{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:33:21Z","timestamp":1786995201145,"version":"build-2736575974"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["2013 R1 A1 A2011547"],"award-info":[{"award-number":["2013 R1 A1 A2011547"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["oooojournal.net","clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.oooo.2016.08.009","type":"journal-article","created":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T19:28:06Z","timestamp":1475177286000},"page":"8-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Differential modulation of zoledronate and etidronate in osseous healing of an extracted socket and tibia defect"],"prefix":"10.1016","volume":"123","author":[{"given":"Shin Saeng","family":"Lim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beomseok","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Sook","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Jung","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.oooo.2016.08.009_bib1","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1016\/S0140-6736(02)08827-X","article-title":"Treatment of postmenopausal osteoporosis","volume":"359","author":"Delmas","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.oooo.2016.08.009_bib2","first-page":"225","article-title":"Mechanisms of action of antiresorptive therapies of postmenopausal osteoporosis","volume":"37","author":"Stepan","year":"2003","journal-title":"Endocr Regul"},{"key":"10.1016\/j.oooo.2016.08.009_bib3","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3816\/CLM.2008.n.013","article-title":"Osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates: Definition and management of the risk related to zoledronic acid","volume":"8","author":"Cafro","year":"2008","journal-title":"Clin Lymphoma Myeloma"},{"key":"10.1016\/j.oooo.2016.08.009_bib4","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1359\/jbmr.0707onj","article-title":"Bisphosphonate-associated osteonecrosis of the jaw: Report of a task force of the American Society for Bone and Mineral Research","volume":"22","author":"Khosla","year":"2007","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.oooo.2016.08.009_bib5","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1093\/jnci\/94.19.1458","article-title":"A\u00a0randomized, placebo-controlled trial of zoledronic acid in patients with hormone-refractory metastatic prostate carcinoma","volume":"94","author":"Saad","year":"2002","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.oooo.2016.08.009_bib6","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1359\/jbmr.1998.13.4.581","article-title":"Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras","volume":"13","author":"Luckman","year":"1998","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.oooo.2016.08.009_bib7","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s00210-010-0596-4","article-title":"Zoledronic acid inhibits RANK expression and migration of osteoclast precursors during osteoclastogenesis","volume":"383","author":"Kimachi","year":"2011","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.oooo.2016.08.009_bib8","first-page":"3917","article-title":"Incidence of bisphosphonate-related osteonecrosis of the jaw in consideration of primary diseases and concomitant therapies","volume":"33","author":"Assaf","year":"2013","journal-title":"Anticancer Res"},{"key":"10.1016\/j.oooo.2016.08.009_bib9","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","article-title":"Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: A growing epidemic","volume":"61","author":"Marx","year":"2003","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2016.08.009_bib10","doi-asserted-by":"crossref","first-page":"e22","DOI":"10.4317\/jced.51213","article-title":"Prognosis factors in the treatment of bisphosphonate-related osteonecrosis of the jaw","volume":"6","author":"Yoshiga","year":"2014","journal-title":"J\u00a0Clin Exp Dent"},{"key":"10.1016\/j.oooo.2016.08.009_bib11","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nrrheum.2011.181","article-title":"Epidemiology and pathogenesis of osteonecrosis of the jaw","volume":"8","author":"Reid","year":"2012","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.oooo.2016.08.009_bib12","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/S1470-2045(06)70726-4","article-title":"Bisphosphonate-associated osteonecrosis: A long-term complication of bisphosphonate treatment","volume":"7","author":"Migliorati","year":"2006","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.oooo.2016.08.009_bib13","doi-asserted-by":"crossref","first-page":"753","DOI":"10.7326\/0003-4819-144-10-200605160-00009","article-title":"Narrative [corrected] review: Bisphosphonates and osteonecrosis of the jaws","volume":"144","author":"Woo","year":"2006","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.oooo.2016.08.009_bib14","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/jbmr.2693","article-title":"Osteonecrosis of the Jaw in the United States Food and Drug Administration's Adverse Event Reporting System (FAERS)","volume":"31","author":"Zhang","year":"2016","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.oooo.2016.08.009_bib15","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.joms.2008.01.038","article-title":"Mandible matrix necrosis in beagle dogs after 3 years of daily oral bisphosphonate treatment","volume":"66","author":"Allen","year":"2008","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2016.08.009_bib16","first-page":"2","article-title":"American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws\u20142009 update","volume":"67","author":"Ruggiero","year":"2009","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2016.08.009_bib17","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1056\/NEJMoa067312","article-title":"Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis","volume":"356","author":"Black","year":"2007","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.oooo.2016.08.009_bib18","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1834-7819.2010.01283.x","article-title":"A\u00a0review of the clinical implications of bisphosphonates in dentistry","volume":"56","author":"Borromeo","year":"2011","journal-title":"Aust Dent J"},{"key":"10.1016\/j.oooo.2016.08.009_bib19","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00223-005-0289-z","article-title":"Calvarial osteoclasts express a higher level of tartrate-resistant acid phosphatase than long bone osteoclasts and activation does not depend on cathepsin K or L activity","volume":"79","author":"Perez-Amodio","year":"2006","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.oooo.2016.08.009_bib20","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.bone.2008.05.009","article-title":"Differences in matrix composition between calvaria and long bone in mice suggest differences in biomechanical properties and resorption: Special emphasis on collagen","volume":"43","author":"van den Bos","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.oooo.2016.08.009_bib21","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1359\/jbmr.080205","article-title":"Frequency and risk factors associated with osteonecrosis of the jaw in cancer patients treated with intravenous bisphosphonates","volume":"23","author":"Hoff","year":"2008","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.oooo.2016.08.009_bib22","first-page":"5161","article-title":"A\u00a0novel model of bisphosphonate-related osteonecrosis of the jaw in rats","volume":"8","author":"Yang","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1016\/j.oooo.2016.08.009_bib23","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00774-010-0162-7","volume":"28","author":"Yoneda","year":"2010","journal-title":"J\u00a0Bone Miner Metab"},{"key":"10.1016\/j.oooo.2016.08.009_bib24","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1242\/dev.117.2.409","article-title":"The triple origin of skull in higher vertebrates: A study in quail-chick chimeras","volume":"117","author":"Couly","year":"1993","journal-title":"Development"},{"key":"10.1016\/j.oooo.2016.08.009_bib25","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1007\/s00198-013-2570-8","article-title":"Early effects of parathyroid hormone on bisphosphonate\/steroid-associated compromised osseous wound healing","volume":"25","author":"Kuroshima","year":"2014","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.oooo.2016.08.009_bib26","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.oraloncology.2008.04.013","article-title":"Bony changes in the jaws of rats treated with zoledronic acid and dexamethasone before dental extractions mimic bisphosphonate-related osteonecrosis in cancer patients","volume":"45","author":"Sonis","year":"2009","journal-title":"Oral Oncol"},{"key":"10.1016\/j.oooo.2016.08.009_bib27","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1016\/j.ajpath.2014.07.010","article-title":"Impaired bone resorption and woven bone formation are associated with development of osteonecrosis of jaw-like lesions by bisphosphonate and anti-receptor activator of NF-kappaB ligand antibody in mice","volume":"184","author":"Williams","year":"2014","journal-title":"Am J Pathol"},{"key":"10.1016\/j.oooo.2016.08.009_bib28","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1359\/jbmr.071031","article-title":"Risedronate reduces osteoclast precursors and cytokine production in postmenopausal osteoporotic women","volume":"23","author":"D'Amelio","year":"2008","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.oooo.2016.08.009_bib29","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1146\/annurev-pathol-011110-130203","article-title":"Disorders of bone remodeling","volume":"6","author":"Feng","year":"2011","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.oooo.2016.08.009_bib30","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1177\/10454411980090020401","article-title":"Is all bone the same? Distinctive distributions and properties of non-collagenous matrix proteins in lamellar vs. woven bone imply the existence of different underlying osteogenic mechanisms","volume":"9","author":"Gorski","year":"1998","journal-title":"Crit Rev Oral Biol Med"},{"key":"10.1016\/j.oooo.2016.08.009_bib31","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.semcdb.2008.07.004","article-title":"Bone remodeling during fracture repair: The cellular picture","volume":"19","author":"Schindeler","year":"2008","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.oooo.2016.08.009_bib32","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1749-799X-9-45","article-title":"Do bisphosphonates affect bone healing? A meta-analysis of randomized controlled trials","volume":"9","author":"Xue","year":"2014","journal-title":"J\u00a0Orthop Surg Res"},{"key":"10.1016\/j.oooo.2016.08.009_bib33","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/0003-9969(75)90059-X","article-title":"An ultrastructural study of the relationship of oral bacteria to the epithelium of healing tooth extraction wounds","volume":"20","author":"McMillan","year":"1975","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.oooo.2016.08.009_bib34","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.ijom.2013.02.007","article-title":"Prevention of osteonecrosis of the jaw by mucoperiosteal coverage in a rat model","volume":"42","author":"Abtahi","year":"2013","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2016.08.009_bib35","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1046\/j.1365-2141.1999.01774.x","article-title":"A\u00a0time kinetic study of the effect of aminobisphosphonate on murine haemopoiesis","volume":"107","author":"Nakamura","year":"1999","journal-title":"Br J Haematol"},{"key":"10.1016\/j.oooo.2016.08.009_bib36","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.joms.2009.08.027","article-title":"Inhibition of necrotic actions of nitrogen-containing bisphosphonates (NBPs) and their elimination from bone by etidronate (a non-NBP): A proposal for possible utilization of etidronate as a substitution drug for NBPs","volume":"68","author":"Oizumi","year":"2010","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2016.08.009_bib37","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.archoralbio.2012.11.010","article-title":"In\u00a0vitro cytotoxicity of zoledronate (nitrogen-containing bisphosphonate: NBP) and\/or etidronate (non-NBP) in tumour cells and periodontal cells","volume":"58","author":"Tanaka","year":"2013","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.oooo.2016.08.009_bib38","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1007\/s00520-009-0710-7","article-title":"A\u00a0novel bioassay model to determine clinically significant bisphosphonate levels","volume":"17","author":"Scheper","year":"2009","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.oooo.2016.08.009_bib39","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1600-0773.1990.tb00750.x","article-title":"Comparison of the distribution of three bisphosphonates in mice","volume":"66","author":"Monkkonen","year":"1990","journal-title":"Pharmacol Toxicol"}],"container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440316302942?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440316302942?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T22:25:43Z","timestamp":1658183143000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212440316302942"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S2212440316302942"],"URL":"https:\/\/doi.org\/10.1016\/j.oooo.2016.08.009","relation":{},"ISSN":["2212-4403"],"issn-type":[{"value":"2212-4403","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential modulation of zoledronate and etidronate in osseous healing of an extracted socket and tibia defect","name":"articletitle","label":"Article Title"},{"value":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oooo.2016.08.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}