{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:54:08Z","timestamp":1781312048251,"version":"3.54.1"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T00:00:00Z","timestamp":1639958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["18-29-01009"],"award-info":[{"award-number":["18-29-01009"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["21-74-20110"],"award-info":[{"award-number":["21-74-20110"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy - Oncolytics"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.omto.2021.12.013","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T02:34:21Z","timestamp":1640054061000},"page":"230-248","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Superior infectivity of the fiber chimeric oncolytic adenoviruses Ad5\/35 and Ad5\/3 over Ad5-delta-24-RGD in primary glioma cultures"],"prefix":"10.1016","volume":"24","author":[{"given":"Aleksei A.","family":"Stepanenko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasiia O.","family":"Sosnovtseva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marat P.","family":"Valikhov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia A.","family":"Chernysheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey A.","family":"Cherepanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaukhar M.","family":"Yusubalieva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt","family":"Ruzsics","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasiia V.","family":"Lipatova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir P.","family":"Chekhonin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omto.2021.12.013_bib1","doi-asserted-by":"crossref","first-page":"492","DOI":"10.3390\/cancers10120492","article-title":"Recent advances in oncolytic virotherapy and Immunotherapy for glioblastoma: a glimmer of hope in the search for an effective therapy?","volume":"10","author":"Stepanenko","year":"2018","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.omto.2021.12.013_bib2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.gene.2018.08.069","article-title":"A compendium of adenovirus genetic modifications for enhanced replication, oncolysis, and tumor immunosurveillance in cancer therapy","volume":"679","author":"Stepanenko","year":"2018","journal-title":"Gene"},{"key":"10.1016\/j.omto.2021.12.013_bib3","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.virusres.2018.08.012","article-title":"Tropism and transduction of oncolytic adenovirus 5 vectors in cancer therapy: focus on fiber chimerism and mosaicism, hexon and pIX","volume":"257","author":"Stepanenko","year":"2018","journal-title":"Virus Res."},{"key":"10.1016\/j.omto.2021.12.013_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3171\/2020.11.FOCUS20860","article-title":"Clinical trials using oncolytic viral therapy to treat adult glioblastoma: a progress report","volume":"50","author":"Lu","year":"2021","journal-title":"Neurosurg. Focus"},{"key":"10.1016\/j.omto.2021.12.013_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3171\/2020.11.FOCUS20854","article-title":"Viral therapies for glioblastoma and high-grade gliomas in adults: a systematic review","volume":"50","author":"Wang","year":"2021","journal-title":"Neurosurg. Focus"},{"key":"10.1016\/j.omto.2021.12.013_bib6","first-page":"821","article-title":"Phase I study of DNX-2401 (Delta-24-RGD) oncolytic adenovirus: replication and immunotherapeutic effects in recurrent malignant glioma","volume":"75","author":"Lang","year":"2018","journal-title":"J.\u00a0Clin. Oncol. JCO."},{"key":"10.1016\/j.omto.2021.12.013_bib7","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1093\/neuonc\/noy082","article-title":"Oncolytic virotherapy in glioblastoma patients induces a tumor macrophage phenotypic shift leading to an altered glioblastoma microenvironment","volume":"20","author":"Van Den Bossche","year":"2018","journal-title":"Neuro. Oncol."},{"key":"10.1016\/j.omto.2021.12.013_bib8","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.1038\/onc.2010.226","article-title":"Identification of a molecular recognition feature in the E1A oncoprotein that binds the SUMO conjugase UBC9 and likely interferes with polySUMOylation","volume":"29","author":"Yousef","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.omto.2021.12.013_bib9","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1126\/science.aab3291","article-title":"DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway","volume":"350","author":"Lau","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.omto.2021.12.013_bib10","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/sj.onc.1203251","article-title":"A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in\u00a0vivo","volume":"19","author":"Fueyo","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.omto.2021.12.013_bib11","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1038\/80474","article-title":"An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy","volume":"6","author":"Heise","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.omto.2021.12.013_bib12","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.ymthe.2004.07.014","article-title":"Impact of E1a modifications on tumor-selective adenoviral replication and toxicity","volume":"10","author":"Sauthoff","year":"2004","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omto.2021.12.013_bib13","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/sj.cgt.7700940","article-title":"Control of E1A under an E2F-1 promoter insulated with the myotonic dystrophy locus insulator reduces the toxicity of oncolytic adenovirus Ad-\u039424RGD","volume":"13","author":"Majem","year":"2006","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.omto.2021.12.013_bib14","doi-asserted-by":"crossref","first-page":"7602","DOI":"10.1128\/JVI.75.16.7602-7611.2001","article-title":"Human papillomavirus E6E7-mediated adenovirus cell killing: selectivity of mutant adenovirus replication in organotypic cultures of human keratinocytes","volume":"75","author":"Balagu\u00e9","year":"2001","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.omto.2021.12.013_bib15","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/sj.gt.3302181","article-title":"A cyclooxygenase-2 promoter-based conditionally replicating adenovirus with enhanced infectivity for treatment of ovarian adenocarcinoma","volume":"11","author":"Kanerva","year":"2004","journal-title":"Gene Ther."},{"key":"10.1016\/j.omto.2021.12.013_bib16","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S1535-6108(02)00060-0","article-title":"Selectively replicating adenoviruses targeting deregulated E2F activity are potent, systemic antitumor agents","volume":"1","author":"Johnson","year":"2002","journal-title":"Cancer Cell"},{"key":"10.1016\/j.omto.2021.12.013_bib17","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1002\/jmv.21264","article-title":"Evaluation of E1A double mutant oncolytic adenovectors in anti-glioma gene therapy","volume":"80","author":"Ulasov","year":"2008","journal-title":"J.\u00a0Med. Virol."},{"key":"10.1016\/j.omto.2021.12.013_bib18","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3390\/v8120337","article-title":"Insights into adenovirus uncoating from interactions with integrins and mediators of host immunity","volume":"8","author":"Nemerow","year":"2016","journal-title":"Viruses"},{"key":"10.1016\/j.omto.2021.12.013_bib19","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.tranon.2017.07.002","article-title":"Immunohistochemical characterization and sensitivity to human adenovirus serotypes 3, 5, and 11p of new cell lines derived from human diffuse grade II to IV gliomas","volume":"10","author":"Niittykoski","year":"2017","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.omto.2021.12.013_bib20","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/jgm.1008","article-title":"Fiber-knob modifications enhance adenoviral tropism and gene transfer in malignant glioma","volume":"9","author":"Zheng","year":"2007","journal-title":"J.\u00a0Gene Med."},{"key":"10.1016\/j.omto.2021.12.013_bib21","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/ijc.10891","article-title":"Expression of the coxsackie and adenovirus receptor in human astrocytic tumors and xenografts","volume":"103","author":"Fuxe","year":"2003","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.omto.2021.12.013_bib22","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1099\/vir.0.80084-0","article-title":"Efficient internalization into low-passage glioma cell lines using adenoviruses other than type 5: an approach for improvement of gene delivery to brain tumours","volume":"85","author":"Skog","year":"2004","journal-title":"J.\u00a0Gen. Virol."},{"key":"10.1016\/j.omto.2021.12.013_bib23","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/1743-422X-7-148","article-title":"Integrin \u03b1v\u03b25 is a primary receptor for adenovirus in CAR-negative cells","volume":"7","author":"Lyle","year":"2010","journal-title":"Virol. J."},{"key":"10.1016\/j.omto.2021.12.013_bib24","first-page":"1141","article-title":"Adenovirus vectors with chimeric type 5 and 35 fiber proteins exhibit enhanced transfection of human pancreatic cancer cells","volume":"33","author":"Toyoda","year":"2008","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.omto.2021.12.013_bib25","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/sj.cgt.7701010","article-title":"Human adenovirus type 35 vector for gene therapy of brain cancer: improved transduction and bypass of pre-existing anti-vector immunity in cancer patients","volume":"14","author":"Brouwer","year":"2007","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.omto.2021.12.013_bib26","first-page":"265","article-title":"Phage libraries displaying cyclic peptides with different ring sizes: ligand specificities of the rgd-directed integrine","volume":"13","author":"Kolvunen","year":"1995","journal-title":"Bio\/Technology"},{"key":"10.1016\/j.omto.2021.12.013_bib27","doi-asserted-by":"crossref","first-page":"9706","DOI":"10.1128\/JVI.72.12.9706-9713.1998","article-title":"An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism","volume":"72","author":"Dmitriev","year":"1998","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.omto.2021.12.013_bib28","first-page":"120","article-title":"A conditionally replicative adenovirus with enhanced infectivity shows improved oncolytic potency","volume":"7","author":"Suzuki","year":"2001","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.omto.2021.12.013_bib29","first-page":"5736","article-title":"Potential of the conditionally replicative adenovirus Ad5-Delta24RGD in the treatment of malignant gliomas and its enhanced effect with radiotherapy","volume":"62","author":"Lamfers","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.omto.2021.12.013_bib30","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1093\/jnci\/95.9.652","article-title":"Preclinical characterization of the antiglioma activity of a tropism-enhanced adenovirus targeted to the retinoblastoma pathway","volume":"95","author":"Fueyo","year":"2003","journal-title":"J.\u00a0Natl. Cancer Inst."},{"key":"10.1016\/j.omto.2021.12.013_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1517\/17425247.2016.1158707","article-title":"Redirecting adenovirus tropism by genetic, chemical, and mechanical modification of the adenovirus surface for cancer gene therapy","volume":"13","author":"Yoon","year":"2016","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.omto.2021.12.013_bib32","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1080\/15384047.2017.1395115","article-title":"A novel fiber chimeric conditionally replicative adenovirus-Ad5\/F35 for tumor therapy","volume":"18","author":"Yang","year":"2017","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.omto.2021.12.013_bib33","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nm.2270","article-title":"Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14","volume":"17","author":"Wang","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.omto.2021.12.013_bib34","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1128\/JVI.06181-11","article-title":"Avidity binding of human adenovirus serotypes 3 and 7 to the membrane cofactor CD46 triggers infection","volume":"86","author":"Trinh","year":"2012","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.omto.2021.12.013_bib35","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1038\/nm952","article-title":"CD46 is a cellular receptor for group B adenoviruses","volume":"9","author":"Gaggar","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.omto.2021.12.013_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms21186828","article-title":"Adenovirus receptor expression in cancer and its multifaceted role in oncolytic adenovirus therapy","volume":"21","author":"Hensen","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.omto.2021.12.013_bib37","doi-asserted-by":"crossref","first-page":"511","DOI":"10.4161\/cbt.2.5.440","article-title":"Enhanced adenovirus infection of melanoma cells by fiber-modification: incorporation of RGD peptide or Ad5\/3 chimerism","volume":"2","author":"Volk","year":"2003","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.omto.2021.12.013_bib38","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.4161\/cbt.4.11.2084","article-title":"Gene transfer to carcinoma of the breast with fiber-modified adenoviral vectors in a tissue slice model system","volume":"4","author":"Stoff-Khalili","year":"2005","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.omto.2021.12.013_bib39","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1158\/1535-7163.MCT-07-0176","article-title":"Treatment of metastatic renal cancer with capsid-modified oncolytic adenoviruses","volume":"6","author":"Guse","year":"2007","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.omto.2021.12.013_bib40","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1158\/1078-0432.CCR-05-2576","article-title":"Infectivity-enhanced adenoviruses deliver efficacy in clinical samples and orthotopic models of disseminated gastric cancer","volume":"12","author":"Kangasniemi","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.omto.2021.12.013_bib41","doi-asserted-by":"crossref","first-page":"4319","DOI":"10.1158\/0008-5472.CAN-04-0064","article-title":"Infectivity-enhanced cyclooxygenase-2-based conditionally replicative adenoviruses for esophageal adenocarcinoma treatment","volume":"64","author":"Davydova","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.omto.2021.12.013_bib42","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/sj.cgt.7700806","article-title":"Complex mosaicism is a novel approach to infectivity enhancement of adenovirus type 5-based vectors","volume":"12","author":"Borovjagin","year":"2005","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.omto.2021.12.013_bib43","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1002\/jgm.1385","article-title":"A chimeric adenovirus with an Ad 3 fiber knob modification augments glioma virotherapy","volume":"11","author":"Nandi","year":"2009","journal-title":"J.\u00a0Gene Med."},{"key":"10.1016\/j.omto.2021.12.013_bib44","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/sj.jid.5701131","article-title":"Evaluation of twenty-one human adenovirus types and one infectivity-enhanced adenovirus for the treatment of malignant melanoma","volume":"128","author":"Hoffmann","year":"2008","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.omto.2021.12.013_bib45","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1089\/hum.2006.132","article-title":"Evaluation of twenty human adenoviral types and one infectivity-enhanced adenovirus for the therapy of soft tissue sarcoma","volume":"18","author":"Hoffmann","year":"2007","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.omto.2021.12.013_bib46","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/jgm.1076","article-title":"Improved glioblastoma treatment with Ad5\/35 fiber chimeric conditionally replicating adenoviruses","volume":"9","author":"Hoffman","year":"2007","journal-title":"J.\u00a0Gene Med."},{"key":"10.1016\/j.omto.2021.12.013_bib47","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1158\/1535-7163.MCT-06-0187","article-title":"Enhanced transduction of malignant glioma with a double targeted Ad5\/3-RGD fiber-modified adenovirus","volume":"5","author":"Tyler","year":"2006","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.omto.2021.12.013_bib48","doi-asserted-by":"crossref","first-page":"e0145272","DOI":"10.1371\/journal.pone.0145272","article-title":"A multi targeting conditionally replicating adenovirus displays enhanced oncolysis while maintaining expression of immunotherapeutic agents","volume":"10","author":"Dobbins","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.omto.2021.12.013_bib49","doi-asserted-by":"crossref","first-page":"6839","DOI":"10.1128\/jvi.70.10.6839-6846.1996","article-title":"Generation of recombinant adenovirus vectors with modified fibers for altering viral tropism","volume":"70","author":"Krasnykh","year":"1996","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.omto.2021.12.013_bib50","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1128\/JVI.74.6.2567-2583.2000","article-title":"Efficient gene transfer into human CD34(+) cells by a retargeted adenovirus vector","volume":"74","author":"Shayakhmetov","year":"2000","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.omto.2021.12.013_bib51","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/gt.2009.65","article-title":"Development of fiber-substituted adenovirus vectors containing foreign peptides in the adenovirus serotype 35 fiber knob","volume":"16","author":"Matsui","year":"2009","journal-title":"Gene Ther."},{"key":"10.1016\/j.omto.2021.12.013_bib52","doi-asserted-by":"crossref","first-page":"e002644","DOI":"10.1136\/jitc-2021-002644","article-title":"CD137 and PD-L1 targeting with immunovirotherapy induces a potent and durable antitumor immune response in glioblastoma models","volume":"9","author":"Puigdelloses","year":"2021","journal-title":"J.\u00a0Immunother. Cancer"},{"key":"10.1016\/j.omto.2021.12.013_bib53","doi-asserted-by":"crossref","first-page":"3894","DOI":"10.1158\/0008-5472.CAN-17-0468","article-title":"Oncolytic adenovirus and tumor-targeting immune modulatory therapy improve autologous cancer vaccination","volume":"77","author":"Jiang","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.omto.2021.12.013_bib54","first-page":"vdz009","article-title":"GITRL-armed Delta-24-RGD oncolytic adenovirus prolongs survival and induces anti-glioma immune memory","volume":"1","author":"Rivera-Molina","year":"2019","journal-title":"Neurooncol. Adv."},{"key":"10.1016\/j.omto.2021.12.013_bib55","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1158\/1535-7163.MCT-06-0403","article-title":"Treatment of prostate cancer with Ad5\/3\u039424hCG allows non-invasive detection of the magnitude and persistence of virus replication in\u00a0vivo","volume":"6","author":"Rajecki","year":"2007","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.omto.2021.12.013_bib56","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12896-019-0514-x","article-title":"Efficient gene transfer into T lymphocytes by fiber-modified human adenovirus 5","volume":"19","author":"Lv","year":"2019","journal-title":"BMC Biotechnol."},{"key":"10.1016\/j.omto.2021.12.013_bib57","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1128\/JVI.02722-06","article-title":"Tropism modification of adenovirus vectors by peptide ligand insertion into various positions of the adenovirus serotype 41 short-fiber knob domain","volume":"81","author":"Hesse","year":"2007","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.omto.2021.12.013_bib58","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1038\/sj.gt.3302346","article-title":"Combining high selectivity of replication with fiber chimerism for effective adenoviral oncolysis of CAR-negative melanoma cells","volume":"11","author":"Rivera","year":"2004","journal-title":"Gene Ther."},{"key":"10.1016\/j.omto.2021.12.013_bib59","doi-asserted-by":"crossref","first-page":"5753","DOI":"10.1158\/0008-5472.CAN-04-0499","article-title":"Oncolytic activity of p53-expressing conditionally replicative adenovirus Ad\u039424-p53 against human malignant glioma","volume":"64","author":"Geoerger","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.omto.2021.12.013_bib60","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.1002\/1873-3468.13680","article-title":"Adenoviral strategies to overcome innate cellular responses to infection","volume":"593","author":"Sohn","year":"2019","journal-title":"FEBS Lett."},{"key":"10.1016\/j.omto.2021.12.013_bib61","first-page":"5738","article-title":"Differential susceptibility of primary and established human glioma cells to adenovirus infection: targeting via the epidermal growth factor receptor achieves fiber receptor-independent gene transfer","volume":"58","author":"Miller","year":"1998","journal-title":"Cancer Res."},{"key":"10.1016\/j.omto.2021.12.013_bib62","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.3171\/jns.2000.92.6.1002","article-title":"Dependence of efficient adenoviral gene delivery in malignant glioma cells on the expression levels of the Coxsackievirus and adenovirus receptor","volume":"92","author":"Asaoka","year":"2000","journal-title":"J.\u00a0Neurosurg."},{"key":"10.1016\/j.omto.2021.12.013_bib63","first-page":"2311","article-title":"Adenovirus type 5 substituted with type 11 or 35 fiber structure increases its infectivity to human cells enabling dual gene transfer in CD46-dependent and -independent manners","volume":"27","author":"Yu","year":"2007","journal-title":"Anticancer Res."},{"key":"10.1016\/j.omto.2021.12.013_bib64","first-page":"831","article-title":"Increased infectivity of adenovirus type 5 bearing type 11 or type 35 fibers to human esophageal and oral carcinoma cells","volume":"14","author":"Yu","year":"2005","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.omto.2021.12.013_bib65","doi-asserted-by":"crossref","first-page":"38210","DOI":"10.18632\/oncotarget.9427","article-title":"Efficacy of CD46-targeting chimeric Ad5\/35 adenoviral gene therapy for colorectal cancers","volume":"7","author":"Cho","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.omto.2021.12.013_bib66","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.virol.2010.03.003","article-title":"Adenovirus 5 and chimeric adenovirus 5\/F35 employ distinct B-lymphocyte intracellular trafficking routes that are independent of their cognate cell surface receptor","volume":"401","author":"Drouin","year":"2010","journal-title":"Virology"},{"key":"10.1016\/j.omto.2021.12.013_bib67","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s42003-020-0849-9","article-title":"Deep splicing plasticity of the human adenovirus type 5 transcriptome drives virus evolution","volume":"3","author":"Donovan-Banfield","year":"2020","journal-title":"Commun. Biol."},{"key":"10.1016\/j.omto.2021.12.013_bib68","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1089\/scd.2019.0092","article-title":"Efficiency of human olfactory ensheathing cell transplantation into spinal cysts to improve mobility of the hind limbs","volume":"28","author":"Stepanova","year":"2019","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.omto.2021.12.013_bib69","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1089\/hgtb.2018.044","article-title":"Novel vector construction based on alternative adenovirus types via homologous recombination","volume":"29","author":"Zhang","year":"2018","journal-title":"Hum. Gene Ther. Methods"},{"key":"10.1016\/j.omto.2021.12.013_bib70","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.meteno.2016.05.003","article-title":"Molecular Cloning Designer Simulator (MCDS): all-in-one molecular cloning and genetic engineering design, simulation and management software for complex synthetic biology and metabolic engineering projects","volume":"3","author":"Shi","year":"2016","journal-title":"Metab. Eng. Commun."},{"key":"10.1016\/j.omto.2021.12.013_bib71","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ab.2006.04.032","article-title":"A rapid and efficient method for purification of recombinant adenovirus with arginine-glycine-aspartic acid-modified fibers","volume":"354","author":"Peng","year":"2006","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.omto.2021.12.013_bib72","doi-asserted-by":"crossref","first-page":"16088","DOI":"10.1038\/s41598-021-94573-y","article-title":"A new insight into aggregation of oncolytic adenovirus Ad5-delta-24-RGD during CsCl gradient ultracentrifugation","volume":"11","author":"Stepanenko","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omto.2021.12.013_bib73","series-title":"Methods in Molecular Biology","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-1-61779-340-0_2","article-title":"Construction of capsid-modified adenoviruses by recombination in yeast and purification by iodixanol-gradient","author":"Gim\u00e9nez-Alejandre","year":"2012"},{"key":"10.1016\/j.omto.2021.12.013_bib74","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jviromet.2013.04.013","article-title":"A rapid Q-PCR titration protocol for adenovirus and helper-dependent adenovirus vectors that produces biologically relevant results","volume":"192","author":"Gallaher","year":"2013","journal-title":"J.\u00a0Virol. Methods"},{"key":"10.1016\/j.omto.2021.12.013_bib75","doi-asserted-by":"crossref","first-page":"e23813","DOI":"10.7554\/eLife.23813","article-title":"Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression","volume":"6","author":"Rocha","year":"2017","journal-title":"Elife"}],"container-title":["Molecular Therapy - Oncolytics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2372770521001856?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2372770521001856?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T06:24:10Z","timestamp":1762496650000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2372770521001856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":75,"alternative-id":["S2372770521001856"],"URL":"https:\/\/doi.org\/10.1016\/j.omto.2021.12.013","relation":{},"ISSN":["2372-7705"],"issn-type":[{"value":"2372-7705","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Superior infectivity of the fiber chimeric oncolytic adenoviruses Ad5\/35 and Ad5\/3 over Ad5-delta-24-RGD in primary glioma cultures","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy - Oncolytics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omto.2021.12.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s).","name":"copyright","label":"Copyright"}]}}