{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:51:27Z","timestamp":1791319887989,"version":"4.3.1"},"reference-count":108,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007813","name":"Korea National University of Transportation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007813","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy Nucleic Acids"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.omtn.2026.103100","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:34:02Z","timestamp":1789540442000},"page":"103100","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Roles of meiotic and mitotic cohesin in stem cell gene regulation and genome stability"],"prefix":"10.1016","volume":"37","author":[{"given":"Soo Min","family":"Cho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Eun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1547-2580","authenticated-orcid":false,"given":"Eui-Hwan","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omtn.2026.103100_bib1","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/s41580-023-00609-8","article-title":"Genome control by SMC complexes","volume":"24","author":"Hoencamp","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.omtn.2026.103100_bib2","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nrm.2016.30","article-title":"SMC complexes: from DNA to chromosomes","volume":"17","author":"Uhlmann","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.omtn.2026.103100_bib3","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/s41580-021-00349-7","article-title":"Genome folding through loop extrusion by SMC complexes","volume":"22","author":"Davidson","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.omtn.2026.103100_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2020.144966","article-title":"Cohesin subunit RAD21: From biology to disease","volume":"758","author":"Cheng","year":"2020","journal-title":"Gene"},{"key":"10.1016\/j.omtn.2026.103100_bib5","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/s41594-018-0070-4","article-title":"Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization","volume":"25","author":"Kojic","year":"2018","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.omtn.2026.103100_bib6","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s41576-018-0060-8","article-title":"Organizational principles of 3D genome architecture","volume":"19","author":"Rowley","year":"2018","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.omtn.2026.103100_bib7","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.semcdb.2018.07.020","article-title":"A tour of 3D genome with a focus on CTCF","volume":"90","author":"Wang","year":"2019","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.omtn.2026.103100_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-416024-8.00001-5","article-title":"Cohesin in gametogenesis","volume":"102","author":"McNicoll","year":"2013","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.omtn.2026.103100_bib9","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1093\/nar\/gkac183","article-title":"Rec8 Cohesin-mediated Axis-loop chromatin architecture is required for meiotic recombination","volume":"50","author":"Sakuno","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.omtn.2026.103100_bib10","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1002\/embj.201387330","article-title":"Meiotic cohesin STAG3 is required for chromosome axis formation and sister chromatid cohesion","volume":"33","author":"Winters","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.omtn.2026.103100_bib11","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1159\/000520682","article-title":"Sexually Dimorphic Properties in Meiotic Chromosome","volume":"16","author":"Ishiguro","year":"2022","journal-title":"Sex. Dev."},{"key":"10.1016\/j.omtn.2026.103100_bib12","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s13059-022-02632-y","article-title":"Meiosis-specific cohesin complexes display essential and distinct roles in mitotic embryonic stem cell chromosomes","volume":"23","author":"Choi","year":"2022","journal-title":"Genome Biol."},{"key":"10.1016\/j.omtn.2026.103100_bib13","doi-asserted-by":"crossref","first-page":"9918","DOI":"10.1038\/s41598-025-94533-w","article-title":"Cohesin and condensin regulate chromosome topology and play an essential role in maintaining pluripotency in embryonic stem cells","volume":"15","author":"Choi","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omtn.2026.103100_bib14","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/bjd.20760","article-title":"Transcriptomic changes during stage progression of mycosis fungoides","volume":"186","author":"Xiao","year":"2022","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.omtn.2026.103100_bib15","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.212100","article-title":"Studying meiotic cohesin in somatic cells reveals that Rec8-containing cohesin requires Stag3 to function and is regulated by Wapl and sororin","volume":"131","author":"Wolf","year":"2018","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.omtn.2026.103100_bib16","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.1016\/j.celrep.2019.05.078","article-title":"Specific Contributions of Cohesin-SA1 and Cohesin-SA2 to TADs and Polycomb Domains in Embryonic Stem Cells","volume":"27","author":"Cuadrado","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.omtn.2026.103100_bib17","first-page":"601","article-title":"Cohesin-Dependent Loop Extrusion: Molecular Mechanics and Role in Cell Physiology","volume":"89","author":"Golov","year":"2024","journal-title":"Biochemistry."},{"key":"10.1016\/j.omtn.2026.103100_bib18","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.59889","article-title":"Cohesin residency determines chromatin loop patterns","volume":"9","author":"Costantino","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.omtn.2026.103100_bib19","doi-asserted-by":"crossref","DOI":"10.1002\/bies.201800109","article-title":"Replisome-Cohesin Interfacing: A Molecular Perspective","volume":"40","author":"Villa-Hern\u00e1ndez","year":"2018","journal-title":"Bioessays"},{"key":"10.1016\/j.omtn.2026.103100_bib20","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1038\/s12276-020-0481-2","article-title":"Maintenance of genome integrity and active homologous recombination in embryonic stem cells","volume":"52","author":"Choi","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.omtn.2026.103100_bib21","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41588-020-00744-4","article-title":"WAPL maintains a cohesin loading cycle to preserve cell-type-specific distal gene regulation","volume":"53","author":"Liu","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.omtn.2026.103100_bib22","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.cell.2013.02.029","article-title":"CTCF and cohesin: linking gene regulatory elements with their targets","volume":"152","author":"Merkenschlager","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.omtn.2026.103100_bib23","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.15252\/embj.201798004","article-title":"Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins","volume":"36","author":"Wutz","year":"2017","journal-title":"EMBO J."},{"key":"10.1016\/j.omtn.2026.103100_bib24","doi-asserted-by":"crossref","first-page":"757","DOI":"10.34133\/research.0757","article-title":"The Functions and Mechanisms of the Cohesin Complex in Regulating the Fate Determinations of","volume":"8","author":"Xiang","year":"2025","journal-title":"Research"},{"key":"10.1016\/j.omtn.2026.103100_bib25","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ceb.2018.01.010","article-title":"Establishing and dissolving cohesion during the vertebrate cell cycle","volume":"52","author":"Morales","year":"2018","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.omtn.2026.103100_bib26","first-page":"679","article-title":"Cohesin in 3D: development, differentiation, and disease","volume":"39","author":"Sol\u00e9-Ferran","year":"2025","journal-title":"Genes Dev."},{"key":"10.1016\/j.omtn.2026.103100_bib27","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1046\/j.1432-1327.1999.00509.x","article-title":"Structural maintenance of chromosomes (SMC) proteins: conserved molecular properties for multiple biological functions","volume":"263","author":"Strunnikov","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.omtn.2026.103100_bib28","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.molcel.2020.07.013","article-title":"A Structure-Based Mechanism for DNA Entry into the Cohesin Ring","volume":"79","author":"Higashi","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.omtn.2026.103100_bib29","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1016\/j.cub.2014.08.011","article-title":"Cohesin's ATPase activity couples cohesin loading onto DNA with Smc3 acetylation","volume":"24","author":"Ladurner","year":"2014","journal-title":"Curr. Biol."},{"key":"10.1016\/j.omtn.2026.103100_bib30","article-title":"Characterization of the interaction between the cohesin subunits Rad21 and SA1\/2","volume":"8","author":"Zhang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.omtn.2026.103100_bib31","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.gde.2020.02.024","article-title":"Specialized functions of cohesins STAG1 and STAG2 in 3D genome architecture","volume":"61","author":"Cuadrado","year":"2020","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.omtn.2026.103100_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.617545","article-title":"Cohesin Components Stag1 and Stag2 Differentially Influence Haematopoietic Mesoderm Development in Zebrafish Embryos","volume":"8","author":"Ketharnathan","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.omtn.2026.103100_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107647","article-title":"MAU2 and NIPBL Variants Impair the Heterodimerization of the Cohesin Loader Subunits and Cause Cornelia de Lange Syndrome","volume":"31","author":"Parenti","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.omtn.2026.103100_bib34","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1038\/s41467-023-36900-7","article-title":"Different NIPBL requirements of cohesin-STAG1 and cohesin-STAG2","volume":"14","author":"Alonso-Gil","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtn.2026.103100_bib35","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1016\/j.celrep.2016.04.085","article-title":"Formation of Chromosomal Domains by Loop Extrusion","volume":"15","author":"Fudenberg","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.omtn.2026.103100_bib36","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.52091","article-title":"ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesin-STAG1 from WAPL","volume":"9","author":"Wutz","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.omtn.2026.103100_bib37","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.cell.2017.09.026","article-title":"Cohesin Loss Eliminates All Loop Domains","volume":"171","author":"Rao","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.omtn.2026.103100_bib38","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1126\/science.aaz3418","article-title":"DNA loop extrusion by human cohesin","volume":"366","author":"Davidson","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.omtn.2026.103100_bib39","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1126\/science.aaz4475","article-title":"Human cohesin compacts DNA by loop extrusion","volume":"366","author":"Kim","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.omtn.2026.103100_bib40","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.tcb.2019.05.007","article-title":"Mitotic Chromosome Mechanics: How Cells Segregate Their Genome","volume":"29","author":"Batty","year":"2019","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.omtn.2026.103100_bib41","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1101\/gad.1844309","article-title":"Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1","volume":"23","author":"Shintomi","year":"2009","journal-title":"Genes Dev."},{"key":"10.1016\/j.omtn.2026.103100_bib42","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1098\/rstb.2004.1607","article-title":"Shugoshin protects cohesin complexes at centromeres","volume":"360","author":"Watanabe","year":"2005","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.omtn.2026.103100_bib43","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00412-024-00823-z","article-title":"Vertebrate centromere architecture: from chromatin threads to functional structures","volume":"133","author":"Andrade Ruiz","year":"2024","journal-title":"Chromosoma"},{"key":"10.1016\/j.omtn.2026.103100_bib44","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.devcel.2012.06.015","article-title":"Separase sensor reveals dual roles for separase coordinating cohesin cleavage and cdk1 inhibition","volume":"23","author":"Shindo","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.omtn.2026.103100_bib45","doi-asserted-by":"crossref","first-page":"5189","DOI":"10.1038\/s41467-019-13209-y","article-title":"Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site","volume":"10","author":"Rosen","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtn.2026.103100_bib46","article-title":"Mapping separase-mediated cleavage in situ","volume":"4","author":"Boukaba","year":"2022","journal-title":"NAR Genom. Bioinf."},{"key":"10.1016\/j.omtn.2026.103100_bib47","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s13046-022-02321-5","article-title":"The multifaceted roles of cohesin in cancer","volume":"41","author":"Di Nardo","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.omtn.2026.103100_bib48","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1080\/15384101.2019.1658476","article-title":"The expanding phenotypes of cohesinopathies: one ring to rule them all","volume":"18","author":"Pich\u00e9","year":"2019","journal-title":"Cell Cycle"},{"key":"10.1016\/j.omtn.2026.103100_bib49","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a026476","article-title":"Cohesin Mutations in Cancer","volume":"6","author":"De Koninck","year":"2016","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.omtn.2026.103100_bib50","first-page":"1","article-title":"Cohesin mutations in human cancer","volume":"1866","author":"Hill","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.omtn.2026.103100_bib51","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.trecan.2019.07.001","article-title":"STAG Mutations in Cancer","volume":"5","author":"Romero-P\u00e9rez","year":"2019","journal-title":"Trends Cancer"},{"key":"10.1016\/j.omtn.2026.103100_bib52","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/ijc.35378","article-title":"Cohesin mutations and chromatin changes in cancer","volume":"158","author":"Swett","year":"2026","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.omtn.2026.103100_bib53","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3390\/genes13020200","article-title":"Rec8 Cohesin: A Structural Platform for Shaping the Meiotic Chromosomes","volume":"13","author":"Sakuno","year":"2022","journal-title":"Genes"},{"key":"10.1016\/j.omtn.2026.103100_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.beem.2021.101594","article-title":"Genetics of ovarian insufficiency and defects of folliculogenesis","volume":"36","author":"Fran\u00e7a","year":"2022","journal-title":"Best Pract. Res. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.omtn.2026.103100_bib55","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.714245","article-title":"The Zebrafish Meiotic Cohesin Complex Protein Smc1b Is Required for Key Events in Meiotic Prophase I","volume":"9","author":"Islam","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.omtn.2026.103100_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2020.144612","article-title":"The multiple facets of the SMC1A gene","volume":"743","author":"Musio","year":"2020","journal-title":"Gene"},{"key":"10.1016\/j.omtn.2026.103100_bib57","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.cub.2019.02.007","article-title":"Prdm9 and Meiotic Cohesin Proteins Cooperatively Promote DNA Double-Strand Break Formation in Mammalian Spermatocytes","volume":"29","author":"Bhattacharyya","year":"2019","journal-title":"Curr. Biol."},{"key":"10.1016\/j.omtn.2026.103100_bib58","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2204071119","article-title":"Ectopic expression of meiotic cohesin generates chromosome instability in cancer cell line","volume":"119","author":"Boukaba","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtn.2026.103100_bib59","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.molcel.2025.02.005","article-title":"A unified model for cohesin function in sister-chromatid cohesion and chromatin loop formation","volume":"85","author":"Uhlmann","year":"2025","journal-title":"Mol. Cell"},{"key":"10.1016\/j.omtn.2026.103100_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111491","article-title":"SMC complexes can traverse physical roadblocks bigger than their ring size","volume":"41","author":"Pradhan","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.omtn.2026.103100_bib61","doi-asserted-by":"crossref","first-page":"783","DOI":"10.15252\/embr.201642544","article-title":"The cohesin REC8 prevents illegitimate inter-sister synaptonemal complex assembly","volume":"17","author":"Ishiguro","year":"2016","journal-title":"EMBO Rep."},{"key":"10.1016\/j.omtn.2026.103100_bib62","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.3390\/genes15091159","article-title":"Positive Selection Drives the Evolution of the Structural Maintenance of Chromosomes (SMC) Complexes","volume":"15","author":"Forni","year":"2024","journal-title":"Genes"},{"key":"10.1016\/j.omtn.2026.103100_bib63","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ceb.2020.04.011","article-title":"Loop extrusion: theory meets single-molecule experiments","volume":"64","author":"Banigan","year":"2020","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.omtn.2026.103100_bib64","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.scr.2017.07.026","article-title":"DMRT proteins and coordination of mammalian spermatogenesis","volume":"24","author":"Zhang","year":"2017","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.omtn.2026.103100_bib65","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1038\/s41467-019-09182-1","article-title":"Staged developmental mapping and X chromosome transcriptional dynamics during mouse spermatogenesis","volume":"10","author":"Ernst","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtn.2026.103100_bib66","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1242\/dev.146811","article-title":"Epigenetic resetting of human pluripotency","volume":"144","author":"Guo","year":"2017","journal-title":"Development"},{"key":"10.1016\/j.omtn.2026.103100_bib67","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1634\/stemcells.2005-0520","article-title":"Mouse embryonic stem cells form follicle-like ovarian structures but do not progress through meiosis","volume":"24","author":"Novak","year":"2006","journal-title":"Stem Cell."},{"key":"10.1016\/j.omtn.2026.103100_bib68","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1126\/science.abn6583","article-title":"Dynamics of CTCF- and cohesin-mediated chromatin looping revealed by live-cell imaging","volume":"376","author":"Gabriele","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.omtn.2026.103100_bib69","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s00294-019-00959-x","article-title":"Meiotic prophase-like pathway for cleavage-independent removal of cohesin for chromosome morphogenesis","volume":"65","author":"Challa","year":"2019","journal-title":"Curr. Genet."},{"key":"10.1016\/j.omtn.2026.103100_bib70","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1038\/s41467-019-10411-w","article-title":"Robust elimination of genome-damaged cells safeguards against brain somatic aneuploidy following Knl1 deletion","volume":"10","author":"Shi","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtn.2026.103100_bib71","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.omtn.2026.103100_bib72","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/nmeth.3999","article-title":"HiChIP: efficient and sensitive analysis of protein-directed genome architecture","volume":"13","author":"Mumbach","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.omtn.2026.103100_bib73","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ceb.2020.11.002","article-title":"Tracking and interpreting long-range chromatin interactions with super-resolution live-cell imaging","volume":"70","author":"Brand\u00e3o","year":"2021","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.omtn.2026.103100_bib74","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1101\/sqb.2017.82.034421","article-title":"Impact of Centrosome Aberrations on Chromosome Segregation and Tissue Architecture in Cancer","volume":"82","author":"Nigg","year":"2017","journal-title":"Cold Spring Harbor Symp. Quant. Biol."},{"key":"10.1016\/j.omtn.2026.103100_bib75","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1038\/s41596-020-0373-x","article-title":"Efficient low-cost chromatin profiling with CUT&Tag","volume":"15","author":"Kaya-Okur","year":"2020","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.omtn.2026.103100_bib76","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1038\/s41467-019-09982-5","article-title":"CUT&Tag for efficient epigenomic profiling of small samples and single cells","volume":"10","author":"Kaya-Okur","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtn.2026.103100_bib77","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nrg.2016.112","article-title":"Organization and function of the 3D genome","volume":"17","author":"Bonev","year":"2016","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.omtn.2026.103100_bib78","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/s41577-022-00774-5","article-title":"Three-dimensional genome organization in immune cell fate and function","volume":"23","author":"Cuartero","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.omtn.2026.103100_bib79","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1080\/19491034.2020.1782024","article-title":"CTCF as a boundary factor for cohesin-mediated loop extrusion: evidence for a multi-step mechanism","volume":"11","author":"Hansen","year":"2020","journal-title":"Nucleus"},{"key":"10.1016\/j.omtn.2026.103100_bib80","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/s41586-023-05961-5","article-title":"CTCF is a DNA-tension-dependent barrier to cohesin-mediated loop extrusion","volume":"616","author":"Davidson","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.omtn.2026.103100_bib81","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.53558","article-title":"Chromosome organization by one-sided and two-sided loop extrusion","volume":"9","author":"Banigan","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.omtn.2026.103100_bib82","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/s41594-022-00821-8","article-title":"Cohesin is required for long-range enhancer action at the Shh locus","volume":"29","author":"Kane","year":"2022","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.omtn.2026.103100_bib83","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.cell.2018.03.072","article-title":"The Energetics and Physiological Impact of Cohesin Extrusion","volume":"173","author":"Vian","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.omtn.2026.103100_bib84","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1021\/acs.biochem.1c00306","article-title":"Inducible Protein Degradation to Understand Genome Architecture","volume":"60","author":"Tallan","year":"2021","journal-title":"Biochemistry"},{"key":"10.1016\/j.omtn.2026.103100_bib85","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1038\/s41588-022-01223-8","article-title":"Enhancer-promoter interactions and transcription are largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1","volume":"54","author":"Hsieh","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.omtn.2026.103100_bib86","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.molcel.2020.03.002","article-title":"Resolving the 3D Landscape of Transcription-Linked Mammalian Chromatin Folding","volume":"78","author":"Hsieh","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.omtn.2026.103100_bib87","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1101\/gr.136507.111","article-title":"Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules","volume":"22","author":"Faure","year":"2012","journal-title":"Genome Res."},{"key":"10.1016\/j.omtn.2026.103100_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114846","article-title":"SRF promotes long-range chromatin loop formation and stem cell pluripotency","volume":"43","author":"Tsaytler","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.omtn.2026.103100_bib89","doi-asserted-by":"crossref","first-page":"483","DOI":"10.2217\/epi-2017-0157","article-title":"Enhancer talk","volume":"10","author":"Snetkova","year":"2018","journal-title":"Epigenomics"},{"key":"10.1016\/j.omtn.2026.103100_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.107341","article-title":"STAG2 mutations regulate 3D genome organization, chromatin loops, and Polycomb signaling in glioblastoma multiforme","volume":"300","author":"Xu","year":"2024","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.omtn.2026.103100_bib91","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41586-019-1778-y","article-title":"Chromatin structure dynamics during the mitosis-to-G1 transition","volume":"576","author":"Zhang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.omtn.2026.103100_bib92","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.molcel.2020.03.003","article-title":"Ultrastructural Details of Mammalian Chromosome Architecture","volume":"78","author":"Krietenstein","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.omtn.2026.103100_bib93","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1012136","article-title":"Learning Micro-C from Hi-C with diffusion models","volume":"20","author":"Liu","year":"2024","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.omtn.2026.103100_bib94","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/s41580-019-0132-4","article-title":"The role of 3D genome organization in development and cell differentiation","volume":"20","author":"Zheng","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.omtn.2026.103100_bib95","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.celrep.2019.12.057","article-title":"Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells","volume":"30","author":"Rhodes","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.omtn.2026.103100_bib96","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1126\/science.1239278","article-title":"Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds","volume":"341","author":"Hou","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.omtn.2026.103100_bib97","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/s41588-020-0643-0","article-title":"CTCF is dispensable for immune cell transdifferentiation but facilitates an acute inflammatory response","volume":"52","author":"Stik","year":"2020","journal-title":"Nat. Genet."},{"key":"10.1016\/j.omtn.2026.103100_bib98","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41576-020-00303-x","article-title":"The relationship between genome structure and function","volume":"22","author":"Oudelaar","year":"2021","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.omtn.2026.103100_bib99","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1186\/s12864-016-2940-7","article-title":"Motif oriented high-resolution analysis of ChIP-seq data reveals the topological order of CTCF and cohesin proteins on DNA","volume":"17","author":"Nagy","year":"2016","journal-title":"BMC Genom."},{"key":"10.1016\/j.omtn.2026.103100_bib100","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1038\/s41467-022-29696-5","article-title":"Analysis of sub-kilobase chromatin topology reveals nano-scale regulatory interactions with variable dependence on cohesin and CTCF","volume":"13","author":"Aljahani","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtn.2026.103100_bib101","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41588-021-00799-x","article-title":"Independence of chromatin conformation and gene regulation during Drosophila dorsoventral patterning","volume":"53","author":"Ing-Simmons","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.omtn.2026.103100_bib102","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.cell.2020.09.014","article-title":"The Self-Organizing Genome: Principles of Genome Architecture and Function","volume":"183","author":"Misteli","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.omtn.2026.103100_bib103","article-title":"Enhancer-targeting CRISPR screens at coronary artery disease loci suggest shared mechanisms of disease risk","author":"Ramste","year":"2025","journal-title":"medRxiv"},{"key":"10.1016\/j.omtn.2026.103100_bib104","first-page":"913","article-title":"Allele-specific and cell-cycle-resolved mapping of cohesin variants at active enhancers in pluripotent cells","volume":"40","author":"Power","year":"2024","journal-title":"Trends Genet."},{"key":"10.1016\/j.omtn.2026.103100_bib105","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.cub.2025.01.044","article-title":"A common molecular mechanism underlying Cornelia de Lange and CHOPS syndromes","volume":"35","author":"Sakata","year":"2025","journal-title":"Curr. Biol."},{"key":"10.1016\/j.omtn.2026.103100_bib106","doi-asserted-by":"crossref","DOI":"10.1080\/15592294.2023.2293411","article-title":"Cut&tag: a powerful epigenetic tool for chromatin profiling","volume":"19","author":"Fu","year":"2024","journal-title":"Epigenetics"},{"key":"10.1016\/j.omtn.2026.103100_bib107","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1038\/nprot.2018.015","article-title":"Targeted in situ genome-wide profiling with high efficiency for low cell numbers","volume":"13","author":"Skene","year":"2018","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.omtn.2026.103100_bib108","first-page":"138","article-title":"Assessing cell lines with inducible depletion of cohesin and condensins components through analysis of metaphase chromosome morphology","volume":"28","author":"Yunusova","year":"2024","journal-title":"Vavilovskii Zhurnal Genet. Selektsii"}],"container-title":["Molecular Therapy Nucleic Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253126002714?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253126002714?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:00:59Z","timestamp":1791316859000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2162253126002714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":108,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["S2162253126002714"],"URL":"https:\/\/doi.org\/10.1016\/j.omtn.2026.103100","relation":{},"ISSN":["2162-2531"],"issn-type":[{"value":"2162-2531","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Roles of meiotic and mitotic cohesin in stem cell gene regulation and genome stability","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy Nucleic Acids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omtn.2026.103100","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}],"article-number":"103100"}}