{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T22:56:05Z","timestamp":1786575365252,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007338","name":"All-India Institute of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oooojournal.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.oooo.2020.08.003","type":"journal-article","created":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T12:27:41Z","timestamp":1596803261000},"page":"557-564","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Single nucleotide polymorphisms and serologic levels of hypoxia-inducible factor1 \u03b1 and vascular endothelial growth factor are associated with increased risk of oral submucous fibrosis in gutka users among a North Indian population"],"prefix":"10.1016","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7055-4269","authenticated-orcid":false,"given":"Shalini R.","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alpana","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidhi","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalaivani","family":"Mani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.oooo.2020.08.003_bib0001","series-title":"Oral and Maxillofacial Pathology","first-page":"315","article-title":"Epithelial pathology","author":"Neville","year":"2002"},{"key":"10.1016\/j.oooo.2020.08.003_bib0002","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jobcr.2013.10.005","article-title":"Prevalence of oral submucous fibrosis among habitual gutkha and areca nut chewers in Moradabad district","volume":"4","author":"Nigam","year":"2014","journal-title":"J Oral Biol Craniofac Res"},{"key":"10.1016\/j.oooo.2020.08.003_bib0003","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/0030-4220(66)90367-7","article-title":"Oral submucous fibrosis","volume":"22","author":"Pindborg","year":"1966","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.oooo.2020.08.003_bib0004","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/j.1600-0528.1985.tb00468.x","article-title":"Malignant transformation rate in oral submucous fibrosis over a 17-year period","volume":"13","author":"Murti","year":"1985","journal-title":"Community Dent Oral Epidemiol"},{"key":"10.1016\/j.oooo.2020.08.003_bib0005","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1007\/s12663-015-0760-y","article-title":"Concomitant association of oral submucous fibrosis and oral squamous cell carcinoma and incidence of malignant transformation of oral submucous fibrosis in a population of central India: a retrospective study","volume":"14","author":"Chourasia","year":"2015","journal-title":"J Maxillofac Oral Surg"},{"key":"10.1016\/j.oooo.2020.08.003_bib0006","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.oooo.2015.11.024","article-title":"Malignant transformation of oral submucous fibrosis: overview of histopathological aspects","volume":"122","author":"Ray","year":"2016","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1016\/j.oooo.2020.08.003_bib0007","doi-asserted-by":"crossref","first-page":"97","DOI":"10.53388\/FTHC201908005","article-title":"Research progress in arecoline-induced oral submucous fibrosis","volume":"1","author":"Jiang","year":"2019","journal-title":"Food Therapy and Health Care"},{"key":"10.1016\/j.oooo.2020.08.003_bib0008","doi-asserted-by":"crossref","first-page":"4054","DOI":"10.7150\/jca.29765","article-title":"Multifaceted mechanisms of areca nuts in oral carcinogenesis: the molecular pathology from precancerous condition to malignant transformation","volume":"10","author":"Li","year":"2019","journal-title":"J Cancer"},{"key":"10.1016\/j.oooo.2020.08.003_bib0009","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1186\/1471-2407-14-950","article-title":"Association between HIF-1 \u03b1 C1772 T\/G1790 A polymorphisms and cancer susceptibility: an updated systematic review and meta-analysis based on 40 case-control studies","volume":"14","author":"Yan","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.oooo.2020.08.003_bib0010","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1475-2867-14-37","article-title":"The association between hypoxia-inducible factor-1 \u03b1 gene G1790 A polymorphism and cancer risk: a meta-analysis of 28 case-control studies","volume":"14","author":"Zhou","year":"2014","journal-title":"Cancer Cell Int"},{"key":"10.1016\/j.oooo.2020.08.003_bib0011","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1016\/j.oraloncology.2010.04.009","article-title":"Association between the polymorphisms in exon 12 of hypoxia-inducible factor-1 \u03b1 and the clinicopathological features of oral squamous cell carcinoma","volume":"46","author":"Shieh","year":"2010","journal-title":"Oral Oncol"},{"key":"10.1016\/j.oooo.2020.08.003_bib0012","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/j.1600-0714.2007.00625.x","article-title":"Upregulation of HIF-1 alpha in malignant transformation of oral submucous fibrosis","volume":"37","author":"Tilakaratne","year":"2008","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.oooo.2020.08.003_bib0013","doi-asserted-by":"crossref","first-page":"e60283","DOI":"10.1371\/journal.pone.0060283","article-title":"Impact of VEGF-C gene polymorphisms and environmental factors on oral cancer susceptibility in Taiwan","volume":"8","author":"Chien","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.oooo.2020.08.003_bib0014","doi-asserted-by":"crossref","first-page":"40","DOI":"10.4103\/jomfp.JOMFP_13_18","article-title":"Coalition of E-cadherin and vascular endothelial growth factor expression in predicting malignant transformation in common oral potentially malignant disorders","volume":"22","author":"Sharada","year":"2018","journal-title":"J Oral Maxillofac Pathol"},{"key":"10.1016\/j.oooo.2020.08.003_bib0015","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/jicd.12103","article-title":"Estimation of vascular endothelial growth factor gene -460 C\/T polymorphism as a biomarker in oral squamous cell carcinoma patients from the Indian subcontinent","volume":"6","author":"Borase","year":"2015","journal-title":"J Investig Clin Dent"},{"key":"10.1016\/j.oooo.2020.08.003_bib0016","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3126\/ajms.v7i5.15064","article-title":"Vascular endothelial growth factor (VEGF) gene polymorphism in oral submucous fibrosis subjects\u2014a preliminary study","volume":"7","author":"Rai","year":"2016","journal-title":"Asian J Med Sci"},{"key":"10.1016\/j.oooo.2020.08.003_bib0017","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4103\/jomfp.JOMFP_143_18","article-title":"Study of salivary arecoline in areca nut chewers","volume":"22","author":"Venkatesh","year":"2018","journal-title":"J Oral Maxillofac Pathol"},{"key":"10.1016\/j.oooo.2020.08.003_bib0018","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1245\/s10434-009-0503-8","article-title":"Polymorphisms in the hypoxia inducible factor 1-\u03b1 and the impact on the prognosis of early stages of oral cancer","volume":"16","author":"Mu\u00f1oz-Guerra","year":"2009","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.oooo.2020.08.003_bib0019","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1007\/s00432-007-0240-y","article-title":"The low VEGF production allele of the +936 C\/T polymorphism is strongly associated with increased risk for oral cancer","volume":"133","author":"Yapijakis","year":"2007","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1016\/j.oooo.2020.08.003_bib0020","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.cancergencyto.2009.11.007","article-title":"VEGFA\u00a0+\u00a0936 C>T polymorphism and cancer risk: a meta-analysis","volume":"198","author":"Xu","year":"2010","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1016\/j.oooo.2020.08.003_bib0021","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1600-0714.2007.00582.x","article-title":"Nomenclature and classification of potentially malignant disorders of the oral mucosa","volume":"36","author":"Warnakulasuriya","year":"2007","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.oooo.2020.08.003_bib0022","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.oraloncology.2011.10.011","article-title":"Proposed clinical classification for oral submucous fibrosis","volume":"48","author":"More","year":"2012","journal-title":"Oral Oncol"},{"key":"10.1016\/j.oooo.2020.08.003_bib0023","first-page":"1561","article-title":"The association between the rs11549465 polymorphism in the hif-1 \u03b1 gene and cancer risk: a meta-analysis","volume":"8","author":"Li","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"10.1016\/j.oooo.2020.08.003_bib0024","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.oraloncology.2011.08.023","article-title":"A high HIF-1 \u03b1 expression genotype is associated with poor prognosis of upper aerodigestive tract carcinoma patients","volume":"48","author":"de Fraga","year":"2012","journal-title":"Oral Oncol"},{"key":"10.1016\/j.oooo.2020.08.003_bib0025","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.tripleo.2007.10.009","article-title":"Vascular endothelial growth factor 936 C\/T polymorphism is associated with vascular invasion in oral squamous cell carcinoma","volume":"106","author":"Cheng","year":"2008","journal-title":"Oral Surg Oral Med Oral Pathol, Oral Radiol Endod"},{"key":"10.1016\/j.oooo.2020.08.003_bib0026","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.arcmed.2010.09.006","article-title":"Vascular endothelial growth factor +936 C\/T and +405 G\/C polymorphisms and cancer risk: a meta-analysis","volume":"41","author":"Cao","year":"2010","journal-title":"Arch Med Res"},{"key":"10.1016\/j.oooo.2020.08.003_bib0027","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1089\/gtmb.2013.0020","article-title":"Vascular endothelial growth factor 936 C>T polymorphism increased oral cancer risk: evidence from a meta-analysis","volume":"17","author":"Mandal","year":"2013","journal-title":"Genet Test Molecular Biomarkers"},{"key":"10.1016\/j.oooo.2020.08.003_bib0028","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/j.1600-0714.2010.00904.x","article-title":"Single nucleotide polymorphisms of the vascular endothelial growth factor gene associated with incidence of oral squamous cell carcinoma","volume":"39","author":"K\u00e4mmerer","year":"2010","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.oooo.2020.08.003_bib0029","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3892\/mco.2014.458","article-title":"Vascular endothelial growth factor polymorphisms as effect modifiers of oral squamous cell carcinoma risk: a systematic review and meta-analysis","volume":"3","author":"Metzger","year":"2015","journal-title":"Mol Clin Oncol"},{"key":"10.1016\/j.oooo.2020.08.003_bib0030","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.oraloncology.2012.05.023","article-title":"Association of VEGF-A genetic polymorphisms with cancer risk and survival in advanced-stage oral squamous cell carcinoma patients","volume":"48","author":"Supic","year":"2012","journal-title":"Oral Oncol"},{"key":"10.1016\/j.oooo.2020.08.003_bib0031","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1002\/hed.23143","article-title":"Oral squamous cell carcinoma arising in background of oral submucous fibrosis: a clinicopathologically distinct disease","volume":"35","author":"Chaturvedi","year":"2013","journal-title":"Head Neck"}],"container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440320311251?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440320311251?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T22:06:11Z","timestamp":1761948371000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212440320311251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S2212440320311251"],"URL":"https:\/\/doi.org\/10.1016\/j.oooo.2020.08.003","relation":{},"ISSN":["2212-4403"],"issn-type":[{"value":"2212-4403","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single nucleotide polymorphisms and serologic levels of hypoxia-inducible factor1 \u03b1 and vascular endothelial growth factor are associated with increased risk of oral submucous fibrosis in gutka users among a North Indian population","name":"articletitle","label":"Article Title"},{"value":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oooo.2020.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}