{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:41:00Z","timestamp":1792514460213,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["oooojournal.net","clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.oooo.2024.07.008","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T01:41:51Z","timestamp":1723167711000},"page":"11-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Antiresorptive therapy in combination with radiation results in enhanced risk for necrosis and associated complications"],"prefix":"10.1016","volume":"139","author":[{"given":"Katharina Theresa","family":"Obermeier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenko","family":"Smolka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Palla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Kraus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Steybe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Tobias","family":"Hartung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian Nepomuk","family":"Fegg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Hildebrandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina","family":"Dewenter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Callahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Poxleitner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Otto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.oooo.2024.07.008_bib0003","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/bcr414","article-title":"The role of bisphosphonates in breast cancer: Development of bisphosphonates","volume":"4","author":"Fleisch","year":"2001","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.oooo.2024.07.008_bib0004","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/jbmr.2405","article-title":"Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus","volume":"30","author":"Khan","year":"2015","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.oooo.2024.07.008_bib0005","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.joms.2022.02.008","article-title":"American Association of Oral and Maxillofacial Surgeons' position paper on medication-related osteonecrosis of the jaws-2022 update","volume":"80","author":"Ruggiero","year":"2022","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2024.07.008_bib0001","first-page":"c85","article-title":"Physiology and pharmacology of nonbisphosphonate drugs implicated in osteonecrosis of the jaw","volume":"78","author":"Troeltzsch","year":"2012","journal-title":"J Can Dent Assoc."},{"key":"10.1016\/j.oooo.2024.07.008_bib0002","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1056\/NEJMoa0809493","article-title":"Denosumab for prevention of fractures in postmenopausal women with osteoporosis","volume":"361","author":"Cummings","year":"2009","journal-title":"N Engl J Med."},{"key":"10.1016\/j.oooo.2024.07.008_bib0006","doi-asserted-by":"crossref","first-page":"e216","DOI":"10.1016\/j.bjoms.2021.03.006","article-title":"Systematic review of medication related osteonecrosis of the jaw (MRONJ) in patients undergoing only antiangiogenic drug therapy: surgery or conservative therapy?","volume":"60","author":"Sacco","year":"2022","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2024.07.008_bib0007","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1007\/s40618-021-01634-0","article-title":"Osteonecrosis of the jaw: a rare but possible side effect in thyroid cancer patients treated with tyrosine-kinase inhibitors and bisphosphonates","volume":"44","author":"Lorusso","year":"2021","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.oooo.2024.07.008_bib0008","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.ijom.2015.01.026","article-title":"Treatment strategies and outcomes of bisphosphonate-related osteonecrosis of the jaw (BRONJ) with characterization of patients: a systematic review","volume":"44","author":"Fliefel","year":"2015","journal-title":"Int J Oral Maxillofac Surg."},{"key":"10.1016\/j.oooo.2024.07.008_bib0009","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s40729-021-00323-0","article-title":"Clinical considerations for medication-related osteonecrosis of the jaw: a comprehensive literature review","volume":"7","author":"Kawahara","year":"2021","journal-title":"Int J Implant Dent"},{"key":"10.1016\/j.oooo.2024.07.008_bib0010","doi-asserted-by":"crossref","first-page":"4634","DOI":"10.1200\/JCO.2008.16.2768","article-title":"Bisphosphonate-related osteonecrosis of the jaws: a case-control study of risk factors in breast cancer patients","volume":"26","author":"Kyrgidis","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.oooo.2024.07.008_bib0011","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1016\/j.joms.2010.07.017","article-title":"Osteonecrosis of the jaw: effect of bisphosphonate type, local concentration, and acidic milieu on the pathomechanism","volume":"68","author":"Otto","year":"2010","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2024.07.008_bib0012","first-page":"629","article-title":"Sur la sensibilite du tissuosseux normal vis-a-vis des rayons X et gamma et sur la mecanisme del'osteoradionecrose","volume":"87","author":"Regaud","year":"1922","journal-title":"CR Soc Biol."},{"key":"10.1016\/j.oooo.2024.07.008_bib0013","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/idj.12318","article-title":"Osteoradionecrosis of the jaws: definition, epidemiology, staging and clinical and radiological findings. A concise review","volume":"68","author":"Chronopoulos","year":"2018","journal-title":"Int Dent J."},{"key":"10.1016\/j.oooo.2024.07.008_bib0014","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.bjoms.2008.04.006","article-title":"Osteoradionecrosis of the jaws: current understanding of its pathophysiology and treatment","volume":"46","author":"Lyons","year":"2008","journal-title":"Br J Oral Maxillofac Surg."},{"key":"10.1016\/j.oooo.2024.07.008_bib0015","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.oraloncology.2016.11.015","article-title":"The prevalence and risk factors associated with osteoradionecrosis of the jaw in oral and oropharyngeal cancer patients treated with intensity-modulated radiation therapy (IMRT): the Memorial Sloan Kettering Cancer Center experience","volume":"64","author":"Owosho","year":"2017","journal-title":"Oral Oncol"},{"key":"10.1016\/j.oooo.2024.07.008_bib0016","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/01.moo.0000170527.59017.ff","article-title":"Osteoradionecrosis of the mandible","volume":"13","author":"Teng","year":"2005","journal-title":"Curr Opin Otolaryngol Head Neck Surg."},{"key":"10.1016\/j.oooo.2024.07.008_bib0017","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0278-2391(83)80005-6","article-title":"A new concept in the treatment of osteoradionecrosis","volume":"41","author":"Marx","year":"1983","journal-title":"J Oral Maxillofac Surg."},{"key":"10.1016\/j.oooo.2024.07.008_bib0018","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.radonc.2004.08.021","article-title":"The radiation-induced fibroatrophic process: Therapeutic perspective via the antioxidant pathway","volume":"73","author":"Delanian","year":"2004","journal-title":"Radiother Oncol."},{"key":"10.1016\/j.oooo.2024.07.008_bib0019","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.clon.2016.03.002","article-title":"Current concepts in osteoradionecrosis after head and neck radiotherapy","volume":"28","author":"Dhanda","year":"2016","journal-title":"Clin Oncol."},{"key":"10.1016\/j.oooo.2024.07.008_bib0020","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1016\/j.jcms.2015.03.006","article-title":"Outcomes of microvascular free flap reconstruction for mandibular osteoradionecrosis: a systematic review","volume":"43","author":"Lee","year":"2015","journal-title":"J Cranio-Maxillofac Surg."},{"key":"10.1016\/j.oooo.2024.07.008_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.archoralbio.2023.105792","article-title":"Bisphosphonates and osteonecrosis of the jaws: clinical and forensic aspects","volume":"155","author":"Nogueira","year":"2023","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.oooo.2024.07.008_bib0022","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0278-2391(83)80005-6","article-title":"A new concept in the treatment of osteoradionecrosis","volume":"41","author":"Marx","year":"1983","journal-title":"J Oral Maxillofac Surg."},{"key":"10.1016\/j.oooo.2024.07.008_bib0023","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.joms.2022.02.008","article-title":"American Association of Oral and Maxillofacial Surgeons' position paper on medication-related osteonecrosis of the jaws\u20142022 update","volume":"80","author":"Ruggiero","year":"2022","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2024.07.008_bib0024","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.joms.2014.04.031","article-title":"American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw\u20142014 update","volume":"72","author":"Ruggiero","year":"2014","journal-title":"J Oral Maxillofac Surg."},{"key":"10.1016\/j.oooo.2024.07.008_bib0025","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0278-2391(83)90294-X","article-title":"Osteoradionecrosis; a new concept of its pathophysiology","volume":"41","author":"Marx","year":"1983","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2024.07.008_bib0026","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.radonc.2020.12.026","article-title":"Assessment of jaw osteonecrosis diagnostic criteria in cancer patients with a history of radiation therapy and exposure to bone-modifying agents","volume":"156","author":"Zadik","year":"2021","journal-title":"Radiother Oncol."},{"key":"10.1016\/j.oooo.2024.07.008_bib0027","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0278-2391(83)80005-6","article-title":"A new concept in the treatment of osteoradionecrosis","volume":"41","author":"Marx","year":"1983","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2024.07.008_bib0040","doi-asserted-by":"crossref","DOI":"10.1177\/11795549211036898","article-title":"Radiation-induced fibrosis in patients with head and neck cancer: a review of pathogenesis and clinical outcomes","volume":"16","author":"Ramia","year":"2022","journal-title":"Clin Med Insights Oncol."},{"key":"10.1016\/j.oooo.2024.07.008_bib0041","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1016\/j.ijom.2016.06.016","article-title":"Osteoradionecrosis and medication-related osteonecrosis of the jaw: similarities and differences","volume":"45","author":"Grisar","year":"2016","journal-title":"Int J Oral Maxillofac Surg."},{"key":"10.1016\/j.oooo.2024.07.008_bib0028","doi-asserted-by":"crossref","first-page":"185","DOI":"10.4103\/njms.njms_125_22","article-title":"Management and outcome of locally advanced oral squamous cell carcinoma","volume":"14","author":"Bera","year":"2023","journal-title":"Natl J Maxillofac Surg"},{"key":"10.1016\/j.oooo.2024.07.008_bib0029","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.canrad.2021.09.004","article-title":"Radiotherapy for laryngeal cancers","volume":"26","author":"Biau","year":"2022","journal-title":"Cancer Radiother"},{"key":"10.1016\/j.oooo.2024.07.008_bib0030","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/hed.21993","article-title":"American College of Radiology. ACR Appropriateness Criteria\u00ae ipsilateral radiation for squamous cell carcinoma of the tonsil","volume":"34","author":"Yeung","year":"2012","journal-title":"Head Neck"},{"key":"10.1016\/j.oooo.2024.07.008_bib0031","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.spinee.2023.09.009","article-title":"Fracture rate after conventional external beam radiation therapy to the spine in multiple myeloma patients","volume":"24","author":"Te Velde","year":"2024","journal-title":"Spine J"},{"key":"10.1016\/j.oooo.2024.07.008_bib0032","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ctrv.2018.06.007","article-title":"Medication-related osteonecrosis of the jaw: prevention, diagnosis and management in patients with cancer and bone metastases","volume":"69","author":"Otto","year":"2018","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.oooo.2024.07.008_bib0033","first-page":"107","article-title":"Effects of antiresorptive therapy on the structural and material properties of bone strength","volume":"26","author":"Kishimoto","year":"2016","journal-title":"Clin Calcium"},{"key":"10.1016\/j.oooo.2024.07.008_bib0042","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s40902-022-00366-2","article-title":"Reconstruction of mandibular defects in osteoradionecrosis and medication-related osteonecrosis of the jaw using fibula free flap and management of postoperative wound infections","volume":"44","author":"Oh","year":"2022","journal-title":"Maxillofac Plast Reconstr Surg."},{"key":"10.1016\/j.oooo.2024.07.008_bib0034","doi-asserted-by":"crossref","first-page":"e750","DOI":"10.1097\/SCS.0000000000008697","article-title":"Vascular analysis of soft tissues around the bone lesion in osteoradionecrosis, medication-related osteonecrosis, and infectious osteomyelitis of the jaw","volume":"33","author":"Wang","year":"2022","journal-title":"J Craniofac Surg."},{"key":"10.1016\/j.oooo.2024.07.008_bib0035","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1089\/jir.2014.0152","article-title":"Ionizing radiation stimulates expression of pro-osteoclastogenic genes in marrow and skeletal tissue","volume":"35","author":"Alwood","year":"2015","journal-title":"J Interferon Cytokine Res"},{"key":"10.1016\/j.oooo.2024.07.008_bib0036","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1056\/NEJMoa0802633","article-title":"Giant osteoclast formation and long-term oral bisphosphonate therapy","volume":"360","author":"Weinstein","year":"2009","journal-title":"N Engl J Med."},{"key":"10.1016\/j.oooo.2024.07.008_bib0037","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s12967-017-1230-8","article-title":"Osteoclast profile of medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy: a comparison with osteoradionecrosis and osteomyelitis","volume":"15","author":"Gross","year":"2017","journal-title":"J Transl Med"},{"key":"10.1016\/j.oooo.2024.07.008_bib0038","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/s00066-007-1598-0","article-title":"Proof of direct radiogenic destruction of collagen in vitro","volume":"183","author":"A\u00e7il","year":"2007","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.oooo.2024.07.008_bib0039","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.3390\/medicina58111690","article-title":"Organic bone matrix component type I and V collagen are not destructed in bisphosphonate-associated osteonecrosis of the jaws","volume":"58","author":"Acil","year":"2022","journal-title":"Medicina (Kaunas)"}],"container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440324004012?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440324004012?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T13:18:47Z","timestamp":1741699127000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212440324004012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S2212440324004012"],"URL":"https:\/\/doi.org\/10.1016\/j.oooo.2024.07.008","relation":{},"ISSN":["2212-4403"],"issn-type":[{"value":"2212-4403","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antiresorptive therapy in combination with radiation results in enhanced risk for necrosis and associated complications","name":"articletitle","label":"Article Title"},{"value":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oooo.2024.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}