{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:06:26Z","timestamp":1761293186017},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","oooojournal.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.oooo.2014.08.023","type":"journal-article","created":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T15:28:31Z","timestamp":1410881311000},"page":"e13-e19","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["mTOR inhibitor-associated stomatitis (mIAS) in three patients with cancer treated with everolimus"],"prefix":"10.1016","volume":"119","author":[{"given":"Eleni-Marina","family":"Kalogirou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos I.","family":"Tosios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evangelia P.","family":"Piperi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Sklavounou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.oooo.2014.08.023_bib1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.oraloncology.2012.11.008","article-title":"A\u00a0review of oral toxicity associated with mTOR inhibitor therapy in cancer patients","volume":"49","author":"Martins","year":"2013","journal-title":"Oral Oncol"},{"key":"10.1016\/j.oooo.2014.08.023_bib2","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.oraloncology.2011.08.009","article-title":"Clinical presentation and management of mTOR inhibitor-associated stomatitis","volume":"47","author":"de Oliveira","year":"2011","journal-title":"Oral Oncol"},{"key":"10.1016\/j.oooo.2014.08.023_bib3","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1016\/j.ejca.2011.03.017","article-title":"Natural history, management and pharmacokinetics of everolimus-induced-oral ulcers: insights into compliance issues","volume":"47","author":"Fert\u00e9","year":"2011","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.oooo.2014.08.023_bib4","unstructured":"Novartis. Afinitor; (everolimus) [prescribing information]. Available at: http:\/\/www.pharma.us.novartis.com\/product\/pi\/pdf\/afinitor.pdf. Accessed August 9, 2014."},{"key":"10.1016\/j.oooo.2014.08.023_bib5","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.2217\/fon.13.141","article-title":"Mammalian target of rapamycin inhibitor-associated stomatitis","volume":"9","author":"Boers-Doets","year":"2013","journal-title":"Future Oncol"},{"key":"10.1016\/j.oooo.2014.08.023_bib6","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/cncr.24696","article-title":"Preliminary characterization of oral lesions associated with inhibitors of mammalian target of rapamycin in cancer patients","volume":"116","author":"Sonis","year":"2010","journal-title":"Cancer"},{"key":"10.1016\/j.oooo.2014.08.023_bib7","unstructured":"National Cancer Institute. Oral complications of chemotherapy and head\/neck radiation (PDQ). Oral Mucositis Available at: http:\/\/www.cancer.gov\/-cancertopics\/pdq\/supportivecare\/oralcomplications\/HealthProfessional\/page5. Accessed August 9, 2014."},{"key":"10.1016\/j.oooo.2014.08.023_bib8","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1634\/theoncologist.2011-0111","article-title":"Oral adverse events associated with tyrosine kinase and mammalian target of rapamycin inhibitors in renal cell carcinoma: a structured literature review","volume":"17","author":"Boers-Doets","year":"2012","journal-title":"Oncologist"},{"key":"10.1016\/j.oooo.2014.08.023_bib9","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.oooo.2013.02.022","article-title":"Oral ulcers in patients with advanced breast cancer receiving everolimus: a case series report on clinical presentation and management","volume":"116","author":"Nicolatou-Galitis","year":"2013","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1016\/j.oooo.2014.08.023_bib10","first-page":"50","article-title":"Oral ulcers in cancer patients who receive mTOR inhibitors: an emerging oral toxicity","volume":"2","author":"Nicolatou-Galitis","year":"2012","journal-title":"Mediterranean Oncol J"},{"key":"10.1016\/j.oooo.2014.08.023_bib11","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1399-0012.2010.01232.x","article-title":"mTOR inhibitor-associated dermatologic and mucosal problems","volume":"24","author":"Campistol","year":"2010","journal-title":"Clin Transplant"},{"key":"10.1016\/j.oooo.2014.08.023_bib12","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1188\/11.CJON.E83-E89","article-title":"Managing stomatitis in patients treated with mammalian target of rapamycin inhibitors","volume":"15","author":"Pilotte","year":"2011","journal-title":"Clin J Oncol Nurs"},{"key":"10.1016\/j.oooo.2014.08.023_bib13","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.ejca.2011.02.014","article-title":"Management of adverse events associated with the use of everolimus in patients with advanced renal cell carcinoma","volume":"47","author":"Porta","year":"2011","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.oooo.2014.08.023_bib14","series-title":"Common Terminology Criteria for Adverse Events v3.0 (CTCAE), Version 3.0","year":"2006"},{"key":"10.1016\/j.oooo.2014.08.023_bib15","doi-asserted-by":"crossref","first-page":"3700","DOI":"10.1016\/j.transproceed.2010.06.023","article-title":"Common occurrence of everolimus-associated aphthous stomatitis in Japanese heart transplant recipients","volume":"42","author":"Sasaoka","year":"2010","journal-title":"Transplant Proc"},{"key":"10.1016\/j.oooo.2014.08.023_bib16","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1200\/JCO.2007.14.0988","article-title":"Phase I pharmacokinetic and pharmacodynamic study of the oral mammalian target of rapamycin inhibitor everolimus in patients with advanced solid tumors","volume":"26","author":"O\u2019Donnell","year":"2008","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.oooo.2014.08.023_bib17","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.cden.2004.08.001","article-title":"Recurrent aphthous stomatitis","volume":"49","author":"Akintoye","year":"2005","journal-title":"Dent Clin North Am"},{"key":"10.1016\/j.oooo.2014.08.023_bib18","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1093\/annonc\/mdu021","article-title":"Adverse event management in patients with advanced cancer receiving oral everolimus: focus on breast cancer","volume":"25","author":"Aapro","year":"2014","journal-title":"Ann Oncol"},{"key":"10.1016\/j.oooo.2014.08.023_bib19","first-page":"E223","article-title":"Management of stomatitis associated with mTOR inhibitors in hormone receptor-positive\/HER-2 negative advanced breast cancer: clinical experience from a single center","volume":"40","author":"Divers","year":"2013","journal-title":"Oncol Nurs Forum"},{"key":"10.1016\/j.oooo.2014.08.023_bib20","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/SPC.0b013e32832e4681","article-title":"Management of\u00a0sorafenib, sunitinib, and temsirolimus toxicity in metastatic renal cell carcinoma","volume":"3","author":"Guevremont","year":"2009","journal-title":"Curr Opin Support Palliat Care"},{"key":"10.1016\/j.oooo.2014.08.023_bib21","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.eururo.2007.11.037","article-title":"Toxicities associated with the administration of sorafenib, sunitinib, and temsirolimus and their management in patients with metastatic renal cell carcinoma","volume":"53","author":"Bhojani","year":"2008","journal-title":"Eur Urol"},{"key":"10.1016\/j.oooo.2014.08.023_bib22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s005209900076","article-title":"Efficacy of treatment to relieve mucositis-induced discomfort","volume":"8","author":"Turhal","year":"2000","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.oooo.2014.08.023_bib23","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1177\/1758834013501016","article-title":"The use of targeted therapies in pancreatic neuroendocrine tumours: patient assessment, treatment administration, and management of adverse events","volume":"5","author":"Cummins","year":"2013","journal-title":"Ther Adv Med Oncol"},{"key":"10.1016\/j.oooo.2014.08.023_bib24","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1067\/moe.2000.105713","article-title":"Randomized clinical trial of the effectiveness of 3 commonly used mouthwashes to treat chemotherapy-induced mucositis","volume":"90","author":"Dodd","year":"2000","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.oooo.2014.08.023_bib25","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.semradonc.2008.09.006","article-title":"Strategies for managing radiation-induced mucositis in head and neck cancer","volume":"19","author":"Rosenthal","year":"2009","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.oooo.2014.08.023_bib26","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1191\/1078155205jp166oa","article-title":"Survey of topical oral solutions for the treatment of chemo-induced oral mucositis","volume":"11","author":"Chan","year":"2005","journal-title":"J\u00a0Oncol Pharm Pract"},{"key":"10.1016\/j.oooo.2014.08.023_bib27","first-page":"CD001973","article-title":"Interventions for treating oral mucositis for patients with cancer receiving treatment","volume":"18","author":"Clarkson","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.oooo.2014.08.023_bib28","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1188\/05.CJON.584-592","article-title":"Current trends in managing oral mucositis","volume":"9","author":"Cawley","year":"2005","journal-title":"Clin J Oncol Nurs"},{"key":"10.1016\/j.oooo.2014.08.023_bib29","first-page":"453","article-title":"The treatment of oral problems in the palliative patient","volume":"72","author":"Wiseman","year":"2006","journal-title":"J\u00a0Can Dent Assoc"}],"container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440314012474?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440314012474?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T15:20:18Z","timestamp":1717341618000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212440314012474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S2212440314012474"],"URL":"https:\/\/doi.org\/10.1016\/j.oooo.2014.08.023","relation":{},"ISSN":["2212-4403"],"issn-type":[{"value":"2212-4403","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"mTOR inhibitor-associated stomatitis (mIAS) in three patients with cancer treated with everolimus","name":"articletitle","label":"Article Title"},{"value":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oooo.2014.08.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}