{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:14:36Z","timestamp":1793830476802,"version":"4.6.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T00:00:00Z","timestamp":1668124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001878"],"award-info":[{"award-number":["82001878"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171972"],"award-info":[{"award-number":["82171972"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0909000"],"award-info":[{"award-number":["2020YFA0909000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA0910000"],"award-info":[{"award-number":["2021YFA0910000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013105","name":"Shanghai Rising-Star Program","doi-asserted-by":"publisher","award":["20QA1406100"],"award-info":[{"award-number":["20QA1406100"]}],"id":[{"id":"10.13039\/501100013105","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy - Oncolytics"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.omto.2022.11.003","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T09:37:20Z","timestamp":1668418640000},"page":"305-314","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Development and comparison of 68Ga\/18F\/64Cu-labeled nanobody tracers probing Claudin18.2"],"prefix":"10.1016","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3190-2480","authenticated-orcid":false,"given":"Weijun","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianghua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxian","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanshan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omto.2022.11.003_bib1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.gene.2011.04.007","article-title":"Claudin-18 gene structure, regulation, and expression is evolutionary conserved in mammals","volume":"481","author":"T\u00fcreci","year":"2011","journal-title":"Gene"},{"key":"10.1016\/j.omto.2022.11.003_bib2","doi-asserted-by":"crossref","first-page":"e1523096","DOI":"10.1080\/2162402X.2018.1523096","article-title":"Characterization of zolbetuximab in pancreatic cancer models","volume":"8","author":"T\u00fcreci","year":"2019","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.omto.2022.11.003_bib3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ejca.2018.05.007","article-title":"A phase I dose-escalation study of IMAB362 (Zolbetuximab) in patients with advanced gastric and gastro-oesophageal junction cancer","volume":"100","author":"Sahin","year":"2018","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.omto.2022.11.003_bib4","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1093\/annonc\/mdz199","article-title":"A multicentre, phase IIa study of zolbetuximab as a single agent in patients with recurrent or refractory advanced adenocarcinoma of the stomach or lower oesophagus: the MONO study","volume":"30","author":"T\u00fcreci","year":"2019","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.omto.2022.11.003_bib5","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.annonc.2021.02.005","article-title":"FAST: a randomised phase II study of zolbetuximab (IMAB362) plus EOX versus EOX alone for first-line treatment of advanced CLDN18.2-positive gastric and gastro-oesophageal adenocarcinoma","volume":"32","author":"Sahin","year":"2021","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.omto.2022.11.003_bib6","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/s10120-020-01153-6","article-title":"Patient-reported outcomes from the phase II FAST trial of zolbetuximab plus EOX compared to EOX alone as first-line treatment of patients with metastatic CLDN18.2+ gastroesophageal adenocarcinoma","volume":"24","author":"Lordick","year":"2021","journal-title":"Gastric Cancer"},{"key":"10.1016\/j.omto.2022.11.003_bib7","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1021\/acs.chemrev.9b00738","article-title":"ImmunoPET: concept, design, and applications","volume":"120","author":"Wei","year":"2020","journal-title":"Chem. Rev."},{"key":"10.1016\/j.omto.2022.11.003_bib8","doi-asserted-by":"crossref","first-page":"2000018","DOI":"10.1002\/adtp.202000018","article-title":"ImmunoPET imaging of TIM-3 in murine melanoma models","volume":"3","author":"Wei","year":"2020","journal-title":"Adv. Ther."},{"key":"10.1016\/j.omto.2022.11.003_bib9","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1007\/s00259-020-04784-0","article-title":"Development and characterization of CD54-targeted immunoPET imaging in solid tumors","volume":"47","author":"Wei","year":"2020","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.omto.2022.11.003_bib10","doi-asserted-by":"crossref","first-page":"1903595","DOI":"10.1002\/advs.201903595","article-title":"Tissue factor-targeted ImmunoPET imaging and radioimmunotherapy of anaplastic thyroid cancer","volume":"7","author":"Wei","year":"2020","journal-title":"Adv. Sci."},{"key":"10.1016\/j.omto.2022.11.003_bib11","doi-asserted-by":"crossref","first-page":"1801237","DOI":"10.1002\/advs.201801237","article-title":"CD146-Targeted multimodal image-guided photoimmunotherapy of melanoma","volume":"6","author":"Wei","year":"2019","journal-title":"Adv. Sci."},{"key":"10.1016\/j.omto.2022.11.003_bib12","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1007\/s00259-021-05216-3","article-title":"ImmunoPET\/NIRF\/Cerenkov multimodality imaging of ICAM-1 in pancreatic ductal adenocarcinoma","volume":"48","author":"Li","year":"2021","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.omto.2022.11.003_bib13","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1158\/1535-7163.MCT-18-0087","article-title":"PET imaging of receptor tyrosine kinases in cancer","volume":"17","author":"Wei","year":"2018","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.omto.2022.11.003_bib14","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/363446a0","article-title":"Naturally occurring antibodies devoid of light chains","volume":"363","author":"Hamers-Casterman","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.omto.2022.11.003_bib15","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1146\/annurev-immunol-042617-053327","article-title":"Exploiting nanobodies' singular traits","volume":"36","author":"Ingram","year":"2018","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.omto.2022.11.003_bib16","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.2967\/jnumed.118.224170","article-title":"Early phase I study of a (99m)Tc-labeled anti-programmed death ligand-1 (PD-L1) single-domain antibody in SPECT\/CT assessment of PD-L1 expression in non-small cell lung cancer","volume":"60","author":"Xing","year":"2019","journal-title":"J.\u00a0Nucl. Med."},{"key":"10.1016\/j.omto.2022.11.003_bib17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2967\/jnumed.115.162024","article-title":"Phase I study of 68Ga-HER2-Nanobody for PET\/CT assessment of HER2 expression in breast carcinoma","volume":"57","author":"Keyaerts","year":"2016","journal-title":"J.\u00a0Nucl. Med."},{"key":"10.1016\/j.omto.2022.11.003_bib18","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.2967\/jnumed.120.255679","article-title":"Phase I trial of (131)I-GMIB-Anti-HER2-VHH1, a new promising candidate for HER2-targeted radionuclide therapy in breast cancer patients","volume":"62","author":"D'Huyvetter","year":"2021","journal-title":"J.\u00a0Nucl. Med."},{"key":"10.1016\/j.omto.2022.11.003_bib19","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1007\/s00259-021-05218-1","article-title":"ImmunoPET imaging of multiple myeloma with [(68)Ga]Ga-NOTA-Nb1053","volume":"48","author":"Wang","year":"2021","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.omto.2022.11.003_bib20","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.1021\/acs.molpharmaceut.1c00733","article-title":"Annotating CD38 expression in multiple myeloma with [(18)F]F-Nb1053","volume":"19","author":"Wei","year":"2022","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.omto.2022.11.003_bib21","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12951-021-00785-9","article-title":"ImmunoPET imaging of human CD8(+) T\u00a0cells\u00a0with\u00a0novel (68)Ga-labeled nanobody companion diagnostic agents","volume":"19","author":"Zhao","year":"2021","journal-title":"J.\u00a0Nanobiotechnology"},{"key":"10.1016\/j.omto.2022.11.003_bib22","doi-asserted-by":"crossref","first-page":"4322","DOI":"10.3390\/cancers13174322","article-title":"Beyond chemotherapy, PD-1, and HER-2: novel targets for gastric and esophageal cancer","volume":"13","author":"Siddiqui","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.omto.2022.11.003_bib23","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.2967\/jnumed.119.240895","article-title":"Quantification of PD-L1 expression with (18)F-BMS-986192 PET\/CT in patients with advanced-stage non-small cell lung cancer","volume":"61","author":"Huisman","year":"2020","journal-title":"J.\u00a0Nucl. Med."},{"key":"10.1016\/j.omto.2022.11.003_bib24","doi-asserted-by":"crossref","first-page":"8420","DOI":"10.1038\/s41598-019-44874-0","article-title":"Targeting CLDN18.2 by CD3 bispecific and ADC modalities for the treatments of gastric and pancreatic cancer","volume":"9","author":"Zhu","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omto.2022.11.003_bib25","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.2967\/jnumed.122.263907","article-title":"Single-domain antibody theranostics on the horizon","volume":"63","author":"Wei","year":"2022","journal-title":"J.\u00a0Nucl. Med."},{"key":"10.1016\/j.omto.2022.11.003_bib26","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1002\/ijc.28400","article-title":"Claudin 18.2 is a target for IMAB362 antibody in pancreatic neoplasms","volume":"134","author":"W\u00f6ll","year":"2014","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.omto.2022.11.003_bib27","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1002\/ijc.28857","article-title":"Aberrantly activated claudin 6 and 18.2 as potential therapy targets in non-small-cell lung cancer","volume":"135","author":"Micke","year":"2014","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.omto.2022.11.003_bib28","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/his.14358","article-title":"Colitis-associated colorectal adenocarcinomas frequently express claudin 18 isoform 2: implications for claudin 18.2 monoclonal antibody therapy","volume":"79","author":"Iwaya","year":"2021","journal-title":"Histopathology"},{"key":"10.1016\/j.omto.2022.11.003_bib29","doi-asserted-by":"crossref","first-page":"7624","DOI":"10.1158\/1078-0432.CCR-08-1547","article-title":"Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development","volume":"14","author":"Sahin","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.omto.2022.11.003_bib30","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2101918118","article-title":"Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice","volume":"118","author":"Pymm","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omto.2022.11.003_bib31","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1126\/science.aaq0620","article-title":"Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin","volume":"362","author":"Laursen","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.omto.2022.11.003_bib32","doi-asserted-by":"crossref","first-page":"529","DOI":"10.2967\/jnumed.117.199596","article-title":"Synthesis and biologic evaluation of a novel (18)F-labeled adnectin as a PET radioligand for imaging PD-L1 expression","volume":"59","author":"Donnelly","year":"2018","journal-title":"J.\u00a0Nucl. Med."}],"container-title":["Molecular Therapy - Oncolytics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2372770522001383?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2372770522001383?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T06:23:51Z","timestamp":1762496631000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2372770522001383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":32,"alternative-id":["S2372770522001383"],"URL":"https:\/\/doi.org\/10.1016\/j.omto.2022.11.003","relation":{},"ISSN":["2372-7705"],"issn-type":[{"value":"2372-7705","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and comparison of 68Ga\/18F\/64Cu-labeled nanobody tracers probing Claudin18.2","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy - Oncolytics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omto.2022.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022","name":"copyright","label":"Copyright"}]}}