{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:27:58Z","timestamp":1793914078511,"version":"4.8.0"},"reference-count":110,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004097","name":"Fondation ARC pour la Recherche sur Le Cancer","doi-asserted-by":"publisher","award":["2024050008233"],"award-info":[{"award-number":["2024050008233"]}],"id":[{"id":"10.13039\/501100004097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","award":["085-2024-136"],"award-info":[{"award-number":["085-2024-136"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","award":["N\\u00B0 085-2024-136"],"award-info":[{"award-number":["N\\u00B0 085-2024-136"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006251","name":"Universit\u00e9 de Bordeaux","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006251","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"EU Framework Programme for Research and Innovation Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"FRM","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"HORIZON EUROPE Framework Programme","doi-asserted-by":"publisher","award":["101119880"],"award-info":[{"award-number":["101119880"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy Oncology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.omton.2026.201197","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T02:16:54Z","timestamp":1775182614000},"page":"201197","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Engineering precision oncology: Targeting tumors and immune cells with lentiviral vectors"],"prefix":"10.1016","volume":"34","author":[{"given":"Julia","family":"Rossi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Martinello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Sorrentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Guyonnet-Duperat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Amintas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jimena","family":"Abrey Recalde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9224-5491","authenticated-orcid":false,"given":"Els","family":"Verhoeyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8372-9945","authenticated-orcid":false,"given":"Sandrine","family":"Dabernat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omton.2026.201197_bib1","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaz3223","article-title":"Chimeric antigen receptor signaling: Functional consequences and design implications","volume":"6","author":"Lindner","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.omton.2026.201197_bib2","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1016\/j.drudis.2021.03.021","article-title":"The era of gene therapy: From preclinical development to clinical application","volume":"26","author":"Alhakamy","year":"2021","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.omton.2026.201197_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2025.105834","article-title":"Viral and non-viral vectors in gene therapy: current state and clinical perspectives","volume":"118","author":"Geng","year":"2025","journal-title":"EBioMedicine"},{"key":"10.1016\/j.omton.2026.201197_bib4","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.3390\/v13081526","article-title":"Designing Lentiviral Vectors for Gene Therapy of Genetic Diseases","volume":"13","author":"Poletti","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.omton.2026.201197_bib5","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1016\/j.gendis.2022.03.007","article-title":"Pseudotyped lentiviral vectors: Ready for translation into targeted cancer gene therapy?","volume":"10","author":"Deng","year":"2023","journal-title":"Genes Dis."},{"key":"10.1016\/j.omton.2026.201197_bib6","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1089\/hum.2021.173","article-title":"Choosing the Right Tool for Genetic Engineering: Clinical Lessons from Chimeric Antigen Receptor-T Cells","volume":"32","author":"Irving","year":"2021","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.omton.2026.201197_bib7","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1182\/blood-2009-05-220798","article-title":"Efficient and stable transduction of resting B lymphocytes and primary chronic lymphocyte leukemia cells using measles virus gp displaying lentiviral vectors","volume":"114","author":"Frecha","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.omton.2026.201197_bib8","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1182\/blood.V99.7.2342","article-title":"Efficient gene transfer into human primary blood lymphocytes by surface-engineered lentiviral vectors that display a T cell-activating polypeptide","volume":"99","author":"Maurice","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.omton.2026.201197_bib9","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1038\/s41591-018-0201-9","article-title":"Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell","volume":"24","author":"Ruella","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.omton.2026.201197_bib10","doi-asserted-by":"crossref","first-page":"7306","DOI":"10.1073\/pnas.1214441110","article-title":"LDL receptor and its family members serve as the cellular receptors for vesicular stomatitis virus","volume":"110","author":"Finkelshtein","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omton.2026.201197_bib11","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrg2141","article-title":"Engineering targeted viral vectors for gene therapy","volume":"8","author":"Waehler","year":"2007","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.omton.2026.201197_bib12","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1006\/mthe.2000.0116","article-title":"VSV-G pseudotyped lentiviral vector particles produced in human cells are inactivated by human serum","volume":"2","author":"DePolo","year":"2000","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omton.2026.201197_bib13","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1099\/vir.0.82221-0","article-title":"Measles virus: cellular receptors, tropism and pathogenesis","volume":"87","author":"Yanagi","year":"2006","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.omton.2026.201197_bib14","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/35022579","article-title":"SLAM (CDw150) is a cellular receptor for measles virus","volume":"406","author":"Tatsuo","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.omton.2026.201197_bib15","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nature10639","article-title":"Adherens junction protein nectin-4 is the epithelial receptor for measles virus","volume":"480","author":"M\u00fchlebach","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.omton.2026.201197_bib16","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0092-8674(93)80071-L","article-title":"The human CD46 molecule is a receptor for measles virus (Edmonston strain)","volume":"75","author":"D\u00f6rig","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.omton.2026.201197_bib17","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.tibtech.2009.02.002","article-title":"Lentiviral vectors with measles virus glycoproteins \u2013 dream team for gene transfer?","volume":"27","author":"Buchholz","year":"2009","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.omton.2026.201197_bib18","doi-asserted-by":"crossref","first-page":"4843","DOI":"10.1182\/blood-2008-05-155945","article-title":"Stable transduction of quiescent T cells without induction of cycle progression by a novel lentiviral vector pseudotyped with measles virus glycoproteins","volume":"112","author":"Frecha","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.omton.2026.201197_bib19","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1038\/mt.2010.178","article-title":"Advances in the Field of Lentivector-based Transduction of T and B Lymphocytes for Gene Therapy","volume":"18","author":"Frecha","year":"2010","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omton.2026.201197_bib20","doi-asserted-by":"crossref","first-page":"5975","DOI":"10.1128\/JVI.00324-11","article-title":"Measles Virus Glycoprotein-Pseudotyped Lentiviral Vector-Mediated Gene Transfer into Quiescent Lymphocytes Requires Binding to both SLAM and CD46 Entry Receptors","volume":"85","author":"Frecha","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.omton.2026.201197_bib21","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1182\/bloodadvances.2017007773","article-title":"Measles virus envelope pseudotyped lentiviral vectors transduce quiescent human HSCs at an efficiency without precedent","volume":"1","author":"L\u00e9vy","year":"2017","journal-title":"Blood Adv."},{"key":"10.1016\/j.omton.2026.201197_bib22","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1182\/blood-2014-02-558163","article-title":"Baboon envelope pseudotyped LVs outperform VSV-G-LVs for gene transfer into early-cytokine-stimulated and resting HSCs","volume":"124","author":"Girard-Gagnepain","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.omton.2026.201197_bib23","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1111\/jth.13520","article-title":"Baboon envelope pseudotyped lentiviral vectors efficiently transduce human B cells and allow active factor IX B cell secretion in vivo in NOD\/SCID\u03b3c-\/- mice","volume":"14","author":"Levy","year":"2016","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.omton.2026.201197_bib24","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/leu.2016.372","article-title":"Baboon envelope pseudotyped lentiviral vectors: a highly efficient new tool to genetically manipulate T-cell acute lymphoblastic leukaemia-initiating cells","volume":"31","author":"Costa","year":"2017","journal-title":"Leukemia"},{"key":"10.1016\/j.omton.2026.201197_bib25","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1182\/bloodadvances.2018027508","article-title":"Baboon envelope LVs efficiently transduced human adult, fetal, and progenitor T cells and corrected SCID-X1 T-cell deficiency","volume":"3","author":"Bernadin","year":"2019","journal-title":"Blood Adv."},{"key":"10.1016\/j.omton.2026.201197_bib26","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.3389\/fimmu.2019.02873","article-title":"Efficient and Robust NK-Cell Transduction With Baboon Envelope Pseudotyped Lentivector","volume":"10","author":"Colamartino","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.omton.2026.201197_bib27","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.3389\/fimmu.2019.02001","article-title":"A Distinct Subset of Highly Proliferative and Lentiviral Vector (LV)-Transducible NK Cells Define a Readily Engineered Subset for Adoptive Cellular Therapy","volume":"10","author":"Bari","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.omton.2026.201197_bib28","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1111\/cas.70090","article-title":"In Vitro Expansion and Transduction of Primary NK Cells Using Feeder Cells Expressing Costimulatory Molecules and IL-21","volume":"116","author":"Tran","year":"2025","journal-title":"Cancer Sci."},{"key":"10.1016\/j.omton.2026.201197_bib29","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1182\/blood-2001-11-0042","article-title":"Lentiviral vectors pseudotyped with a modified RD114 envelope glycoprotein show increased stability in sera and augmented transduction of primary lymphocytes and CD34+ cells derived from human and nonhuman primates","volume":"100","author":"Sandrin","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.omton.2026.201197_bib30","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1006\/mthe.2002.0603","article-title":"Preferential Transduction of Human Hepatocytes with Lentiviral Vectors Pseudotyped by Sendai Virus F Protein","volume":"5","author":"Kowolik","year":"2002","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omton.2026.201197_bib31","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1084\/jem.20021756","article-title":"Infectious Hepatitis C Virus Pseudo-particles Containing Functional E1\u2013E2 Envelope Protein Complexes","volume":"197","author":"Bartosch","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.omton.2026.201197_bib32","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1089\/hum.2004.15.1091","article-title":"Selective Transduction of Malignant Glioma by Lentiviral Vectors Pseudotyped with Lymphocytic Choriomeningitis Virus Glycoproteins","volume":"15","author":"Miletic","year":"2004","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.omton.2026.201197_bib33","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1128\/JVI.73.5.3649-3660.1999","article-title":"Transduction of human progenitor hematopoietic stem cells by human immunodeficiency virus type 1-based vectors is cell cycle dependent","volume":"73","author":"Sutton","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/j.omton.2026.201197_bib34","doi-asserted-by":"crossref","first-page":"512","DOI":"10.4049\/jimmunol.158.1.512","article-title":"Nuclear import of HIV-1 DNA in resting CD4+ T cells requires a cyclosporin A-sensitive pathway","volume":"158","author":"Sun","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.omton.2026.201197_bib35","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1182\/blood-2013-11-540641","article-title":"Mystery solved: VSV-G-LVs do not allow efficient gene transfer into unstimulated T cells, B cells, and HSCs because they lack the LDL receptor","volume":"123","author":"Amirache","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.omton.2026.201197_bib36","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1002\/j.1460-2075.1992.tb05376.x","article-title":"Human immunodeficiency virus infection of cells arrested in the cell cycle","volume":"11","author":"Lewis","year":"1992","journal-title":"EMBO J."},{"key":"10.1016\/j.omton.2026.201197_bib37","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1084\/jem.174.6.1477","article-title":"Productive human immunodeficiency virus type 1 (HIV-1) infection of nonproliferating human monocytes","volume":"174","author":"Weinberg","year":"1991","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.omton.2026.201197_bib38","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1128\/JVI.72.4.3161-3168.1998","article-title":"Progression to the G1b phase of the cell cycle is required for completion of human immunodeficiency virus type 1 reverse transcription in T cells","volume":"72","author":"Korin","year":"1998","journal-title":"J. Virol."},{"key":"10.1016\/j.omton.2026.201197_bib39","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1182\/blood-2002-07-2224","article-title":"IL-7 surface-engineered lentiviral vectors promote survival and efficient gene transfer in resting primary T lymphocytes","volume":"101","author":"Verhoeyen","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.omton.2026.201197_bib40","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1084\/jem.189.11.1735","article-title":"Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes","volume":"189","author":"Unutmaz","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.omton.2026.201197_bib41","doi-asserted-by":"crossref","first-page":"9103","DOI":"10.1128\/JVI.76.18.9103-9111.2002","article-title":"Modalities of interleukin-7-induced human immunodeficiency virus permissiveness in quiescent T lymphocytes","volume":"76","author":"Ducrey-Rundquist","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.omton.2026.201197_bib42","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/S1471-4906(01)02028-2","article-title":"Interleukin-7: master regulator of peripheral T-cell homeostasis?","volume":"22","author":"Fry","year":"2001","journal-title":"Trends Immunol."},{"key":"10.1016\/j.omton.2026.201197_bib43","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.4049\/jimmunol.166.5.3019","article-title":"IL-7 administration alters the CD4:CD8 ratio, increases T cell numbers, and increases T cell function in the absence of activation","volume":"166","author":"Geiselhart","year":"1950","journal-title":"J. Immunol."},{"key":"10.1016\/j.omton.2026.201197_bib44","doi-asserted-by":"crossref","first-page":"6869","DOI":"10.4049\/jimmunol.167.12.6869","article-title":"IL-7 enhances the survival and maintains the size of naive T cells","volume":"167","author":"Rathmell","year":"1950","journal-title":"J. Immunol."},{"key":"10.1016\/j.omton.2026.201197_bib45","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1182\/blood-2003-01-0297","article-title":"Human T lymphocytes transduced by lentiviral vectors in the absence of TCR activation maintain an intact immune competence","volume":"102","author":"Cavalieri","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.omton.2026.201197_bib46","first-page":"401","article-title":"Efficient gene delivery to quiescent interleukin-2 (IL-2)-dependent cells by murine leukemia virus-derived vectors harboring IL-2 chimeric envelope glycoproteins","volume":"94","author":"Maurice","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.omton.2026.201197_bib47","doi-asserted-by":"crossref","first-page":"5909","DOI":"10.4049\/jimmunol.161.11.5909","article-title":"IL-7-dependent extrathymic expansion of CD45RA+ T cells enables preservation of a naive repertoire","volume":"161","author":"Soares","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.omton.2026.201197_bib48","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1182\/blood-2003-06-1770","article-title":"Impaired bone marrow homing of cytokine-activated CD34+ cells in the NOD\/SCID model","volume":"103","author":"Ahmed","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.omton.2026.201197_bib49","doi-asserted-by":"crossref","first-page":"11939","DOI":"10.1073\/pnas.95.20.11939","article-title":"HIV, but not murine leukemia virus, vectors mediate high efficiency gene transfer into freshly isolated G0\/G1 human hematopoietic stem cells","volume":"95","author":"Uchida","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omton.2026.201197_bib50","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1182\/blood.V90.2.865","article-title":"Cytokine-facilitated transduction leads to low-level engraftment in nonablated hosts","volume":"90","author":"Kittler","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.omton.2026.201197_bib51","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1073\/pnas.95.3.1195","article-title":"Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin","volume":"95","author":"Kimura","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omton.2026.201197_bib52","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S1525-0016(03)00005-4","article-title":"Cytokines, including stem cell factor alone, enhance lentiviral transduction in nondividing human LTCIC and NOD\/SCID repopulating cells","volume":"7","author":"Zielske","year":"2003","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omton.2026.201197_bib53","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1182\/blood-2003-03-0944","article-title":"Thrombopoietin stimulates Hoxb4 expression: an explanation for the favorable effects of TPO on hematopoietic stem cells","volume":"102","author":"Kirito","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.omton.2026.201197_bib54","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.1182\/blood-2004-12-4736","article-title":"Novel lentiviral vectors displaying \u201cearly-acting cytokines\u201d selectively promote survival and transduction of NOD\/SCID repopulating human hematopoietic stem cells","volume":"106","author":"Verhoeyen","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.omton.2026.201197_bib55","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1182\/blood-2011-04-346619","article-title":"A novel lentiviral vector targets gene transfer into human hematopoietic stem cells in marrow from patients with bone marrow failure syndrome and in vivo in humanized mice","volume":"119","author":"Frecha","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.omton.2026.201197_bib56","doi-asserted-by":"crossref","first-page":"8033","DOI":"10.1073\/pnas.90.17.8033","article-title":"Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells","volume":"90","author":"Burns","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omton.2026.201197_bib57","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/s41467-018-03432-4","article-title":"Structural basis for the recognition of LDL-receptor family members by VSV glycoprotein","volume":"9","author":"Nikolic","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omton.2026.201197_bib58","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/s41592-022-01436-z","article-title":"Antigen identification and high-throughput interaction mapping by reprogramming viral entry","volume":"19","author":"Dobson","year":"2022","journal-title":"Nat. Methods"},{"key":"10.1016\/j.omton.2026.201197_bib59","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1038\/s41587-023-02085-z","article-title":"In vivo human T cell engineering with enveloped delivery vehicles","volume":"42","author":"Hamilton","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.omton.2026.201197_bib60","doi-asserted-by":"crossref","first-page":"4904","DOI":"10.1016\/j.cell.2022.11.016","article-title":"Engineered cell entry links receptor biology with single-cell genomics","volume":"185","author":"Yu","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.omton.2026.201197_bib61","doi-asserted-by":"crossref","first-page":"13543","DOI":"10.1128\/JVI.02240-13","article-title":"Characteristics of Oncolytic Vesicular Stomatitis Virus Displaying Tumor-Targeting Ligands","volume":"87","author":"Ammayappan","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.omton.2026.201197_bib62","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S0140-6736(25)01030-X","article-title":"In-vivo B-cell maturation antigen CAR T-cell therapy for relapsed or refractory multiple myeloma","volume":"406","author":"Xu","year":"2025","journal-title":"Lancet"},{"key":"10.1016\/j.omton.2026.201197_bib63","doi-asserted-by":"crossref","first-page":"4937","DOI":"10.1016\/j.ymthe.2025.06.036","article-title":"Targeted in vivo delivery of genetic medicines utilizing an engineered lentiviral vector platform results in CAR T and NK cell generation","volume":"33","author":"Andorko","year":"2025","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omton.2026.201197_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.omtn.2024.102115","article-title":"Engineering lentivirus envelope VSV-G for liver targeted delivery of IDOL-shRNA to ameliorate hypercholesterolemia and atherosclerosis","volume":"35","author":"Wang","year":"2024","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.omton.2026.201197_bib65","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.3390\/v16121940","article-title":"PD1-Targeted Transgene Delivery to Treg Cells","volume":"16","author":"Zhuchkov","year":"2024","journal-title":"Viruses"},{"key":"10.1016\/j.omton.2026.201197_bib66","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3390\/v8100294","article-title":"Measles to the Rescue: A Review of Oncolytic Measles Virus","volume":"8","author":"Aref","year":"2016","journal-title":"Viruses"},{"key":"10.1016\/j.omton.2026.201197_bib67","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1128\/JVI.78.1.302-313.2004","article-title":"Selectively Receptor-Blind Measles Viruses: Identification of Residues Necessary for SLAM- or CD46-Induced Fusion and Their Localization on a New Hemagglutinin Structural Model","volume":"78","author":"Vongpunsawad","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.omton.2026.201197_bib68","first-page":"2448","article-title":"Measles virus blind to its epithelial cell receptor remains virulent in rhesus monkeys but cannot cross the airway epithelium and is not shed","volume":"118","author":"Leonard","year":"2008","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.omton.2026.201197_bib69","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nbt1060","article-title":"Rescue and propagation of fully retargeted oncolytic measles viruses","volume":"23","author":"Nakamura","year":"2005","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.omton.2026.201197_bib70","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-43076-7","article-title":"Carcinoembryonic antigen-expressing oncolytic measles virus derivative in recurrent glioblastoma: a phase 1 trial","volume":"15","author":"Galanis","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omton.2026.201197_bib71","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1089\/hgtb.2012.054","article-title":"Specific Targeting of Human Interleukin (IL)-13 Receptor \u03b12-Positive Cells with Lentiviral Vectors Displaying IL-13","volume":"23","author":"Ou","year":"2012","journal-title":"Hum. Gene Ther. Methods"},{"key":"10.1016\/j.omton.2026.201197_bib72","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1038\/mt.2008.128","article-title":"Targeted Cell Entry of Lentiviral Vectors","volume":"16","author":"Funke","year":"2008","journal-title":"Mol Ther J Am Soc Gene Ther"},{"key":"10.1016\/j.omton.2026.201197_bib73","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0079047","article-title":"CD19 and CD20 Targeted Vectors Induce Minimal Activation of Resting B Lymphocytes. Alici E","volume":"8","author":"Kneissl","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.omton.2026.201197_bib74","doi-asserted-by":"crossref","first-page":"4334","DOI":"10.1182\/blood-2012-02-412973","article-title":"T-cell receptor gene transfer exclusively to human CD8+ cells enhances tumor cell killing","volume":"120","author":"Zhou","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.omton.2026.201197_bib75","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.4049\/jimmunol.1500956","article-title":"Exclusive Transduction of Human CD4+ T Cells upon Systemic Delivery of CD4-Targeted Lentiviral Vectors","volume":"195","author":"Zhou","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.omton.2026.201197_bib76","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.ymthe.2019.03.012","article-title":"The Future: In Vivo CAR T Cell Gene Therapy","volume":"27","author":"Mhaidly","year":"2019","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omton.2026.201197_bib77","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.ymthe.2022.05.018","article-title":"Precision medicine: In vivo CAR therapy as a showcase for receptor-targeted vector platforms","volume":"30","author":"Michels","year":"2022","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omton.2026.201197_bib78","doi-asserted-by":"crossref","first-page":"3210","DOI":"10.1038\/s41596-021-00510-8","article-title":"Genetic in vivo engineering of human T lymphocytes in mouse models","volume":"16","author":"Weidner","year":"2021","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.omton.2026.201197_bib79","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201809158","article-title":"In vivo generation of human CD 19- CAR T cells results in B-cell depletion and signs of cytokine release syndrome","volume":"10","author":"Pfeiffer","year":"2018","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.omton.2026.201197_bib80","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2019.1671761","article-title":"In vivo generated human CAR T cells eradicate tumor cells","volume":"8","author":"Agarwal","year":"2019","journal-title":"OncoImmunology"},{"key":"10.1016\/j.omton.2026.201197_bib81","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1016\/j.ymthe.2020.05.005","article-title":"In Vivo Generation of CAR T Cells Selectively in Human CD4+ Lymphocytes","volume":"28","author":"Agarwal","year":"2020","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omton.2026.201197_bib82","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.omtm.2022.06.004","article-title":"In vivo generation of CAR T cells in the presence of human myeloid cells","volume":"26","author":"Ho","year":"2022","journal-title":"Mol. Ther., Methods Clin. Dev."},{"key":"10.1016\/j.omton.2026.201197_bib83","doi-asserted-by":"crossref","DOI":"10.1186\/s13046-024-03179-5","article-title":"In vivo CAR T cell therapy against angioimmunoblastic T cell lymphoma","volume":"43","author":"Krug","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.omton.2026.201197_bib84","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1038\/mt.2012.96","article-title":"Lentiviral Vectors Displaying Modified Measles Virus gp Overcome Pre-existing Immunity in In Vivo-like Transduction of Human T and B Cells","volume":"20","author":"L\u00e9vy","year":"2012","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omton.2026.201197_bib85","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005641","article-title":"Receptor-Targeted Nipah Virus Glycoproteins Improve Cell-Type Selective Gene Delivery and Reveal a Preference for Membrane-Proximal Cell Attachment","volume":"12","author":"Bender","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.omton.2026.201197_bib86","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nature03838","article-title":"EphrinB2 is the entry receptor for Nipah virus, an emergent deadly paramyxovirus","volume":"436","author":"Negrete","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.omton.2026.201197_bib87","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.0020007","article-title":"Two Key Residues in EphrinB3 Are Critical for Its Use as an Alternative Receptor for Nipah Virus","volume":"2","author":"Negrete","year":"2006","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.omton.2026.201197_bib88","doi-asserted-by":"crossref","first-page":"10804","DOI":"10.1128\/JVI.00999-07","article-title":"Single Amino Acid Changes in the Nipah and Hendra Virus Attachment Glycoproteins Distinguish EphrinB2 from EphrinB3 Usage","volume":"81","author":"Negrete","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.omton.2026.201197_bib89","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/gt.2011.209","article-title":"Targeted lentiviral vectors pseudotyped with the Tupaia paramyxovirus glycoproteins","volume":"20","author":"Enkirch","year":"2013","journal-title":"Gene Ther."},{"key":"10.1016\/j.omton.2026.201197_bib90","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002281","article-title":"Rapid and Efficient Clearance of Blood-borne Virus by Liver Sinusoidal Endothelium","volume":"7","author":"Ganesan","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.omton.2026.201197_bib91","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1128\/JVI.02032-12","article-title":"Nipah Virus Envelope-Pseudotyped Lentiviruses Efficiently Target ephrinB2-Positive Stem Cell Populations In Vitro and Bypass the Liver Sink When Administered In Vivo","volume":"87","author":"Palomares","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.omton.2026.201197_bib92","first-page":"5702","article-title":"Combining T-cell-specific activation and in vivo gene delivery through CD3-targeted lentiviral vectors","volume":"4","author":"Frank","year":"2020","journal-title":"Blood Adv."},{"key":"10.1016\/j.omton.2026.201197_bib93","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1754-1611-5-1","article-title":"Production of lentiviral vectors with enhanced efficiency to target dendritic cells by attenuating mannosidase activity of mammalian cells","volume":"5","author":"Tai","year":"2011","journal-title":"J. Biol. Eng."},{"key":"10.1016\/j.omton.2026.201197_bib94","doi-asserted-by":"crossref","first-page":"8016","DOI":"10.1128\/JVI.75.17.8016-8020.2001","article-title":"Antibody-Directed Targeting of Retroviral Vectors via Cell Surface Antigens","volume":"75","author":"Morizono","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.omton.2026.201197_bib95","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nm1192","article-title":"Lentiviral vector retargeting to P-glycoprotein on metastatic melanoma through intravenous injection","volume":"11","author":"Morizono","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.omton.2026.201197_bib96","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1038\/sj.mt.6300271","article-title":"A Novel Dual-targeted Lentiviral Vector Leads to Specific Transduction of Prostate Cancer Bone Metastases In Vivo After Systemic Administration","volume":"15","author":"Pariente","year":"2007","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omton.2026.201197_bib97","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/cgt.2009.28","article-title":"Lentiviruses with trastuzumab bound to their envelopes can target and kill prostate cancer cells","volume":"16","author":"Zhang","year":"2009","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.omton.2026.201197_bib98","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.virol.2018.09.017","article-title":"Versatile targeting system for lentiviral vectors involving biotinylated targeting molecules","volume":"525","author":"Situ","year":"2018","journal-title":"Virology"},{"key":"10.1016\/j.omton.2026.201197_bib99","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02990-19","article-title":"Efficient and Highly Specific Gene Transfer Using Mutated Lentiviral Vectors Redirected with Bispecific Antibodies","volume":"11","author":"Parker","year":"2020","journal-title":"mBio"},{"key":"10.1016\/j.omton.2026.201197_bib100","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1089\/hum.2005.16.223","article-title":"Cell type-specific targeting with sindbis pseudotyped lentiviral vectors displaying anti-CCR5 single-chain antibodies","volume":"16","author":"Aires da Silva","year":"2005","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.omton.2026.201197_bib101","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1007\/s12033-016-9973-7","article-title":"Sindbis Virus-Pseudotyped Lentiviral Vectors Carrying VEGFR2-Specific Nanobody for Potential Transductional Targeting of Tumor Vasculature","volume":"58","author":"Ahani","year":"2016","journal-title":"Mol. Biotechnol."},{"key":"10.1016\/j.omton.2026.201197_bib102","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/jgm.1339","article-title":"Redirecting lentiviral vectors by insertion of integrin-tageting peptides into envelope proteins","volume":"11","author":"Morizono","year":"2009","journal-title":"J. Gene Med."},{"key":"10.1016\/j.omton.2026.201197_bib103","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-29253-5","article-title":"A simple strategy for retargeting lentiviral vectors to desired cell types via a disulfide-bond-forming protein-peptide pair","volume":"8","author":"Kasaraneni","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omton.2026.201197_bib104","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01860-17","article-title":"Retargeting Lentiviruses via SpyCatcher-SpyTag Chemistry for Gene Delivery into Specific Cell Types","volume":"8","author":"Kasaraneni","year":"2017","journal-title":"mBio"},{"key":"10.1016\/j.omton.2026.201197_bib105","doi-asserted-by":"crossref","DOI":"10.3389\/fgeed.2021.604371","article-title":"Baboon Envelope Pseudotyped \u2018Nanoblades\u2019 Carrying Cas9\/gRNA Complexes Allow Efficient Genome Editing in Human T, B, and CD34+ Cells and Knock-in of AAV6-Encoded Donor DNA in CD34+ Cells","volume":"3","author":"Gutierrez-Guerrero","year":"2021","journal-title":"Front. Genome Ed."},{"key":"10.1016\/j.omton.2026.201197_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.omtn.2025.102495","article-title":"Ligand-modified rAAV6 vectors with nanoblades allow high-level gene knockin in HSPCs without compromising cell survival","volume":"36","author":"Gutierrez-Guerrero","year":"2025","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.omton.2026.201197_bib107","doi-asserted-by":"crossref","first-page":"10059","DOI":"10.1093\/nar\/gkad676","article-title":"Engineered lentivirus-derived nanoparticles (LVNPs) for delivery of CRISPR\/Cas ribonucleoprotein complexes supporting base editing, prime editing and in vivo gene modification","volume":"51","author":"Haldrup","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.omton.2026.201197_bib108","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.cell.2021.12.021","article-title":"Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins","volume":"185","author":"Banskota","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.omton.2026.201197_bib109","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1038\/s41587-023-02078-y","article-title":"Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo","volume":"42","author":"An","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.omton.2026.201197_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.omtn.2024.102318","article-title":"Cell-targeted gene modification by delivery of CRISPR-Cas9 ribonucleoprotein complexes in pseudotyped lentivirus-derived nanoparticles","volume":"35","author":"Nielsen","year":"2024","journal-title":"Mol. Ther. Nucleic Acids"}],"container-title":["Molecular Therapy Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950329926000731?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950329926000731?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:21:10Z","timestamp":1793913670000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2950329926000731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":110,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S2950329926000731"],"URL":"https:\/\/doi.org\/10.1016\/j.omton.2026.201197","relation":{},"ISSN":["2950-3299"],"issn-type":[{"value":"2950-3299","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Engineering precision oncology: Targeting tumors and immune cells with lentiviral vectors","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omton.2026.201197","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}],"article-number":"201197"}}