{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T14:35:58Z","timestamp":1772721358088,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23593078"],"award-info":[{"award-number":["23593078"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25463278"],"award-info":[{"award-number":["25463278"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25463279"],"award-info":[{"award-number":["25463279"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oooojournal.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.oooo.2013.12.400","type":"journal-article","created":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T10:46:49Z","timestamp":1387536409000},"page":"462-470","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"title":["Lactobacillus salivarius WB21\u2013containing tablets for the treatment of oral malodor: a double-blind, randomized, placebo-controlled crossover trial"],"prefix":"10.1016","volume":"117","author":[{"given":"Nao","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Yoneda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunari","family":"Tanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akie","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosaku","family":"Iha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Seno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Iwamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Masuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Hirofuji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.oooo.2013.12.400_bib1","first-page":"13","article-title":"Production and origin of oral malodor: a review of mechanisms and methods of analysis","volume":"48","author":"Tonzetich","year":"1977","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.oooo.2013.12.400_bib2","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1177\/00220345910700110801","article-title":"Reproducibility and sensitivity of oral malodor measurements with a portable sulfide monitor","volume":"70","author":"Rosenberg","year":"1999","journal-title":"J\u00a0Dent Res"},{"key":"10.1016\/j.oooo.2013.12.400_bib3","first-page":"89","article-title":"Oral malodor associated with internal resorption","volume":"48","author":"Yoneda","year":"2006","journal-title":"J\u00a0Oral Sci"},{"key":"10.1016\/j.oooo.2013.12.400_bib4","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1136\/bmj.308.6923.217","article-title":"What to do about halitosis","volume":"308","author":"Scully","year":"1994","journal-title":"BMJ"},{"key":"10.1016\/j.oooo.2013.12.400_bib5","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1177\/10454411900010040401","article-title":"Oral malodor","volume":"1","author":"Kleinberg","year":"1990","journal-title":"Crit Rev Oral Biol Med"},{"key":"10.1016\/j.oooo.2013.12.400_bib6","first-page":"257","article-title":"Examination, classification, and treatment of halitosis: clinical perspectives","volume":"66","author":"Yaegaki","year":"2000","journal-title":"J\u00a0Can Dent Assoc"},{"key":"10.1016\/j.oooo.2013.12.400_bib7","series-title":"Oral Health Care","first-page":"121","article-title":"Relationship between oral malodor and oral microbiota","author":"Suzuki","year":"2012"},{"key":"10.1016\/j.oooo.2013.12.400_bib8","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1601-0825.2007.01386.x","article-title":"Probiotics: contributions to oral health","volume":"13","author":"Meurman","year":"2007","journal-title":"Oral Dis"},{"key":"10.1016\/j.oooo.2013.12.400_bib9","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S0003-9969(02)00112-7","article-title":"Short-term consumption of probiotic-containing cheese and its effect on dental caries risk factors","volume":"47","author":"Ahola","year":"2002","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.oooo.2013.12.400_bib10","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1080\/00016350600801709","article-title":"Salivary mutans streptococci and lactobacilli levels after ingestion of the probiotic bacterium Lactobacillus reuteri ATCC 55730 by straws or tablets","volume":"64","author":"\u00c7aglar","year":"2006","journal-title":"Acta Odontol Scand"},{"key":"10.1016\/j.oooo.2013.12.400_bib11","first-page":"105","article-title":"Suppression of periodontal pathogenic bacteria in the saliva of humans by the administration of Lactobacillus salivarius TI2711","volume":"45","author":"Ishikawa","year":"2003","journal-title":"Journal of the Japanese Society of Periodontology"},{"key":"10.1016\/j.oooo.2013.12.400_bib12","first-page":"315","article-title":"Effect of oral Lactobacillus salivarius TI 2711 (LS1) administration on periodontopathic bacteria in subgingival plaque","volume":"48","author":"Matsuoka","year":"2006","journal-title":"Journal of the Japanese Society of Periodontology"},{"key":"10.1016\/j.oooo.2013.12.400_bib13","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1111\/j.1572-0241.1998.00600.x","article-title":"Lactic acid-mediated suppression of Helicobacter pylori by the oral administration of Lactobacillus salivarius as a probiotic in a gnotobiotic murine model","volume":"93","author":"Aiba","year":"1998","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.oooo.2013.12.400_bib14","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1111\/j.1600-051X.2008.01306.x","article-title":"Improvement of periodontal condition by probiotics with Lactobacillus salivarius WB21: a randomized, double-blind, placebo-controlled study","volume":"35","author":"Shimauchi","year":"2008","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.oooo.2013.12.400_bib15","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.1600-051X.2009.01392.x","article-title":"Probiotic effects of orally administered Lactobacillus salivarius WB21-containing tablets on periodontopathic bacteria: a double-blinded, placebo-controlled, randomized clinical trial","volume":"36","author":"Mayanagi","year":"2009","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.oooo.2013.12.400_bib16","doi-asserted-by":"crossref","first-page":"017106","DOI":"10.1088\/1752-7155\/6\/1\/017106","article-title":"Effects of oil drops containing Lactobacillus salivarius WB21 on periodontal health and oral microbiota producing volatile sulfur compounds","volume":"6","author":"Suzuki","year":"2013","journal-title":"J\u00a0Breath Res"},{"key":"10.1016\/j.oooo.2013.12.400_bib17","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.tripleo.2010.03.032","article-title":"Effects of probiotic Lactobacillus salivarius WB21 on halitosis and oral health: an open-label pilot study","volume":"110","author":"Iwamoto","year":"2010","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.oooo.2013.12.400_bib18","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1111\/j.1600-0765.2010.01285.x","article-title":"Relationship between oral malodor and the menstrual cycle","volume":"45","author":"Kawamoto","year":"2010","journal-title":"J\u00a0Periodontal Res"},{"key":"10.1016\/j.oooo.2013.12.400_bib19","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3109\/00016356408993968","article-title":"Periodontal disease in pregnancy, II: correlation between oral hygiene and periodontal condition","volume":"22","author":"Silness","year":"1964","journal-title":"Acta Odontol Scand"},{"key":"10.1016\/j.oooo.2013.12.400_bib20","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0020-6539(20)33801-6","article-title":"The relationship between alcohol consumption and oral malodor","volume":"59","author":"Suzuki","year":"2009","journal-title":"Int Dent J"},{"key":"10.1016\/j.oooo.2013.12.400_bib21","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/srep00215","article-title":"Discrimination of the oral microbiota associated with high hydrogen sulfide and methyl mercaptan production","volume":"2","author":"Takeshita","year":"2012","journal-title":"Sci Rep"},{"key":"10.1016\/j.oooo.2013.12.400_bib22","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.1128\/JCM.42.7.3128-3136.2004","article-title":"Quantitative analysis if diverse Lactobacillus species present in advanced dental caries","volume":"42","author":"Byun","year":"2004","journal-title":"J\u00a0Clin Microbiol"},{"key":"10.1016\/j.oooo.2013.12.400_bib23","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1600-0765.1992.tb01673.x","article-title":"Volatile sulfur compounds in mouth air from clinical healthy subjects and patients with periodontal disease","volume":"27","author":"Yaegaki","year":"1992","journal-title":"J\u00a0Periodontal Res"},{"key":"10.1016\/j.oooo.2013.12.400_bib24","first-page":"307","article-title":"An inventory of patients' response to treatment at a multidisciplinary breath odor clinic","volume":"30","author":"Delanghe","year":"1999","journal-title":"Quintessence Int"},{"key":"10.1016\/j.oooo.2013.12.400_bib25","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/ajcn\/87.1.91","article-title":"Molecular analysis of yogurt containing Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus thermophiles in human intestinal microbiota","volume":"87","author":"Garcia-Albiach","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.oooo.2013.12.400_bib26","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1080\/00016350802089467","article-title":"Short-term effect of ice-cream containing Bifidobacterium lactis Bb-12 on the number of salivary mutans streptococci and lactobacilli","volume":"66","author":"\u00c7aglar","year":"2008","journal-title":"Acta Odontol Scand"},{"issue":"suppl 1","key":"10.1016\/j.oooo.2013.12.400_bib27","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1097\/MCG.0b013e3181ed0e71","article-title":"Evaluation of the intestinal colonization by microencapsulated probiotic bacteria in comparison with the same uncoated strains","volume":"44","author":"Del Piano","year":"2010","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1016\/j.oooo.2013.12.400_bib28","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/1475-2891-12-87","article-title":"Daily consumption of a symbiotic yogurt decreases energy intake but does not improve gastrointestinal transit time: a double-blind, randomized, crossover study in healthy adults","volume":"12","author":"Tulk","year":"2013","journal-title":"Nutr J"},{"key":"10.1016\/j.oooo.2013.12.400_bib29","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1177\/00220345950740070801","article-title":"Volatile fatty acids, metabolic by-products of periodontopathic bacteria, inhibit lymphocyte proliferation and cytokine production","volume":"74","author":"Kurita-Ochiai","year":"1995","journal-title":"J\u00a0Dent Res"},{"key":"10.1016\/j.oooo.2013.12.400_bib30","doi-asserted-by":"crossref","first-page":"4260","DOI":"10.1128\/AEM.00166-10","article-title":"Production of indole from L-tryptophan and effects of these compounds on biofilm formation by Fusobacterium nucleatum ATCC 25586","volume":"76","author":"Sasaki-Imamura","year":"2010","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.oooo.2013.12.400_bib31","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1128\/MMBR.66.3.486-505.2002","article-title":"Communication among oral bacteria","volume":"66","author":"Kolenbrander","year":"2002","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1016\/j.oooo.2013.12.400_bib32","doi-asserted-by":"crossref","first-page":"4729","DOI":"10.1128\/IAI.66.10.4729-4732.1998","article-title":"Role of Fusobacterium nucleatum and coaggregation in anaerobe survival in planktonic and biofilm oral microbial communities during aeration","volume":"66","author":"Bradshaw","year":"1998","journal-title":"Infect Immun"},{"key":"10.1016\/j.oooo.2013.12.400_bib33","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.micpath.2012.08.005","article-title":"Porphyromonas gingivalis entry into gingival epithelial cells modulated by Fusobacterium nucleatum is dependent on lipid rafts","volume":"53","author":"Saito","year":"2012","journal-title":"Microb Pathog"},{"key":"10.1016\/j.oooo.2013.12.400_bib34","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1399-302X.2004.00175.x","article-title":"Synergy between Tannerella forsythia and Fusobacterium nucleatum in biofilm formation","volume":"20","author":"Sharma","year":"2005","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.oooo.2013.12.400_bib35","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1023\/B:BILE.0000015450.59100.60","article-title":"Antagonistic activity of lactic acid bacteria as probiotics against selected bacteria of Enterobaceriacae family in the presence of polyols and their galactosyl derivatives","volume":"26","author":"Klewicki","year":"2004","journal-title":"Biotechnol Lett"},{"key":"10.1016\/j.oooo.2013.12.400_bib36","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1365-2567.2006.02358.x","article-title":"Functional modulation\u00a0of human intestinal epithelial cell responses by Bifidobacterium infantis and Lactobacillus salivarius","volume":"118","author":"O'Hara","year":"2006","journal-title":"Immunol"},{"key":"10.1016\/j.oooo.2013.12.400_bib37","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1756-0500-3-44","article-title":"Strain-dependent release of cytokines modulated by Lactobacillus salivarius human isolates in an in vitro model","volume":"3","author":"Drago","year":"2010","journal-title":"BMC Res Notes"},{"key":"10.1016\/j.oooo.2013.12.400_bib38","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1128\/AEM.02481-10","article-title":"Isolation of Lactobacillus salivarius 1077 (NRRL B-50053) and characterization of its bacteriocin, including the antimicrobial activity spectrum","volume":"77","author":"Svetoch","year":"2011","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.oooo.2013.12.400_bib39","doi-asserted-by":"crossref","first-page":"5196","DOI":"10.1128\/AEM.00507-12","article-title":"Influence of adhesion and bacteriocin production by Lactobacillus salivarius on the intestinal epithelial cell transcriptional response","volume":"78","author":"O'Callaghan","year":"2012","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.oooo.2013.12.400_bib40","doi-asserted-by":"crossref","first-page":"e31113","DOI":"10.1371\/journal.pone.0031113","article-title":"Effect of Lactobacillus salivarius bacteriocin ABP118 on the mouse and pig intestinal microbiota","volume":"7","author":"Riboulet-Bisson","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.oooo.2013.12.400_bib41","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00784-003-0214-7","article-title":"Biofilms and the tongue: therapeutical approaches for the control of halitosis","volume":"7","author":"Rold\u00e1n","year":"2003","journal-title":"Clin Oral Investig"}],"container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440313020889?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440313020889?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T21:58:08Z","timestamp":1761947888000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212440313020889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S2212440313020889"],"URL":"https:\/\/doi.org\/10.1016\/j.oooo.2013.12.400","relation":{},"ISSN":["2212-4403"],"issn-type":[{"value":"2212-4403","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lactobacillus salivarius WB21\u2013containing tablets for the treatment of oral malodor: a double-blind, randomized, placebo-controlled crossover trial","name":"articletitle","label":"Article Title"},{"value":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oooo.2013.12.400","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}