{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:04:03Z","timestamp":1790255043705,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["1418\/15"],"award-info":[{"award-number":["1418\/15"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy Oncology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.omton.2026.201288","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:43:00Z","timestamp":1782920580000},"page":"201288","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lnk Governs chemokine-directed trafficking of CD8+ T cells in melanoma"],"prefix":"10.1016","volume":"34","author":[{"given":"Yael","family":"Derdikman Ofir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miran","family":"Aswad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Hayun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonina","family":"Pechkovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghazal","family":"Kheshaiboun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narmeen","family":"Ghanayiem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmine","family":"Khier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaniv","family":"Zohar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yishai","family":"Ofran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6189-8609","authenticated-orcid":false,"given":"Igal","family":"Louria-Hayon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omton.2026.201288_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1601773","article-title":"Tumor-infiltrating lymphocytes in cancer immunotherapy: from chemotactic recruitment to translational modeling","volume":"16","author":"Kraja","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.omton.2026.201288_bib2","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1126\/science.1129139","article-title":"Type, density, and location of immune cells within human colorectal tumors predict clinical outcome","volume":"313","author":"Galon","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.omton.2026.201288_bib3","article-title":"CAR-T Cell Therapy in Hematological Malignancies: Current Opportunities and Challenges","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.omton.2026.201288_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.840956","article-title":"A Bibliometric and Knowledge-Map Analysis of CAR-T Cells From 2009 to 2021","volume":"13","author":"Miao","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.omton.2026.201288_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1352805","article-title":"Adoptive T cell therapy for solid tumors: current landscape and future challenges","volume":"15","author":"Albarr\u00e1n","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.omton.2026.201288_bib6","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/s41590-022-01219-w","article-title":"Stem-like precursors are the fount to sustain persistent CD8+ T cell responses","volume":"23","author":"Zehn","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.omton.2026.201288_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.739161","article-title":"Tumor-Associated Extracellular Matrix: How to Be a Potential Aide to Anti-tumor Immunotherapy?","volume":"9","author":"He","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.omton.2026.201288_bib8","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.it.2024.07.009","article-title":"The extracellular matrix in solid tumor immunotherapy","volume":"45","author":"Cho","year":"2024","journal-title":"Trends Immunol."},{"key":"10.1016\/j.omton.2026.201288_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1340702","article-title":"Crosstalk between T lymphocyte and extracellular matrix in tumor microenvironment","volume":"15","author":"Lv","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.omton.2026.201288_bib10","first-page":"eabp8964","article-title":"The extracellular matrix and the immune system: A mutually dependent relationship","volume":"379","author":"Sutherland","year":"2023","journal-title":"Science (1979)"},{"key":"10.1016\/j.omton.2026.201288_bib11","first-page":"5245","article-title":"Infiltration of tumors by systemically transferred tumor-reactive T lymphocytes is required for antitumor efficacy","volume":"59","author":"Mukai","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.omton.2026.201288_bib12","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nri.2015.16","article-title":"T cell migration, search strategies and mechanisms","volume":"16","author":"Krummel","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.omton.2026.201288_bib13","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3389\/fonc.2013.00231","article-title":"Ways to enhance lymphocyte trafficking into tumors and fitness of tumor infiltrating lymphocytes","volume":"3","author":"Bellone","year":"2013","journal-title":"Front. Oncol."},{"key":"10.1016\/j.omton.2026.201288_bib14","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nrc1388","article-title":"Cancer and the chemokine network","volume":"4","author":"Balkwill","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.omton.2026.201288_bib15","doi-asserted-by":"crossref","first-page":"7168","DOI":"10.1158\/0008-5472.CAN-14-2458","article-title":"Trafficking of T Cells into Tumors","volume":"74","author":"Slaney","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.omton.2026.201288_bib16","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1586\/1744666X.2014.894886","article-title":"The CXCL8\/IL-8 chemokine family and its receptors in inflammatory diseases","volume":"10","author":"Russo","year":"2014","journal-title":"Expert Rev. Clin. Immunol."},{"key":"10.1016\/j.omton.2026.201288_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/pr.113.007724","article-title":"International union of pharmacology. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors","volume":"66","author":"Bachelerie","year":"2014","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.omton.2026.201288_bib18","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1007\/s00262-012-1245-1","article-title":"CXCR1 as a novel target for directing reactive T cells toward melanoma: Implications for adoptive cell transfer immunotherapy","volume":"61","author":"Sapoznik","year":"2012","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.omton.2026.201288_bib19","doi-asserted-by":"crossref","first-page":"111","DOI":"10.2217\/fon.09.128","article-title":"CXCL8 and its cognate receptors in melanoma progression and metastasis","volume":"6","author":"Singh","year":"2010","journal-title":"Future Oncol."},{"key":"10.1016\/j.omton.2026.201288_bib20","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1016\/j.ejca.2009.07.007","article-title":"Functional activity of CXCL8 receptors, CXCR1 and CXCR2, on human malignant melanoma progression","volume":"45","author":"Gabellini","year":"2009","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.omton.2026.201288_bib21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1189\/jlb.72.1.9","article-title":"Role of CXCL1 in tumorigenesis of melanoma","volume":"72","author":"Dhawan","year":"2002","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.omton.2026.201288_bib22","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.1182\/blood-2004-03-1067","article-title":"IL-8 responsiveness defines a subset of CD8 T cells poised to kill","volume":"104","author":"Hess","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.omton.2026.201288_bib23","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1089\/10430340260355374","article-title":"Redirecting Migration of T Cells to Chemokine Secreted from Tumors by Genetic Modification with CXCR2","volume":"13","author":"Kershaw","year":"2002","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.omton.2026.201288_bib24","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.4049\/jimmunol.173.4.2231","article-title":"Cutting Edge: Expression of Chemokine Receptor CXCR1 on Human Effector CD8 + T Cells","volume":"173","author":"Takata","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.omton.2026.201288_bib25","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1097\/00008390-199506000-00006","article-title":"Serum interleukin-8 (IL-8) is elevated in patients with metastatic melanoma and correlates with tumour load","volume":"5","author":"Scheibenbogen","year":"1995","journal-title":"Melanoma Res."},{"key":"10.1016\/j.omton.2026.201288_bib26","doi-asserted-by":"crossref","first-page":"20599","DOI":"10.1073\/pnas.1319665110","article-title":"Lnk adaptor suppresses radiation resistance and radiation-induced B-cell malignancies by inhibiting IL-11 signaling","volume":"110","author":"Louria-Hayon","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omton.2026.201288_bib27","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/j.bcp.2011.06.023","article-title":"The adaptor Lnk (SH2B3): An emerging regulator in vascular cells and a link between immune and inflammatory signaling","volume":"82","author":"Devalli\u00e8re","year":"2011","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.omton.2026.201288_bib28","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1096\/fj.11-193383","article-title":"LNK (SH2B3) is a key regulator of integrin signaling in endothelial cells and targets \u03b1-parvin to control cell adhesion and migration","volume":"26","author":"Devalli\u00e8re","year":"2012","journal-title":"FASEB J."},{"key":"10.1016\/j.omton.2026.201288_bib29","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-09711-y","article-title":"LNK suppresses interferon signaling in melanoma","volume":"10","author":"Ding","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omton.2026.201288_bib30","doi-asserted-by":"crossref","first-page":"943","DOI":"10.2337\/db24-0655","article-title":"Reduced Function of the Adaptor SH2B3 Promotes T1D via Altered Cytokine-Regulated, T-Cell\u2013Intrinsic Immune Tolerance","volume":"74","author":"Watson","year":"2025","journal-title":"Diabetes"},{"key":"10.1016\/j.omton.2026.201288_bib31","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1084\/jem.20011883","article-title":"Cytokine Signaling and Hematopoietic Homeostasis Are Disrupted in Lnk-deficient Mice","volume":"195","author":"Velazquez","year":"2002","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.omton.2026.201288_bib32","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1084\/jem.20011170","article-title":"Enhanced Hematopoiesis by Hematopoietic Progenitor Cells Lacking Intracellular Adaptor Protein, Lnk","volume":"195","author":"Takaki","year":"2002","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.omton.2026.201288_bib33","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.devcel.2005.03.019","article-title":"Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice","volume":"8","author":"Ema","year":"2005","journal-title":"Dev. Cell"},{"key":"10.1016\/j.omton.2026.201288_bib34","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1172\/JCI76327","article-title":"Lymphocyte adaptor protein LNK deficiency exacerbates hypertension and end-organ inflammation","volume":"125","author":"Saleh","year":"2015","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.omton.2026.201288_bib35","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1161\/HYPERTENSIONAHA.114.04736","article-title":"Mutation of SH2B3 (LNK), a genome-wide association study candidate for hypertension, attenuates Dahl salt-sensitive hypertension via inflammatory modulation","volume":"65","author":"Rudemiller","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.omton.2026.201288_bib36","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/s41419-025-07948-8","article-title":"Lnk deficiency attenuates the immunosuppressive capacity of MDSCs via ferroptosis to suppress tumor development","volume":"16","author":"Zhou","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.omton.2026.201288_bib37","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1002\/eji.201343883","article-title":"Lnk prevents inflammatory CD8+ T-cell proliferation and contributes to intestinal homeostasis","volume":"44","author":"Katayama","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.omton.2026.201288_bib38","first-page":"S616","article-title":"The emerging role of chemokine receptor CXCR2 in cancer progression. Transl","volume":"5","author":"Jaffer","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.omton.2026.201288_bib39","doi-asserted-by":"crossref","first-page":"5458","DOI":"10.1158\/1078-0432.CCR-10-0712","article-title":"Transduction of tumor-specific T cells with CXCR2 chemokine receptor improves migration to tumor and antitumor immune responses","volume":"16","author":"Peng","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.omton.2026.201288_bib40","first-page":"3525","article-title":"Modeling and Imaging 3-Dimensional Collective Cell Invasion","volume":"58","author":"Scott","year":"2011","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.omton.2026.201288_bib41","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1038\/sj.onc.1208442","article-title":"KSHV-GPCR and CXCR2 transforming capacity and angiogenic responses are mediated through a JAK2-STAT3-dependent pathway","volume":"24","author":"Burger","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.omton.2026.201288_bib42","doi-asserted-by":"crossref","first-page":"4705","DOI":"10.4049\/jimmunol.0901511","article-title":"The role of macrophage-derived IL-1 in induction and maintenance of angiogenesis","volume":"183","author":"Carmi","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.omton.2026.201288_bib43","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1084\/jem.184.3.1101","article-title":"A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)","volume":"184","author":"Bleul","year":"1996","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.omton.2026.201288_bib44","doi-asserted-by":"crossref","first-page":"6735","DOI":"10.1158\/1078-0432.CCR-07-4843","article-title":"The interleukin-8 pathway in cancer","volume":"14","author":"Waugh","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.omton.2026.201288_bib45","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3390\/ijms20010098","article-title":"IL-8 Secreted from M2 Macrophages Promoted Prostate Tumorigenesis via STAT3\/MALAT1 Pathway","volume":"20","author":"Zheng","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.omton.2026.201288_bib46","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.1182\/blood-2004-10-4093","article-title":"Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways","volume":"105","author":"Tong","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.omton.2026.201288_bib47","doi-asserted-by":"crossref","DOI":"10.1186\/s12935-020-01197-9","article-title":"LNK promotes the growth and metastasis of triple negative breast cancer via activating JAK\/STAT3 and ERK1\/2 pathway","volume":"20","author":"Lv","year":"2020","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.omton.2026.201288_bib48","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1038\/onc.2014.34","article-title":"LNK (SH2B3): Paradoxical effects in ovarian cancer","volume":"34","author":"Ding","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.omton.2026.201288_bib49","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.bbrc.2009.12.025","article-title":"Pharmacological targeting reveals distinct roles for CXCR2\/CXCR1 and CCR2 in a mouse model of arthritis","volume":"391","author":"Min","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Molecular Therapy Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950329926001645?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950329926001645?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:33:15Z","timestamp":1790253195000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2950329926001645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S2950329926001645"],"URL":"https:\/\/doi.org\/10.1016\/j.omton.2026.201288","relation":{},"ISSN":["2950-3299"],"issn-type":[{"value":"2950-3299","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lnk Governs chemokine-directed trafficking of CD8+ T cells in melanoma","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omton.2026.201288","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}],"article-number":"201288"}}