated Trp53 and Brca2 Knockout to Generate Improved Murine Models of Ovarian High-Grade Serous Carcinoma","volume":"76","author":"Walton","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.omtn.2026.102963_bib51","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3109\/07853899609092940","article-title":"High-dose chemotherapy with autologous stem cell support in advanced ovarian cancer","volume":"28","author":"Gr\u00e9nman","year":"1996","journal-title":"Ann. Med."},{"key":"10.1016\/j.omtn.2026.102963_bib52","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1097\/00001622-199110000-00018","article-title":"Chemotherapy and complications in gynecologic cancer","volume":"3","author":"ten Bokkel Huinink","year":"1991","journal-title":"Curr. Opin. Oncol."},{"key":"10.1016\/j.omtn.2026.102963_bib53","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1038\/s41416-020-0802-1","article-title":"Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours","volume":"122","author":"Hong","year":"2020","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.omtn.2026.102963_bib54","first-page":"114","article-title":"Highly malignant intra-hepatic metastatic hepatocellular carcinoma in rats","volume":"3","author":"Guo","year":"2010","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.omtn.2026.102963_bib55","first-page":"223","article-title":"Sprague-Dawley rats bearing McA-RH7777 cells for study of hepatoma and transarterial chemoembolization","volume":"33","author":"Cho","year":"2013","journal-title":"Anticancer Res."},{"key":"10.1016\/j.omtn.2026.102963_bib56","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1016\/j.jvir.2020.01.026","article-title":"Sodium Cholate Bile Acid-Stabilized Ferumoxytol-Doxorubicin-Lipiodol Emulsion for Transcatheter Arterial Chemoembolization of Hepatocellular Carcinoma","volume":"31","author":"Kwak","year":"2020","journal-title":"J. Vasc. Interv. Radiol."},{"key":"10.1016\/j.omtn.2026.102963_bib57","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12920-019-0514-7","article-title":"GENT2: an updated gene expression database for normal and tumor tissues","volume":"12","author":"Park","year":"2019","journal-title":"BMC Med. Genom."},{"key":"10.1016\/j.omtn.2026.102963_bib58","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1010022","article-title":"SPOROS: A pipeline to analyze DISE\/6mer seed toxicity","volume":"18","author":"Bartom","year":"2022","journal-title":"PLOS Comp Biol"},{"key":"10.1016\/j.omtn.2026.102963_bib59","doi-asserted-by":"crossref","first-page":"793","DOI":"10.3233\/JAD-200917","article-title":"tRNA-Derived Fragments in Alzheimer's Disease: Implications for New Disease Biomarkers and Neuropathological Mechanisms","volume":"79","author":"Wu","year":"2021","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.omtn.2026.102963_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.105058","article-title":"Small RNA modifications in Alzheimer's disease","volume":"145","author":"Zhang","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.omtn.2026.102963_bib61","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1101\/gr.131508.111","article-title":"Cooperation between Polycomb and androgen receptor during oncogenic transformation","volume":"22","author":"Zhao","year":"2012","journal-title":"Genome Res."},{"key":"10.1016\/j.omtn.2026.102963_bib62","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.38621","article-title":"CD95\/Fas ligand mRNA is toxic to cells","volume":"7","author":"Putzbach","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.omtn.2026.102963_bib63","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nature03702","article-title":"MicroRNA expression profiles classify human cancers","volume":"435","author":"Lu","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.omtn.2026.102963_bib64","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/ng2003","article-title":"Impaired microRNA processing enhances cellular transformation and tumorigenesis","volume":"39","author":"Kumar","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.omtn.2026.102963_bib65","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1158\/0008-5472.CAN-06-2698","article-title":"Characterization of microRNA expression levels and their biological correlates in human cancer cell lines","volume":"67","author":"Gaur","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.omtn.2026.102963_bib66","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2174\/2211536605666161208154633","article-title":"Exploring Mechanisms of MicroRNA Downregulation in Cancer","volume":"6","author":"Williams","year":"2017","journal-title":"MicroRNA"},{"key":"10.1016\/j.omtn.2026.102963_bib67","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.cmet.2012.07.017","article-title":"Role of microRNA processing in adipose tissue in stress defense and longevity","volume":"16","author":"Mori","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.omtn.2026.102963_bib68","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/s41586-021-03524-0","article-title":"Global miRNA dosage control of embryonic germ layer specification","volume":"593","author":"Cui","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.omtn.2026.102963_bib69","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.molcel.2015.01.004","article-title":"Stress induces p38 MAPK-mediated phosphorylation and inhibition of Drosha-dependent cell survival","volume":"57","author":"Yang","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.omtn.2026.102963_bib70","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41573-024-00912-9","article-title":"RNAi-based drug design: considerations and future directions","volume":"23","author":"Tang","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.omtn.2026.102963_bib71","first-page":"121","article-title":"CXCL10\/IP-10 in infectious diseases pathogenesis and potential therapeutic implications","volume":"22","author":"Liu","year":"2011","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.omtn.2026.102963_bib72","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/eji.200636420","article-title":"IL-18 enhances IFN-gamma-induced production of CXCL9, CXCL10, and CXCL11 in human keratinocytes","volume":"37","author":"Kanda","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.omtn.2026.102963_bib73","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/cgt.2008.62","article-title":"TNF-alpha and the IFN-gamma-inducible protein 10 (IP-10\/CXCL-10) delivered by parvoviral vectors act in synergy to induce antitumor effects in mouse glioblastoma","volume":"16","author":"Enderlin","year":"2009","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.omtn.2026.102963_bib74","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1124\/molpharm.124.000895","article-title":"The Growing Class of Novel RNAi Therapeutics","volume":"106","author":"Traber","year":"2024","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.omtn.2026.102963_bib75","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/sj.cdd.4402269","article-title":"Molecular characteristics of immunogenic cancer cell death","volume":"15","author":"Tesniere","year":"2008","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.omtn.2026.102963_bib76","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1126\/science.aah4199","article-title":"Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance","volume":"355","author":"Ku","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.omtn.2026.102963_bib77","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095649","article-title":"Pathway-specific engineered mouse allograft models functionally recapitulate human serous epithelial ovarian cancer","volume":"9","author":"Szabova","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.omtn.2026.102963_bib78","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.omtn.2026.102963_bib79","doi-asserted-by":"crossref","first-page":"R36","DOI":"10.1186\/gb-2013-14-4-r36","article-title":"TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions","volume":"14","author":"Kim","year":"2013","journal-title":"Genome Biol."},{"key":"10.1016\/j.omtn.2026.102963_bib80","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq--a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.omtn.2026.102963_bib81","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.omtn.2026.102963_bib82","doi-asserted-by":"crossref","first-page":"D543","DOI":"10.1093\/nar\/gkae1011","article-title":"The PRIDE database at 20 years: 2025 update","volume":"53","author":"Perez-Riverol","year":"2025","journal-title":"Nucleic Acids Res."}],"container-title":["Molecular Therapy Nucleic Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253126001344?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253126001344?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T01:18:15Z","timestamp":1794273495000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2162253126001344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":82,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S2162253126001344"],"URL":"https:\/\/doi.org\/10.1016\/j.omtn.2026.102963","relation":{},"ISSN":["2162-2531"],"issn-type":[{"value":"2162-2531","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Developing a pan cancer therapy based on DISE-inducing short RNAs","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy Nucleic Acids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omtn.2026.102963","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}],"article-number":"102963"}}