{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T07:04:53Z","timestamp":1793084693723,"version":"4.5.0"},"reference-count":67,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy: Oncology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.omton.2024.200858","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T17:46:57Z","timestamp":1723139217000},"page":"200858","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Galunisertib promotes bevacizumab-induced vascular normalization in nasopharyngeal carcinoma: Multi-parameter MRI evaluation"],"prefix":"10.1016","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7183-0835","authenticated-orcid":false,"given":"Jing","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhua","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongxue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3599-5055","authenticated-orcid":false,"given":"Bo","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omton.2024.200858_bib1","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1056\/NEJMoa1701717","article-title":"Analysis of Plasma Epstein-Barr Virus DNA to Screen for Nasopharyngeal Cancer","volume":"377","author":"Chan","year":"2017","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.omton.2024.200858_bib2","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1038\/s41591-021-01444-0","article-title":"Toripalimab or placebo plus chemotherapy as first-line treatment in advanced nasopharyngeal carcinoma: a multicenter randomized phase 3 trial","volume":"27","author":"Mai","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.omton.2024.200858_bib3","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1002\/ijc.32869","article-title":"Immune checkpoint inhibitors in advanced nasopharyngeal carcinoma: Beyond an era of chemoradiation?","volume":"146","author":"Masterson","year":"2020","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.omton.2024.200858_bib4","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/1787854","article-title":"The Treatment Combining Antiangiogenesis with Chemoradiotherapy Impinges on the Peripheral Circulation Vascular Endothelial Cells and Therapeutic Effect in the Patients with Locally Advanced Nasopharyngeal Carcinoma","volume":"2022","author":"Gong","year":"2022","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.omton.2024.200858_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.esmoop.2021.100313","article-title":"Bevacizumab versus placebo in combination with paclitaxel and carboplatin as first-line treatment for recurrent or metastatic nasopharyngeal carcinoma: a multicentre, randomised, open-label, phase II trial","volume":"6","author":"Zhou","year":"2021","journal-title":"ESMO Open"},{"key":"10.1016\/j.omton.2024.200858_bib6","doi-asserted-by":"crossref","DOI":"10.1177\/1073274820922553","article-title":"Apatinib Combined With Radiotherapy Enhances Antitumor Effects in\u00a0an In\u00a0Vivo Nasopharyngeal Carcinoma Model","volume":"27","author":"Liu","year":"2020","journal-title":"Cancer Control"},{"key":"10.1016\/j.omton.2024.200858_bib7","article-title":"STING agonist-based treatment promotes vascular normalization and tertiary lymphoid structure formation in the therapeutic melanoma microenvironment","volume":"9","author":"Chelvanambi","year":"2021","journal-title":"J.\u00a0Immunother. Cancer"},{"key":"10.1016\/j.omton.2024.200858_bib8","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1002\/hep.30889","article-title":"Dual Programmed Death Receptor-1 and Vascular Endothelial Growth Factor Receptor-2 Blockade Promotes Vascular Normalization and Enhances Antitumor Immune Responses in Hepatocellular Carcinoma","volume":"71","author":"Shigeta","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.omton.2024.200858_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109167","article-title":"Inducing vascular normalization: A promising strategy for immunotherapy","volume":"112","author":"Luo","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.omton.2024.200858_bib10","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1038\/13524","article-title":"Tumor-host interactions in the gallbladder suppress distal angiogenesis and tumor growth: involvement of transforming growth factor beta1","volume":"5","author":"Gohongi","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.omton.2024.200858_bib11","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s13045-022-01349-6","article-title":"TGFB signaling in the tumor metabolic microenvironment and targeted therapies","volume":"15","author":"Shi","year":"2022","journal-title":"J.\u00a0Hematol. Oncol."},{"key":"10.1016\/j.omton.2024.200858_bib12","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.3390\/biom11111643","article-title":"The Role of TGFB in Bone Metastases","volume":"11","author":"Trivedi","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.omton.2024.200858_bib13","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s12943-022-01569-x","article-title":"Targeting TGFB signal transduction for fibrosis and cancer therapy","volume":"21","author":"Peng","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.omton.2024.200858_bib14","doi-asserted-by":"crossref","first-page":"455","DOI":"10.4155\/fmc-2021-0344","article-title":"Targeting TGFB: triumphs and challenges","volume":"14","author":"Acharya","year":"2022","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.omton.2024.200858_bib15","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.ccell.2021.08.008","article-title":"Simultaneous targeting of TGFB\/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion","volume":"39","author":"Lan","year":"2021","journal-title":"Cancer Cell"},{"key":"10.1016\/j.omton.2024.200858_bib16","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/s41419-021-03882-7","article-title":"Prrx1 promotes stemness and angiogenesis via activating TGFB\/smad pathway and upregulating proangiogenic factors in glioma","volume":"12","author":"Chen","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.omton.2024.200858_bib17","doi-asserted-by":"crossref","first-page":"4512","DOI":"10.1158\/1078-0432.CCR-04-2571","article-title":"Blockade of transforming growth factor-beta signaling suppresses progression of androgen-independent human prostate cancer in nude mice","volume":"11","author":"Zhang","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.omton.2024.200858_bib18","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1093\/jnci\/djp058","article-title":"Diffuse-type gastric carcinoma: progression, angiogenesis, and transforming growth factor beta signaling","volume":"101","author":"Komuro","year":"2009","journal-title":"J.\u00a0Natl. Cancer Inst."},{"key":"10.1016\/j.omton.2024.200858_bib19","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1111\/j.1349-7006.2009.01248.x","article-title":"c-Ski overexpression promotes tumor growth and angiogenesis through inhibition of transforming growth factor-beta signaling in diffuse-type gastric carcinoma","volume":"100","author":"Kiyono","year":"2009","journal-title":"Cancer Sci."},{"key":"10.1016\/j.omton.2024.200858_bib20","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/s11671-020-03416-8","article-title":"microRNA-18a from M2 Macrophages Inhibits TGFBR3 to Promote Nasopharyngeal Carcinoma Progression and Tumor Growth via TGFB Signaling Pathway","volume":"15","author":"Peng","year":"2020","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.omton.2024.200858_bib21","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.omto.2021.01.006","article-title":"Inhibition of tumor invasion and metastasis by targeting TGFB-Smad-MMP2 pathway with Asiatic acid and Naringenin","volume":"20","author":"Lian","year":"2021","journal-title":"Mol. Ther. Oncolytics"},{"key":"10.1016\/j.omton.2024.200858_bib22","doi-asserted-by":"crossref","first-page":"12559","DOI":"10.1074\/jbc.RA120.012492","article-title":"Targeting all transforming growth factor-\u03b2 isoforms with an Fc chimeric receptor impairs tumor growth and angiogenesis of oral squamous cell cancer","volume":"295","author":"Takahashi","year":"2020","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.omton.2024.200858_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellimm.2020.104041","article-title":"Oncolytic adenovirus targeting TGFB enhances anti-tumor responses of mesothelin-targeted chimeric antigen receptor T\u00a0cell therapy against breast cancer","volume":"348","author":"Li","year":"2020","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.omton.2024.200858_bib24","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1093\/carcin\/bgab122","article-title":"GDF10 inhibits cell proliferation and epithelial-mesenchymal transition in nasopharyngeal carcinoma by the transforming growth factor-\u03b2\/Smad and NF-\u03baB pathways","volume":"43","author":"He","year":"2022","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.omton.2024.200858_bib25","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1007\/s00432-021-03701-8","article-title":"Targeting tumor vascularization: promising strategies for vascular normalization","volume":"147","author":"Zheng","year":"2021","journal-title":"J.\u00a0Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.omton.2024.200858_bib26","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-3-031-03873-0_3","article-title":"Magnetic Resonance Imaging Basics","volume":"1380","author":"Minhas","year":"2022","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.omton.2024.200858_bib27","doi-asserted-by":"crossref","first-page":"106934","DOI":"10.1016\/j.ejso.2023.05.009","article-title":"Association of dynamic contrast-enhanced MRI and 18F-Fluorodeoxyglucose PET\/CT parameters with neoadjuvant therapy response and survival in esophagogastric cancer","volume":"10","author":"Withey","year":"2023","journal-title":"Eur. J. Surg. Oncol."},{"key":"10.1016\/j.omton.2024.200858_bib28","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.tranon.2018.01.002","article-title":"Endostar Combined with Gemcitabine and Cisplatin Chemotherapy for Patients with Metastatic Nasopharyngeal Carcinoma: an Update","volume":"11","author":"Jin","year":"2018","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.omton.2024.200858_bib29","doi-asserted-by":"crossref","first-page":"7909","DOI":"10.2147\/OTT.S181842","article-title":"Clinical evaluation of vascular normalization induced by recombinant human endostatin in nasopharyngeal carcinoma via dynamic contrast-enhanced ultrasonography","volume":"11","author":"Yang","year":"2018","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.omton.2024.200858_bib30","doi-asserted-by":"crossref","first-page":"7245","DOI":"10.7150\/thno.44427","article-title":"Dual inhibition of PFKFB3 and VEGF normalizes tumor vasculature, reduces lactate production, and improves chemotherapy in glioblastoma: insights from protein expression profiling and MRI","volume":"10","author":"Zhang","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.omton.2024.200858_bib31","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1097\/HEP.0000000000000362","article-title":"Hepatocellular carcinomas, exhibiting intratumor fibrosis, express cancer-specific extracellular matrix remodeling and WNT\/TGFB signatures, associated with poor outcome","volume":"78","author":"Desert","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.omton.2024.200858_bib32","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1042\/bj3470407","article-title":"Involvement of activator protein 1 complexes in the epithelium-specific activation of the laminin gamma2-chain gene promoter by hepatocyte growth factor (scatter factor)","volume":"347","author":"Olsen","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.omton.2024.200858_bib33","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1002\/cam4.3880","article-title":"Phase 1b study of galunisertib and ramucirumab in patients with advanced hepatocellular carcinoma","volume":"10","author":"Harding","year":"2021","journal-title":"Cancer Med."},{"key":"10.1016\/j.omton.2024.200858_bib34","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.85974","article-title":"TGFB and VEGF cooperatively control the immunotolerant tumor environment and the efficacy of cancer immunotherapies","volume":"1","author":"Courau","year":"2016","journal-title":"JCI Insight"},{"key":"10.1016\/j.omton.2024.200858_bib35","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.trecan.2021.10.004","article-title":"Revisiting the HIF switch in the tumor and its immune microenvironment","volume":"8","author":"Cowman","year":"2022","journal-title":"Trends Cancer"},{"key":"10.1016\/j.omton.2024.200858_bib36","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1158\/0008-5472.CAN-20-3558","article-title":"Tumor-Derived Pericytes Driven by EGFR Mutations Govern the Vascular and Immune Microenvironment of Gliomas","volume":"81","author":"Segura-Collar","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.omton.2024.200858_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2020.100715","article-title":"Tumor microenvironment and epithelial mesenchymal transition as targets to overcome tumor multidrug resistance","volume":"53","author":"Erin","year":"2020","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.omton.2024.200858_bib38","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41580-018-0080-4","article-title":"New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer","volume":"20","author":"Dongre","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.omton.2024.200858_bib39","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nature16064","article-title":"Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer","volume":"527","author":"Zheng","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.omton.2024.200858_bib40","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1093\/carcin\/bgab011","article-title":"LAMC2 promotes cancer progression and gemcitabine resistance through modulation of EMT and ATP-binding cassette transporters in pancreatic ductal adenocarcinoma","volume":"42","author":"Okada","year":"2021","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.omton.2024.200858_bib41","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/cdd.2014.228","article-title":"LAMC2 enhances the metastatic potential of lung adenocarcinoma","volume":"22","author":"Moon","year":"2015","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.omton.2024.200858_bib42","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1186\/s13046-022-02516-w","article-title":"LAMC2 marks a tumor-initiating cell population with an aggressive signature in pancreatic cancer","volume":"41","author":"Cave","year":"2022","journal-title":"J.\u00a0Exp. Clin. Cancer Res."},{"key":"10.1016\/j.omton.2024.200858_bib43","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/j.ajpath.2019.03.012","article-title":"Silencing of LAMC2 Reverses Epithelial-Mesenchymal Transition and Inhibits Angiogenesis in Cholangiocarcinoma via Inactivation of the Epidermal Growth Factor Receptor Signaling Pathway","volume":"189","author":"Pei","year":"2019","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.omton.2024.200858_bib44","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13244-019-0703-0","article-title":"How clinical imaging can assess cancer biology","volume":"10","author":"Garc\u00eda-Figueiras","year":"2019","journal-title":"Insights Imaging"},{"key":"10.1016\/j.omton.2024.200858_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejrad.2021.109900","article-title":"Advanced MRI assessment of non-enhancing peritumoral signal abnormality in brain lesions","volume":"143","author":"Mart\u00edn-Noguerol","year":"2021","journal-title":"Eur. J. Radiol."},{"key":"10.1016\/j.omton.2024.200858_bib46","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.3390\/cancers12071979","article-title":"DCE-MRI of Tumor Hypoxia and Hypoxia-Associated Aggressiveness","volume":"12","author":"Gaustad","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.omton.2024.200858_bib47","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-14341-9","article-title":"Aberrant glioblastoma neovascularization patterns and their correlation with DCE-MRI-derived parameters following temozolomide and bevacizumab treatment","volume":"7","author":"Xue","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omton.2024.200858_bib48","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1177\/02841851211032450","article-title":"The diagnostic efficiency of the perfusion-related parameters in assessing the vascular disrupting agent (CA4P) response in a rabbit VX2 liver tumor model","volume":"63","author":"Meng","year":"2022","journal-title":"Acta Radiol."},{"key":"10.1016\/j.omton.2024.200858_bib49","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00330-019-06370-x","article-title":"Gastric cancer and image-derived quantitative parameters: Part 2-a critical review of DCE-MRI and 18F-FDG PET\/CT findings","volume":"30","author":"Tang","year":"2020","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.omton.2024.200858_bib50","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.amjmed.2015.02.018","article-title":"Intravenous Imaging Contrast Media Complications: The Basics That Every Clinician Needs to Know","volume":"128","author":"Rose","year":"2015","journal-title":"Am. J. Med."},{"key":"10.1016\/j.omton.2024.200858_bib51","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.neo.2018.05.006","article-title":"DCE-MRI of Sunitinib-Induced Changes in Tumor Microvasculature and Hypoxia: A Study of Pancreatic Ductal Adenocarcinoma Xenografts","volume":"20","author":"Wegner","year":"2018","journal-title":"Neoplasia"},{"key":"10.1016\/j.omton.2024.200858_bib52","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/jmri.28012","article-title":"Monitoring Bevacizumab-Induced Tumor Vascular Normalization by Intravoxel Incoherent Motion Diffusion-Weighted MRI","volume":"56","author":"Li","year":"2022","journal-title":"J.\u00a0Magn. Reson. Imaging."},{"key":"10.1016\/j.omton.2024.200858_bib53","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/mrm.1910270116","article-title":"The capillary network: a link between IVIM and classical perfusion","volume":"27","author":"Le Bihan","year":"1992","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.omton.2024.200858_bib54","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/jgh.14315","article-title":"Amide proton transfer imaging to predict tumor response to neoadjuvant chemotherapy in locally advanced rectal cancer","volume":"34","author":"Nishie","year":"2019","journal-title":"J.\u00a0Gastroenterol. Hepatol."},{"key":"10.1016\/j.omton.2024.200858_bib55","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1148\/radiol.2020191376","article-title":"Identification of Early Response to Anti-Angiogenic Therapy in Recurrent Glioblastoma: Amide Proton Transfer-weighted and Perfusion-weighted MRI compared with Diffusion-weighted MRI","volume":"295","author":"Park","year":"2020","journal-title":"Radiology"},{"key":"10.1016\/j.omton.2024.200858_bib56","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13058-018-0982-2","article-title":"Amide chemical exchange saturation transfer at 7 T: a possible biomarker for detecting early response to neoadjuvant chemotherapy in breast cancer patients","volume":"20","author":"Krikken","year":"2018","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.omton.2024.200858_bib57","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1002\/jmri.24067","article-title":"Three-dimensional amide proton transfer MR imaging of gliomas: Initial experience and comparison with gadolinium enhancement","volume":"38","author":"Zhou","year":"2013","journal-title":"J.\u00a0Magn. Reson. Imaging."},{"key":"10.1016\/j.omton.2024.200858_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejrad.2020.109068","article-title":"Relaxation-compensated CEST (chemical exchange saturation transfer) imaging in breast cancer diagnostics at 7T","volume":"129","author":"Loi","year":"2020","journal-title":"Eur. J. Radiol."},{"key":"10.1016\/j.omton.2024.200858_bib59","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1002\/jmri.27212","article-title":"Comparative Analysis of Amide Proton Transfer MRI and Diffusion-Weighted Imaging in Assessing p53 and Ki-67 Expression of Rectal Adenocarcinoma","volume":"52","author":"Li","year":"2020","journal-title":"J.\u00a0Magn. Reson. Imaging."},{"key":"10.1016\/j.omton.2024.200858_bib60","article-title":"Laminin \u03b32-mediating T\u00a0cell exclusion attenuates response to anti-PD-1 therapy","volume":"7","author":"Li","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.omton.2024.200858_bib61","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1172\/JCI131507","article-title":"Inactivation of endothelial ZEB1 impedes tumor progression and sensitizes tumors to conventional therapies","volume":"130","author":"Fu","year":"2020","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.omton.2024.200858_bib62","doi-asserted-by":"crossref","first-page":"512","DOI":"10.3390\/jcm10030512","article-title":"Endoglin Expression and Microvessel Density as Prognostic Factors in Pediatric Rhabdomyosarcoma","volume":"10","author":"Radzikowska","year":"2021","journal-title":"J.\u00a0Clin. Med."},{"key":"10.1016\/j.omton.2024.200858_bib63","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0168632","article-title":"Dynamic Contrast-Enhanced MRI Perfusion Parameters as Imaging Biomarkers of Angiogenesis","volume":"11","author":"Kim","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.omton.2024.200858_bib64","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/s41419-020-2680-0","article-title":"Stabilization of HIF-1\u03b1 alleviates osteoarthritis via enhancing mitophagy","volume":"11","author":"Hu","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.omton.2024.200858_bib65","doi-asserted-by":"crossref","first-page":"e4989","DOI":"10.1097\/MD.0000000000004989","article-title":"Overexpression of CD39 in hepatocellular carcinoma is an independent indicator of poor outcome after radical resection","volume":"95","author":"Cai","year":"2016","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.omton.2024.200858_bib66","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1158\/0008-5472.CAN-18-2168","article-title":"Tumor pH and Protein Concentration Contribute to the Signal of Amide Proton Transfer Magnetic Resonance Imaging","volume":"79","author":"Ray","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.omton.2024.200858_bib67","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3389\/fonc.2018.00524","article-title":"Monitoring the Process of Endostar-Induced Tumor Vascular Normalization by Non-contrast Intravoxel Incoherent Motion Diffusion-Weighted MRI","volume":"8","author":"Pan","year":"2018","journal-title":"Front. Oncol."}],"container-title":["Molecular Therapy: Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950329924001000?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950329924001000?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,3]],"date-time":"2024-11-03T06:35:12Z","timestamp":1730615712000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2950329924001000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":67,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S2950329924001000"],"URL":"https:\/\/doi.org\/10.1016\/j.omton.2024.200858","relation":{},"ISSN":["2950-3299"],"issn-type":[{"value":"2950-3299","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Galunisertib promotes bevacizumab-induced vascular normalization in nasopharyngeal carcinoma: Multi-parameter MRI evaluation","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy: Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omton.2024.200858","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc. on behalf of The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}],"article-number":"200858"}}