{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:22:34Z","timestamp":1789428154417,"version":"build-2803163510"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003030","name":"Government of Catalonia Agency for Administration of University and Research Grants","doi-asserted-by":"publisher","award":["SGR21\/01169"],"award-info":[{"award-number":["SGR21\/01169"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2020-119692RB-C22"],"award-info":[{"award-number":["PID2020-119692RB-C22"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2020-119692RB-C21"],"award-info":[{"award-number":["PID2020-119692RB-C21"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2023-146637OB-C22"],"award-info":[{"award-number":["PID2023-146637OB-C22"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2023-146637OB-C21"],"award-info":[{"award-number":["PID2023-146637OB-C21"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy Oncology"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.omton.2024.200928","type":"journal-article","created":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T11:44:55Z","timestamp":1734781495000},"page":"200928","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["KPC pancreatic cancer cells are a novel immunocompetent murine model supporting human adenovirus replication and tumor oncolysis"],"prefix":"10.1016","volume":"33","author":[{"given":"Marc","family":"Otero-Mateo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Estrany Jr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Arcas-M\u00e1rquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Moya-Borrego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Castellano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miquel","family":"Castany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon","family":"Alemany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0801-3338","authenticated-orcid":false,"given":"Cristina","family":"Fillat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omton.2024.200928_bib1","article-title":"Oncolytic Adenovirus: Prospects for Cancer Immunotherapy","volume":"12","author":"Zhao","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.omton.2024.200928_bib2","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.omtm.2020.01.001","article-title":"Oncolytic Viruses and the Immune System: The Dynamic Duo","volume":"17","author":"Lemos de Matos","year":"2020","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.omton.2024.200928_bib3","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00284-17","article-title":"Pathology in Permissive Syrian Hamsters after Infection with Species C Human Adenovirus (HAdV-C) Is the Result of Virus Replication: HAdV-C6 Replicates More and Causes More Pathology than HAdV-C5","volume":"91","author":"Tollefson","year":"2017","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.omton.2024.200928_bib4","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0168-1702(89)90026-9","article-title":"Restricted replication of human adenovirus type 5 in mouse cell lines","volume":"14","author":"Blair","year":"1989","journal-title":"Virus. Res."},{"key":"10.1016\/j.omton.2024.200928_bib5","doi-asserted-by":"crossref","first-page":"45415","DOI":"10.18632\/oncotarget.17557","article-title":"Mesenchymal stem cell carriers enhance antitumor efficacy of oncolytic adenoviruses in an immunocompetent mouse model","volume":"8","author":"Rinc\u00f3n","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.omton.2024.200928_bib6","first-page":"1","article-title":"Defining a murine ovarian cancer model for the evaluation of conditionally-replicative adenovirus (CRAd) virotherapy agents","volume":"12","author":"Gonz\u00e1lez-Pastor","year":"2019","journal-title":"J.\u00a0Ovarian Res."},{"key":"10.1016\/j.omton.2024.200928_bib7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/cgt.2014.64","article-title":"A novel immunocompetent murine model for replicating oncolytic adenoviral therapy","volume":"22","author":"Zhang","year":"2015","journal-title":"Cancer. Gene. Ther."},{"key":"10.1016\/j.omton.2024.200928_bib8","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/S1525-0016(03)00199-0","article-title":"Novel immunocompetent murine tumor models for the assessment of replication-competent oncolytic adenovirus efficacy","volume":"8","author":"Halld\u00e9n","year":"2003","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omton.2024.200928_bib9","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1038\/mt.2012.116","article-title":"Failure of translation of human adenovirus mRNA in murine cancer cells can be partially overcome by L4-100K expression in\u00a0vitro and in\u00a0vivo","volume":"20","author":"Young","year":"2012","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omton.2024.200928_bib10","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1158\/0008-5472.CAN-17-1882","article-title":"Zeb1 in Stromal Myofibroblasts Promotes Kras-Driven Development of Pancreatic Cancer","volume":"78","author":"Sangrador","year":"2018","journal-title":"Cancer. Res."},{"key":"10.1016\/j.omton.2024.200928_bib11","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jconrel.2014.07.008","article-title":"A genetic fiber modification to achieve matrix-metalloprotease-activated infectivity of oncolytic adenovirus","volume":"192","author":"Jos\u00e9","year":"2014","journal-title":"J.\u00a0Control. Release."},{"key":"10.1016\/j.omton.2024.200928_bib12","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/onc.2013.66","article-title":"Coxsackie and adenovirus receptor is a critical regulator for the survival and growth of oral squamous carcinoma cells","volume":"33","author":"Saito","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.omton.2024.200928_bib13","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nm.2270","article-title":"Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14","volume":"17","author":"Wang","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.omton.2024.200928_bib14","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.omto.2021.03.002","article-title":"Cancer imaging and therapy utilizing a novel NIS-expressing adenovirus: The role of adenovirus death protein deletion","volume":"20","author":"Robertson","year":"2021","journal-title":"Mol. Ther. Oncolytics"},{"key":"10.1016\/j.omton.2024.200928_bib15","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.7150\/thno.40902","article-title":"Oligopeptide-modified poly(beta-amino ester)s-coated AdNuPARmE1A: Boosting the efficacy of intravenously administered therapeutic adenoviruses","volume":"10","author":"Brugada-Vil\u00e0","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.omton.2024.200928_bib16","doi-asserted-by":"crossref","first-page":"4720","DOI":"10.1128\/JVI.02032-10","article-title":"Human adenovirus type 5 induces cell lysis through autophagy and autophagy-triggered caspase activity","volume":"85","author":"Jiang","year":"2011","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.omton.2024.200928_bib17","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1593\/neo.81674","article-title":"Urokinase-type plasminogen activator receptor transcriptionally controlled adenoviruses eradicate pancreatic tumors and liver metastasis in mouse models","volume":"11","author":"Huch","year":"2009","journal-title":"Neoplasia"},{"key":"10.1016\/j.omton.2024.200928_bib18","doi-asserted-by":"crossref","first-page":"22700","DOI":"10.18632\/oncotarget.15169","article-title":"A NOTCH-sensitive uPAR-regulated oncolytic adenovirus effectively suppresses pancreatic tumor growth and triggers synergistic anticancer effects with gemcitabine and nab-paclitaxel","volume":"8","author":"Mato-Berciano","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.omton.2024.200928_bib19","article-title":"VCN-01 disrupts pancreatic cancer stroma and exerts antitumor effects","volume":"9","author":"Bazan-Peregrino","year":"2021","journal-title":"J.\u00a0Immunother. Cancer"},{"key":"10.1016\/j.omton.2024.200928_bib20","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.4708","article-title":"Estimated Projection of US Cancer Incidence and Death to 2040","volume":"4","author":"Rahib","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.omton.2024.200928_bib21","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ymthe.2018.09.016","article-title":"Bioselection Reveals miR-99b and miR-485 as Enhancers of Adenoviral Oncolysis in Pancreatic Cancer","volume":"27","author":"Rovira-Rigau","year":"2019","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omton.2024.200928_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.875188","article-title":"An Extensive Review on Preclinical and Clinical Trials of Oncolytic Viruses Therapy for Pancreatic Cancer","volume":"12","author":"Nisar","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.omton.2024.200928_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102786","article-title":"Patient-derived pancreatic tumour organoids identify therapeutic responses to oncolytic adenoviruses","volume":"56","author":"Raimondi","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.omton.2024.200928_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-01799-x","article-title":"TGF-\u03b2-mediated epithelial-mesenchymal transition and tumor-promoting effects in CMT64 cells are reflected in the transcriptomic signature of human lung adenocarcinoma","volume":"11","author":"Miyashita","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omton.2024.200928_bib25","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.ccell.2024.04.009","article-title":"Understanding the complexity of p53 in a new era of tumor suppression","volume":"42","author":"Liu","year":"2024","journal-title":"Cancer. Cell."},{"key":"10.1016\/j.omton.2024.200928_bib26","article-title":"Host Calcium Channels and Pumps in Viral Infections","volume":"9","author":"Chen","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.omton.2024.200928_bib27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/15548627.2017.1384887","article-title":"Ion channels in the regulation of autophagy","volume":"14","author":"Kondratskyi","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.omton.2024.200928_bib28","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ceca.2017.08.005","article-title":"The regulation of autophagy by calcium signals: Do we have a consensus?","volume":"70","author":"Bootman","year":"2018","journal-title":"Cell. Calcium."},{"key":"10.1016\/j.omton.2024.200928_bib29","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/mt.2010.22","article-title":"Verapamil enhances the antitumoral efficacy of oncolytic adenoviruses","volume":"18","author":"Gros","year":"2010","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omton.2024.200928_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2018.00089","article-title":"Ryanodine receptors in autophagy: Implications for neurodegenerative diseases?","volume":"12","author":"Vervliet","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.omton.2024.200928_bib31","doi-asserted-by":"crossref","first-page":"18975","DOI":"10.1074\/jbc.M112.427062","article-title":"Cardiomyocyte ATP production, metabolic flexibility, and survival require calcium flux through cardiac ryanodine receptors in\u00a0vivo","volume":"288","author":"Bround","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.omton.2024.200928_bib32","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1523\/JNEUROSCI.1820-22.2022","article-title":"A Gating Mutation in Ryanodine Receptor Type 2 Rescues Phenotypes of Alzheimer\u2019s Disease Mouse Models by Upregulating Neuronal Autophagy","volume":"43","author":"Zhang","year":"2023","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.omton.2024.200928_bib33","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.4161\/auto.25239","article-title":"PRKCB\/protein kinase C, beta and the mitochondrial axis as key regulators of autophagy","volume":"9","author":"Patergnani","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.omton.2024.200928_bib34","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20160445","article-title":"Protein kinase C \u03b2 inhibits autophagy and sensitizes cervical cancer Hela cells to cisplatin","volume":"37","author":"Li","year":"2017","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.omton.2024.200928_bib35","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.ymthe.2020.01.003","article-title":"Immune Modulation by Telomerase-Specific Oncolytic Adenovirus Synergistically Enhances Antitumor Efficacy with Anti-PD1 Antibody","volume":"28","author":"Kanaya","year":"2020","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omton.2024.200928_bib36","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2023.2241710","article-title":"Effective intravenous delivery of adenovirus armed with TNF\u03b1 and IL-2 improves anti-PD-1 checkpoint blockade in non-small cell lung cancer","volume":"12","author":"Kudling","year":"2023","journal-title":"OncoImmunology"},{"key":"10.1016\/j.omton.2024.200928_bib37","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/gt.2011.106","article-title":"Improved systemic antitumor therapy with oncolytic adenoviruses by replacing the fiber shaft HSG-binding domain with RGD","volume":"19","author":"Rojas","year":"2012","journal-title":"Gene. Ther."},{"key":"10.1016\/j.omton.2024.200928_bib38","doi-asserted-by":"crossref","DOI":"10.1038\/srep27546","article-title":"Codon optimization of the adenoviral fiber negatively impacts structural protein expression and viral fitness","volume":"6","author":"Villanueva","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omton.2024.200928_bib39","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nmeth.4197","article-title":"Salmon provides fast and bias-aware quantification of transcript expression","volume":"14","author":"Patro","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.omton.2024.200928_bib40","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome. Biol."},{"key":"10.1016\/j.omton.2024.200928_bib41","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovations"}],"container-title":["Molecular Therapy Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S295032992400170X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S295032992400170X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T02:59:36Z","timestamp":1762657176000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S295032992400170X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S295032992400170X"],"URL":"https:\/\/doi.org\/10.1016\/j.omton.2024.200928","relation":{},"ISSN":["2950-3299"],"issn-type":[{"value":"2950-3299","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"KPC pancreatic cancer cells are a novel immunocompetent murine model supporting human adenovirus replication and tumor oncolysis","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omton.2024.200928","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc. on behalf of The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}],"article-number":"200928"}}