{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:16:55Z","timestamp":1792689415712,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oooojournal.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.oooo.2019.08.004","type":"journal-article","created":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T02:11:40Z","timestamp":1565748700000},"page":"491-497.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Systematic review of the use of pentoxifylline and tocopherol for the treatment of medication-related osteonecrosis of the jaw"],"prefix":"10.1016","volume":"128","author":[{"given":"Jiean Joseph","family":"Heifetz-Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samer","family":"Abdelsamie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conor B.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5415-1718","authenticated-orcid":false,"given":"Stephanie","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen F.","family":"Fielding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0471-4065","authenticated-orcid":false,"given":"Joseph P.","family":"Mulligan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.oooo.2019.08.004_bib0001","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","article-title":"Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic","volume":"61","author":"Marx","year":"2003","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2019.08.004_bib0002","first-page":"1793","article-title":"Denosumab and anti-angiogenetic drug-related osteonecrosis of the jaw: an uncommon but potentially severe disease","volume":"33","author":"Sivolella","year":"2013","journal-title":"Anticancer Res"},{"key":"10.1016\/j.oooo.2019.08.004_bib0003","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s10006-012-0379-9","article-title":"Osteonecrosis of the mandible due to anti-angiogenic agent, bevacizumab","volume":"17","author":"Pakosch","year":"2013","journal-title":"Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2019.08.004_bib0004","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.joms.2014.04.031","article-title":"American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw\u20142014 update","volume":"72","author":"Ruggiero","year":"2014","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2019.08.004_bib0005","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.oraloncology.2014.08.016","article-title":"A systematic review of therapeutical approaches in bisphosphonates-related osteonecrosis of the jaw (BRONJ)","volume":"50","author":"Rupel","year":"2014","journal-title":"Oral Oncol"},{"key":"10.1016\/j.oooo.2019.08.004_bib0006","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.ijom.2015.01.026","article-title":"Treatment strategies and outcomes of bisphosphonate-related osteonecrosis of the jaw (BRONJ) with characterization of patients: a systematic review","volume":"44","author":"Fliefel","year":"2015","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2019.08.004_bib0007","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.oooo.2012.05.017","article-title":"Intravenous bisphosphonate\u2013related osteonecrosis of the jaw: long-term follow-up of 109 patients","volume":"115","author":"Watters","year":"2013","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1016\/j.oooo.2019.08.004_bib0008","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.oooo.2018.09.008","article-title":"Medication-related osteonecrosis of the jaw: definition and best practice for prevention, diagnosis, and treatment","volume":"127","author":"Nicolatou-Galitis","year":"2019","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1016\/j.oooo.2019.08.004_bib0009","first-page":"e195","article-title":"Medication-related osteonecrosis of the jaw associated with implant and regenerative treatments: systematic review","volume":"24","author":"Granate-Marques","year":"2019","journal-title":"Med Oral Patol Oral Cirugia Bucal"},{"key":"10.1016\/j.oooo.2019.08.004_bib0010","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.5037\/jomr.2018.9302","article-title":"Dental implant placement in patients on bisphosphonate therapy: a systematic review","volume":"9","author":"Gelazius","year":"2018","journal-title":"J Oral Maxillofac Res"},{"key":"10.1016\/j.oooo.2019.08.004_bib0011","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.oooo.2015.08.007","article-title":"Periodontal disease preceding osteonecrosis of the jaw (ONJ) in cancer patients receiving antiresorptives alone or combined with targeted therapies: report of 5 cases and literature review","volume":"120","author":"Nicolatou-Galitis","year":"2015","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1016\/j.oooo.2019.08.004_bib0012","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.14219\/jada.archive.2011.0108","article-title":"Managing the care of patients receiving antiresorptive therapy for prevention and treatment of osteoporosis","volume":"142","author":"Hellstein","year":"2011","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.oooo.2019.08.004_bib0013","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1248\/bpb.b16-01020","article-title":"Underlying mechanisms and therapeutic strategies for bisphosphonate-related osteonecrosis of the jaw (BRONJ)","volume":"40","author":"Endo","year":"2017","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.oooo.2019.08.004_bib0014","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1007\/s11914-018-0474-4","article-title":"Current understanding of the pathophysiology of osteonecrosis of the jaw","volume":"16","author":"Chang","year":"2018","journal-title":"Curr Osteoporos Rep"},{"key":"10.1016\/j.oooo.2019.08.004_bib0015","article-title":"Interventions for managing medication-related osteonecrosis of the jaw","volume":"10","author":"Beth-Tasdogan","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.oooo.2019.08.004_bib0016","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.joms.2005.07.010","article-title":"Bisphosphonate-induced exposed bone (osteonecrosis\/osteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment","volume":"63","author":"Marx","year":"2005","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2019.08.004_bib0017","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1111\/odi.12333","article-title":"Management of bisphosphonate-related osteonecrosis of the jaw: a literature review","volume":"21","author":"Spanou","year":"2015","journal-title":"Oral Dis"},{"key":"10.1016\/j.oooo.2019.08.004_bib0018","doi-asserted-by":"crossref","first-page":"e320","DOI":"10.4317\/medoral.19458","article-title":"Alternative treatments for oral bisphosphonate-related osteonecrosis of the jaws: a pilot study comparing fibrin rich in growth factors and teriparatide","volume":"19","author":"Pelaz","year":"2014","journal-title":"Med Oral Patol Oral Cirugia Bucal"},{"key":"10.1016\/j.oooo.2019.08.004_bib0019","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/j.ijom.2012.04.020","article-title":"Use of platelet-rich plasma in the treatment of bisphosphonate-related osteonecrosis of the jaw","volume":"41","author":"Bocanegra-P\u00e9rez","year":"2012","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2019.08.004_bib0020","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1016\/j.joms.2011.02.078","article-title":"Bisphosphonate-related osteonecrosis of the jaws\u2013an initial case series report of treatment combining partial bone resection and autologous platelet-rich plasma","volume":"69","author":"Curi","year":"2011","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2019.08.004_bib0021","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3390\/dj4040041","article-title":"Role of teriparatide in medication-related osteonecrosis of the jaws (MRONJ)","volume":"4","author":"Kwon","year":"2016","journal-title":"Dent J"},{"key":"10.1016\/j.oooo.2019.08.004_bib0022","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/odi.12489","article-title":"Hyperbaric oxygen therapy and osteonecrosis","volume":"23","author":"Ceponis","year":"2017","journal-title":"Oral Dis"},{"key":"10.1016\/j.oooo.2019.08.004_bib0023","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/j.joms.2007.03.019","article-title":"Hyperbaric oxygen treatment and bisphosphonate-induced osteonecrosis of the jaw: a case series","volume":"65","author":"Freiberger","year":"2007","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2019.08.004_bib0024","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.oooo.2018.02.004","article-title":"Pentoxifylline, tocopherol, and clodronate for the treatment of mandibular osteoradionecrosis: a systematic review","volume":"125","author":"Martos-Fern\u00e1ndez","year":"2018","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1016\/j.oooo.2019.08.004_bib0025","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/hed.20121","article-title":"Major healing of refractory mandible osteoradionecrosis after treatment combining pentoxifylline and tocopherol: a phase II trial","volume":"27","author":"Delanian","year":"2005","journal-title":"Head Neck"},{"key":"10.1016\/j.oooo.2019.08.004_bib0026","doi-asserted-by":"crossref","first-page":"8570","DOI":"10.1200\/JCO.2005.02.4729","article-title":"Kinetics of response to long-term treatment combining pentoxifylline and tocopherol in patients with superficial radiation-induced fibrosis","volume":"23","author":"Delanian","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.oooo.2019.08.004_bib0027","doi-asserted-by":"crossref","DOI":"10.1136\/openhrt-2015-000365","article-title":"Pentoxifylline for vascular health: a brief review of the literature","volume":"3","author":"McCarty","year":"2016","journal-title":"Open Heart"},{"key":"10.1016\/j.oooo.2019.08.004_bib0028","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.freeradbiomed.2014.03.035","article-title":"Natural forms of vitamin E: metabolism, antioxidant, and anti-inflammatory activities and their role in disease prevention and therapy","volume":"72","author":"Jiang","year":"2014","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.oooo.2019.08.004_bib0029","doi-asserted-by":"crossref","first-page":"g7647","DOI":"10.1136\/bmj.g7647","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: Elaboration and explanation","volume":"349","author":"Shamseer","year":"2015","journal-title":"BMJ"},{"key":"10.1016\/j.oooo.2019.08.004_bib0030","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.joms.2013.06.188","article-title":"Pentoxifylline and tocopherol in the treatment of yearly zoledronic acid\u2013related osteonecrosis of the jaw in a corticosteroid-induced osteoporosis","volume":"72","author":"Magremanne","year":"2014","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2019.08.004_bib0031","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.oooo.2016.06.019","article-title":"Pentoxifylline and tocopherol in the management of cancer patients with medication-related osteonecrosis of the jaw: an observational retrospective study of initial case series","volume":"122","author":"Owosho","year":"2016","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1016\/j.oooo.2019.08.004_bib0032","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.tripleo.2010.05.067","article-title":"Management of bisphosphonate-associated osteonecrosis: pentoxifylline and tocopherol in addition to antimicrobial therapy. An initial case series","volume":"110","author":"Epstein","year":"2010","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.oooo.2019.08.004_bib0033","first-page":"S41","article-title":"Medical treatment of bisphosphonate-related osteonecrosis of the jaws (BRONJ) and fast track referral system","volume":"49","author":"Cheng","year":"2011","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2019.08.004_bib0034","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ijom.2017.02.513","article-title":"Bisphosphonate-related osteonecrosis of the jaws: our experience in up to 120 cases","volume":"46","author":"Ribeiro da Silva","year":"2017","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2019.08.004_bib0035","unstructured":"Pentoxifylline and tocopherol (PENTO) in the treatment of medication-related osteonecrosis of the jaw (MRONJ). Full Text View. ClinicalTrials.gov. Available at: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03040778. Accessed May 18, 2019."},{"key":"10.1016\/j.oooo.2019.08.004_bib0036","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.joms.2012.04.001","article-title":"What is the role of hyperbaric oxygen in the management of bisphosphonate-related osteonecrosis of the jaw: a randomized controlled trial of hyperbaric oxygen as an adjunct to surgery and antibiotics","volume":"70","author":"Freiberger","year":"2012","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2019.08.004_bib0037","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1007\/s00198-014-2622-8","article-title":"Distinctive role of 6-month teriparatide treatment on intractable bisphosphonate-related osteonecrosis of the jaw","volume":"25","author":"Kim","year":"2014","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.oooo.2019.08.004_bib0038","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s00198-012-1918-9","article-title":"Lack of response to teriparatide therapy for bisphosphonate-associated osteonecrosis of the jaw","volume":"24","author":"Narv\u00e1ez","year":"2013","journal-title":"Osteoporos Int"}],"container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440319313811?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440319313811?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T22:03:55Z","timestamp":1761948235000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212440319313811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["S2212440319313811"],"URL":"https:\/\/doi.org\/10.1016\/j.oooo.2019.08.004","relation":{},"ISSN":["2212-4403"],"issn-type":[{"value":"2212-4403","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systematic review of the use of pentoxifylline and tocopherol for the treatment of medication-related osteonecrosis of the jaw","name":"articletitle","label":"Article Title"},{"value":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oooo.2019.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}