{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T20:26:45Z","timestamp":1778099205908,"version":"3.51.4"},"reference-count":23,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","oooojournal.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.oooo.2015.07.003","type":"journal-article","created":{"date-parts":[[2015,7,11]],"date-time":"2015-07-11T09:35:11Z","timestamp":1436607311000},"page":"588-593.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["A randomized double-blind, multiple-arm trial comparing the efficacy of submucosal injections of hyaluronidase, dexamethasone, and combination of dexamethasone and hyaluronidase in the management of oral submucous fibrosis"],"prefix":"10.1016","volume":"120","author":[{"given":"Rajitha","family":"Alora Veedu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Balan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pramod","family":"Sankar S","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.oooo.2015.07.003_bib1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.oraloncology.2008.05.016","article-title":"Potentially malignant disorders of the oral and oropharyngeal mucosa; terminology, classification and present concepts of management","volume":"45","author":"Van der Waal","year":"2009","journal-title":"Oral Oncol"},{"key":"10.1016\/j.oooo.2015.07.003_bib2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1600-0714.1995.tb01156.x","article-title":"Etiology of oral submucous fibrosis with special reference to the role of areca nut chewing","volume":"24","author":"Murti","year":"1995","journal-title":"J\u00a0Oral Pathol Med"},{"key":"10.1016\/j.oooo.2015.07.003_bib3","first-page":"109","article-title":"The clinical importance of changes in the 0 to 10 numeric rating scale for worst, least, and average pain intensity: analyses of data from clinical trials of duloxetine in pain disorders","volume":"11","author":"John","year":"2010","journal-title":"J\u00a0Pain"},{"key":"10.1016\/j.oooo.2015.07.003_bib4","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1600-0714.2008.00696.x","article-title":"Physiotherapeutic treatment improves oral opening in oral submucous fibrosis","volume":"38","author":"Cox","year":"2009","journal-title":"J\u00a0Oral Pathol Med"},{"key":"10.1016\/j.oooo.2015.07.003_bib5","first-page":"483","article-title":"Treatment modalities in oral submucous fibrosis: how they stand today? Study of 600 cases","volume":"7","author":"Gupta","year":"1992","journal-title":"Ind J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2015.07.003_bib6","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/j.1600-0714.1995.tb01209.x","article-title":"Clinical evaluation of different treatment methods for oral submucous fibrosis. A 10-year experience with 150 cases","volume":"24","author":"Lai","year":"1995","journal-title":"J\u00a0Oral Pathol Med"},{"key":"10.1016\/j.oooo.2015.07.003_bib7","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/sj.bdj.4805876","article-title":"Oral sub mucous fibrosis. Its pathogenesis and management","volume":"160","author":"Canniff","year":"1986","journal-title":"Br Dent J"},{"key":"10.1016\/j.oooo.2015.07.003_bib8","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1600-0714.1998.tb01915.x","article-title":"Role of chewing and smoking habits in the etiology of oral submucous fibrosis (OSF): a case-control study","volume":"27","author":"Shah","year":"1998","journal-title":"J\u00a0Oral Pathol Med"},{"key":"10.1016\/j.oooo.2015.07.003_bib9","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1177\/000348945706600420","article-title":"Submucous fibrosis of the palate and cheek","volume":"66","author":"DeSa","year":"1957","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1016\/j.oooo.2015.07.003_bib10","first-page":"198","article-title":"The effect of arecoline on the palatal and buccal mucosa of the Wistar rat. An optical and electron microscope study","volume":"16","author":"Sirsat","year":"1962","journal-title":"Indian J Med Sci"},{"key":"10.1016\/j.oooo.2015.07.003_bib11","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/0030-4220(80)90329-1","article-title":"Incidence and early forms of oral submucous fibrosis","volume":"50","author":"Pindborg","year":"1980","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.oooo.2015.07.003_bib12","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0030-4220(92)90300-F","article-title":"Silver-binding nucleolar organizer region proteins as a possible prognostic indicator in oral submucous fibrosis","volume":"74","author":"Rajendran","year":"1992","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.oooo.2015.07.003_bib13","doi-asserted-by":"crossref","first-page":"205","DOI":"10.4103\/0972-1363.169515","article-title":"Nucleolar Organizer regions\u2014a tissue marker in oral submucous fibrosis","volume":"16","author":"Balan","year":"2004","journal-title":"J\u00a0Ind Acad Oral Med Radiol"},{"key":"10.1016\/j.oooo.2015.07.003_bib14","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1600-0714.1990.tb00804.x","article-title":"A\u00a0case-control study of oral submucous fibrosis with special reference to the etiologic role of areca nut","volume":"19","author":"Sinor","year":"1990","journal-title":"J\u00a0Oral Pathol Med"},{"key":"10.1016\/j.oooo.2015.07.003_bib15","first-page":"789","article-title":"Submucous fibrosis of the oral cavity 1\u2014clinical features, studies on epidemiology","volume":"35","author":"Wahi","year":"1966","journal-title":"Notes Bull"},{"key":"10.1016\/j.oooo.2015.07.003_bib16","first-page":"489","article-title":"Submucous fibrosis of palate and buccal mucous membrane","volume":"31","author":"George","year":"1958","journal-title":"J\u00a0Ind Med Assoc"},{"key":"10.1016\/j.oooo.2015.07.003_bib17","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/0278-2391(88)90043-2","article-title":"Oral submucous fibrosis\u2014a new treatment regimen","volume":"46","author":"Gupta","year":"1988","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2015.07.003_bib18","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1017\/S0022215100096286","article-title":"Oral submucous fibrosis\u2014treatment with hyalase","volume":"99","author":"Kakar","year":"1985","journal-title":"J\u00a0Laryngol Otol"},{"key":"10.1016\/j.oooo.2015.07.003_bib19","first-page":"62","article-title":"Submucous fibrosis of the palate","volume":"70","author":"Sirsat","year":"1960","journal-title":"Arch Pathol"},{"key":"10.1016\/j.oooo.2015.07.003_bib20","unstructured":"Laxmipathy G. Hyalase in submucous fibrosis in oral cavity. Presentation at 32nd Annual Conference of Association of Otolaryngologist of India. Jaipur.\u00a01980."},{"key":"10.1016\/j.oooo.2015.07.003_bib21","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1600-0714.1999.tb01997.x","article-title":"Deficiency in collagen and fibronectin phagocytosis by human buccal mucosa fibroblasts in\u00a0vitro as a possible mechanism for oral submucous","volume":"28","author":"Tsai","year":"1999","journal-title":"J\u00a0Oral Pathol Med"},{"key":"10.1016\/j.oooo.2015.07.003_bib22","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/0278-2391(91)90002-4","article-title":"Management of oral submucous fibrosis: a conservative approach","volume":"49","author":"Borle","year":"1991","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2015.07.003_bib23","first-page":"410","article-title":"Oral Submucous fibrosis \u2013 a new approach in management\u2014report of 80 cases. Abstract of paper presented at BAOMS. Autumn Meeting in Harrogate September 22\u201329, 1991","volume":"29","author":"Khanna","year":"1991","journal-title":"Br J Oral Maxillofac Surg"}],"container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440315010822?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440315010822?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T05:12:10Z","timestamp":1691817130000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212440315010822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["S2212440315010822"],"URL":"https:\/\/doi.org\/10.1016\/j.oooo.2015.07.003","relation":{},"ISSN":["2212-4403"],"issn-type":[{"value":"2212-4403","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A randomized double-blind, multiple-arm trial comparing the efficacy of submucosal injections of hyaluronidase, dexamethasone, and combination of dexamethasone and hyaluronidase in the management of oral submucous fibrosis","name":"articletitle","label":"Article Title"},{"value":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oooo.2015.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}