{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:56:50Z","timestamp":1777438610782,"version":"3.51.4"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy - Oncolytics"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.omto.2022.03.007","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T21:51:49Z","timestamp":1647381109000},"page":"43-56","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Development of a low-seroprevalence, \u03b1v\u03b26 integrin-selective virotherapy based on human adenovirus type 10"],"prefix":"10.1016","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1378-6981","authenticated-orcid":false,"given":"Emily A.","family":"Bates","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3569-4500","authenticated-orcid":false,"given":"James A.","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4645-0248","authenticated-orcid":false,"given":"Jana","family":"V\u00e1\u0148ov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5518-5650","authenticated-orcid":false,"given":"Davor","family":"Nesti\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie S.","family":"Meniel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Koushyar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6972-1928","authenticated-orcid":false,"given":"Tabitha G.","family":"Cunliffe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3493-1084","authenticated-orcid":false,"given":"Rosie M.","family":"Mundy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise","family":"Moses","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanni K.","family":"Uusi-Kerttula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8232-0531","authenticated-orcid":false,"given":"Alexander T.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0028-9396","authenticated-orcid":false,"given":"David K.","family":"Cole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragomira","family":"Majhen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9290-0369","authenticated-orcid":false,"given":"Pierre J.","family":"Rizkallah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toby","family":"Phesse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Chester","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9302-1761","authenticated-orcid":false,"given":"Alan L.","family":"Parker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.omto.2022.03.007_bib1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1556\/EuJMI.4.2014.1.2","article-title":"Human adenovirus: viral pathogen with increasing importance","volume":"4","author":"Ghebremedhin","year":"2014","journal-title":"Eur. J. Microbiol. Immunol. (Bp)"},{"key":"10.1016\/j.omto.2022.03.007_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1099\/vir.0.003087-0","article-title":"Adenoviruses: update on structure and function","volume":"90","author":"Russell","year":"2009","journal-title":"J.\u00a0Gen. Virol."},{"key":"10.1016\/j.omto.2022.03.007_bib4","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1038\/nm952","article-title":"CD46 is a cellular receptor for group B adenoviruses","volume":"9","author":"Gaggar","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.omto.2022.03.007_bib5","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nm.2270","article-title":"Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11, and 14","volume":"17","author":"Wang","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.omto.2022.03.007_bib6","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/j.meegid.2011.04.031","article-title":"Molecular evolution of human species D adenoviruses","volume":"11","author":"Robinson","year":"2011","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.omto.2022.03.007_bib7","doi-asserted-by":"crossref","first-page":"eaax3567","DOI":"10.1126\/sciadv.aax3567","article-title":"Human adenovirus type 26 uses sialic acid\u2013bearing glycans as a primary cell entry receptor","volume":"5","author":"Baker","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.omto.2022.03.007_bib8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1006\/viro.2002.1503","article-title":"Adenovirus type 37 binds to cell surface sialic acid through a charge-dependent interaction","volume":"302","author":"Arnberg","year":"2002","journal-title":"Virology"},{"key":"10.1016\/j.omto.2022.03.007_bib9","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2020732118","article-title":"Human species D adenovirus hexon capsid protein mediates cell entry through a direct interaction with CD46","volume":"118","author":"Persson","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U\u00a0S\u00a0A"},{"key":"10.1016\/j.omto.2022.03.007_bib10","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2174\/1566523213666131125095046","article-title":"Adenovirus vectors for gene therapy, vaccination and cancer gene therapy","volume":"13","author":"Wold","year":"2013","journal-title":"Curr. Gene Ther."},{"key":"10.1016\/j.omto.2022.03.007_bib11","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.omtm.2020.01.001","article-title":"Oncolytic viruses and the immune system: the dynamic duo","volume":"17","author":"Lemos de Matos","year":"2020","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.omto.2022.03.007_bib12","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0092-8674(93)90231-E","article-title":"Integrins \u03b1v\u03b23 and \u03b1v\u03b25 promote adenovirus internalization but not virus attachment","volume":"73","author":"Wickham","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.omto.2022.03.007_bib13","doi-asserted-by":"crossref","first-page":"15191","DOI":"10.1073\/pnas.261452898","article-title":"The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction","volume":"98","author":"Cohen","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U\u00a0S\u00a0A"},{"key":"10.1016\/j.omto.2022.03.007_bib14","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0090-4295(02)01748-X","article-title":"Integrin alpha(v) and coxsackie adenovirus receptor expression in clinical bladder cancer","volume":"60","author":"Sachs","year":"2002","journal-title":"Urology"},{"key":"10.1016\/j.omto.2022.03.007_bib15","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/sj.cgt.7700947","article-title":"Expression of the coxsackievirus- and adenovirus receptor in gastrointestinal cancer correlates with tumor differentiation","volume":"13","author":"Korn","year":"2006","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.omto.2022.03.007_bib16","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1182\/blood-2006-04-008532","article-title":"Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes","volume":"108","author":"Parker","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.omto.2022.03.007_bib17","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.cell.2008.01.016","article-title":"Adenovirus serotype 5 hexon mediates liver gene transfer","volume":"132","author":"Waddington","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.omto.2022.03.007_bib18","doi-asserted-by":"crossref","first-page":"5483","DOI":"10.1073\/pnas.0711757105","article-title":"Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in\u00a0vivo","volume":"105","author":"Kalyuzhniy","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U\u00a0S\u00a0A"},{"key":"10.1016\/j.omto.2022.03.007_bib19","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1056\/NEJM199509283331302","article-title":"A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis","volume":"333","author":"Knowles","year":"1995","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.omto.2022.03.007_bib20","first-page":"2345","article-title":"Inhibitory effects of human sera on adenovirus-mediated gene transfer into rat liver","volume":"18","author":"Kuriyama","year":"1998","journal-title":"Anticancer Res."},{"key":"10.1016\/j.omto.2022.03.007_bib21","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1089\/hum.1998.9.14-2121","article-title":"Impact of preexisting and induced humoral and cellular immune responses in an adenovirus-based gene therapy phase I clinical trial for localized mesothelioma","volume":"9","author":"Molnar-Kimber","year":"1998","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.omto.2022.03.007_bib22","doi-asserted-by":"crossref","first-page":"8263","DOI":"10.1128\/JVI.77.15.8263-8271.2003","article-title":"Replication-deficient human adenovirus type 35 vectors for gene transfer and vaccination: efficient human cell infection and bypass of preexisting adenovirus immunity","volume":"77","author":"Vogels","year":"2003","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.omto.2022.03.007_bib23","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1128\/JVI.01878-08","article-title":"Effect of neutralizing sera on factor X-mediated adenovirus serotype 5 gene transfer","volume":"83","author":"Parker","year":"2009","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.omto.2022.03.007_bib24","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1038\/sj.gt.3300994","article-title":"Immune responses to adenovirus and adeno-associated virus in humans","volume":"6","author":"Chirmule","year":"1999","journal-title":"Gene Ther."},{"key":"10.1016\/j.omto.2022.03.007_bib25","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1055\/s-0036-1584923","article-title":"Adenovirus: epidemiology, global spread of novel serotypes, and advances in treatment and prevention","volume":"37","author":"Lynch","year":"2016","journal-title":"Semin. Respir. Crit. Care Med."},{"key":"10.1016\/j.omto.2022.03.007_bib26","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1158\/1078-0432.CCR-18-1089","article-title":"Ad5NULL-A20 - a tropism-modified, \u03b1v\u03b26 integrin-selective oncolytic adenovirus for epithelial ovarian cancer therapies","volume":"24","author":"Uusi-Kerttula","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.omto.2022.03.007_bib27","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.1128\/JVI.75.6.2972-2981.2001","article-title":"Adenovirus type 5 viral particles pseudotyped with mutagenized fiber proteins show diminished infectivity of coxsackie B-adenovirus receptor-bearing cells","volume":"75","author":"Jakubczak","year":"2001","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.omto.2022.03.007_bib28","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1128\/JVI.74.6.2804-2813.2000","article-title":"Identification of contact residues and definition of the CAR-binding site of adenovirus type 5 fiber protein","volume":"74","author":"Kirby","year":"2000","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.omto.2022.03.007_bib29","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1006\/mthe.2001.0489","article-title":"Ablating adenovirus type 5 fiber-CAR binding and HI loop insertion of the SIGYPLP peptide generate an endothelial cell-selective adenovirus","volume":"4","author":"Nicklin","year":"2001","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omto.2022.03.007_bib30","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1099\/0022-1317-80-6-1519","article-title":"Molecular determinants of adenovirus serotype 5 fibre binding to its cellular receptor CAR","volume":"80","author":"Santis","year":"1999","journal-title":"J.\u00a0Gen. Virol."},{"key":"10.1016\/j.omto.2022.03.007_bib31","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1128\/JVI.01480-07","article-title":"Foot-and-Mouth disease virus forms a highly stable, EDTA-resistant complex with its principal receptor, integrin \u03b1v\u03b26: implications for infectiousness","volume":"82","author":"DiCara","year":"2008","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.omto.2022.03.007_bib32","doi-asserted-by":"crossref","first-page":"27926","DOI":"10.18632\/oncotarget.8545","article-title":"Pseudotyped \u03b1v\u03b26 integrin-targeted adenovirus vectors for ovarian cancer therapies","volume":"7","author":"Uusi-Kerttula","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.omto.2022.03.007_bib33","doi-asserted-by":"crossref","first-page":"12840","DOI":"10.1038\/s41598-019-49150-9","article-title":"Systemic delivery and SPECT\/CT in\u00a0vivo imaging of 125I-labelled oncolytic adenoviral mutants in models of pancreatic cancer","volume":"9","author":"Stella Man","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omto.2022.03.007_bib34","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1158\/1535-7163.MCT-17-0671","article-title":"The novel oncolytic adenoviral mutant ad5-3\u0394-A20T retargeted to \u03b1v\u03b26 integrins efficiently eliminates pancreatic cancer cells","volume":"17","author":"Man","year":"2018","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.omto.2022.03.007_bib35","doi-asserted-by":"crossref","first-page":"6416","DOI":"10.1128\/JVI.00445-09","article-title":"In\u00a0vivo retargeting of adenovirus type 5 to alphavbeta6 integrin results in reduced hepatotoxicity and improved tumor uptake following systemic delivery","volume":"83","author":"Coughlan","year":"2009","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.omto.2022.03.007_bib36","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.ymthe.2016.10.012","article-title":"Targeting of aberrant \u03b1v\u03b26 integrin expression in solid tumors using chimeric antigen receptor-engineered T\u00a0cells","volume":"25","author":"Whilding","year":"2017","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omto.2022.03.007_bib37","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/carcin\/23.2.237","article-title":"Overexpression of alpha(v)beta6 integrin in serous epithelial ovarian cancer regulates extracellular matrix degradation via the plasminogen activation cascade","volume":"23","author":"Ahmed","year":"2002","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.omto.2022.03.007_bib38","doi-asserted-by":"crossref","first-page":"e65","DOI":"10.1038\/oncsis.2013.27","article-title":"Binding of \u03b1v\u03b21 and \u03b1v\u03b26 integrins to tenascin-C induces epithelial-mesenchymal transition-like change of breast cancer cells","volume":"2","author":"Katoh","year":"2013","journal-title":"Oncogenesis"},{"key":"10.1016\/j.omto.2022.03.007_bib39","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.canlet.2014.08.021","article-title":"Interleukin-8 promotes cell migration through integrin \u03b1v\u03b26 upregulation in colorectal cancer","volume":"354","author":"Sun","year":"2014","journal-title":"Cancer Lett."},{"key":"10.1016\/j.omto.2022.03.007_bib40","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1172\/JCI200523183","article-title":"Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma","volume":"115","author":"Bates","year":"2005","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.omto.2022.03.007_bib41","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/path.4923","article-title":"Pro-migratory and TGF-\u03b2-activating functions of \u03b1v\u03b26 integrin in pancreatic cancer are differentially regulated via an Eps8-dependent GTPase switch","volume":"243","author":"Tod","year":"2017","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.omto.2022.03.007_bib42","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.3390\/cancers11091221","article-title":"Integrin-mediated TGF\u03b2 activation modulates the tumour microenvironment","volume":"11","author":"Brown","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.omto.2022.03.007_bib43","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1136\/bjo.67.2.111","article-title":"Adenovirus serotypes isolated from ocular infections in London","volume":"67","author":"Darougar","year":"1983","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.omto.2022.03.007_bib44","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000308579","article-title":"[Keractoconjunctivitis caused by type 10 adenovirus]","volume":"174","author":"Zografos","year":"1977","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.omto.2022.03.007_bib45","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/0002-9394(57)91470-8","article-title":"Adenoviruses as etiologic agents in conjunctivitis and Keratoconjunctivitis","volume":"43","author":"Huebner","year":"1957","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.omto.2022.03.007_bib46","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/s41467-019-08599-y","article-title":"Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions","volume":"10","author":"Baker","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omto.2022.03.007_bib47","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1099\/jgv.0.000978","article-title":"Generation and characterization of a novel candidate gene therapy and vaccination vector based on human species D adenovirus type 56","volume":"99","author":"Duffy","year":"2018","journal-title":"J.\u00a0Gen. Virol."},{"key":"10.1016\/j.omto.2022.03.007_bib48","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/sj.onc.1202284","article-title":"The adenovirus E4orf6 protein contributes to malignant transformation by antagonizing E1A-induced accumulation of the tumor suppressor protein p53","volume":"18","author":"Nevels","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.omto.2022.03.007_bib49","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1099\/vir.0.81956-0","article-title":"Novel replication-incompetent adenoviral B-group vectors: high vector stability and yield in PER.C6 cells","volume":"87","author":"Havenga","year":"2006","journal-title":"J.\u00a0Gen. Virol."},{"key":"10.1016\/j.omto.2022.03.007_bib56","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1182\/blood-2009-03-208835","article-title":"Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer","volume":"114","author":"Alba","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.omto.2022.03.007_bib50","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0002-9394(14)75015-9","article-title":"Adenovirus type 10 Keratoconjunctivitis with increased intraocular pressure","volume":"90","author":"Hara","year":"1980","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.omto.2022.03.007_bib51","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1182\/blood-2008-09-178459","article-title":"Human erythrocytes bind and inactivate type 5 adenovirus by presenting Coxsackie virus-adenovirus receptor and complement receptor 1","volume":"113","author":"Carlisle","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.omto.2022.03.007_bib52","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jconrel.2012.05.025","article-title":"Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses","volume":"164","author":"Bradshaw","year":"2012","journal-title":"J.\u00a0Control Release"},{"key":"10.1016\/j.omto.2022.03.007_bib53","doi-asserted-by":"crossref","first-page":"659","DOI":"10.2144\/000112993","article-title":"Re-engineering adenovirus vector systems to enable high-throughput analyses of gene function","volume":"45","author":"Stanton","year":"2008","journal-title":"Biotechniques"},{"key":"10.1016\/j.omto.2022.03.007_bib54","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.3390\/v13081483","article-title":"In\u00a0vitro and in\u00a0vivo evaluation of human adenovirus type 49 as a vector for therapeutic applications","volume":"13","author":"Bates","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.omto.2022.03.007_bib55","doi-asserted-by":"crossref","unstructured":"Nesti\u0107, D., Uil, T.G., Ma, J., Roy, S., Vellinga, J., Baker, A.H., Custers, J., and Majhen, D. \u03b1v\u03b23 integrin is required for efficient infection of epithelial cells with human adenovirus type 26. J. Virol. 93, e01474-18.","DOI":"10.1128\/JVI.01474-18"}],"container-title":["Molecular Therapy - Oncolytics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2372770522000493?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2372770522000493?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T06:22:27Z","timestamp":1762496547000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2372770522000493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":55,"alternative-id":["S2372770522000493"],"URL":"https:\/\/doi.org\/10.1016\/j.omto.2022.03.007","relation":{},"ISSN":["2372-7705"],"issn-type":[{"value":"2372-7705","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of a low-seroprevalence, \u03b1v\u03b26 integrin-selective virotherapy based on human adenovirus type 10","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy - Oncolytics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omto.2022.03.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s).","name":"copyright","label":"Copyright"}]}}