{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T17:39:32Z","timestamp":1776447572346,"version":"3.51.2"},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oooojournal.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.oooo.2023.04.014","type":"journal-article","created":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T01:20:33Z","timestamp":1682904033000},"page":"255-262","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["A retrospective comparative fractal and radiomorphometric analysis of the effect of 3 generations of anti-epileptic drugs on the mandible"],"prefix":"10.1016","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9947-5679","authenticated-orcid":false,"given":"Katibe Tugce","family":"Temur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guldane","family":"Magat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevgi","family":"Ozcan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.oooo.2023.04.014_bib0001","doi-asserted-by":"crossref","first-page":"248","DOI":"10.4103\/2249-4863.192338","article-title":"Impact of antiepileptic drugs on bone health: need for monitoring, treatment, and prevention strategies","volume":"5","author":"Arora","year":"2016","journal-title":"J Family Med Prim Care"},{"key":"10.1016\/j.oooo.2023.04.014_bib0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4158\/EP12119.OR","article-title":"The association of newer anticonvulsant medications and bone mineral density","volume":"14","author":"Lee","year":"2012","journal-title":"Endocr Pract"},{"issue":"suppl 2","key":"10.1016\/j.oooo.2023.04.014_bib0003","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.3949\/ccjm.71.Suppl_2.S42","article-title":"Bone disease associated with antiepileptic drugs","volume":"71","author":"Pack","year":"2004","journal-title":"Cleve Clin J Med"},{"key":"10.1016\/j.oooo.2023.04.014_bib0004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clineuro.2009.10.011","article-title":"Bone and calcium metabolism and antiepileptic drugs","volume":"112","author":"Verrotti","year":"2010","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.oooo.2023.04.014_bib0005","article-title":"Nuevos f\u00e1rmacos antiepil\u00e9pticos en Pediatr\u00eda [New anti-epileptic drugs in Paediatrics]","volume":"91","author":"M\u00e1laga","year":"2019","journal-title":"An Pediatr (Engl Ed)"},{"issue":"75","key":"10.1016\/j.oooo.2023.04.014_bib0006","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ejps.2015.04.008","article-title":"Dried blood spots for monitoring and individualization of antiepileptic drug treatment","volume":"30","author":"Milosheska","year":"2015","journal-title":"Eur J Pharm Sci"},{"key":"10.1016\/j.oooo.2023.04.014_bib0007","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/FTD.0b013e31827c11e7","article-title":"Therapeutic drug monitoring of antiepileptic drugs by use of saliva","volume":"1","author":"Patsalos","year":"2013","journal-title":"Ther Drug Monit"},{"key":"10.1016\/j.oooo.2023.04.014_bib0008","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1212\/WNL.57.3.445","article-title":"Decreased bone mass and increased bone turnover with valproate therapy in adults with epilepsy","volume":"57","author":"Sato","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.oooo.2023.04.014_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.eplepsyres.2021.106619","article-title":"The effects of antiepileptic drugs on bone health: a systematic review","volume":"173","author":"Griepp","year":"2021","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.oooo.2023.04.014_bib0010","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.eplepsyres.2012.09.002","article-title":"Effects of levetiracetam as a monotherapy on bone mineral density and biochemical markers of bone metabolism in patients with epilepsy","volume":"104","author":"Koo","year":"2013","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.oooo.2023.04.014_bib0011","first-page":"3","article-title":"Uses and limitations of bone mineral density measurements in the management of osteoporosis","volume":"7","author":"Small","year":"2005","journal-title":"MedGenMed"},{"key":"10.1016\/j.oooo.2023.04.014_bib0012","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s12018-016-9222-4","article-title":"Bone quality assessment techniques: geometric, compositional, and mechanical characterization from macroscale to nanoscale","volume":"14","author":"Hunt","year":"2016","journal-title":"Clin Rev Bone Miner Metab"},{"key":"10.1016\/j.oooo.2023.04.014_bib0013","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1259\/dmfr.25.5.9161180","article-title":"Usefulness of panoramic radiography in the diagnosis of postmenopausal osteoporosis in women. Width and morphology of inferior cortex of the mandible","volume":"25","author":"Taguchi","year":"1996","journal-title":"Dentomaxillofac Radiol"},{"key":"10.1016\/j.oooo.2023.04.014_bib0014","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1016\/j.tripleo.2008.03.007","article-title":"G\u00fcneri P, et al. Mandibular bone changes in sickle cell anemia: fractal analysis","volume":"106","author":"Demirba\u015f","year":"2008","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.oooo.2023.04.014_bib0015","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1259\/dmfr\/30969642","article-title":"Technical factors in fractal analysis of periapical radiographs","volume":"35","author":"Jolley","year":"2006","journal-title":"Dentomaxillofac Radiol"},{"key":"10.1016\/j.oooo.2023.04.014_bib0016","doi-asserted-by":"crossref","first-page":"20130366","DOI":"10.1259\/dmfr.20130366","article-title":"Digital orthopantomograms in osteoporosis detection: mandibular density and mandibular radiographic indices as skeletal BMD predictors","volume":"43","author":"Savic Pavicin","year":"2014","journal-title":"Dentomaxillofac Radiol"},{"key":"10.1016\/j.oooo.2023.04.014_bib0017","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1007\/s11548-016-1438-8","article-title":"Quantitative assessment of mandibular cortical erosion on dental panoramic radiographs for screening osteoporosis","volume":"11","author":"Muramatsu","year":"2016","journal-title":"Int J Comput Assist Radiol Surg"},{"key":"10.1016\/j.oooo.2023.04.014_bib0018","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/sj.dmfr.4600203","article-title":"Morphology of the mandibular cortex on panoramic radiographs as an indicator of bone quality","volume":"26","author":"Klemetti","year":"1997","journal-title":"Dentomaxillofac Radiol"},{"key":"10.1016\/j.oooo.2023.04.014_bib0019","first-page":"73","article-title":"Decreased bone density induced by antiepileptic drugs can cause accelerated orthodontic tooth movement in male Wistar rats","volume":"16","author":"Akhoundi","year":"2018","journal-title":"Int Orthod"},{"key":"10.1016\/j.oooo.2023.04.014_bib0020","first-page":"32","article-title":"Mandibular bone density and calcium content affected by long-term anticonvulsant treatment in rats","volume":"9","author":"Parara","year":"2009","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"10.1016\/j.oooo.2023.04.014_bib0021","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1358\/mf.2004.26.10.872558","article-title":"Effects of the antiepileptics phenytoin and zonisamide on dentin formation and bone mineral density of the mandible in growing rats","volume":"26","author":"Takahashi","year":"2004","journal-title":"Methods Find Exp Clin Pharmacol"},{"key":"10.1016\/j.oooo.2023.04.014_bib0022","first-page":"201","article-title":"Applicability of dental panoramic radiomorphometric and fractal dimension analysis in the evaluation of antiepileptic drug-induced osteoporosis","volume":"23","author":"Ustao\u011flu","year":"2019","journal-title":"Int J Med Dent"},{"key":"10.1016\/j.oooo.2023.04.014_bib0023","first-page":"534","article-title":"Dental implants in persons with severe epilepsy and multiple disabilities: a long-term retrospective study","volume":"24","author":"Cune","year":"2009","journal-title":"Int J Oral Maxillofac Implants"},{"key":"10.1016\/j.oooo.2023.04.014_bib0024","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.jocd.2016.07.008","article-title":"Bone mineral changes in epilepsy patients during initial years of antiepileptic drug therapy","volume":"19","author":"Ahmad","year":"2016","journal-title":"J Clin Densitom"},{"key":"10.1016\/j.oooo.2023.04.014_bib0025","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s11282-019-00419-9","article-title":"The effect of selective serotonin reuptake inhibitors on the human mandible","volume":"37","author":"Co\u015fgunarslan","year":"2021","journal-title":"Oral Radiol"},{"key":"10.1016\/j.oooo.2023.04.014_bib0026","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jcm.2016.02.012","article-title":"A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research","volume":"15","author":"Koo","year":"2016","journal-title":"J Chiropr Med"},{"key":"10.1016\/j.oooo.2023.04.014_bib0027","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2307\/2529310","article-title":"The measurement of observer agreement for categorical data","volume":"1","author":"Landis","year":"1977","journal-title":"Biometrics"},{"key":"10.1016\/j.oooo.2023.04.014_bib0028","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/sj\/dmfr\/4600630","article-title":"Fractal dimension on dental radiographs","volume":"30","author":"Bollen","year":"2001","journal-title":"Dentomaxillofac Radiol"},{"key":"10.1016\/j.oooo.2023.04.014_bib0029","doi-asserted-by":"crossref","first-page":"633","DOI":"10.2165\/00023210-200115080-00006","article-title":"Adverse effects of antiepileptic drugs on bone structure","volume":"15","author":"Pack","year":"2001","journal-title":"CNS Drugs"},{"key":"10.1016\/j.oooo.2023.04.014_bib0030","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1212\/01.wnl.0000310981.44676.de","article-title":"Bone health in young women with epilepsy after one year of antiepileptic drug monotherapy","volume":"70","author":"Pack","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.oooo.2023.04.014_bib0031","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1177\/1759720X11410769","article-title":"Antiepileptics and bone health","volume":"3","author":"Meier","year":"2011","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"10.1016\/j.oooo.2023.04.014_bib0032","doi-asserted-by":"crossref","first-page":"84","DOI":"10.4103\/jmgims.jmgims_45_16","article-title":"Serum calcium deficiency and bone mineral density in patients on long-term anti-epileptic therapy","volume":"23","author":"Rahatekar","year":"2018","journal-title":"J Mahatma Gandhi Inst Med Sci"},{"key":"10.1016\/j.oooo.2023.04.014_bib0033","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.3390\/ijms17081242","article-title":"The impact of anti-epileptic drugs on growth and bone metabolism","volume":"17","author":"Fan","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.oooo.2023.04.014_bib0034","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.phrs.2003.11.011","article-title":"The effect of valproate on bone mineral density in adult epileptic patients","volume":"50","author":"Boluk","year":"2004","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.oooo.2023.04.014_bib0035","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1111\/j.0013-9580.2004.18804.x","article-title":"Fracture risk associated with use of antiepileptic drugs","volume":"45","author":"Vestergaard","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.oooo.2023.04.014_bib0036","doi-asserted-by":"crossref","first-page":"4228","DOI":"10.1021\/pr1005263","article-title":"Valproate and bone loss: ITRAQ proteomics show that valproate reduces collagens and osteonectin in SMA cells","volume":"9","author":"Fuller","year":"2010","journal-title":"J Proteome Res"},{"key":"10.1016\/j.oooo.2023.04.014_bib0037","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.drudis.2009.01.004","article-title":"Insights into liaison between antiepileptic drugs and bone","volume":"14","author":"Khanna","year":"2009","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.oooo.2023.04.014_bib0038","first-page":"416","article-title":"Inhibitory effect of zonisamide on human carbonic anhydrase in vitro","volume":"43","author":"Masuda","year":"1993","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.oooo.2023.04.014_bib0039","doi-asserted-by":"crossref","first-page":"36","DOI":"10.64719\/pb.4609","article-title":"Antiepileptic drugs and bone health: current concepts","volume":"50","author":"Siniscalchi","year":"2020","journal-title":"Psychopharmacol Bull"},{"key":"10.1016\/j.oooo.2023.04.014_bib0040","first-page":"3687","article-title":"Effects of levetiracetam and lacosamide on therapeutic efficacy and neural function in patients with epilepsy","volume":"20","author":"Liu","year":"2020","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.oooo.2023.04.014_bib0041","doi-asserted-by":"crossref","first-page":"394","DOI":"10.5507\/bp.2014.006","article-title":"The effect of lacosamide on bone tissue in orchidectomised male albino Wistar rats","volume":"159","author":"Simko","year":"2015","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"key":"10.1016\/j.oooo.2023.04.014_bib0042","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/j.1600-0765.2007.01056.x","article-title":"Fractal analysis of dental radiographs to detect periodontitis-induced trabecular changes","volume":"43","author":"Updike","year":"2008","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.oooo.2023.04.014_bib0043","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.oooo.2021.01.017","article-title":"Investigation of mandibular fractal dimension on digital panoramic radiographs in bruxist individuals","volume":"131","author":"Eninan\u00e7","year":"2021","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1016\/j.oooo.2023.04.014_bib0044","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s11282-022-00639-6","article-title":"Evaluation of bone changes on dental panoramic radiography using mandibular indexes and fractal dimension analysis in children with familial Mediterranean fever","volume":"39","author":"Altunok \u00dcnl\u00fc","year":"2023","journal-title":"Oral Radiol"}],"container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440323004431?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440323004431?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T22:14:50Z","timestamp":1761948890000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212440323004431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S2212440323004431"],"URL":"https:\/\/doi.org\/10.1016\/j.oooo.2023.04.014","relation":{},"ISSN":["2212-4403"],"issn-type":[{"value":"2212-4403","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A retrospective comparative fractal and radiomorphometric analysis of the effect of 3 generations of anti-epileptic drugs on the mandible","name":"articletitle","label":"Article Title"},{"value":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oooo.2023.04.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}