{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:06:38Z","timestamp":1790255198979,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013108","name":"Special Foundation for the Development of Strategic Emerging Industries of Shenzhen","doi-asserted-by":"publisher","award":["F-2022-Z99-502266"],"award-info":[{"award-number":["F-2022-Z99-502266"]}],"id":[{"id":"10.13039\/501100013108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2021A1515010004"],"award-info":[{"award-number":["2021A1515010004"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008100","name":"Southern University of Science and Technology","doi-asserted-by":"publisher","award":["Y01416133"],"award-info":[{"award-number":["Y01416133"]}],"id":[{"id":"10.13039\/501100008100","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20210324130601005"],"award-info":[{"award-number":["JCYJ20210324130601005"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["RCBS20221008093104016"],"award-info":[{"award-number":["RCBS20221008093104016"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20190809143601759"],"award-info":[{"award-number":["JCYJ20190809143601759"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2304400"],"award-info":[{"award-number":["2022YFC2304400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2304401"],"award-info":[{"award-number":["2022YFC2304401"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["SZSM202311034"],"award-info":[{"award-number":["SZSM202311034"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy Oncology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.omton.2026.201251","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T15:12:35Z","timestamp":1779981155000},"page":"201251","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["A tri-component organoid model reveals field-cancerized fibroblasts as key drivers of LUAD recurrence and drug resistance"],"prefix":"10.1016","volume":"34","author":[{"given":"Kun","family":"Qiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Chua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qibin","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoze","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguan Soon","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumin","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1001-7837","authenticated-orcid":false,"given":"Liang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangjian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omton.2026.201251_bib1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.omton.2026.201251_bib2","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1002\/cncr.35128","article-title":"Lung cancer statistics","volume":"130","author":"Kratzer","year":"2023","journal-title":"Cancer"},{"key":"10.1016\/j.omton.2026.201251_bib3","first-page":"17","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.omton.2026.201251_bib4","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.492","article-title":"Cancer-associated fibroblasts enact field cancerization by promoting extratumoral oxidative stress","volume":"8","author":"Chan","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.omton.2026.201251_bib5","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/s41586-023-05729-x","article-title":"The evolution of non-small cell lung cancer metastases in TRACERx","volume":"616","author":"Al Bakir","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.omton.2026.201251_bib6","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.cell.2017.01.018","article-title":"Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future","volume":"168","author":"McGranahan","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.omton.2026.201251_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22020746","article-title":"Field Cancerization in NSCLC: A New Perspective on MicroRNAs in Macrophage Polarization","volume":"22","author":"Pirlog","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.omton.2026.201251_bib8","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/dju004","article-title":"Transcriptomic architecture of the adjacent airway field cancerization in non-small cell lung cancer","volume":"106","author":"Kadara","year":"2014","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.omton.2026.201251_bib9","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1513\/pats.201201-004MS","article-title":"Field cancerization in non-small cell lung cancer: implications in disease pathogenesis","volume":"9","author":"Kadara","year":"2012","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.omton.2026.201251_bib10","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12943-019-0961-y","article-title":"Reactive oxygen species: a volatile driver of field cancerization and metastasis","volume":"18","author":"Liao","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.omton.2026.201251_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellimm.2017.12.003","article-title":"Cancer-associated fibroblasts in tumor microenvironment - Accomplices in tumor malignancy","volume":"343","author":"Liao","year":"2019","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.omton.2026.201251_bib12","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.9702","article-title":"Comparison of Survival Rates After a Combination of Local Treatment and Systemic Therapy vs Systemic Therapy Alone for Treatment of Stage IV Non-Small Cell Lung Cancer","volume":"2","author":"Uhlig","year":"2019","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.omton.2026.201251_bib13","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.1200\/JCO.2017.74.6065","article-title":"Systemic Therapy for Stage IV Non-Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update","volume":"35","author":"Hanna","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.omton.2026.201251_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14194562","article-title":"Current Landscape of Therapeutic Resistance in Lung Cancer and Promising Strategies to Overcome Resistance","volume":"14","author":"Ashrafi","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.omton.2026.201251_bib15","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3389\/fonc.2018.00267","article-title":"Drug Resistance in Non-Small Cell Lung Cancer: A Potential for NOTCH Targeting?","volume":"8","author":"Sosa Iglesias","year":"2018","journal-title":"Front. Oncol."},{"key":"10.1016\/j.omton.2026.201251_bib16","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/s41580-020-0259-3","article-title":"Human organoids: model systems for human biology and medicine","volume":"21","author":"Kim","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.omton.2026.201251_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202303481","article-title":"Attenuating Epithelial-to-Mesenchymal Transition in Cancer through Angiopoietin-Like 4 Inhibition in a 3D Tumor Microenvironment Model","volume":"13","author":"Liao","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.omton.2026.201251_bib18","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1186\/s12967-024-05870-9","article-title":"Isolation and identification of patient-derived liver cancer stem cells and development of personalized treatment strategies","volume":"22","author":"Guo","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.omton.2026.201251_bib19","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1158\/0008-5472.CAN-15-0727","article-title":"Maintaining Tumor Heterogeneity in Patient-Derived Tumor Xenografts","volume":"75","author":"Cassidy","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.omton.2026.201251_bib20","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2018100300","article-title":"Long-term expanding human airway organoids for disease modeling","volume":"38","author":"Sachs","year":"2019","journal-title":"EMBO J."},{"key":"10.1016\/j.omton.2026.201251_bib21","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1158\/1078-0432.CCR-19-1376","article-title":"Organoid Cultures as Preclinical Models of Non-Small Cell Lung Cancer","volume":"26","author":"Shi","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.omton.2026.201251_bib22","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/978-1-0716-1811-0_24","article-title":"Pleural Effusion Aspirate for Use in 3D Lung Cancer Modeling and Chemotherapy Screening","volume":"2394","author":"Mazzocchi","year":"2022","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.omton.2026.201251_bib23","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.bbcan.2017.12.005","article-title":"Circulating tumor cell-derived organoids: Current challenges and promises in medical research and precision medicine","volume":"1869","author":"Praharaj","year":"2018","journal-title":"Biochim. Biophys. Acta. Rev. Cancer"},{"key":"10.1016\/j.omton.2026.201251_bib24","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1200\/JCO.2016.70.5053","article-title":"ERCC1 as Predictor of Platinum Benefit in Non-Small-Cell Lung Cancer","volume":"35","author":"Postel-Vinay","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.omton.2026.201251_bib25","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1200\/JCO.22.00727","article-title":"Toripalimab Plus Chemotherapy for Patients With Treatment-Naive Advanced Non-Small-Cell Lung Cancer: A Multicenter Randomized Phase III Trial (CHOICE-01)","volume":"41","author":"Wang","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.omton.2026.201251_bib26","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal and scalable single-cell analysis","volume":"42","author":"Hao","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.omton.2026.201251_bib27","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and analysis of cell-cell communication using CellChat","volume":"12","author":"Jin","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omton.2026.201251_bib28","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."}],"container-title":["Molecular Therapy Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S295032992600127X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S295032992600127X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:34:04Z","timestamp":1790253244000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S295032992600127X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S295032992600127X"],"URL":"https:\/\/doi.org\/10.1016\/j.omton.2026.201251","relation":{},"ISSN":["2950-3299"],"issn-type":[{"value":"2950-3299","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A tri-component organoid model reveals field-cancerized fibroblasts as key drivers of LUAD recurrence and drug resistance","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omton.2026.201251","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}],"article-number":"201251"}}