{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T14:25:17Z","timestamp":1770906317299,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31570989"],"award-info":[{"award-number":["31570989"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY15 H140002"],"award-info":[{"award-number":["LY15 H140002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oooojournal.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.oooo.2018.03.005","type":"journal-article","created":{"date-parts":[[2018,3,21]],"date-time":"2018-03-21T19:44:55Z","timestamp":1521661495000},"page":"165-173","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Evaluation of the diagnostic value of immunoglobulin clonal gene rearrangements in patients with parotid gland MALT lymphoma using BIOMED-2 protocol"],"prefix":"10.1016","volume":"126","author":[{"given":"Yamin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chongshang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hangfei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiafei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaxiong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiyong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.oooo.2018.03.005_bib0010","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1002\/1097-0142(19831015)52:8<1410::AID-CNCR2820520813>3.0.CO;2-3","article-title":"Malignant lymphoma of mucosa-associated lymphoid tissue. A distinctive type of B-cell lymphoma","volume":"52","author":"Isaacson","year":"1983","journal-title":"Cancer"},{"key":"10.1016\/j.oooo.2018.03.005_bib0015","first-page":"139","article-title":"Mucosa-associated lymphoid tissue lymphoma","volume":"36","author":"Isaacson","year":"1999","journal-title":"Semin Hematol"},{"key":"10.1016\/j.oooo.2018.03.005_bib0020","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1177\/2040620712453595","article-title":"Marginal zone lymphoma: old, new, targeted, and epigenetic therapies","volume":"3","author":"Joshi","year":"2012","journal-title":"Ther Adv Hematol"},{"key":"10.1016\/j.oooo.2018.03.005_bib0025","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1093\/annonc\/mdp395","article-title":"Significant efficacy of 2-CdA with or without rituximab in the treatment of splenic marginal zone lymphoma (SMZL)","volume":"21","author":"Cervetti","year":"2010","journal-title":"Ann Oncol"},{"key":"10.1016\/j.oooo.2018.03.005_bib0030","doi-asserted-by":"crossref","first-page":"5019","DOI":"10.1182\/blood-2011-01-293050","article-title":"The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications","volume":"117","author":"Campo","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.oooo.2018.03.005_bib0035","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.1182\/blood-2005-09-3679","article-title":"Infection-associated lymphomas derived from marginal zone B cells: a model of antigen-driven lymphoproliferation","volume":"107","author":"Suarez","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.oooo.2018.03.005_bib0040","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1023\/A:1008313229892","article-title":"Primary extranodal non-Hodgkin's lymphomas. Part 2: Head and neck, central nervous system and other less common sites","volume":"10","author":"Zucca","year":"1999","journal-title":"Ann Oncol"},{"key":"10.1016\/j.oooo.2018.03.005_bib0045","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/art.24150","article-title":"Systems biology analysis of Sjogren's syndrome and mucosa-associated lymphoid tissue lymphoma in parotid glands","volume":"60","author":"Hu","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.oooo.2018.03.005_bib0050","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1309\/AJCP0HT6ZGSZKNFT","article-title":"Clonal relationship of extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue involving different sites","volume":"134","author":"Konoplev","year":"2010","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.oooo.2018.03.005_bib0055","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.oraloncology.2007.01.016","article-title":"Clinical analysis of salivary gland tumor cases in West China in past 50 years","volume":"44","author":"Li","year":"2008","journal-title":"Oral Oncol"},{"key":"10.1016\/j.oooo.2018.03.005_bib0060","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/hed.23543","article-title":"Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue of the salivary glands: a population-based study from 1994 to 2009","volume":"37","author":"Vazquez","year":"2015","journal-title":"Head Neck"},{"key":"10.1016\/j.oooo.2018.03.005_bib0065","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1038\/leu.2012.246","article-title":"EuroClonality\/BIOMED-2 guidelines for interpretation and reporting of Ig\/TCR clonality testing in suspected lymphoproliferations","volume":"26","author":"Langerak","year":"2012","journal-title":"Leukemia"},{"key":"10.1016\/j.oooo.2018.03.005_bib0070","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/modpathol.3800758","article-title":"Immunoglobulin VH gene analysis in gastric MALT lymphomas","volume":"20","author":"Sakuma","year":"2007","journal-title":"Mod Pathol"},{"key":"10.1016\/j.oooo.2018.03.005_bib0075","doi-asserted-by":"crossref","first-page":"5727","DOI":"10.3748\/wjg.v19.i34.5727","article-title":"Clonal immunoglobulin heavy chain and T-cell receptor gamma gene rearrangements in primary gastric lymphoma","volume":"19","author":"Shan","year":"2013","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.oooo.2018.03.005_bib0080","doi-asserted-by":"crossref","first-page":"77009","DOI":"10.18632\/oncotarget.20330","article-title":"The value of detecting immunoglobulin gene rearrangements in the diagnosis of B-cell lymphoma","volume":"8","author":"Lu","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.oooo.2018.03.005_bib0085","first-page":"495","article-title":"Significance of BIOMED-2 standardized IG\/TCR gene rearrangement detection in paraffin-embedded section in lymphoma diagnosis","volume":"35","author":"Ai","year":"2014","journal-title":"Zhonghua Xue Ye Xue Za Zhi"},{"key":"10.1016\/j.oooo.2018.03.005_bib0090","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1111\/apm.12250","article-title":"Application of the BIOMED-2 standardized primer system for the diagnosis of primary gastric B-cell non-Hodgkin's lymphoma","volume":"122","author":"Jia","year":"2014","journal-title":"APMIS"},{"key":"10.1016\/j.oooo.2018.03.005_bib0095","doi-asserted-by":"crossref","first-page":"953","DOI":"10.3892\/ijo.2014.2790","article-title":"Diagnostic value of immunoglobulin \u03ba light chain gene rearrangement analysis in B-cell lymphomas","volume":"46","author":"Kokovic","year":"2015","journal-title":"Int J Oncol"},{"key":"10.1016\/j.oooo.2018.03.005_bib0100","series-title":"Encyclopedia of Cancer","first-page":"169","article-title":"Ann Arbor Staging System","author":"Schwab","year":"2009"},{"key":"10.1016\/j.oooo.2018.03.005_bib0105","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/jso.20901","article-title":"Primary non-Hodgkins lymphomas of the major salivary glands","volume":"97","author":"Roh","year":"2008","journal-title":"J Surg Oncol"},{"key":"10.1016\/j.oooo.2018.03.005_bib0110","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ijrobp.2010.09.046","article-title":"Primary mucosa-associated lymphoid tissue lymphoma of the salivary glands: a multicenter Rare Cancer Network study","volume":"82","author":"Anacak","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.oooo.2018.03.005_bib0115","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1038\/sj.leu.2403202","article-title":"Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936","volume":"17","author":"Van Dongen","year":"2003","journal-title":"Leukemia"},{"key":"10.1016\/j.oooo.2018.03.005_bib0120","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/0167-5699(92)90043-7","article-title":"VDJ recombination","volume":"13","author":"Alt","year":"1992","journal-title":"Immunol Today"},{"key":"10.1016\/j.oooo.2018.03.005_bib0125","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1182\/blood-2007-02-069625","article-title":"Immunoglobulin gene rearrangements and the pathogenesis of multiple myeloma","volume":"110","author":"Gonzalez","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.oooo.2018.03.005_bib0130","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/sj.leu.2404479","article-title":"Significantly improved PCR-based clonality testing in B-cell malignancies by use of multiple immunoglobulin gene targets. Report of the BIOMED-2 Concerted Action BHM4-CT98-3936","volume":"21","author":"Evans","year":"2007","journal-title":"Leukemia"},{"key":"10.1016\/j.oooo.2018.03.005_bib0135","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1007\/s12094-014-1188-4","article-title":"Diagnostic usefulness of immunoglobulin light chains (Ig\u03ba, Ig\u03bb) and incomplete IGH D-J clonal gene rearrangements in patients with B-cell non-Hodgkin lymphomas using BIOMED-2 protocol","volume":"16","author":"Ghorbian","year":"2014","journal-title":"Clin Transl Oncol"},{"key":"10.1016\/j.oooo.2018.03.005_bib0140","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1136\/jcp.2006.038984","article-title":"Improved clonality assessment in germinal centre\/post-germinal centre non-Hodgkin's lymphomas with high rates of somatic hypermutation","volume":"60","author":"Catherwood","year":"2007","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.oooo.2018.03.005_bib0145","first-page":"43","article-title":"Detection of immunoglobulin IGH gene rearrangements on formalin-fixed, paraffin embedded tissue in lymphoid malignancies","volume":"60","author":"Moharrami","year":"2014","journal-title":"Cell Mol Biol (Noisy-Le-Grand)"},{"key":"10.1016\/j.oooo.2018.03.005_bib0150","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1080\/10428190701493894","article-title":"A limited number of IgH-primers binding to framework region 1 is sufficient to detect the majority of mature small B-cell non-Hodgkin lymphomas on formalin-fixed paraffin-embedded tissue by PCR","volume":"48","author":"Nelson","year":"2007","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.oooo.2018.03.005_bib0155","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.5858\/arpa.2012-0666-OA","article-title":"The utility of the BIOMED-2 primers in the detection of 2 clonal, B-lymphoproliferative disorders simultaneously involving the same site","volume":"137","author":"Ly","year":"2013","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.oooo.2018.03.005_bib0160","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1007\/s12094-014-1188-4","article-title":"Evaluation diagnostic usefulness of immunoglobulin light chains (Ig-\u03ba, Ig-\u03bb) and incomplete IGH D-J clonal gene rearrangements in patients with B-cell non-Hodgkin lymphomas using BIOMED-2 protocol","volume":"16","author":"Ghorbian","year":"2014","journal-title":"Clin Transl Oncol"},{"key":"10.1016\/j.oooo.2018.03.005_bib0165","doi-asserted-by":"crossref","first-page":"951","DOI":"10.7754\/Clin.Lab.2015.141139","article-title":"Molecular analysis of IGH and incomplete IGH D-J clonality gene rearrangements in Hodgkin lymphoma malignancies","volume":"61","author":"Ghorbian","year":"2015","journal-title":"Clin Lab"},{"key":"10.1016\/j.oooo.2018.03.005_bib0170","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s12308-012-0138-8","article-title":"Considerations for the use of formalin-fixed and paraffin-embedded tissue specimens for clonality analysis","volume":"5","author":"Lenze","year":"2012","journal-title":"J Hematopathol"},{"key":"10.1016\/j.oooo.2018.03.005_bib0175","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S1525-1578(10)60685-X","article-title":"Immunoglobulin heavy chain gene analysis in lymphomas: a multi-center study demonstrating the heterogeneity of performance of polymerase chain reaction assays","volume":"4","author":"Bagg","year":"2002","journal-title":"J Mol Diagn"},{"key":"10.1016\/j.oooo.2018.03.005_bib0180","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/pin.12566","article-title":"Improved clonality detection in B-cell lymphoma using a semi-nested modification of the BIOMED-2 PCR assay for IGH rearrangement: a paraffin-embedded tissue study","volume":"67","author":"Sakamoto","year":"2017","journal-title":"Pathol Int"},{"key":"10.1016\/j.oooo.2018.03.005_bib0185","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1136\/annrheumdis-2013-203305","article-title":"Primary Sj\u00f6gren's syndrome and malignancy risk: a systematic review and meta-analysis","volume":"73","author":"Liang","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.oooo.2018.03.005_bib0190","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/00004728-200307000-00011","article-title":"Clinical and imaging findings of lymphoma in patients with Sj\u00f6gren syndrome","volume":"27","author":"Tonami","year":"2003","journal-title":"J Comput Assist Tomogr"},{"key":"10.1016\/j.oooo.2018.03.005_bib0195","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/j.ijom.2016.08.016","article-title":"Lymphoepithelial infiltrate of palatal minor salivary glands: implications for diagnostic work-up","volume":"45","author":"Medeiros","year":"2016","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2018.03.005_bib0200","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00428-003-0824-0","article-title":"Vascular endothelial cell participation in formation of lymphoepithelial lesions (epi-myoepithelial islands) in lymphoepithelial sialadenitis (benign lymphoepithelial lesion)","volume":"443","author":"Metwaly","year":"2003","journal-title":"Virchows Arch"},{"key":"10.1016\/j.oooo.2018.03.005_bib0205","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1182\/asheducation-2005.1.307","article-title":"Clinical presentation and management of marginal zone lymphomas","volume":"2005","author":"Thieblemont","year":"2005","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.oooo.2018.03.005_bib0210","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1748-717X-8-2","article-title":"Radiotherapy in marginal zone lymphoma","volume":"8","author":"Deinbeck","year":"2013","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.oooo.2018.03.005_bib0215","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.1002\/cncr.25226","article-title":"Long-term outcome in localized extranodal mucosa-associated lymphoid tissue lymphomas treated with radiotherapy","volume":"116","author":"Goda","year":"2010","journal-title":"Cancer"},{"key":"10.1016\/j.oooo.2018.03.005_bib0220","doi-asserted-by":"crossref","DOI":"10.1155\/2009\/424935","article-title":"Controversies on rituximab therapy in Sjogren syndrome-associated lymphoproliferation","volume":"2009","author":"Quartuccio","year":"2009","journal-title":"Int J Rheumatol"},{"key":"10.1016\/j.oooo.2018.03.005_bib0225","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00277-013-1865-3","article-title":"Rituximab plus bendamustine is active in pretreated patients with extragastric marginal zone B cell lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma)","volume":"93","author":"Kiesewetter","year":"2014","journal-title":"Ann Hematol"},{"key":"10.1016\/j.oooo.2018.03.005_bib0230","doi-asserted-by":"crossref","first-page":"903","DOI":"10.4103\/0973-1482.157345","article-title":"Novel diagnostic biomarker for patients with non-Hodgkin's lymphoma by IgH gene rearrangement","volume":"12","author":"Bo","year":"2016","journal-title":"J Cancer Res Ther"}],"container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440318308435?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440318308435?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T22:01:00Z","timestamp":1761948060000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212440318308435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S2212440318308435"],"URL":"https:\/\/doi.org\/10.1016\/j.oooo.2018.03.005","relation":{},"ISSN":["2212-4403"],"issn-type":[{"value":"2212-4403","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of the diagnostic value of immunoglobulin clonal gene rearrangements in patients with parotid gland MALT lymphoma using BIOMED-2 protocol","name":"articletitle","label":"Article Title"},{"value":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oooo.2018.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}