{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:06:29Z","timestamp":1790255189001,"version":"4.1.0"},"reference-count":63,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006827","name":"Florida Department of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006827","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008746","name":"National Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008746","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy Oncology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.omton.2026.201331","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T16:14:39Z","timestamp":1787328879000},"page":"201331","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting LKB1-inactivated lung cancers with a stapled peptide inhibitor of the CRTC-CREB pathway"],"prefix":"10.1016","volume":"34","author":[{"given":"Xin","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory H.","family":"Bird","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Liang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xzaviar K.","family":"Solone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3060-3454","authenticated-orcid":false,"given":"Michael C.","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0869-2334","authenticated-orcid":false,"given":"Loren D.","family":"Walensky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0076-2617","authenticated-orcid":false,"given":"Lizi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omton.2026.201331_bib1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.omton.2026.201331_bib2","first-page":"10","article-title":"Cancer statistics, 2025","volume":"75","author":"Siegel","year":"2025","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.omton.2026.201331_bib3","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.jtho.2021.11.003","article-title":"The 2021 WHO Classification of Lung Tumors: Impact of Advances Since 2015","volume":"17","author":"Nicholson","year":"2022","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.omton.2026.201331_bib4","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nature25183","article-title":"The biology and management of non-small cell lung cancer","volume":"553","author":"Herbst","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.omton.2026.201331_bib5","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1056\/NEJMoa050753","article-title":"Erlotinib in previously treated non-small-cell lung cancer","volume":"353","author":"Shepherd","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.omton.2026.201331_bib6","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1056\/NEJMoa1713137","article-title":"Osimertinib in Untreated EGFR-Mutated Advanced Non-Small-Cell Lung Cancer","volume":"378","author":"Soria","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.omton.2026.201331_bib7","doi-asserted-by":"crossref","first-page":"4275","DOI":"10.1158\/1078-0432.CCR-08-0168","article-title":"EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer","volume":"14","author":"Koivunen","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.omton.2026.201331_bib8","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1158\/1078-0432.CCR-14-2791","article-title":"Therapeutic targeting of anaplastic lymphoma kinase in lung cancer: a paradigm for precision cancer medicine","volume":"21","author":"Katayama","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.omton.2026.201331_bib9","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1056\/NEJMoa1917239","article-title":"KRAS(G12C) Inhibition with Sotorasib in Advanced Solid Tumors","volume":"383","author":"Hong","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.omton.2026.201331_bib10","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1056\/NEJMoa1200690","article-title":"Safety, activity, and immune correlates of anti-PD-1 antibody in cancer","volume":"366","author":"Topalian","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.omton.2026.201331_bib11","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1056\/NEJMoa1501824","article-title":"Pembrolizumab for the treatment of non-small-cell lung cancer","volume":"372","author":"Garon","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.omton.2026.201331_bib12","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1056\/NEJMoa1801946","article-title":"Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden","volume":"378","author":"Hellmann","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.omton.2026.201331_bib13","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1056\/NEJMoa1910231","article-title":"Nivolumab plus Ipilimumab in Advanced Non-Small-Cell Lung Cancer","volume":"381","author":"Hellmann","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.omton.2026.201331_bib14","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nrc2676","article-title":"The LKB1-AMPK pathway: metabolism and growth control in tumour suppression","volume":"9","author":"Shackelford","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.omton.2026.201331_bib15","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/34432","article-title":"A serine\/threonine kinase gene defective in Peutz-Jeghers syndrome","volume":"391","author":"Hemminki","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.omton.2026.201331_bib16","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1056\/NEJM198706113162404","article-title":"Increased risk of cancer in the Peutz-Jeghers syndrome","volume":"316","author":"Giardiello","year":"1987","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.omton.2026.201331_bib17","doi-asserted-by":"crossref","first-page":"D941","DOI":"10.1093\/nar\/gky1015","article-title":"COSMIC: the Catalogue Of Somatic Mutations In Cancer","volume":"47","author":"Tate","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.omton.2026.201331_bib18","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nature13385","article-title":"Comprehensive molecular profiling of lung adenocarcinoma","volume":"511","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.omton.2026.201331_bib19","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nature07423","article-title":"Somatic mutations affect key pathways in lung adenocarcinoma","volume":"455","author":"Ding","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.omton.2026.201331_bib20","doi-asserted-by":"crossref","first-page":"5911","DOI":"10.1038\/sj.onc.1210418","article-title":"Prevalence and specificity of LKB1 genetic alterations in lung cancers","volume":"26","author":"Matsumoto","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.omton.2026.201331_bib21","first-page":"3659","article-title":"Inactivation of LKB1\/STK11 is a common event in adenocarcinomas of the lung","volume":"62","author":"Sanchez-Cespedes","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.omton.2026.201331_bib22","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1158\/2159-8290.CD-18-0099","article-title":"STK11\/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS-Mutant Lung Adenocarcinoma","volume":"8","author":"Skoulidis","year":"2018","journal-title":"Cancer Discov."},{"key":"10.1016\/j.omton.2026.201331_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0238358","article-title":"STK11 (LKB1) mutations in metastatic NSCLC: Prognostic value in the real world","volume":"15","author":"Shire","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.omton.2026.201331_bib24","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1200\/JCO.2017.75.3384","article-title":"Molecular Determinants of Response to Anti-Programmed Cell Death (PD)-1 and Anti-Programmed Death-Ligand 1 (PD-L1) Blockade in Patients With Non-Small-Cell Lung Cancer Profiled With Targeted Next-Generation Sequencing","volume":"36","author":"Rizvi","year":"2018","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.omton.2026.201331_bib25","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1158\/2159-8290.CD-20-1543","article-title":"Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional STK11 Mutations in Patients with Non-Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown","volume":"11","author":"Pore","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.omton.2026.201331_bib26","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/nature06030","article-title":"LKB1 modulates lung cancer differentiation and metastasis","volume":"448","author":"Ji","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.omton.2026.201331_bib27","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nature10937","article-title":"A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response","volume":"483","author":"Chen","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.omton.2026.201331_bib28","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1158\/2159-8290.CD-18-1237","article-title":"An LKB1-SIK Axis Suppresses Lung Tumor Growth and Controls Differentiation","volume":"9","author":"Murray","year":"2019","journal-title":"Cancer Discov."},{"key":"10.1016\/j.omton.2026.201331_bib29","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1158\/2159-8290.CD-18-1261","article-title":"The AMPK-Related Kinases SIK1 and SIK3 Mediate Key Tumor-Suppressive Effects of LKB1 in NSCLC","volume":"9","author":"Hollstein","year":"2019","journal-title":"Cancer Discov."},{"key":"10.1016\/j.omton.2026.201331_bib30","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.66095","article-title":"Dependency of human and murine LKB1-inactivated lung cancer on aberrant CRTC-CREB activation","volume":"10","author":"Zhou","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.omton.2026.201331_bib31","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/onc.2011.247","article-title":"Altered LKB1\/CREB-regulated transcription co-activator (CRTC) signaling axis promotes esophageal cancer cell migration and invasion","volume":"31","author":"Gu","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.omton.2026.201331_bib32","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaw6455","article-title":"The CREB coactivator CRTC2 promotes oncogenesis in LKB1-mutant non-small cell lung cancer","volume":"5","author":"Rod\u00f3n","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.omton.2026.201331_bib33","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1038\/onc.2009.453","article-title":"Enhanced activity of the CREB co-activator Crtc1 in LKB1 null lung cancer","volume":"29","author":"Komiya","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.omton.2026.201331_bib34","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.trecan.2018.12.002","article-title":"Adaptive Transcriptional Responses by CRTC Coactivators in Cancer","volume":"5","author":"Tasoulas","year":"2019","journal-title":"Trends Cancer"},{"key":"10.1016\/j.omton.2026.201331_bib35","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nrm3072","article-title":"CREB and the CRTC co-activators: sensors for hormonal and metabolic signals","volume":"12","author":"Altarejos","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.omton.2026.201331_bib36","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1093\/jnci\/dju358","article-title":"Role of LKB1-CRTC1 on glycosylated COX-2 and response to COX-2 inhibition in lung cancer","volume":"107","author":"Cao","year":"2015","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.omton.2026.201331_bib37","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1172\/JCI85250","article-title":"cAMP\/CREB-regulated LINC00473 marks LKB1-inactivated lung cancer and mediates tumor growth","volume":"126","author":"Chen","year":"2016","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.omton.2026.201331_bib38","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nature22359","article-title":"CPS1 maintains pyrimidine pools and DNA synthesis in KRAS\/LKB1-mutant lung cancer cells","volume":"546","author":"Kim","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.omton.2026.201331_bib39","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1093\/jnci\/djy166","article-title":"Role of INSL4 Signaling in Sustaining the Growth and Viability of LKB1-Inactivated Lung Cancer","volume":"111","author":"Yang","year":"2019","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.omton.2026.201331_bib40","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1016\/j.jmb.2018.04.038","article-title":"Structural Insights into the CRTC2-CREB Complex Assembly on CRE","volume":"430","author":"Song","year":"2018","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.omton.2026.201331_bib41","doi-asserted-by":"crossref","first-page":"20865","DOI":"10.1073\/pnas.1219028109","article-title":"Mechanism of CREB recognition and coactivation by the CREB-regulated transcriptional coactivator CRTC2","volume":"109","author":"Luo","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omton.2026.201331_bib42","doi-asserted-by":"crossref","first-page":"6275","DOI":"10.1021\/jm4011675","article-title":"Hydrocarbon-stapled peptides: principles, practice, and progress","volume":"57","author":"Walensky","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.omton.2026.201331_bib43","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1126\/science.1099191","article-title":"Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix","volume":"305","author":"Walensky","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.omton.2026.201331_bib44","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nature08543","article-title":"Direct inhibition of the NOTCH transcription factor complex","volume":"462","author":"Moellering","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.omton.2026.201331_bib45","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2209044119","article-title":"Inhibition of FOXP3 by stapled alpha-helical peptides dampens regulatory T cell function","volume":"119","author":"Hawley","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omton.2026.201331_bib46","doi-asserted-by":"crossref","first-page":"17942","DOI":"10.1073\/pnas.1208396109","article-title":"Inhibition of oncogenic Wnt signaling through direct targeting of \u03b2-catenin","volume":"109","author":"Grossmann","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omton.2026.201331_bib47","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1038\/s41589-020-0625-7","article-title":"Targeting a helix-in-groove interaction between E1 and E2 blocks ubiquitin transfer","volume":"16","author":"Cathcart","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.omton.2026.201331_bib48","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.ccr.2010.10.024","article-title":"A stapled p53 helix overcomes HDMX-mediated suppression of p53","volume":"18","author":"Bernal","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.omton.2026.201331_bib49","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1172\/JCI46231","article-title":"A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers","volume":"122","author":"LaBelle","year":"2012","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.omton.2026.201331_bib50","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1021\/acschembio.5b00214","article-title":"Cellular Uptake and Ultrastructural Localization Underlie the Pro-apoptotic Activity of a Hydrocarbon-stapled BIM BH3 Peptide","volume":"10","author":"Edwards","year":"2015","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.omton.2026.201331_bib51","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nchembio.2153","article-title":"Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices","volume":"12","author":"Bird","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.omton.2026.201331_bib52","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1038\/s41587-019-0222-z","article-title":"Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice","volume":"37","author":"Mourtada","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.omton.2026.201331_bib53","doi-asserted-by":"crossref","first-page":"5236","DOI":"10.1158\/1078-0432.CCR-21-0715","article-title":"Phase 1 Trial of ALRN-6924, a Dual Inhibitor of MDMX and MDM2, in Patients with Solid Tumors and Lymphomas Bearing Wild-type TP53","volume":"27","author":"Saleh","year":"2021","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.omton.2026.201331_bib54","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/s41467-023-44361-1","article-title":"A stapled lipopeptide platform for preventing and treating highly pathogenic viruses of pandemic potential","volume":"15","author":"Bird","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omton.2026.201331_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2022.117021","article-title":"Development of a penetratin-conjugated stapled peptide that inhibits Wnt\/\u03b2-catenin signaling","volume":"73","author":"Tsuchiya","year":"2022","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.omton.2026.201331_bib56","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abm3108","article-title":"A novel \u03b2-catenin\/BCL9 complex inhibitor blocks oncogenic Wnt signaling and disrupts cholesterol homeostasis in colorectal cancer","volume":"8","author":"Tanton","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.omton.2026.201331_bib57","doi-asserted-by":"crossref","first-page":"6184","DOI":"10.1021\/acs.jmedchem.2c02037","article-title":"Stapled Peptides as Direct Inhibitors of Nrf2-sMAF Transcription Factors","volume":"66","author":"Modi","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.omton.2026.201331_bib58","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/35085068","article-title":"Transcriptional regulation by the phosphorylation-dependent factor CREB","volume":"2","author":"Mayr","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.omton.2026.201331_bib59","doi-asserted-by":"crossref","first-page":"9401","DOI":"10.1021\/acs.jmedchem.3c00623","article-title":"Discovery of Sulanemadlin (ALRN-6924), the First Cell-Permeating, Stabilized \u03b1-Helical Peptide in Clinical Development","volume":"66","author":"Guerlavais","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.omton.2026.201331_bib60","doi-asserted-by":"crossref","first-page":"E3445","DOI":"10.1073\/pnas.1303002110","article-title":"Stapled \u03b1-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy","volume":"110","author":"Chang","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omton.2026.201331_bib61","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/d41573-025-00206-8","article-title":"Betting on \u03b2-catenin inhibitors in oncology","volume":"25","author":"Mullard","year":"2026","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.omton.2026.201331_bib62","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/nm1717","article-title":"Dual role of proapoptotic BAD in insulin secretion and beta cell survival","volume":"14","author":"Danial","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.omton.2026.201331_bib63","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.1021\/bi00713a027","article-title":"Determination of the helix and beta form of proteins in aqueous solution by circular dichroism","volume":"13","author":"Chen","year":"1974","journal-title":"Biochemistry"}],"container-title":["Molecular Therapy Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950329926002079?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950329926002079?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:39:55Z","timestamp":1790253595000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2950329926002079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":63,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S2950329926002079"],"URL":"https:\/\/doi.org\/10.1016\/j.omton.2026.201331","relation":{},"ISSN":["2950-3299"],"issn-type":[{"value":"2950-3299","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting LKB1-inactivated lung cancers with a stapled peptide inhibitor of the CRTC-CREB pathway","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omton.2026.201331","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}],"article-number":"201331"}}