{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:01:26Z","timestamp":1789153286274,"version":"build-2803163510"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oooojournal.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.oooo.2022.12.002","type":"journal-article","created":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T17:57:54Z","timestamp":1671299874000},"page":"128-135","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Fascio-cutaneous and fascio-periosteal free flaps for treatment of intermediate stage osteoradionecrosis of the jaws"],"prefix":"10.1016","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2421-2609","authenticated-orcid":false,"given":"Michael J.L.","family":"Hurrell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsu-Hui","family":"Low","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sydney","family":"Ch'ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan R.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.oooo.2022.12.002_bib0001","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0266-4356(92)90181-H","article-title":"The conservative management of osteoradionecrosis of the mandible with ultrasound therapy","volume":"30","author":"Harris","year":"1992","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2022.12.002_bib0002","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.oooo.2017.08.004","article-title":"Osteoradionecrosis: a review of pathophysiology, prevention and pharmacologic management using pentoxifylline, alpha-tocopherol, and clodronate","volume":"124","author":"Rivero","year":"2017","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1016\/j.oooo.2022.12.002_bib0003","first-page":"629","article-title":"Sur la sensibilite du tissu osseux normal vis-a-vis des rayons X et gamma et sur la mecanisme de l'osteoradionecrose","volume":"87","author":"Regaud","year":"1922","journal-title":"CR Soc Biol (Paris)"},{"key":"10.1016\/j.oooo.2022.12.002_bib0004","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.ijrobp.2020.12.043","article-title":"Osteoradionecrosis: exposing the evidence not the bone","volume":"109","author":"Frankart","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.oooo.2022.12.002_bib0005","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.joms.2020.11.026","article-title":"Fasciocutaneous flaps for refractory intermediate stage osteoradionecrosis of the mandible\u2014is it time for a shift in management?","volume":"79","author":"Gigliotti","year":"2021","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2022.12.002_bib0006","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.ijom.2019.03.894","article-title":"Is there a role for pentoxifylline and tocopherol in the management of advanced osteoradionecrosis of the jaws with pathological fractures? Case reports and review of the literature","volume":"48","author":"Breik","year":"2019","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2022.12.002_bib0007","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1001\/archotol.129.1.72","article-title":"Influence of prior hyperbaric oxygen therapy in complications following microvascular reconstruction for advanced osteoradionecrosis","volume":"129","author":"Gal","year":"2003","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.oooo.2022.12.002_bib0008","doi-asserted-by":"crossref","first-page":"4893","DOI":"10.1200\/JCO.2004.09.006","article-title":"Hyperbaric oxygen therapy for radionecrosis of the jaw: A randomized, placebo-controlled, double-blind trial from the ORN96 study group","volume":"22","author":"Annane","year":"2004","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.oooo.2022.12.002_bib0009","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1634\/theoncologist.2016-0298","article-title":"The use of hyperbaric oxygen for the prevention and management of osteoradionecrosis of the jaw: a Dana-Farber\/Brigham and Women's Cancer Center multidisciplinary guideline","volume":"22","author":"Sultan","year":"2017","journal-title":"Oncologist"},{"key":"10.1016\/j.oooo.2022.12.002_bib0010","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.radonc.2004.08.021","article-title":"The radiation-induced fibroatrophic process: therapeutic perspective via the antioxidant pathway","volume":"73","author":"Delanian","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.oooo.2022.12.002_bib0011","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.ijrobp.2010.03.029","article-title":"Complete restoration of refractory mandibular osteoradionecrosis by prolonged treatment with a pentoxifylline-tocopherol-clodronate combination (PENTOCLO): a phase II trial","volume":"80","author":"Delanian","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.oooo.2022.12.002_bib0012","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.bjoms.2010.11.017","article-title":"Pentoxifylline and tocopherol in the management of patients with osteoradionecrosis, the Portsmouth experience","volume":"50","author":"McLeod","year":"2012","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2022.12.002_bib0013","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.oraloncology.2010.08.007","article-title":"Paradigm shifts in the management of osteoradionecrosis of the mandible","volume":"46","author":"Jacobson","year":"2010","journal-title":"Oral Oncol"},{"key":"10.1016\/j.oooo.2022.12.002_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.amjoto.2019.102343","article-title":"Osteoradionecrosis of the mandible: why not to be more aggressive in earlier stage?","volume":"41","author":"Al Deek","year":"2020","journal-title":"Am J Otolaryngol"},{"key":"10.1016\/j.oooo.2022.12.002_bib0015","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/hed.10171","article-title":"Management of mandibular osteoradionecrosis corresponding to the severity of osteoradionecrosis and the method of radiotherapy","volume":"25","author":"Notani","year":"2003","journal-title":"Head Neck"},{"key":"10.1016\/j.oooo.2022.12.002_bib0016","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/0278-2391(87)90399-5","article-title":"Osteoradionecrosis: clinical experience and a proposal for classification","volume":"45","author":"Epstein","year":"1987","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2022.12.002_bib0017","first-page":"17","article-title":"Infectious diseases of the jaws","volume":"28","author":"Meyer","year":"1970","journal-title":"J Oral Surg"},{"key":"10.1016\/j.oooo.2022.12.002_bib0018","first-page":"147","article-title":"Proceedings: the management of teeth related to the treatment of oral cancer","volume":"7","author":"Daly","year":"1972","journal-title":"Proc Natl Cancer Conf"},{"key":"10.1016\/j.oooo.2022.12.002_bib0019","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1148\/119.3.665","article-title":"Osteonecrosis in patients treated with definitive radiotherapy for squamous cell carcinomas of the oral cavity and naso-and oropharynx","volume":"119","author":"Bedwinek","year":"1976","journal-title":"Radiology"},{"key":"10.1016\/j.oooo.2022.12.002_bib0020","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0278-2391(83)80005-6","article-title":"A new concept in the treatment of osteoradionecrosis","volume":"41","author":"Marx","year":"1983","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2022.12.002_bib0021","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.radonc.2021.11.021","article-title":"Hyperbaric oxygen treatment of mandibular osteoradionecrosis: combined data from the two randomized clinical trials DAHANCA-21 and NWHHT2009-1","volume":"166","author":"Forner","year":"2022","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.oooo.2022.12.002_bib0022","article-title":"Hyperbaric oxygen therapy for late radiation tissue injury","volume":"4","author":"Bennett","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.oooo.2022.12.002_bib0023","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1089\/wound.2016.0718","article-title":"Hyperbaric oxygen therapy: side effects defined and quantified","volume":"6","author":"Heyboer","year":"2017","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"10.1016\/j.oooo.2022.12.002_bib0024","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/hed.20121","article-title":"Major healing of refractory mandible osteoradionecrosis after treatment combining pentoxifylline and tocopherol: a phase II trial","volume":"27","author":"Delanian","year":"2005","journal-title":"Head Neck"},{"key":"10.1016\/j.oooo.2022.12.002_bib0025","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.bjoms.2015.11.027","article-title":"Use of pentoxifylline and tocopherol in the management of osteoradionecrosis","volume":"54","author":"Patel","year":"2016","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2022.12.002_bib0026","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.bjoms.2014.02.017","article-title":"Osteoradionecrosis\u2014a review of current concepts in defining the extent of the disease and a new classification proposal","volume":"52","author":"Lyons","year":"2014","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2022.12.002_bib0027","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.bjoms.2021.07.019","article-title":"Patients\u2019 experience and perceived concerns regarding obtaining and taking prescriptions for head and neck osteoradionecrosis","volume":"60","author":"Willcocks","year":"2022","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2022.12.002_bib0028","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.bjoms.2019.01.028","article-title":"Treatment of mandibular osteoradionecrosis by periosteal free flaps","volume":"57","author":"Bettoni","year":"2019","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2022.12.002_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.amjoto.2019.07.006","article-title":"Mandibular rescue: application of the ALT fascia free flap to arrest osteoradionecrosis of the mandible","volume":"40","author":"Haffey","year":"2019","journal-title":"Am J Otolaryngol"}],"container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440322012986?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440322012986?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T22:14:54Z","timestamp":1761948894000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212440322012986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S2212440322012986"],"URL":"https:\/\/doi.org\/10.1016\/j.oooo.2022.12.002","relation":{},"ISSN":["2212-4403"],"issn-type":[{"value":"2212-4403","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fascio-cutaneous and fascio-periosteal free flaps for treatment of intermediate stage osteoradionecrosis of the jaws","name":"articletitle","label":"Article Title"},{"value":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oooo.2022.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}