{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T02:05:09Z","timestamp":1780452309744,"version":"3.54.1"},"reference-count":55,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oooojournal.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.oooo.2019.10.008","type":"journal-article","created":{"date-parts":[[2020,2,23]],"date-time":"2020-02-23T23:40:26Z","timestamp":1582501226000},"page":"e257-e263","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Replacing one evil with another: Is the fibula really a dispensable spare part available for transfer in patients with medication-related osteonecrosis of the jaws?"],"prefix":"10.1016","volume":"129","author":[{"given":"Jan-Dirk","family":"Raguse","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrej","family":"Trampuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Sanchez","family":"Boehm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Nahles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedicta","family":"Beck-Broichsitter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4987-2913","authenticated-orcid":false,"given":"Max","family":"Heiland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5477-623X","authenticated-orcid":false,"given":"Norbert","family":"Neckel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.oooo.2019.10.008_bib0001","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s10006-012-0376-z","article-title":"The phosphorous necrosis of the jaws and what can we learn from the past: a comparison of \u201cphossy\u201d and \u201cbisphossy\u201d jaw","volume":"18","author":"Jacobsen","year":"2014","journal-title":"Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2019.10.008_bib0002","series-title":"Oesterreichisch Medizinisches Jahrbuch German","first-page":"257","article-title":"Nekrose der Kieferknochen in Folge der Einwirkung von Phosphord\u00e4mpfen","author":"Lorinser","year":"1845"},{"key":"10.1016\/j.oooo.2019.10.008_bib0003","article-title":"Interventions for managing medication-related osteonecrosis of the jaw","volume":"10","author":"Beth-Tasdogan","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.oooo.2019.10.008_bib0004","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","article-title":"Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic","volume":"61","author":"Marx","year":"2003","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2019.10.008_bib0005","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1248\/bpb.b16-01020","article-title":"Underlying mechanisms and therapeutic strategies for bisphosphonate-related osteonecrosis of the jaw (BRONJ)","volume":"40","author":"Endo","year":"2017","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.oooo.2019.10.008_bib0006","doi-asserted-by":"crossref","first-page":"4253","DOI":"10.1200\/JCO.2003.99.132","article-title":"Bisphosphanates and oral cavity avascular bone necrosis","volume":"21","author":"Migliorati","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.oooo.2019.10.008_bib0007","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.ijom.2015.01.026","article-title":"Treatment strategies and outcomes of bisphosphonate-related osteonecrosis of the jaw (BRONJ) with characterization of patients: a systematic review","volume":"44","author":"Fliefel","year":"2015","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2019.10.008_bib0008","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1016\/j.joms.2007.11.006","article-title":"Uncovering the cause of \u201cphossy jaw\u201d Circa 1858 to 1906: oral and maxillofacial surgery closed case files-case closed","volume":"66","author":"Marx","year":"2008","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2019.10.008_bib0009","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/8768162","article-title":"Medication-related osteonecrosis of the jaw: new insights into molecular mechanisms and cellular therapeutic approaches","volume":"2016","author":"Lombard","year":"2016","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.oooo.2019.10.008_bib0010","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0022-3565(24)38786-5","article-title":"Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates","volume":"296","author":"Dunford","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.oooo.2019.10.008_bib0011","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.joms.2014.04.031","article-title":"American association of oral and maxillofacial surgeons position paper on medication-related osteonecrosis of the jaw\u20142014 update","volume":"72","author":"Ruggiero","year":"2014","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2019.10.008_bib0012","first-page":"20","article-title":"Osteonecrosis of the jaw related to everolimus and bisphosphonate: a unique case report","volume":"4","author":"Giancola","year":"2013","journal-title":"Ann Stomatol (Roma)"},{"key":"10.1016\/j.oooo.2019.10.008_bib0013","doi-asserted-by":"crossref","first-page":"e302","DOI":"10.1016\/j.bjoms.2013.09.008","article-title":"Osteonecrosis of the jaw related to everolimus: a case report","volume":"51","author":"Kim","year":"2013","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2019.10.008_bib0014","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.3346\/jkms.2018.33.e38","article-title":"Incidence rate of atypical femoral fracture after bisphosphonates treatment in Korea","volume":"33","author":"Lee","year":"2018","journal-title":"J Korean Med Sci"},{"key":"10.1016\/j.oooo.2019.10.008_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.joms.2009.03.001","article-title":"Comprehensive review of bisphosphonate therapy: implications for the oral and maxillofacial surgery patient","volume":"67","author":"Ruggiero","year":"2009","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2019.10.008_bib0016","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1002\/dvdy.20833","article-title":"Recent advances in craniofacial morphogenesis","volume":"235","author":"Chai","year":"2006","journal-title":"Dev Dyn"},{"key":"10.1016\/j.oooo.2019.10.008_bib0017","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00223-016-0223-6","article-title":"Bone structure and turnover status in postmenopausal women with atypical femur fracture after prolonged bisphosphonate therapy","volume":"100","author":"Qiu","year":"2017","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.oooo.2019.10.008_bib0018","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1002\/jbmr.1893","article-title":"Bisphosphonates and risk of subtrochanteric, femoral shaft, and atypical femur fracture: a systematic review and meta-analysis","volume":"28","author":"Gedmintas","year":"2013","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.oooo.2019.10.008_bib0019","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1056\/NEJMoa1010650","article-title":"Bisphosphonate use and atypical fractures of the femoral shaft","volume":"364","author":"Schilcher","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.oooo.2019.10.008_bib0020","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3109\/17453674.2014.916488","article-title":"Histology of 8 atypical femoral fractures: remodeling but no healing","volume":"85","author":"Schilcher","year":"2014","journal-title":"Acta Orthop"},{"key":"10.1016\/j.oooo.2019.10.008_bib0021","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s11914-018-0464-6","article-title":"Current understanding of epidemiology, pathophysiology, and management of atypical femur fractures","volume":"16","author":"Starr","year":"2018","journal-title":"Curr Osteoporos Rep"},{"key":"10.1016\/j.oooo.2019.10.008_bib0022","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/jbmr.1731","article-title":"Microindentation for in vivo measurement of bone tissue material properties in atypical femoral fracture patients and controls","volume":"28","author":"Guerri-Fernandez","year":"2013","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.oooo.2019.10.008_bib0023","series-title":"Changes in Bone Tissue Properties with Osteoporosis Treatment","author":"Brock","year":"2015"},{"key":"10.1016\/j.oooo.2019.10.008_bib0024","doi-asserted-by":"crossref","first-page":"92","DOI":"10.15171\/jlms.2018.19","article-title":"Combined approach to treat medication-related osteonecrosis of the jaws","volume":"9","author":"Merigo","year":"2018","journal-title":"J Lasers Med Sci"},{"key":"10.1016\/j.oooo.2019.10.008_bib0025","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.ijom.2017.01.023","article-title":"Surgical resection and vascularized bone reconstruction in advanced stage medication-related osteonecrosis of the jaw","volume":"46","author":"Caldroney","year":"2017","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2019.10.008_bib0026","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1111\/odi.12333","article-title":"Management of bisphosphonate-related osteonecrosis of the jaw: a literature review","volume":"21","author":"Spanou","year":"2015","journal-title":"Oral Dis"},{"key":"10.1016\/j.oooo.2019.10.008_bib0027","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.jcms.2018.03.005","article-title":"Double-layer closure techniques after bone surgery of medication-related osteonecrosis of the jaw\u2014a single center cohort study","volume":"46","author":"Ristow","year":"2018","journal-title":"J Cranio-Maxillofac Surg"},{"key":"10.1016\/j.oooo.2019.10.008_bib0028","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ctrv.2018.06.007","article-title":"Medication-related osteonecrosis of the jaw: prevention, diagnosis and management in patients with cancer and bone metastases","volume":"69","author":"Otto","year":"2018","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.oooo.2019.10.008_bib0029","series-title":"Antiresorptive Drug-Related Osteonecrosis of the Jaw (ARONJ)\u2014A Guide to Research","author":"Fleisher","year":"2016"},{"key":"10.1016\/j.oooo.2019.10.008_bib0030","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.joms.2008.12.007","article-title":"Reconstruction of defects caused by bisphosphonate-induced osteonecrosis of the jaws","volume":"67","author":"Marx","year":"2009","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2019.10.008_bib0031","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/9858921","article-title":"Microsurgical reconstruction of the jaws using vascularised free flap technique in patients with medication-related osteonecrosis: a systematic review","volume":"2018","author":"Sacco","year":"2018","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.oooo.2019.10.008_bib0032","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1055\/s-0037-1607309","article-title":"Effect of preoperative medical status on microsurgical free flap reconstructions: a matched cohort analysis of 969 cases","volume":"34","author":"Ehrl","year":"2018","journal-title":"J Reconstr Microsurg"},{"key":"10.1016\/j.oooo.2019.10.008_bib0033","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.jcms.2014.02.005","article-title":"Outcome of microvascular free flaps in a high-volume training centre","volume":"42","author":"Al-Dam","year":"2014","journal-title":"J Craniomaxillofac Surg"},{"key":"10.1016\/j.oooo.2019.10.008_bib0034","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1002\/jbmr.1894","article-title":"Periapical disease and bisphosphonates induce osteonecrosis of the jaws in mice","volume":"28","author":"Kang","year":"2013","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.oooo.2019.10.008_bib0035","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1002\/jbmr.379","article-title":"Periodontal disease and bisphosphonates induce osteonecrosis of the jaws in the rat","volume":"26","author":"Aghaloo","year":"2011","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.oooo.2019.10.008_bib0036","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00784-009-0300-6","article-title":"Importance of microcracks in etiology of bisphosphonate-related osteonecrosis of the jaw: a possible pathogenetic model of symptomatic and non-symptomatic osteonecrosis of the jaw based on scanning electron microscopy findings","volume":"14","author":"Hoefert","year":"2010","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.oooo.2019.10.008_bib0037","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.joms.2007.11.035","article-title":"Identification of microbial biofilms in osteonecrosis of the jaws secondary to bisphosphonate therapy","volume":"66","author":"Sedghizadeh","year":"2008","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2019.10.008_bib0038","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1177\/0022034515572021","article-title":"Infection and medication-related osteonecrosis of the jaw","volume":"94","author":"Katsarelis","year":"2015","journal-title":"J Dent Res"},{"key":"10.1016\/j.oooo.2019.10.008_bib0039","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/452737","article-title":"Is bisphosphonate-related osteonecrosis of the jaw an infection? A histological and microbiological ten-year summary","volume":"2014","author":"Hinson","year":"2014","journal-title":"Int J Dent"},{"key":"10.1016\/j.oooo.2019.10.008_bib0040","series-title":"StatPearls","article-title":"Actinomycosis","author":"Sharma","year":"2019"},{"key":"10.1016\/j.oooo.2019.10.008_bib0041","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.tripleo.2009.06.019","article-title":"The clinical spectrum of Actinomyces-associated lesions of the oral mucosa and jawbones: correlations with histomorphometric analysis","volume":"108","author":"Kaplan","year":"2009","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.oooo.2019.10.008_bib0042","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/ID.0b013e3182310f03","article-title":"Identification and treatment of bisphosphonate-associated actinomycotic osteonecrosis of the jaws","volume":"20","author":"Lee","year":"2011","journal-title":"Implant Dent"},{"key":"10.1016\/j.oooo.2019.10.008_bib0043","first-page":"183","article-title":"Actinomycosis: etiology, clinical features, diagnosis, treatment, and management","volume":"7","author":"Valour","year":"2014","journal-title":"Infect Drug Resist"},{"key":"10.1016\/j.oooo.2019.10.008_bib0044","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.archoralbio.2014.05.002","article-title":"Important aspects regarding the role of microorganisms in bisphosphonate-related osteonecrosis of the jaws","volume":"59","author":"Boff","year":"2014","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.oooo.2019.10.008_bib0045","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.joms.2012.12.005","article-title":"Pamidronate enhances bacterial adhesion to bone hydroxyapatite. Another puzzle in the pathology of bisphosphonate-related osteonecrosis of the jaw?","volume":"71","author":"Kos","year":"2013","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2019.10.008_bib0046","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jbmr.1998","article-title":"Atypical subtrochanteric and diaphyseal femoral fractures: second report of a task force of the American Society for Bone and Mineral Research","volume":"29","author":"Shane","year":"2014","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.oooo.2019.10.008_bib0047","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/01.sap.0000241948.36784.4e","article-title":"Free fibula donor-site morbidity: clinical and biomechanical analysis","volume":"58","author":"Farhadi","year":"2007","journal-title":"Ann Plast Surg"},{"key":"10.1016\/j.oooo.2019.10.008_bib0048","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1097\/PRS.0b013e3182402d9a","article-title":"What is the price to pay for a free fibula flap? A systematic review of donor-site morbidity following free fibula flap surgery","volume":"129","author":"Ling","year":"2012","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.oooo.2019.10.008_bib0049","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/micr.30205","article-title":"Functional donor site morbidity longer than one year after fibula free flap: a prospective biomechanical analysis","volume":"38","author":"Rendenbach","year":"2018","journal-title":"Microsurgery"},{"key":"10.1016\/j.oooo.2019.10.008_bib0050","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jcms.2015.10.027","article-title":"Prospective biomechanical analysis of donor-site morbidity after fibula free flap","volume":"44","author":"Rendenbach","year":"2016","journal-title":"J Craniomaxillofac Surg"},{"key":"10.1016\/j.oooo.2019.10.008_bib0051","first-page":"104","article-title":"Evolution of atypical femur fractures and the association with bisphosphonates","volume":"72","author":"Takemoto","year":"2014","journal-title":"Bull Hospital Jt Dis (2013)"},{"key":"10.1016\/j.oooo.2019.10.008_bib0052","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/00003086-198404000-00047","article-title":"Role of the fibula in weight-bearing","author":"Takebe","year":"1984","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.oooo.2019.10.008_bib0053","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1007\/s00590-013-1381-0","article-title":"The effect of partial fibulectomy on contact pressure of the knee: a cadaveric study","volume":"24","author":"Yazdi","year":"2014","journal-title":"Eur J Orthop Surg Traumatol"},{"key":"10.1016\/j.oooo.2019.10.008_bib0054","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s00223-009-9261-7","article-title":"Geometry of a weight-bearing and non-weight-bearing bone in the legs of young, old, and very old men","volume":"85","author":"McNeil","year":"2009","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.oooo.2019.10.008_bib0055","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1080\/17843286.2017.1348001","article-title":"Incidence of osteonecrosis of the jaw in patients with bone metastases treated sequentially with bisphosphonates and denosumab","volume":"73","author":"Loyson","year":"2018","journal-title":"Acta Clin Belg"}],"container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440319315408?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440319315408?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T22:05:29Z","timestamp":1761948329000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212440319315408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":55,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S2212440319315408"],"URL":"https:\/\/doi.org\/10.1016\/j.oooo.2019.10.008","relation":{},"ISSN":["2212-4403"],"issn-type":[{"value":"2212-4403","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Replacing one evil with another: Is the fibula really a dispensable spare part available for transfer in patients with medication-related osteonecrosis of the jaws?","name":"articletitle","label":"Article Title"},{"value":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oooo.2019.10.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}