{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T07:26:32Z","timestamp":1761981992800,"version":"build-2065373602"},"reference-count":36,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,17]],"date-time":"2015-09-17T00:00:00Z","timestamp":1442448000000},"content-version":"vor","delay-in-days":351,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.oooo.2014.07.012","type":"journal-article","created":{"date-parts":[[2014,8,2]],"date-time":"2014-08-02T20:30:10Z","timestamp":1407011410000},"page":"483-489","source":"Crossref","is-referenced-by-count":14,"title":["Stromal myofibroblasts in squamous cell carcinoma of the tongue in young patients \u2013 a multicenter collaborative study"],"prefix":"10.1016","volume":"118","author":[{"given":"Felipe Paiva","family":"Fonseca","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Della","family":"Coletta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina Barbosa","family":"Azevedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina","family":"Prado Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Maria","family":"Pires Soubhia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glauco Issamu","family":"Miyahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Carlos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Farthing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith D.","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul M.","family":"Speight","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo Agustin","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oslei Paes","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcio Ajudarte","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan Roger","family":"Santos-Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.oooo.2014.07.012_bib1","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.oraloncology.2006.11.007","article-title":"Stromal myofibroblasts and malignant transformation in a 4 NQO rat tongue carcinogenesis model","volume":"43","author":"Vered","year":"2007","journal-title":"Oral Oncol"},{"key":"10.1016\/j.oooo.2014.07.012_bib2","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.oraloncology.2008.06.002","article-title":"Global epidemiology of oral and oropharyngeal cancer","volume":"45","author":"Warnakulasuriya","year":"2009","journal-title":"Oral Oncol"},{"key":"10.1016\/j.oooo.2014.07.012_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/701932","article-title":"Challenges of the oral cancer burden in India","volume":"2012","author":"Coelho","year":"2012","journal-title":"J\u00a0Cancer Epidemiol"},{"key":"10.1016\/j.oooo.2014.07.012_bib4","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1002\/hed.23143","article-title":"Oral squamous cell carcinoma arising in background of oral submucous fibrosis: A clinicopathologically distinct disease","volume":"35","author":"Chaturvedi","year":"2013","journal-title":"Head Neck"},{"key":"10.1016\/j.oooo.2014.07.012_bib5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s12307-009-0020-0","article-title":"Stromal myofibroblasts accompany modifications in the epithelial phenotype of tongue dysplastic and malignant lesions","volume":"2","author":"Vered","year":"2009","journal-title":"Cancer Microenviron"},{"key":"10.1016\/j.oooo.2014.07.012_bib6","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1097\/SCS.0b013e31820fe1cb","article-title":"Squamous cell carcinoma of the tongue and floor of the mouth: Analysis of survival rate and independent prognostic factors in the Amazon region","volume":"22","author":"Pontes","year":"2011","journal-title":"J\u00a0Craniofac Surg"},{"key":"10.1016\/j.oooo.2014.07.012_bib7","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.bjoms.2008.05.004","article-title":"Clinical and histopathological analysis of oral squamous cell carcinoma in young people. A descriptive study in Brazilians","volume":"47","author":"Ribeiro","year":"2009","journal-title":"Br J Oral and Maxillofacial Surgery"},{"key":"10.1016\/j.oooo.2014.07.012_bib8","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/hed.2880160202","article-title":"Oral tongue cancer in young adults less than 40 years of age: Rationale for aggressive therapy","volume":"16","author":"Sarkaria","year":"1994","journal-title":"Head Neck"},{"key":"10.1016\/j.oooo.2014.07.012_bib9","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1097\/00005537-200010000-00009","article-title":"More aggressive behavior of squamous cell carcinoma of the anterior tongue in young women","volume":"110","author":"Vargas","year":"2000","journal-title":"Laryngoscope"},{"key":"10.1016\/j.oooo.2014.07.012_bib10","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1600-0714.2007.00548.x","article-title":"Analysis of histopathological and immunohistochemical differences of oral squamous cell carcinoma in young and old patients in Sri Lanka","volume":"36","author":"Siriwardena","year":"2007","journal-title":"J\u00a0Oral Pathol Med"},{"key":"10.1016\/j.oooo.2014.07.012_bib11","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1349-7006.2009.01357.x","article-title":"Tumor-host histopathologic variables, stromal myofibroblasts and risk score, are significantly associated with recurrent disease in tongue cancer","volume":"101","author":"Vered","year":"2010","journal-title":"Cancer Sci"},{"key":"10.1016\/j.oooo.2014.07.012_bib12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/ijc.10577","article-title":"Incidence and survival of squamous cell carcinoma of the tongue in Scandinavia, with special reference to young adults","volume":"101","author":"Annertz1","year":"2002","journal-title":"Int J Cancer"},{"key":"10.1016\/j.oooo.2014.07.012_bib13","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1600-0714.2004.00291.x","article-title":"Clinico-pathological features of squamous cell carcinoma of the oral cavity in patients <40 years of age","volume":"34","author":"Sasaki","year":"2005","journal-title":"J\u00a0Oral Pathol Med"},{"key":"10.1016\/j.oooo.2014.07.012_bib14","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1758-3284-4-28","article-title":"Squamous cell carcinoma of the oral cavity and the oropharynx in patients less than 40 years of age: A 20-year analysis","volume":"4","author":"Udeabor","year":"2012","journal-title":"Head Neck Oncol"},{"key":"10.1016\/j.oooo.2014.07.012_bib15","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1054\/ijom.2003.0503","article-title":"Analysis of 587 cases of oral squamous cell carcinoma in northern Thailand with a focus on young people","volume":"33","author":"Iamaroon","year":"2004","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2014.07.012_bib16","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s12105-009-0135-0","article-title":"Head and neck squamous cell carcinoma in the young: A spectrum or a distinct group? Part 1","volume":"3","author":"Toner","year":"2009","journal-title":"Head Neck Pathol"},{"key":"10.1016\/j.oooo.2014.07.012_bib17","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1111\/j.1365-2559.2011.03863.x","article-title":"High incidences of DNA ploidy abnormalities in tongue squamous cell carcinoma of young patients: An international collaborative study","volume":"58","author":"Santos-Silva","year":"2011","journal-title":"Histopathology"},{"key":"10.1016\/j.oooo.2014.07.012_bib18","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s12105-009-0137-y","article-title":"Head and neck squamous cell carcinoma in the young: A spectrum or a distinct group? Part 2","volume":"3","author":"Toner","year":"2009","journal-title":"Head Neck Pathol"},{"key":"10.1016\/j.oooo.2014.07.012_bib19","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.oraloncology.2011.06.011","article-title":"Myofibroblasts in the stroma of oral cancer promote tumorigenesis via secretion of Activin A","volume":"47","author":"Sobral","year":"2011","journal-title":"Oral Oncol"},{"key":"10.1016\/j.oooo.2014.07.012_bib20","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1600-0714.2010.00999.x","article-title":"Significance of myofibroblasts in oral squamous cell carcinoma","volume":"40","author":"Thode","year":"2011","journal-title":"J\u00a0Oral Pathol Med"},{"key":"10.1016\/j.oooo.2014.07.012_bib21","first-page":"2917","article-title":"Occurrence of stromal myofibroblasts in the invasive ductal breast cancer tissue is an unfavorable prognostic factor","volume":"27","author":"Surowiak","year":"2007","journal-title":"Anticancer Res"},{"key":"10.1016\/j.oooo.2014.07.012_bib22","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1158\/1078-0432.CCR-06-2191","article-title":"Stromal myofibroblasts predict disease recurrence for colorectal cancer","volume":"3","author":"Tsujino","year":"2007","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.oooo.2014.07.012_bib23","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/j.1365-2559.2007.02873.x","article-title":"Myofibroblasts in the stroma of oral squamous cell carcinoma are associated with poor prognosis","volume":"51","author":"Kellermann","year":"2007","journal-title":"Histopathology"},{"key":"10.1016\/j.oooo.2014.07.012_bib24","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.oraloncology.2007.07.001","article-title":"Mutual paracrine effects of oral squamous cell carcinoma cells and normal oral fibroblasts: Induction of fibroblast to myofibroblast transdifferentiation and modulation of tumor cell proliferation","volume":"44","author":"Kellermann","year":"2008","journal-title":"Oral Oncol"},{"key":"10.1016\/j.oooo.2014.07.012_bib25","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/path.2830","article-title":"Stromal features are predictive of disease mortality in oral cancer patients","volume":"223","author":"Marsh","year":"2011","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.oooo.2014.07.012_bib26","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s12105-012-0334-y","article-title":"Immunohistochemical expression of p16, p21, p27 and cyclin D1 in oral nevi and melanoma","volume":"6","author":"Andrade","year":"2012","journal-title":"Head Neck Pathol"},{"key":"10.1016\/j.oooo.2014.07.012_bib27","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.oraloncology.2006.11.021","article-title":"Oral cancer survival in young people in South East England","volume":"43","author":"Warnakulasuriya","year":"2007","journal-title":"Oral Oncol"},{"key":"10.1016\/j.oooo.2014.07.012_bib28","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.oraloncology.2003.08.015","article-title":"An analysis of risk factors for oral cancer in young people: A case-control study","volume":"40","author":"Llewellyn","year":"2004","journal-title":"Oral Oncol"},{"key":"10.1016\/j.oooo.2014.07.012_bib29","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1001\/archotol.128.3.268","article-title":"Head and neck cancer incidence trends in young Americans, 1973-1997, with a special analysis for tongue cancer","volume":"128","author":"Schantz","year":"2002","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.oooo.2014.07.012_bib30","first-page":"E227","article-title":"Risk factors for oral squamous cell carcinoma in young and older Brazilian patients: A comparative analysis","volume":"13","author":"Hirota","year":"2008","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"10.1016\/j.oooo.2014.07.012_bib31","first-page":"650","article-title":"Prognostic features, human papillomavirus status, and epidermal growth factor receptor expression in oral squamous cell carcinoma in young adults","volume":"33","author":"Thomas","year":"2012","journal-title":"Am J Otolaryngol Head Neck Med Surg"},{"key":"10.1016\/j.oooo.2014.07.012_bib32","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/PAI.0b013e31823277f6","article-title":"Immunohistochemical comparative analysis of cell proliferation and angiogenic index in squamous cell carcinomas of the tongue between young and older patients","volume":"20","author":"Benevenuto","year":"2012","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"10.1016\/j.oooo.2014.07.012_bib33","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/hed.10004","article-title":"Presentation, treatment, and outcome of oral cavity cancer: A national cancer data base report","volume":"24","author":"Funk","year":"2002","journal-title":"Head Neck"},{"key":"10.1016\/j.oooo.2014.07.012_bib34","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00428-003-0965-1","article-title":"CD34+ fibrocytes, a-smooth muscle antigen-positive myofibroblasts, and CD117 expression in the stroma of invasive squamous cell carcinomas of the oral cavity, pharynx, and larynx","volume":"444","author":"Barth","year":"2004","journal-title":"Virchows Arch"},{"key":"10.1016\/j.oooo.2014.07.012_bib35","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.1600-0714.2009.00768.x","article-title":"Evaluation of myofibroblasts in oral epithelial dysplasia and squamous cell carcinoma","volume":"38","author":"Etemad-Moghadam","year":"2009","journal-title":"J\u00a0Oral Pathol Med"},{"key":"10.1016\/j.oooo.2014.07.012_bib36","doi-asserted-by":"crossref","first-page":"E733","DOI":"10.4317\/medoral.17834","article-title":"Stromal myofibroblasts in oral leukoplakia and oral squamous cell carcinoma","volume":"17","author":"de-Assis","year":"2012","journal-title":"Med Oral Patol Oral Cir Bucal"}],"container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440314006567?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440314006567?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T21:06:06Z","timestamp":1717189566000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212440314006567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S2212440314006567"],"URL":"https:\/\/doi.org\/10.1016\/j.oooo.2014.07.012","relation":{},"ISSN":["2212-4403"],"issn-type":[{"type":"print","value":"2212-4403"}],"subject":[],"published":{"date-parts":[[2014,10]]}}}