{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T04:23:18Z","timestamp":1784175798294,"version":"3.55.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oooojournal.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.oooo.2022.08.016","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T03:06:13Z","timestamp":1662519973000},"page":"257-267","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["HCG11 inhibits salivary adenoid cystic carcinoma by upregulating EphA2 via binding to miR-1297"],"prefix":"10.1016","volume":"135","author":[{"given":"Shujuan","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.oooo.2022.08.016_bib0001","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12935-018-0518-y","article-title":"Loss of PIM1 correlates with progression and prognosis of salivary adenoid cystic carcinoma (SACC)","volume":"18","author":"Xu","year":"2018","journal-title":"Cancer Cell Int"},{"key":"10.1016\/j.oooo.2022.08.016_bib0002","doi-asserted-by":"crossref","first-page":"190","DOI":"10.4143\/crt.2008.40.4.190","article-title":"Association of single nucleotide polymorphisms in PIM-1 gene with the risk of Korean lung cancer","volume":"40","author":"Kim","year":"2008","journal-title":"Cancer Res Treat"},{"key":"10.1016\/j.oooo.2022.08.016_bib0003","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.oraloncology.2019.04.014","article-title":"Prognostic importance of the lymphovascular invasion in head and neck adenoid cystic carcinoma: a systematic review and meta-analysis","volume":"93","author":"Martins-Andrade","year":"2019","journal-title":"Oral Oncol"},{"key":"10.1016\/j.oooo.2022.08.016_bib0004","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.ijom.2020.07.034","article-title":"Neck involvement and disease recurrence in adenoid cystic carcinoma of the minor salivary glands: the role of surgery in primary and progressive disease","volume":"50","author":"Moratin","year":"2021","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2022.08.016_bib0005","first-page":"214","article-title":"[Treatment plan and prognosis of salivary adenoid cystic carcinoma with lung metastasis]","volume":"37","author":"Su","year":"2019","journal-title":"Hua Xi Kou Qiang Yi Xue Za Zhi"},{"key":"10.1016\/j.oooo.2022.08.016_bib0006","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s13045-020-00944-9","article-title":"Targeting EphA2 in cancer","volume":"13","author":"Xiao","year":"2020","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.oooo.2022.08.016_bib0007","doi-asserted-by":"crossref","first-page":"8037","DOI":"10.1007\/s11033-020-05767-y","article-title":"The EphA2 and cancer connection: potential for immune-based interventions","volume":"47","author":"London","year":"2020","journal-title":"Mol Biol Rep"},{"key":"10.1016\/j.oooo.2022.08.016_bib0008","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.canlet.2019.02.019","article-title":"ProNGF increases breast tumor aggressiveness through functional association of TrkA with EphA2","volume":"449","author":"L\u00e9v\u00eaque","year":"2019","journal-title":"Cancer Lett"},{"key":"10.1016\/j.oooo.2022.08.016_bib0009","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0209342","article-title":"Identification of long intergenic non-coding RNAs (lincRNAs) deregulated in gastrointestinal stromal tumors (GISTs)","volume":"13","author":"Gyvyte","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.oooo.2022.08.016_bib0010","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.canlet.2018.12.011","article-title":"S897 phosphorylation of EphA2 is indispensable for EphA2-dependent nasopharyngeal carcinoma cell invasion, metastasis and stem properties","volume":"444","author":"Li","year":"2019","journal-title":"Cancer Lett"},{"key":"10.1016\/j.oooo.2022.08.016_bib0011","first-page":"845","article-title":"Biological significance of EPHA2 expression in neuroblastoma","volume":"35","author":"Kung","year":"2009","journal-title":"Int J Oncol"},{"key":"10.1016\/j.oooo.2022.08.016_bib0012","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/1756-0500-7-131","article-title":"Intracranial extension of adenoid cystic carcinoma: potential involvement of EphA2 expression and epithelial-mesenchymal transition in tumor metastasis: a case report","volume":"7","author":"Fukai","year":"2014","journal-title":"BMC Res Notes"},{"key":"10.1016\/j.oooo.2022.08.016_bib0013","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.joms.2012.10.026","article-title":"EphA2\/ephrinA1 mRNA expression and protein production in adenoid cystic carcinoma of salivary gland","volume":"71","author":"Shao","year":"2013","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2022.08.016_bib0014","first-page":"1518","article-title":"EphA2 silencing promotes growth, migration, and metastasis in salivary adenoid cystic carcinoma: in vitro and in vivo study","volume":"8","author":"Wang","year":"2016","journal-title":"Am J Transl Res"},{"key":"10.1016\/j.oooo.2022.08.016_bib0015","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.oooo.2022.08.016_bib0016","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.3390\/cells8111352","article-title":"MicroRNAs in inflammatory heart diseases and sepsis-induced cardiac dysfunction: a potential scope for the future?","volume":"8","author":"Mirna","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.oooo.2022.08.016_bib0017","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.molimm.2020.09.016","article-title":"MiR-26a targets EphA2 to resist intracellular Listeria monocytogenes in macrophages","volume":"128","author":"Zhang","year":"2020","journal-title":"Mol Immunol"},{"key":"10.1016\/j.oooo.2022.08.016_bib0018","doi-asserted-by":"crossref","first-page":"L584","DOI":"10.1152\/ajplung.00073.2017","article-title":"MicroRNA dysregulation in lung injury: the role of the miR-26a\/EphA2 axis in regulation of endothelial permeability","volume":"315","author":"Good","year":"2018","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.oooo.2022.08.016_bib0019","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1186\/s12885-017-3875-3","article-title":"miR-302b inhibits tumorigenesis by targeting EphA2 via Wnt\/\u03b2-catenin\/EMT signaling cascade in gastric cancer","volume":"17","author":"Huang","year":"2017","journal-title":"BMC Cancer"},{"key":"10.1016\/j.oooo.2022.08.016_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111863","article-title":"Dual role of microRNA-1297 in the suppression and progression of human malignancies","volume":"141","author":"Alizadeh-Fanalou","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.oooo.2022.08.016_bib0021","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1111\/cas.15447","article-title":"Comprehensive network analysis of dysregulated genes revealed MNX1-AS1\/hsa-miR-4697-3p\/HOXB13 axis in OC chemotherapy response","volume":"113","author":"Wu","year":"2022","journal-title":"Cancer Sci"},{"key":"10.1016\/j.oooo.2022.08.016_bib0022","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.856560","article-title":"The LINC01929\/miR-6875-5p\/ADAMTS12 axis in the ceRNA network regulates the development of advanced bladder cancer","volume":"12","author":"Xiong","year":"2022","journal-title":"Front Oncol"},{"key":"10.1016\/j.oooo.2022.08.016_bib0023","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1016\/j.ymthe.2018.08.018","article-title":"Upregulation of lncRNA ADAMTS9-AS2 promotes salivary adenoid cystic carcinoma metastasis via PI3K\/Akt and MEK\/Erk signaling","volume":"26","author":"Xie","year":"2018","journal-title":"Mol Ther"},{"key":"10.1016\/j.oooo.2022.08.016_bib0024","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/odi.13759","article-title":"CASC9 plays a role in salivary adenoid cystic carcinoma in vitro by upregulation of ACLY","volume":"28","author":"Xie","year":"2022","journal-title":"Oral Dis"},{"key":"10.1016\/j.oooo.2022.08.016_bib0025","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1111\/jog.15083","article-title":"LncRNA HCG11 represses ovarian cancer cell growth via AKT signaling pathway","volume":"48","author":"Chen","year":"2022","journal-title":"J Obstet Gynaecol Res"},{"key":"10.1016\/j.oooo.2022.08.016_bib0026","doi-asserted-by":"crossref","first-page":"552","DOI":"10.3892\/mmr.2021.12191","article-title":"Long non-coding RNA HCG11 suppresses the malignant phenotype of non\u2011small cell lung cancer cells by targeting a miR\u2011875\/SATB2 axis","volume":"24","author":"Su","year":"2021","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.oooo.2022.08.016_bib0027","article-title":"Long noncoding RNA HCG11 acts as a tumor suppressor in gastric cancer by regulating miR-942-5p\/BRMS1 axis","volume":"2021","author":"Zhang","year":"2021","journal-title":"J Oncol"},{"key":"10.1016\/j.oooo.2022.08.016_bib0028","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1177\/0022034511401407","article-title":"TGF-beta1 promotes migration and invasion of salivary adenoid cystic carcinoma","volume":"90","author":"Dong","year":"2011","journal-title":"J Dent Res"},{"key":"10.1016\/j.oooo.2022.08.016_bib0029","doi-asserted-by":"crossref","first-page":"8412","DOI":"10.3390\/ijms22168412","article-title":"The clinical impact of the EPH\/ephrin system in cancer: unwinding the thread","volume":"22","author":"Pergaris","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.oooo.2022.08.016_bib0030","first-page":"4386","article-title":"ANXA1 binds and stabilizes EphA2 to promote nasopharyngeal carcinoma growth and metastasis","volume":"80","author":"Feng","year":"2020","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.oooo.2022.08.016_bib0031","article-title":"EPHA2 promotes the invasion and migration of human tongue squamous cell carcinoma Cal-27 cells by enhancing AKT\/mTOR signaling pathway","volume":"2021","author":"Wang","year":"2021","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.oooo.2022.08.016_bib0032","doi-asserted-by":"crossref","first-page":"574","DOI":"10.3892\/ijo.2020.5069","article-title":"MicroRNA\u2011103a\u20113p promotes metastasis by targeting TPD52 in salivary adenoid cystic carcinoma","volume":"57","author":"Fu","year":"2020","journal-title":"Int J Oncol"},{"key":"10.1016\/j.oooo.2022.08.016_bib0033","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1038\/labinvest.2015.105","article-title":"miR-21 regulates tumor progression through the miR-21-PDCD4-Stat3 pathway in human salivary adenoid cystic carcinoma","volume":"95","author":"Jiang","year":"2015","journal-title":"Lab Invest"},{"key":"10.1016\/j.oooo.2022.08.016_bib0034","first-page":"4237","article-title":"Role of miR-21 in the growth and metastasis of human salivary adenoid cystic carcinoma","volume":"17","author":"Yan","year":"2018","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.oooo.2022.08.016_bib0035","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1093\/jjco\/hyx073","article-title":"miR-582-5p inhibits invasion and migration of salivary adenoid cystic carcinoma cells by targeting FOXC1","volume":"47","author":"Wang","year":"2017","journal-title":"Jpn J Clin Oncol"},{"key":"10.1016\/j.oooo.2022.08.016_bib0036","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1186\/s12935-019-1018-4","article-title":"MicroRNA-140-5p inhibits salivary adenoid cystic carcinoma progression and metastasis via targeting survivin","volume":"19","author":"Qiao","year":"2019","journal-title":"Cancer Cell Int"},{"key":"10.1016\/j.oooo.2022.08.016_bib0037","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.2147\/CMAR.S297868","article-title":"Long noncoding RNA GAS5 accelerates cholangiocarcinoma progression by regulating hsa-miR-1297","volume":"13","author":"Li","year":"2021","journal-title":"Cancer Manag Res"},{"key":"10.1016\/j.oooo.2022.08.016_bib0038","doi-asserted-by":"crossref","first-page":"12129","DOI":"10.18632\/aging.202923","article-title":"Long noncoding RNA DLGAP1-AS1 promotes the progression of glioma by regulating the miR-1297\/EZH2 axis","volume":"13","author":"Liu","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.oooo.2022.08.016_bib0039","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1158\/0008-5472.CAN-19-0819","article-title":"Long noncoding RNA MRPL23-AS1 promotes adenoid cystic carcinoma lung metastasis","volume":"80","author":"Chen","year":"2020","journal-title":"Cancer Res"},{"key":"10.1016\/j.oooo.2022.08.016_bib0040","doi-asserted-by":"crossref","first-page":"7062","DOI":"10.1002\/cam4.3203","article-title":"Long noncoding RNA HCG11 inhibited growth and invasion in cervical cancer by sponging miR-942-5p and targeting GFI1","volume":"9","author":"Zhang","year":"2020","journal-title":"Cancer Med"},{"key":"10.1016\/j.oooo.2022.08.016_bib0041","doi-asserted-by":"crossref","first-page":"e12615","DOI":"10.1111\/cpr.12615","article-title":"Long non-coding RNA HCG11 modulates glioma progression through cooperating with miR-496\/CPEB3 axis","volume":"52","author":"Chen","year":"2019","journal-title":"Cell Prolif"},{"key":"10.1016\/j.oooo.2022.08.016_bib0042","doi-asserted-by":"crossref","first-page":"552","DOI":"10.3892\/mmr.2021.12191","article-title":"Long non\u2011coding RNA HCG11 suppresses the malignant phenotype of non\u2011small cell lung cancer cells by targeting a miR\u2011875\/SATB2 axis","volume":"24","author":"Su","year":"2021","journal-title":"Mol Med Rep"}],"container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221244032201118X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221244032201118X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T22:13:24Z","timestamp":1761948804000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221244032201118X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S221244032201118X"],"URL":"https:\/\/doi.org\/10.1016\/j.oooo.2022.08.016","relation":{},"ISSN":["2212-4403"],"issn-type":[{"value":"2212-4403","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HCG11 inhibits salivary adenoid cystic carcinoma by upregulating EphA2 via binding to miR-1297","name":"articletitle","label":"Article Title"},{"value":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oooo.2022.08.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}