{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:11:05Z","timestamp":1762899065263},"reference-count":60,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","oooojournal.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.oooo.2014.08.020","type":"journal-article","created":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T15:28:24Z","timestamp":1410881304000},"page":"e33-e40","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Craniofacial manifestations of \u03b2-thalassemia major"],"prefix":"10.1016","volume":"119","author":[{"given":"Bahram","family":"Javid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasser","family":"Said-Al-Naief","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.oooo.2014.08.020_bib1","first-page":"92","article-title":"Hemoglobin structure and respiratory transport","volume":"239","author":"Perutz","year":"1978","journal-title":"Sci\u00a0Am"},{"key":"10.1016\/j.oooo.2014.08.020_bib2","first-page":"237","article-title":"Haemoglobin synthesis in thalassemia: two new molecular mechanisms for the production of the clinical picture of thalassemia","volume":"10","author":"Weatherall","year":"1972","journal-title":"Hamatol Bluttransfus"},{"key":"10.1016\/j.oooo.2014.08.020_bib3","first-page":"532","article-title":"Hemoglobinopathies: Clinical manifestations, diagnosis, and treatment","volume":"108","author":"Kohne","year":"2011","journal-title":"Dtsch Arztebl Int"},{"key":"10.1016\/j.oooo.2014.08.020_bib4","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1136\/bmj.329.7475.1115","article-title":"Lessons from thalassemia screening in Iran","volume":"13","author":"Christianson","year":"2004","journal-title":"BMJ"},{"key":"10.1016\/j.oooo.2014.08.020_bib5","doi-asserted-by":"crossref","first-page":"a011692","DOI":"10.1101\/cshperspect.a011692","article-title":"World distribution, population genetics, and health burden of the hemoglobinopathies","volume":"2","author":"Williams","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.oooo.2014.08.020_bib6","first-page":"564","article-title":"Identification of \u03b1-globin chain variants: A\u00a0report from Iran","volume":"15","author":"Akbari","year":"2012","journal-title":"Arch Iran Med"},{"key":"10.1016\/j.oooo.2014.08.020_bib7","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/humu.10044","article-title":"A\u00a0relational database of human hemoglobin variants and thalassemia mutations at the globin gene server","volume":"19","author":"Hardison","year":"2002","journal-title":"Hum Mutat"},{"key":"10.1016\/j.oooo.2014.08.020_bib8","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/GIM.0b013e3181cd68ed","article-title":"Beta-thalassemia","volume":"12","author":"Cao","year":"2010","journal-title":"Genet Med"},{"key":"10.1016\/j.oooo.2014.08.020_bib9","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1258\/0004563041731600","article-title":"Detection and quantitation of normal and variant haemoglobins: An analytical review","volume":"41","author":"Wild","year":"2004","journal-title":"Ann Clin Biochem"},{"key":"10.1016\/j.oooo.2014.08.020_bib10","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/sj.jp.7211873","article-title":"Homozygous alpha-thalassemia in a growth retarded, non-hydropic premature newborn","volume":"28","author":"Ng","year":"2008","journal-title":"J\u00a0Perinatol"},{"key":"10.1016\/j.oooo.2014.08.020_bib11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1750-1172-5-11","article-title":"Beta-thalassemia","volume":"5","author":"Galanello","year":"2010","journal-title":"Orphanet J Rare Dis"},{"issue":"Suppl 2","key":"10.1016\/j.oooo.2014.08.020_bib12","first-page":"263","article-title":"Pathophysiology of beta thalassaemia","author":"Origa","year":"2011","journal-title":"Pediatr Endocrinol Rev"},{"key":"10.1016\/j.oooo.2014.08.020_bib13","first-page":"36","article-title":"Thalassemias and their dental implications","volume":"7","author":"Soriano","year":"2002","journal-title":"Med Oral"},{"key":"10.1016\/j.oooo.2014.08.020_bib14","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1182\/blood.V94.9.3199","article-title":"Why are hemoglobin F levels increased in HbE\/beta thalassemia?","volume":"94","author":"Rees","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.oooo.2014.08.020_bib15","first-page":"135","article-title":"Dyserythropoiesis in iron deficiency and in beta-thalassemia","volume":"17","author":"Zago","year":"1984","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.oooo.2014.08.020_bib16","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1365-3148.2011.01102.x","article-title":"Fresh blood for transfusion in adults with beta-thalassemia","volume":"21","author":"Priddee","year":"2011","journal-title":"Transfus Med"},{"key":"10.1016\/j.oooo.2014.08.020_bib17","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1542\/peds.50.1.92","article-title":"Body growth in Cooley's anemia (homozygous beta-thalassemia) with a correlative study as to other aspects of the illness in 138 cases","volume":"50","author":"Logothetis","year":"1972","journal-title":"Pediatrics"},{"key":"10.1016\/j.oooo.2014.08.020_bib18","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1001\/archpedi.1971.02100150074007","article-title":"Cephalofacial deformities in thalassemia major (Cooley's anemia). A correlative study among 138 cases","volume":"121","author":"Logothetis","year":"1971","journal-title":"Am J Dis Child"},{"key":"10.1016\/j.oooo.2014.08.020_bib19","doi-asserted-by":"crossref","DOI":"10.1002\/jbmr.2266","article-title":"Thalassemia bone disease: A 19 year longitudinal analysis","author":"Wong","year":"2014","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.oooo.2014.08.020_bib20","doi-asserted-by":"crossref","first-page":"152","DOI":"10.4066\/AMJ.2012.107","article-title":"Subclinical hemorrhagic tendency exists in patients with \u03b2-thalassemia major in early childhood","volume":"5","author":"Maiti","year":"2012","journal-title":"Australas Med J"},{"key":"10.1016\/j.oooo.2014.08.020_bib21","series-title":"Guidelines for the Clinical Management of Thalassemia. 2nd ed","year":"2008"},{"key":"10.1016\/j.oooo.2014.08.020_bib22","series-title":"In Wintrobe's Clinical Hematology Vol. 42","first-page":"1319","article-title":"Thalassemias and related disorders: Quantitative disorders of hemoglobin synthesis","author":"Borgna-Pignatti","year":"2004"},{"key":"10.1016\/j.oooo.2014.08.020_bib23","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1046\/j.1365-2141.2003.04732.x","article-title":"Hepatocellular carcinoma in the thalassemia syndromes","volume":"124","author":"Borgna-Pignatti","year":"2004","journal-title":"Br J Haematol"},{"key":"10.1016\/j.oooo.2014.08.020_bib24","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1196\/annals.1345.006","article-title":"Survival and complications in thalassemia","volume":"1054","author":"Borgna-Pignatti","year":"2005","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.oooo.2014.08.020_bib25","first-page":"1187","article-title":"Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine","volume":"89","author":"Borgna-Pignatti","year":"2004","journal-title":"Haematologica"},{"key":"10.1016\/j.oooo.2014.08.020_bib26","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1182\/blood-2003-09-3167","article-title":"Thalassemia Clinical Research Network. Complications of beta-thalassemia major in North America","volume":"104","author":"Cunningham","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.oooo.2014.08.020_bib27","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1532-429X-13-34","article-title":"Effect of deferiprone or deferoxamine on right ventricular function in thalassemia major patients with myocardial iron overload","volume":"13","author":"Smith","year":"2011","journal-title":"J\u00a0Cardiovasc Magn Reson"},{"key":"10.1016\/j.oooo.2014.08.020_bib28","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1532-429X-14-8","article-title":"Effects of combined deferiprone with deferoxamine on right ventricular function in thalassemia major","volume":"14","author":"Alpendurada","year":"2012","journal-title":"J\u00a0Cardiovasc Magn Reson"},{"key":"10.1016\/j.oooo.2014.08.020_bib29","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/BF00361428","article-title":"The \u201clamellated\u201d skull in beta-thalassemia","volume":"18","author":"Orzincolo","year":"1989","journal-title":"Skeletal Radiol"},{"key":"10.1016\/j.oooo.2014.08.020_bib30","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/00008480-200302000-00005","article-title":"Stem cell transplantation for hemoglobinopathies","volume":"15","author":"Gaziev","year":"2003","journal-title":"Curr Opin Pediatr"},{"key":"10.1016\/j.oooo.2014.08.020_bib31","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1182\/blood-2013-05-502658","article-title":"Long-term health-related quality of life evaluated more than 20 years after hematopoietic stem cell transplantatation for thalassemia","volume":"122","author":"La Nasa","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.oooo.2014.08.020_bib32","doi-asserted-by":"crossref","first-page":"e61637","DOI":"10.1371\/journal.pone.0061637","article-title":"Improved clinical outcomes of high risk \u03b2 thalassemia major patients undergoing a HLA matched related allogeneic stem cell transplant with a treosulfan based conditioning regimen and peripheral blood stem cell grafts","volume":"8","author":"Mathews","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.oooo.2014.08.020_bib33","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1365-2141.2008.07016.x","article-title":"Cord blood stem cell transplantation for hemoglobinopathies","volume":"141","author":"Pinto","year":"2008","journal-title":"Br J Haematol"},{"key":"10.1016\/j.oooo.2014.08.020_bib34","first-page":"9","article-title":"The prevalence of sensorineural hearing loss in \u03b2-thalassaemia patient treated with desferrioxamine","volume":"69","author":"Kong","year":"2014","journal-title":"Med J Malaysia"},{"key":"10.1016\/j.oooo.2014.08.020_bib35","doi-asserted-by":"crossref","first-page":"63","DOI":"10.5005\/jcdp-7-4-63","article-title":"Dental development in patients with thalassemia major","volume":"7","author":"Hazza'a","year":"2006","journal-title":"J\u00a0Contemp Dent Pract"},{"key":"10.1016\/j.oooo.2014.08.020_bib36","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/0030-4220(84)90273-1","article-title":"The asplenic patient: A consideration for antimicrobial prophylaxis","volume":"57","author":"Terezhalmy","year":"1984","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.oooo.2014.08.020_bib37","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.bone.2010.10.173","article-title":"Bone disease and skeletal complications in patients with \u03b2-thalassemia major","volume":"48","author":"Haidar","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.oooo.2014.08.020_bib38","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1179\/bjo.23.2.157","article-title":"Effects of thalassaemia major on components of the craniofacial complex","volume":"23","author":"Ba\u015fsimit\u00e7i","year":"1996","journal-title":"Br J Orthod"},{"key":"10.1016\/j.oooo.2014.08.020_bib39","first-page":"339","article-title":"Alpha and \u03b2 thalassemia","volume":"80","author":"Muncie","year":"2009","journal-title":"American Family Physician"},{"key":"10.1016\/j.oooo.2014.08.020_bib40","doi-asserted-by":"crossref","first-page":"107","DOI":"10.5992\/AJCS-D-14-00002.1","article-title":"Surgical correction of facial skeletal deformity of patients with thalessemia","volume":"31","author":"Badri","year":"2014","journal-title":"Am J\u00a0Cosmetic Surg"},{"key":"10.1016\/j.oooo.2014.08.020_bib41","first-page":"67","article-title":"Dental caries and gingival status of 3-14 year old beta thalassemia major patients attending paediatric OPD of vanivilas hospital, Bangalore","volume":"2","author":"Kaur","year":"2012","journal-title":"Arch Oral Sci Res"},{"key":"10.1016\/j.oooo.2014.08.020_bib42","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4103\/2231-6027.171156","article-title":"Dental and periodontal health status of beta thalassemia major and sickle cell anemic patients: A comparative study","volume":"5","author":"Singh","year":"2013","journal-title":"Int Oral Health"},{"key":"10.1016\/j.oooo.2014.08.020_bib43","first-page":"9","article-title":"Betathalassemia and its orodental implications. II. A clinical study","volume":"39","author":"Bucci","year":"1990","journal-title":"Minerva Stomatol"},{"key":"10.1016\/j.oooo.2014.08.020_bib44","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.tripleo.2009.09.027","article-title":"Oral Candida flora in a group of Jordanian patients with beta-thalassemia major","volume":"109","author":"Hazza'a","year":"2010","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.oooo.2014.08.020_bib45","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00784-002-0179-y","article-title":"Oral condition, chemistry of saliva, and salivary levels of Streptococcus mutans in thalassemic patients","volume":"6","author":"Lugli\u00e8","year":"2002","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.oooo.2014.08.020_bib46","first-page":"118","article-title":"Defective phagocytic and bactericidal function of polymorphonuclear leukocytes in patients with beta-thalassaemia major","volume":"8","author":"Skoutelis","year":"1984","journal-title":"J\u00a0Infect"},{"key":"10.1016\/j.oooo.2014.08.020_bib47","first-page":"1","article-title":"Immune cell function in iron overload","volume":"75","author":"de Sousa","year":"1989","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.oooo.2014.08.020_bib48","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1259\/dmfr\/38094141","article-title":"Radiographic features of the jaws and teeth in thalassaemia major","volume":"35","author":"Hazza'a","year":"2006","journal-title":"Dentomaxillofac Radiol"},{"key":"10.1016\/j.oooo.2014.08.020_bib49","first-page":"893","article-title":"Altered T and B lymphocytes in multitransfused patients of thalassemia major","volume":"30","author":"Dua","year":"1993","journal-title":"Indian Pediatr"},{"key":"10.1016\/j.oooo.2014.08.020_bib50","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1365-263X.1992.tb00016.x","article-title":"Flow rate and chemistry of parotid saliva related to dental caries and gingivitis in patients with thalassemia major","volume":"2","author":"Siamopoulou-Mavridou","year":"1992","journal-title":"Int J Paediatr Dent"},{"key":"10.1016\/j.oooo.2014.08.020_bib51","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1128\/CDLI.1.1.38-43.1994","article-title":"Autoimmune hemolytic anemia in chronic Mucocutaneous candidiasis","volume":"1","author":"Oyefara","year":"1991","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1016\/j.oooo.2014.08.020_bib52","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1097\/00043426-200011000-00027","article-title":"Infections in E-beta thalassemia","volume":"22","author":"Wanachiwanawin","year":"2000","journal-title":"J\u00a0Pediatr Hematol Oncol"},{"key":"10.1016\/j.oooo.2014.08.020_bib53","first-page":"47","article-title":"Identification of patients with defects in the globin genes","volume":"7","author":"Dell'edera","year":"2013","journal-title":"J\u00a0Prenat Med"},{"key":"10.1016\/j.oooo.2014.08.020_bib54","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1620\/tjem.223.223","article-title":"Elevated hemoglobin A2 as a marker for \u03b2-thalassemia trait in pregnant women","volume":"223","author":"Ou","year":"2011","journal-title":"Tohoku J Exp Med"},{"key":"10.1016\/j.oooo.2014.08.020_bib55","first-page":"204","article-title":"Transabdominal chorionic villus sampling (CVS) for prenatal diagnosis of genetic disorders","volume":"16","author":"Ahmed","year":"2006","journal-title":"Coll Physicians Surg Pak"},{"key":"10.1016\/j.oooo.2014.08.020_bib56","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0140-6736(97)02174-0","article-title":"Presence of fetal DNA in maternal plasma and serum","volume":"350","author":"Lo","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.oooo.2014.08.020_bib57","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1002\/pd.4196","article-title":"Noninvasive prenatal diagnosis experience in the \u00c7ukurova Region of Southern Turkey: Detecting paternal mutations of sickle cell anemia and \u03b2-thalassemia in cell-free fetal DNA using high-resolution melting analysis","volume":"11","author":"Yenilmez","year":"2013","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.oooo.2014.08.020_bib58","series-title":"Prevention of Thalassaemias and Other Haemoglobin Disorders. Vol. 2: Laboratory Protocols","author":"Old","year":"2012"},{"key":"10.1016\/j.oooo.2014.08.020_bib59","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1089\/gte.2006.0502","article-title":"Molecular analysis of alpha\/beta-thalassemia in a southern Chinese population","volume":"11","author":"Ye","year":"2007","journal-title":"Genet Test"},{"key":"10.1016\/j.oooo.2014.08.020_bib60","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1309\/AJCPD0PJGFT0SXMK","article-title":"Prevalence of elevated hemoglobin A2 measured by the CAPILLARYS system","volume":"131","author":"Yang","year":"2009","journal-title":"Am J Clin Pathol"}],"container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440314012449?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440314012449?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T15:20:11Z","timestamp":1717341611000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212440314012449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S2212440314012449"],"URL":"https:\/\/doi.org\/10.1016\/j.oooo.2014.08.020","relation":{},"ISSN":["2212-4403"],"issn-type":[{"value":"2212-4403","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Craniofacial manifestations of \u03b2-thalassemia major","name":"articletitle","label":"Article Title"},{"value":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oooo.2014.08.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}