{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:30:54Z","timestamp":1791930654773,"version":"4.3.4"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008667","name":"National Cancer Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008667","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003645","name":"National Cancer Center","doi-asserted-by":"publisher","award":["NCC-1910011"],"award-info":[{"award-number":["NCC-1910011"]}],"id":[{"id":"10.13039\/501100003645","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy Oncolytics"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.omto.2021.09.001","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T02:47:49Z","timestamp":1631587669000},"page":"138-150","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Local adenoviral delivery of soluble CD200R-Ig enhances antitumor immunity by inhibiting CD200-\u03b2-catenin-driven M2 macrophage"],"prefix":"10.1016","volume":"23","author":[{"given":"Seung-Phil","family":"Shin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A-Ra","family":"Goh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0000-7232","authenticated-orcid":false,"given":"Ji-Min","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2348-2693","authenticated-orcid":false,"given":"Hyeon-Gu","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7498-1775","authenticated-orcid":false,"given":"Seok-Jun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Kwang","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Jung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2233-9449","authenticated-orcid":false,"given":"Yong-Soo","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungho","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuh-Seog","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4478-1043","authenticated-orcid":false,"given":"Sang-Jin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omto.2021.09.001_bib1","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1126\/science.271.5256.1734","article-title":"Enhancement of antitumor immunity by CTLA-4 blockade","volume":"271","author":"Leach","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.omto.2021.09.001_bib2","doi-asserted-by":"crossref","first-page":"4712","DOI":"10.1073\/pnas.0830997100","article-title":"Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients","volume":"100","author":"Hodi","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omto.2021.09.001_bib3","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/nm730","article-title":"Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion","volume":"8","author":"Dong","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.omto.2021.09.001_bib4","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1200\/JCO.2009.26.7609","article-title":"Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates","volume":"28","author":"Brahmer","year":"2010","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.omto.2021.09.001_bib5","doi-asserted-by":"crossref","first-page":"3860","DOI":"10.1038\/onc.2014.317","article-title":"Bidirectional effect of CD200 on breast cancer development and metastasis, with ultimate outcome determined by tumor aggressiveness and a cancer-induced inflammatory response","volume":"34","author":"Erin","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.omto.2021.09.001_bib6","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.it.2008.07.005","article-title":"Cancer stem cells, CD200 and immunoevasion","volume":"29","author":"Kawasaki","year":"2008","journal-title":"Trends Immunol."},{"key":"10.1016\/j.omto.2021.09.001_bib7","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jri.2015.05.005","article-title":"The CD200 tolerance-signaling molecule and its receptor, CD200R1, are expressed in human placental villus trophoblast and in peri-implant decidua by 5\u00a0weeks\u2019 gestation","volume":"112","author":"Clark","year":"2015","journal-title":"J.\u00a0Reprod. Immunol."},{"key":"10.1016\/j.omto.2021.09.001_bib8","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1038\/leu.2015.62","article-title":"The immunosuppressive ligands PD-L1 and CD200 are linked in AML T-cell immunosuppression: identification of a new immunotherapeutic synapse","volume":"29","author":"Coles","year":"2015","journal-title":"Leukemia"},{"key":"10.1016\/j.omto.2021.09.001_bib9","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/B978-0-12-800100-4.00005-2","article-title":"The CD200-CD200R1 inhibitory signaling pathway: immune regulation and host-pathogen interactions","volume":"121","author":"Vaine","year":"2014","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.omto.2021.09.001_bib10","doi-asserted-by":"crossref","first-page":"e000189","DOI":"10.1136\/jitc-2019-000189","article-title":"CD200 promotes immunosuppression in the pancreatic tumor microenvironment","volume":"8","author":"Choueiry","year":"2020","journal-title":"J.\u00a0Immunother. Cancer"},{"key":"10.1016\/j.omto.2021.09.001_bib11","doi-asserted-by":"crossref","first-page":"699","DOI":"10.4049\/jimmunol.180.2.699","article-title":"Blockade of CD200 in the presence or absence of antibody effector function: implications for anti-CD200 therapy","volume":"180","author":"Kretz-Rommel","year":"2008","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.omto.2021.09.001_bib12","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/mt.2012.252","article-title":"Adenovirus expressing both thymidine kinase and soluble PD1 enhances antitumor immunity by strengthening CD8 T-cell response","volume":"21","author":"Shin","year":"2013","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omto.2021.09.001_bib13","doi-asserted-by":"crossref","first-page":"E1583","DOI":"10.3390\/cancers11101583","article-title":"CD200 Induces Epithelial-to-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma via \u03b2-Catenin-Mediated Nuclear Translocation","volume":"11","author":"Shin","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.omto.2021.09.001_bib14","doi-asserted-by":"crossref","first-page":"5595","DOI":"10.4049\/jimmunol.178.9.5595","article-title":"CD200 expression on tumor cells suppresses antitumor immunity: new approaches to cancer immunotherapy","volume":"178","author":"Kretz-Rommel","year":"2007","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.omto.2021.09.001_bib15","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1158\/1078-0432.CCR-16-1829","article-title":"Checkpoint Proteins in Pediatric Brain and Extracranial Solid Tumors: Opportunities for Immunotherapy","volume":"23","author":"Ring","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.omto.2021.09.001_bib16","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1093\/bioinformatics\/btp536","article-title":"QuickGO: a web-based tool for Gene Ontology searching","volume":"25","author":"Binns","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.omto.2021.09.001_bib17","doi-asserted-by":"crossref","first-page":"554","DOI":"10.3389\/fimmu.2014.00554","article-title":"Myeloid colony-stimulating factors as regulators of macrophage polarization","volume":"5","author":"Hamilton","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.omto.2021.09.001_bib18","doi-asserted-by":"crossref","first-page":"154939","DOI":"10.1016\/j.cyto.2019.154939","article-title":"Who\u2019s in charge here? Macrophage colony stimulating factor and granulocyte macrophage colony stimulating factor: Competing factors in macrophage polarization","volume":"127","author":"Trus","year":"2020","journal-title":"Cytokine"},{"key":"10.1016\/j.omto.2021.09.001_bib19","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/s41419-018-0319-1","article-title":"S100A4 promotes lung tumor development through \u03b2-catenin pathway-mediated autophagy inhibition","volume":"9","author":"Hou","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.omto.2021.09.001_bib20","first-page":"284","article-title":"Regulation of M-CSF expression by M-CSF: role of protein kinase C and transcription factor NF kappa B","volume":"59","author":"Brach","year":"1991","journal-title":"Pathobiology"},{"key":"10.1016\/j.omto.2021.09.001_bib21","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/ni.3306","article-title":"Molecular control of activation and priming in macrophages","volume":"17","author":"Glass","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.omto.2021.09.001_bib22","doi-asserted-by":"crossref","first-page":"e1426517","DOI":"10.1080\/2162402X.2018.1426517","article-title":"Merkel cell carcinoma expresses the immunoregulatory ligand CD200 and induces immunosuppressive macrophages and regulatory T\u00a0cells","volume":"7","author":"Gaiser","year":"2018","journal-title":"OncoImmunology"},{"key":"10.1016\/j.omto.2021.09.001_bib23","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.ejca.2009.11.005","article-title":"Multimodal approach using oncolytic adenovirus, cetuximab, chemotherapy and radiotherapy in HNSCC low passage tumour cell cultures","volume":"46","author":"Dias","year":"2010","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.omto.2021.09.001_bib24","first-page":"4175","article-title":"Variability of adenovirus receptor density influences gene transfer efficiency and therapeutic response in head and neck cancer","volume":"5","author":"Li","year":"1999","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.omto.2021.09.001_bib25","doi-asserted-by":"crossref","DOI":"10.2217\/fnl.13.14","article-title":"Understanding the neurobiology of CD200 and the CD200 receptor: a therapeutic target for controlling inflammation in human brains?","volume":"8","author":"Walker","year":"2013","journal-title":"Future Neurol."},{"key":"10.1016\/j.omto.2021.09.001_bib26","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S1471-4906(02)02302-5","article-title":"Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes","volume":"23","author":"Mantovani","year":"2002","journal-title":"Trends Immunol."},{"key":"10.1016\/j.omto.2021.09.001_bib27","first-page":"6359","article-title":"Selective replication and oncolysis in p53 mutant tumors with ONYX-015, an E1B-55kD gene-deleted adenovirus, in patients with advanced head and neck cancer: a phase II trial","volume":"60","author":"Nemunaitis","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.omto.2021.09.001_bib28","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/hed.23608","article-title":"CD200: association with cancer stem cell features and response to chemoradiation in head and neck squamous cell carcinoma","volume":"37","author":"Jung","year":"2015","journal-title":"Head Neck"},{"key":"10.1016\/j.omto.2021.09.001_bib29","series-title":"The cBiol. cancer genomics portal: an open platform for exploring multidimensional cancer genomics data","author":"Cerami","year":"2012"},{"key":"10.1016\/j.omto.2021.09.001_bib30","doi-asserted-by":"crossref","first-page":"pl1","DOI":"10.1126\/scisignal.2004088","article-title":"Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal","volume":"6","author":"Gao","year":"2013","journal-title":"Sci. Signal."},{"key":"10.1016\/j.omto.2021.09.001_bib31","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1038\/cdd.2014.88","article-title":"Ablation of galectin-3 induces p27(KIP1)-dependent premature senescence without oncogenic stress","volume":"21","author":"Kim","year":"2014","journal-title":"Cell Death Differ."}],"container-title":["Molecular Therapy Oncolytics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2372770521001285?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2372770521001285?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T12:36:27Z","timestamp":1784723787000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2372770521001285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":31,"alternative-id":["S2372770521001285"],"URL":"https:\/\/doi.org\/10.1016\/j.omto.2021.09.001","relation":{},"ISSN":["2372-7705"],"issn-type":[{"value":"2372-7705","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Local adenoviral delivery of soluble CD200R-Ig enhances antitumor immunity by inhibiting CD200-\u03b2-catenin-driven M2 macrophage","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy Oncolytics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omto.2021.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors.","name":"copyright","label":"Copyright"}]}}