{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T15:51:51Z","timestamp":1788277911584,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oooojournal.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.oooo.2021.09.007","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T17:23:37Z","timestamp":1632158617000},"page":"e105-e112","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Oral manifestations associated with inherited hyperhomocysteinemia: A first case description"],"prefix":"10.1016","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8658-6732","authenticated-orcid":false,"given":"Bachar","family":"Husseini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgard","family":"Nehme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8885-602X","authenticated-orcid":false,"given":"Karim","family":"Senni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude Sader","family":"Ghorra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalil","family":"Younes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Roffino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Ghorra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9313-6729","authenticated-orcid":false,"given":"Sylvie","family":"Changotade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Younes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.oooo.2021.09.007_bib0001","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.3390\/ijms17101733","article-title":"The molecular and cellular effect of homocysteine metabolism imbalance on human health","volume":"17","author":"\u0160kovierov\u00e1","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.oooo.2021.09.007_bib0002","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s10897-016-9956-7","article-title":"MTHFR: addressing genetic counseling dilemmas using evidence-based literature","volume":"25","author":"Levin","year":"2016","journal-title":"J Genet Couns"},{"key":"10.1016\/j.oooo.2021.09.007_bib0003","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.3390\/nu5051531","article-title":"Homocysteine lowering by folate-rich diet or pharmacological supplementations in subjects with moderate hyperhomocysteinemia","volume":"5","author":"Zappacosta","year":"2013","journal-title":"Nutrients"},{"key":"10.1016\/j.oooo.2021.09.007_bib0004","series-title":"Madame Curie Bioscience Database","first-page":"41","article-title":"Molecular biology of methylenetetrahydrofolate reductase (MTHFR) and overview of mutations\/polymorphisms","author":"Leclerc","year":"2005"},{"key":"10.1016\/j.oooo.2021.09.007_bib0005","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.3748\/wjg.v10.i12.1699","article-title":"Hyperhomocysteinemia, endoplasmic reticulum stress, and alcoholic liver injury","volume":"10","author":"Ji","year":"2004","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.oooo.2021.09.007_bib0006","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.3390\/nu7042176","article-title":"B vitamins, homocysteine and bone health","volume":"7","author":"Fratoni","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/j.oooo.2021.09.007_bib0007","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1902\/jop.2010.100271","article-title":"Elevated plasma homocysteine levels in chronic periodontitis: a hospital-based case-control study","volume":"82","author":"Joseph","year":"2011","journal-title":"J Periodontol"},{"key":"10.1016\/j.oooo.2021.09.007_bib0008","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1139\/cjpp-2020-0224","article-title":"Hyperhomocysteinemia: an instigating factor for periodontal disease","volume":"99","author":"Stanisic","year":"2021","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.oooo.2021.09.007_bib0009","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/978-1-60327-369-5_2","article-title":"Monitoring gene expression: quantitative real-time RT-PCR","volume":"1027","author":"Wagner","year":"2013","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.oooo.2021.09.007_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmg.2014.10.004","article-title":"Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: epidemiology, metabolism and the associated diseases","volume":"58","author":"Liew","year":"2015","journal-title":"Eur J Med Genet"},{"key":"10.1016\/j.oooo.2021.09.007_bib0011","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000437098","article-title":"Homocysteine-induced endothelial dysfunction","volume":"67","author":"Lai","year":"2015","journal-title":"Ann Nutr Metab"},{"key":"10.1016\/j.oooo.2021.09.007_bib0012","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1369\/0022155414545787","article-title":"Picrosirius red staining: a useful tool to appraise collagen networks in normal and pathological tissues","volume":"62","author":"Lattouf","year":"2014","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.oooo.2021.09.007_bib0013","first-page":"215","article-title":"Selective staining technique for identification of human skin elastic fibers","volume":"32","author":"Godeau","year":"1984","journal-title":"Pathol Biol (Paris)"},{"key":"10.1016\/j.oooo.2021.09.007_bib0014","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/BF02411252","article-title":"Bone acid phosphatase: tartrate-resistant acid phosphatase as a marker of osteoclast function","volume":"34","author":"Minkin","year":"1982","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.oooo.2021.09.007_bib0015","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S0945-053X(98)90108-1","article-title":"Hyperhomocysteinemia induces elastolysis in minipig arteries: structural consequences, arterial site specificity and effect of captopril-hydrochlorothiazide","volume":"17","author":"Charpiot","year":"1998","journal-title":"Matrix Biol"},{"key":"10.1016\/j.oooo.2021.09.007_bib0016","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s11010-009-0270-7","article-title":"Homocysteine modulates the proteolytic potential of human arterial smooth muscle cells through a reactive oxygen species dependent mechanism","volume":"335","author":"Ke","year":"2010","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.oooo.2021.09.007_bib0017","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1515\/CCLM.2007.362","article-title":"The role of hyperhomocysteinemia as well as folate, vitamin B6 and B12 deficiencies in osteoporosis: a systematic review","volume":"45","author":"Herrmann","year":"2007","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.oooo.2021.09.007_bib0018","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1515\/jomb-2017-0051","article-title":"Association between MTHFR 677C>T polymorphism and vitamin B12 deficiency: a case-control study","volume":"37","author":"Al-Batayneh","year":"2018","journal-title":"J Med Biochem"},{"key":"10.1016\/j.oooo.2021.09.007_bib0019","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.ajhg.2009.02.011","article-title":"Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations","volume":"84","author":"Tanaka","year":"2009","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.oooo.2021.09.007_bib0020","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/jcpe.12483","article-title":"Serum vitamin B12 is inversely associated with periodontal progression and risk of tooth loss: a prospective cohort study","volume":"43","author":"Zong","year":"2016","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.oooo.2021.09.007_bib0021","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1600-0765.1998.tb02307.x","article-title":"Evidence that cyclosporin A administration induces the formation of new cementum-like islets inside the gingival connective tissue","volume":"33","author":"Ayanoglou","year":"1998","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.oooo.2021.09.007_bib0022","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3389\/fnut.2019.00049","article-title":"Hyperhomocysteinemia as a risk factor and potential nutraceutical target for certain pathologies","volume":"6","author":"Tinelli","year":"2019","journal-title":"Front Nutr"},{"key":"10.1016\/j.oooo.2021.09.007_bib0023","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1359\/jbmr.060406","article-title":"Homocysteine enhances bone resorption by stimulation of osteoclast formation and activity through increased intracellular ROS generation","volume":"21","author":"Koh","year":"2006","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.oooo.2021.09.007_bib0024","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1111\/j.1582-4934.2008.00104.x","article-title":"Stimulation of osteoblast activity by homocysteine","volume":"12","author":"Herrmann","year":"2008","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.oooo.2021.09.007_bib0025","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1006\/bbrc.1999.1391","article-title":"Influence of homocysteine on matrix metalloproteinase-2: activation and activity","volume":"263","author":"Bescond","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.oooo.2021.09.007_bib0026","doi-asserted-by":"crossref","first-page":"34946","DOI":"10.1074\/jbc.M504748200","article-title":"Modification of the structure and function of fibrillin-1 by homocysteine suggests a potential pathogenetic mechanism in homocystinuria","volume":"280","author":"Hubmacher","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.oooo.2021.09.007_bib0027","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.yjmcc.2005.11.009","article-title":"A fibrillin-1-fragment containing the elastin-binding-protein GxxPG consensus sequence upregulates matrix metalloproteinase-1: biochemical and computational analysis","volume":"40","author":"Booms","year":"2006","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.oooo.2021.09.007_bib0028","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1083\/jcb.201003089","article-title":"Fibrillin-1 and -2 differentially modulate endogenous TGF-\u03b2 and BMP bioavailability during bone formation","volume":"190","author":"Nistala","year":"2010","journal-title":"J Cell Biol"},{"key":"10.1016\/j.oooo.2021.09.007_bib0029","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1083\/jcb.200608167","article-title":"Fibrillin-1 regulates the bioavailability of TGF\u03b21","volume":"176","author":"Chaudhry","year":"2007","journal-title":"J Cell Biol"},{"key":"10.1016\/j.oooo.2021.09.007_bib0030","doi-asserted-by":"crossref","first-page":"13874","DOI":"10.1074\/jbc.M707820200","article-title":"Targeting of bone morphogenetic protein growth factor complexes to fibrillin","volume":"283","author":"Sengle","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.oooo.2021.09.007_bib0031","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1067\/moe.2002.121430","article-title":"Oral manifestations of patients with Marfan syndrome: a case-control study","volume":"93","author":"De Coster","year":"2002","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.oooo.2021.09.007_bib0032","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.tice.2008.09.003","article-title":"Pertinent cell population to characterize periodontal disease","volume":"41","author":"Younes","year":"2009","journal-title":"Tissue Cell"}],"container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440321006386?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440321006386?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T22:11:07Z","timestamp":1761948667000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212440321006386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S2212440321006386"],"URL":"https:\/\/doi.org\/10.1016\/j.oooo.2021.09.007","relation":{},"ISSN":["2212-4403"],"issn-type":[{"value":"2212-4403","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oral manifestations associated with inherited hyperhomocysteinemia: A first case description","name":"articletitle","label":"Article Title"},{"value":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oooo.2021.09.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}