{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T22:25:47Z","timestamp":1782167147957,"version":"3.54.5"},"reference-count":36,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008532","name":"Universidade Federal do Rio Grande do Norte","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008532","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oooojournal.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.oooo.2023.01.009","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T12:45:58Z","timestamp":1675255558000},"page":"530-538","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["SNAIL1 is involved in the control of the epithelial-mesenchymal transition in oral tongue squamous cell carcinoma"],"prefix":"10.1016","volume":"135","author":[{"given":"Everton Freitas","family":"de Morais","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah Gil de Farias","family":"Morais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gl\u00f3ria Maria","family":"de Fran\u00e7a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio Haach","family":"T\u00e9o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9bel Cavalcanti","family":"Galv\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuula","family":"Salo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo D.","family":"Coletta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roseana de Almeida","family":"Freitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.oooo.2023.01.009_bib0001","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.oooo.2023.01.009_bib0002","doi-asserted-by":"crossref","first-page":"140","DOI":"10.14639\/0392-100X-N2055","article-title":"Oral tongue carcinoma: prognostic changes according to the updated 2020 version of the AJCC\/UICC TNM staging system","volume":"42","author":"Tagliabue","year":"2022","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"10.1016\/j.oooo.2023.01.009_bib0003","first-page":"612","volume":"125","author":"Speight","year":"2018","journal-title":"Oral potentially malignant disorders: risk of progression to malignancy. Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1016\/j.oooo.2023.01.009_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.archoralbio.2020.104904","article-title":"Biological role of epithelial-mesenchymal-transition-inducing transcription factors in head and neck squamous cell carcinoma: a systematic review","volume":"119","author":"de Morais","year":"2020","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.oooo.2023.01.009_bib0005","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.3390\/jcm10081658","article-title":"Potential non-invasive biomarkers for early diagnosis of oral squamous cell carcinoma","volume":"10","author":"Dikova","year":"2021","journal-title":"J Clin Med"},{"key":"10.1016\/j.oooo.2023.01.009_bib0006","doi-asserted-by":"crossref","first-page":"5931","DOI":"10.1073\/pnas.1918167117","article-title":"The functional activity of E-cadherin controls tumor cell metastasis at multiple steps","volume":"117","author":"Na","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.oooo.2023.01.009_bib0007","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.oooo.2018.11.003","article-title":"Twist and E-cadherin deregulation might predict poor prognosis in lower lip squamous cell carcinoma","volume":"127","author":"de Morais","year":"2019","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1016\/j.oooo.2023.01.009_bib0008","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0199442","article-title":"Reciprocal expression of Slug and Snail in human oral cancer cells","volume":"13","author":"Nakamura","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.oooo.2023.01.009_bib0009","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1186\/s12885-020-07495-9","article-title":"The Axin2-snail axis promotes bone invasion by activating cancer-associated fibroblasts in oral squamous cell carcinoma","volume":"20","author":"An","year":"2020","journal-title":"BMC Cancer"},{"key":"10.1016\/j.oooo.2023.01.009_bib0010","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.2147\/CMAR.S196450","article-title":"S100A16 regulated by Snail promotes the chemoresistance of nonmuscle invasive bladder cancer through the AKT\/Bcl-2 pathway","volume":"11","author":"Wang","year":"2019","journal-title":"Cancer Manag Res"},{"key":"10.1016\/j.oooo.2023.01.009_bib0011","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/cjp2.202","article-title":"The epithelial-mesenchymal transition regulators Twist, Slug, and Snail are associated with aggressive tumour features and poor outcome in prostate cancer patients","volume":"7","author":"B\u00f8rretzen","year":"2021","journal-title":"J Pathol Clin Res"},{"key":"10.1016\/j.oooo.2023.01.009_bib0012","series-title":"WHO Classification of Head and Neck Tumours","author":"El-Naggar","year":"2017"},{"key":"10.1016\/j.oooo.2023.01.009_bib0013","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ijom.2014.10.004","article-title":"A simple novel prognostic model for early stage oral tongue cancer","volume":"44","author":"Almangush","year":"2015","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2023.01.009_bib0014","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/1756-9966-28-158","article-title":"Significance of Twist expression and its association with E-cadherin in esophageal squamous cell carcinoma","volume":"28","author":"Sasaki","year":"2009","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.oooo.2023.01.009_bib0015","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1600-0765.2011.01412.x","article-title":"Molecular events associated with ciclosporin A-induced gingival overgrowth are attenuated by Smad7 overexpression in fibroblasts","volume":"47","author":"Sobral","year":"2012","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.oooo.2023.01.009_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2020.112092","article-title":"Stanniocalcin 2 contributes to aggressiveness and is a prognostic marker for oral squamous cell carcinoma","volume":"393","author":"Ferreira do Carmo","year":"2020","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.oooo.2023.01.009_bib0017","first-page":"981","article-title":"A novel human leiomyoma tissue derived matrix for cell culture studies. BMC Cancer","volume":"15","author":"Salo","year":"2015","journal-title":"BioMed Central"},{"key":"10.1016\/j.oooo.2023.01.009_bib0018","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3389\/fbioe.2019.00217","article-title":"Addressing patient specificity in the engineering of tumor models","volume":"7","author":"Bray","year":"2019","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.oooo.2023.01.009_bib0019","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/jop.12096","article-title":"E-cadherin downregulation and Twist overexpression since early stages of oral carcinogenesis","volume":"43","author":"de Freitas Silva","year":"2014","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.oooo.2023.01.009_bib0020","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1002\/ijc.32644","article-title":"SNAIL1 employs \u03b2-Catenin-LEF1 complexes to control colorectal cancer cell invasion and proliferation","volume":"146","author":"Freihen","year":"2020","journal-title":"Int J Cancer"},{"key":"10.1016\/j.oooo.2023.01.009_bib0021","doi-asserted-by":"crossref","first-page":"700","DOI":"10.7150\/thno.47800","article-title":"PLAGL2 promotes the proliferation and migration of gastric cancer cells via USP37-mediated deubiquitination of Snail1","volume":"11","author":"Wu","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.oooo.2023.01.009_bib0022","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3892\/ol.2021.12445","article-title":"Expression of twist, slug and snail in esophageal squamous cell carcinoma and their prognostic significance","volume":"21","author":"Xu","year":"2021","journal-title":"Oncol Lett"},{"key":"10.1016\/j.oooo.2023.01.009_bib0023","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3892\/or.2015.4348","article-title":"Snail-induced EMT promotes cancer stem cell-like properties in head and neck cancer cells","volume":"35","author":"Ota","year":"2016","journal-title":"Oncol Rep"},{"key":"10.1016\/j.oooo.2023.01.009_bib0024","first-page":"3743","article-title":"Marked epithelial to mesenchymal transition in surgical margins of oral cancer-an in vitro study","volume":"19","author":"Lazarevic","year":"2020","journal-title":"Oncol Lett"},{"key":"10.1016\/j.oooo.2023.01.009_bib0025","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.prp.2018.06.004","article-title":"Subcellular localization and expression of E-cadherin and SNAIL are relevant since early stages of oral carcinogenesis","volume":"214","author":"Lopes","year":"2018","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.oooo.2023.01.009_bib0026","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.3390\/cells8101118","article-title":"The E-cadherin and N-cadherin switch in epithelial-to-mesenchymal transition: signaling, therapeutic implications, and challenges","volume":"8","author":"Loh","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.oooo.2023.01.009_bib0027","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.1007\/s00018-008-8281-1","article-title":"The cell-cell adhesion molecule E-cadherin","volume":"65","author":"van Roy","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.oooo.2023.01.009_bib0028","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1186\/s12885-018-4845-0","article-title":"N-cadherin in cancer metastasis, its emerging role in haematological malignancies and potential as a therapeutic target in cancer","volume":"18","author":"Mrozik","year":"2018","journal-title":"BMC Cancer"},{"key":"10.1016\/j.oooo.2023.01.009_bib0029","doi-asserted-by":"crossref","first-page":"595","DOI":"10.3892\/ijo.2015.3270","article-title":"N-cadherin promotes epithelial-mesenchymal transition and cancer stem cell-like traits via ErbB signaling in prostate cancer cells","volume":"48","author":"Wang","year":"2016","journal-title":"Int J Oncol"},{"key":"10.1016\/j.oooo.2023.01.009_bib0030","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.21873\/anticanres.13305","article-title":"Cytoplasmic E-Cadherin expression is associated with higher tumour level of VEGFA, lower response rate to irinotecan-based treatment and poorer prognosis in patients with metastatic colorectal cancer","volume":"39","author":"Bendardaf","year":"2019","journal-title":"Anticancer Res"},{"key":"10.1016\/j.oooo.2023.01.009_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.archoralbio.2022.105387","article-title":"Epithelial-mesenchymal transition modulates lower lip carcinogenesis and promotes cancer progression","volume":"136","author":"de Farias Morais","year":"2022","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.oooo.2023.01.009_bib0032","doi-asserted-by":"crossref","first-page":"e285","DOI":"10.4317\/medoral.20953","article-title":"Histopathological grading systems analysis of oral squamous cell carcinomas of young patients","volume":"21","author":"Frare","year":"2016","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"10.1016\/j.oooo.2023.01.009_bib0033","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/jop.13118","article-title":"Histopathologic grading and its relationship with outcome in oral tongue squamous cell carcinoma","volume":"50","author":"Silva","year":"2021","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.oooo.2023.01.009_bib0034","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1172\/JCI39104","article-title":"The basics of epithelial-mesenchymal transition","volume":"119","author":"Kalluri","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.oooo.2023.01.009_bib0035","doi-asserted-by":"crossref","first-page":"6307","DOI":"10.21873\/anticanres.13841","article-title":"Twist and Snail\/Slug expression in oropharyngeal squamous cell carcinoma in correlation with lymph node metastasis","volume":"39","author":"Cho","year":"2019","journal-title":"Anticancer Res"},{"key":"10.1016\/j.oooo.2023.01.009_bib0036","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/s41580-021-00428-9","article-title":"Guidelines and definitions for research on epithelial-mesenchymal transition","volume":"22","author":"Yang","year":"2021","journal-title":"Nat Rev Mol Cell Biol"}],"container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440323000111?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440323000111?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T22:14:07Z","timestamp":1761948847000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212440323000111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S2212440323000111"],"URL":"https:\/\/doi.org\/10.1016\/j.oooo.2023.01.009","relation":{},"ISSN":["2212-4403"],"issn-type":[{"value":"2212-4403","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SNAIL1 is involved in the control of the epithelial-mesenchymal transition in oral tongue squamous cell carcinoma","name":"articletitle","label":"Article Title"},{"value":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oooo.2023.01.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}