{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T12:13:43Z","timestamp":1785932023444,"version":"3.56.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003579","name":"University of Toronto","doi-asserted-by":"publisher","award":["46076"],"award-info":[{"award-number":["46076"]}],"id":[{"id":"10.13039\/501100003579","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oooojournal.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.oooo.2025.03.006","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T08:56:26Z","timestamp":1742720186000},"page":"312-321","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Plexiform ameloblastoma: a potential diagnostic challenge"],"prefix":"10.1016","volume":"140","author":[{"given":"Michelle","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Bradley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bayardo","family":"Perez-Ordonez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagen","family":"Klieb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Blanas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5060-7738","authenticated-orcid":false,"given":"Marco A.O.","family":"Magalhaes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.oooo.2025.03.006_bib0001","series-title":"Oral and Maxillofacial Pathology","first-page":"685","article-title":"Odontogenic cysts and tumors","author":"Neville","year":"2024"},{"key":"10.1016\/j.oooo.2025.03.006_bib0002","series-title":"WHO classification of head and neck tumours (beta version ahead of print)","article-title":"Odontogenic and maxillofacial bone tumours","author":"Tilakaratne","year":"2022"},{"key":"10.1016\/j.oooo.2025.03.006_bib0003","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1002\/1097-0142(197711)40:5<2278::AID-CNCR2820400539>3.0.CO;2-L","article-title":"Unicystic ameloblastoma: a prognostically distinct entity","volume":"40","author":"Robinson","year":"1977","journal-title":"Cancer"},{"key":"10.1016\/j.oooo.2025.03.006_bib0004","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/odi.12646","article-title":"Ameloblastoma: current etiopathological concepts and management","volume":"24","author":"Effiom","year":"2018","journal-title":"Oral diseases"},{"key":"10.1016\/j.oooo.2025.03.006_bib0005","first-page":"E26","article-title":"Ameloblastomas of the mandible and maxilla","volume":"97","author":"Petrovic","year":"2018","journal-title":"Ear Nose Throat J"},{"key":"10.1016\/j.oooo.2025.03.006_bib0006","doi-asserted-by":"crossref","DOI":"10.1111\/jop.13510","article-title":"Clinicoradiologic features of ameloblastomas: a single-centre study of 155 cases","author":"Smit","year":"2024","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.oooo.2025.03.006_bib0007","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/1097-0142(197009)26:3<699::AID-CNCR2820260331>3.0.CO;2-K","article-title":"Ameloblastoma: delineation of early histopathologic features of neoplasia","volume":"26","author":"Vickers","year":"1970","journal-title":"Cancer"},{"key":"10.1016\/j.oooo.2025.03.006_bib0008","doi-asserted-by":"crossref","first-page":"e76","DOI":"10.4317\/medoral.18006","article-title":"Histopathology of ameloblastoma of the jaws; some critical observations based on a 40 years single institution experience","volume":"17","author":"Hertog","year":"2012","journal-title":"Medicina oral, patologia oral y cirugia bucal"},{"key":"10.1016\/j.oooo.2025.03.006_bib0009","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s12105-016-0734-5","article-title":"Ameloblastoma: 25 year experience at a single institution","volume":"10","author":"Milman","year":"2016","journal-title":"Head Neck Pathol"},{"key":"10.1016\/j.oooo.2025.03.006_bib0010","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.oooo.2024.03.007","article-title":"A radiologic-pathologic study of the histopathologic variants of ameloblastomas and their proliferation indices","volume":"138","author":"Smit","year":"2024","journal-title":"Oral Surg, Oral Med, Oral Pathol Oral Radiol"},{"key":"10.1016\/j.oooo.2025.03.006_bib0011","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1097\/00000478-200010000-00008","article-title":"Unicystic ameloblastoma: a clinicopathologic study of 33 Chinese patients","volume":"24","author":"Li","year":"2000","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.oooo.2025.03.006_bib0012","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1111\/jop.12740","article-title":"Unicystic ameloblastoma: analysis of 370 cases in a single center in Sri Lanka","volume":"47","author":"Siriwardena","year":"2018","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.oooo.2025.03.006_bib0013","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.bjoms.2021.07.022","article-title":"Unicystic ameloblastoma: analysis of surgical management and recurrence risk factors","volume":"60","author":"Titinchi","year":"2022","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2025.03.006_bib0014","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1111\/jop.12443","article-title":"BRAFV600E mutation in the diagnosis of unicystic ameloblastoma","volume":"45","author":"Pereira","year":"2016","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.oooo.2025.03.006_bib0015","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/jop.13538","article-title":"Molecular pathogenesis of ameloblastoma","volume":"53","author":"Marin-Marquez","year":"2024","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.oooo.2025.03.006_bib0016","doi-asserted-by":"crossref","first-page":"5517","DOI":"10.1158\/1078-0432.CCR-14-1069","article-title":"Activating FGFR2-RAS-BRAF mutations in ameloblastoma","volume":"20","author":"Brown","year":"2014","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.oooo.2025.03.006_bib0017","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/path.4317","article-title":"High frequency of BRAF V600E mutations in ameloblastoma","volume":"232","author":"Kurppa","year":"2014","journal-title":"J Pathol"},{"key":"10.1016\/j.oooo.2025.03.006_bib0018","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/ng.2986","article-title":"Identification of recurrent SMO and BRAF mutations in ameloblastomas","volume":"46","author":"Sweeney","year":"2014","journal-title":"Nat Genet"},{"key":"10.1016\/j.oooo.2025.03.006_bib0019","first-page":"19","article-title":"Ameloblastoma: a review of recent molecular pathogenetic discoveries","volume":"7","author":"Brown","year":"2015","journal-title":"Biomark Cancer"},{"key":"10.1016\/j.oooo.2025.03.006_bib0020","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1177\/0022034518798810","article-title":"The mutational profile of unicystic ameloblastoma","volume":"98","author":"Heikinheimo","year":"2019","journal-title":"J Dent Res"},{"key":"10.1016\/j.oooo.2025.03.006_bib0021","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1097\/PAI.0000000000000904","article-title":"Comparison of immunohistochemistry and DNA sequencing for BRAF V600E mutation detection in mandibular ameloblastomas","volume":"29","author":"da Silva Marcelino","year":"2021","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"10.1016\/j.oooo.2025.03.006_bib0022","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ijom.2023.06.001","article-title":"Utility of BRAF V600E immunohistochemistry in the diagnosis of mandibular ameloblastomas","volume":"53","author":"Ji","year":"2024","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.oooo.2025.03.006_bib0023","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/jop.13278","article-title":"Diagnostic accuracy of immunohistochemistry compared with molecular tests for detection of BRAF V600E mutation in ameloblastomas: systematic review and meta-analysis","volume":"51","author":"Martins-de-Barros","year":"2022","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.oooo.2025.03.006_bib0024","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1038\/s41379-022-01105-8","article-title":"The diagnostic utility of BRAF VE1 mutation-specific immunohistochemistry in ameloblastoma","volume":"35","author":"Mendez","year":"2022","journal-title":"Mod Pathol"},{"key":"10.1016\/j.oooo.2025.03.006_bib0025","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/jop.13577","article-title":"MMP13 expression and activity suggest its role in bone resorption in ameloblastomas","volume":"53","author":"Valeriano","year":"2024","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.oooo.2025.03.006_bib0026","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/jop.13542","article-title":"Clinicopathological characteristics and diagnostic accuracy of BRAF mutations in ameloblastoma: a Bayesian network analysis","volume":"53","author":"Zhang","year":"2024","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.oooo.2025.03.006_bib0027","series-title":"Development of the tooth and its supporting tissues. Oral Histology","first-page":"79","author":"Nanci","year":"2008"},{"key":"10.1016\/j.oooo.2025.03.006_bib0028","first-page":"137","article-title":"Inverted apicobasal polarity in health and disease","author":"Pasquier","year":"2024","journal-title":"J Cell Sci"},{"key":"10.1016\/j.oooo.2025.03.006_bib0029","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1111\/jop.13155","article-title":"BRAF p.V600E status in epithelial areas of ameloblastoma with different histological aspects: implications to the clinical practice","volume":"50","author":"Sant'Ana","year":"2021","journal-title":"J Oral Pathol Med"}],"container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440325008363?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440325008363?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:50:01Z","timestamp":1753318201000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212440325008363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S2212440325008363"],"URL":"https:\/\/doi.org\/10.1016\/j.oooo.2025.03.006","relation":{},"ISSN":["2212-4403"],"issn-type":[{"value":"2212-4403","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plexiform ameloblastoma: a potential diagnostic challenge","name":"articletitle","label":"Article Title"},{"value":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oooo.2025.03.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}