{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T16:25:33Z","timestamp":1774542333992,"version":"3.50.1"},"reference-count":59,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T00:00:00Z","timestamp":1755388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003474","name":"University of Toronto Faculty of Dentistry","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003474","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oooojournal.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.oooo.2025.08.001","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T16:24:37Z","timestamp":1756398277000},"page":"75-85","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Spongiotic gingival hyperplasia: identifying new mechanisms and a survey of clinical approach"],"prefix":"10.1016","volume":"141","author":[{"given":"Justin","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Will","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Dempster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepika","family":"Chugh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Posluns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5060-7738","authenticated-orcid":false,"given":"Marco","family":"Magalhaes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.oooo.2025.08.001_bib0001","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.oooo.2020.10.024","article-title":"Localized juvenile spongiotic gingival hyperplasia: microscopic variations and proposed change to nomenclature","volume":"131","author":"Theofilou","year":"2021","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1016\/j.oooo.2025.08.001_bib0002","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1902\/jop.2007.060502","article-title":"Juvenile spongiotic gingivitis","volume":"78","author":"Darling","year":"2007","journal-title":"J Periodontol"},{"key":"10.1016\/j.oooo.2025.08.001_bib0003","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.tripleo.2008.04.024","article-title":"Localized juvenile spongiotic gingival hyperplasia","volume":"106","author":"Chang","year":"2008","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.oooo.2025.08.001_bib0004","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s12105-018-0903-9","article-title":"Spongiotic gingival hyperplasia synchronously involving multiple sites: case report and review of the literature","volume":"12","author":"Siamantas","year":"2018","journal-title":"Head Neck Pathol"},{"key":"10.1016\/j.oooo.2025.08.001_bib0005","series-title":"Oral and Maxillofacial Pathology","author":"Neville","year":"2023"},{"key":"10.1016\/j.oooo.2025.08.001_bib0006","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/jop.12214","article-title":"Localized juvenile spongiotic gingival hyperplasia featuring unusual p16INK4A labeling and negative human papillomavirus status by polymerase chain reaction","volume":"44","author":"Argyris","year":"2015","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.oooo.2025.08.001_bib0007","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/cup.13549","article-title":"Localized juvenile spongiotic gingival hyperplasia: a report of 27 cases","volume":"46","author":"Wang","year":"2019","journal-title":"J Cutan Pathol"},{"key":"10.1016\/j.oooo.2025.08.001_bib0008","first-page":"360","article-title":"Localized juvenile spongiotic gingival hyperplasia: a report of 3 cases","volume":"35","author":"Solomon","year":"2013","journal-title":"Pediatr Dent"},{"key":"10.1016\/j.oooo.2025.08.001_bib0009","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.adaj.2018.10.001","article-title":"Reappraising localized juvenile spongiotic gingival hyperplasia","volume":"150","author":"Vargo","year":"2019","journal-title":"J Am Dent Assoc 1939"},{"key":"10.1016\/j.oooo.2025.08.001_bib0010","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/his.12774","article-title":"Naidu A. Localized juvenile spongiotic gingival hyperplasia possibly originates from the junctional gingival epithelium\u2014an immunohistochemical study","volume":"68","author":"Allon","year":"2016","journal-title":"Histopathology"},{"key":"10.1016\/j.oooo.2025.08.001_bib0011","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/cap.10241","article-title":"Novel treatment approach of localized juvenile spongiotic gingival hyperplasia with use of Nd:YAG laser","volume":"13","author":"Goldberg","year":"2023","journal-title":"Clin Adv Periodontics"},{"key":"10.1016\/j.oooo.2025.08.001_bib0012","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/ipd.12278","article-title":"Cryotherapy for localized juvenile spongiotic gingival hyperplasia: preliminary findings on two cases","volume":"27","author":"Nogueira","year":"2017","journal-title":"Int J Paediatr Dent"},{"key":"10.1016\/j.oooo.2025.08.001_bib0013","unstructured":"Adult Orthodontics v2. American Association of Orthodontists. Accessed July 7, 2022. https:\/\/www3.aaoinfo.org\/_\/adult-orthodontics\/"},{"key":"10.1016\/j.oooo.2025.08.001_bib0014","first-page":"7","article-title":"A review of oral pathology in orthodontics. Part 1: Soft-tissue pathology","volume":"165","author":"Hankinson","year":"2024","journal-title":"Am J Orthod Dentofac Orthop Off Publ Am Assoc Orthod Its Const Soc Am Board Orthod"},{"key":"10.1016\/j.oooo.2025.08.001_bib0015","doi-asserted-by":"crossref","first-page":"5537","DOI":"10.4103\/jfmpc.jfmpc_1197_20","article-title":"Oral mucosal ulceration during orthodontic treatment: The perception of patients and knowledge and attitude of the orthodontic practitioners","volume":"9","author":"AlDahash","year":"2020","journal-title":"J Fam Med Prim Care"},{"key":"10.1016\/j.oooo.2025.08.001_bib0016","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1365-263X.2010.01078.x","article-title":"Oral mucosal lesions during orthodontic treatment","volume":"21","author":"Baricevic","year":"2011","journal-title":"Int J Paediatr Dent"},{"key":"10.1016\/j.oooo.2025.08.001_bib0017","doi-asserted-by":"crossref","first-page":"84","DOI":"10.23736\/S0026-4970.18.04127-4","article-title":"Oral mucosal complications in orthodontic treatment","volume":"68","author":"Manuelli","year":"2019","journal-title":"Minerva Stomatol"},{"key":"10.1016\/j.oooo.2025.08.001_bib0018","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1051\/odfen\/2018056","article-title":"Orthodontics and oral mucosal lesions in children and teenagers","volume":"21","author":"Sicard","year":"2018","journal-title":"J Dentofac Anom Orthod"},{"key":"10.1016\/j.oooo.2025.08.001_bib0019","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/sj.bdj.4810891","article-title":"Orthodontics. Part 6: Risks in orthodontic treatment","volume":"196","author":"Travess","year":"2004","journal-title":"Br Dent J"},{"key":"10.1016\/j.oooo.2025.08.001_bib0020","first-page":"198","article-title":"Localized juvenile spongiotic gingival inflammation: a report on 3 cases","volume":"87","author":"Petru\u0163iu","year":"2014","journal-title":"Clujul Med 1957"},{"key":"10.1016\/j.oooo.2025.08.001_bib0021","unstructured":"Orthodontics (MSc) Explore UM University of Manitoba. Accessed July 6, 2022. https:\/\/umanitoba.ca\/explore\/programs-of-study\/orthodontics-msc"},{"key":"10.1016\/j.oooo.2025.08.001_bib0022","unstructured":"D.E.S. en orthodontie - Universit\u00e9 de Montr\u00e9al - Guide d\u2019admission. Accessed July 6, 2022. https:\/\/admission.umontreal.ca\/programmes\/des-en-orthodontie\/structure-du-programme\/"},{"key":"10.1016\/j.oooo.2025.08.001_bib0023","unstructured":"Dentistry | School of Graduate Studies (SGS) Calendar. Accessed July 6, 2022. https:\/\/sgs.calendar.utoronto.ca\/degree\/Dentistry"},{"key":"10.1016\/j.oooo.2025.08.001_bib0024","unstructured":"Curriculum. Accessed July 6, 2022. https:\/\/www.schulich.uwo.ca\/dentistry\/\/future_students\/graduate_orthodontics\/curriculum.html"},{"key":"10.1016\/j.oooo.2025.08.001_bib0025","unstructured":"Masters (MSc) Orthodontics School of Dentistry. Accessed July 6, 2022. https:\/\/www.ualberta.ca\/school-of-dentistry\/programs-and-admissions\/graduate-studies\/msc-orthodontics.html"},{"key":"10.1016\/j.oooo.2025.08.001_bib0026","unstructured":"Program Course Requirements Faculty of Dentistry. Accessed July 6, 2022. https:\/\/www.dentistry.ubc.ca\/combined-msc-and-diploma-in-orthodontics\/program-course-requirements\/"},{"key":"10.1016\/j.oooo.2025.08.001_bib0027","unstructured":"BBTools User Guide. DOE Joint Genome Institute. Accessed June 3, 2024. https:\/\/jgi.doe.gov\/data-and-tools\/software-tools\/bbtools\/bb-tools-user-guide\/"},{"key":"10.1016\/j.oooo.2025.08.001_bib0028","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat Methods"},{"key":"10.1016\/j.oooo.2025.08.001_bib0029","doi-asserted-by":"crossref","first-page":"giab008","DOI":"10.1093\/gigascience\/giab008","article-title":"Twelve years of SAMtools and BCFtools","volume":"10","author":"Danecek","year":"2021","journal-title":"GigaScience"},{"key":"10.1016\/j.oooo.2025.08.001_bib0030","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq\u2014a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.oooo.2025.08.001_bib0031","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nmeth.4197","article-title":"Salmon provides fast and bias-aware quantification of transcript expression","volume":"14","author":"Patro","year":"2017","journal-title":"Nat Methods"},{"key":"10.1016\/j.oooo.2025.08.001_bib0032","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.oooo.2025.08.001_bib0033","series-title":"Practical Guide to Life Science Databases","first-page":"27","article-title":"The GeneCards Suite","author":"Safran","year":"2021"},{"key":"10.1016\/j.oooo.2025.08.001_bib0034","doi-asserted-by":"crossref","first-page":"1.30.1","DOI":"10.1002\/cpbi.5","article-title":"The GeneCards Suite: from gene data mining to disease genome sequence analyses","volume":"54","author":"Stelzer","year":"2016","journal-title":"Curr Protoc Bioinforma"},{"key":"10.1016\/j.oooo.2025.08.001_bib0035","doi-asserted-by":"crossref","first-page":"iyad031","DOI":"10.1093\/genetics\/iyad031","article-title":"The Gene Ontology knowledgebase in 2023","volume":"224","author":"Aleksander","year":"2023","journal-title":"Genetics"},{"key":"10.1016\/j.oooo.2025.08.001_bib0036","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene Ontology: tool for the unification of biology","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/j.oooo.2025.08.001_bib0037","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1010348","article-title":"Nine quick tips for pathway enrichment analysis","volume":"18","author":"Chicco","year":"2022","journal-title":"PLoS Comput Biol"},{"key":"10.1016\/j.oooo.2025.08.001_bib0038","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1093\/bioinformatics\/btz931","article-title":"ShinyGO: a graphical gene-set enrichment tool for animals and plants","volume":"36","author":"Ge","year":"2020","journal-title":"Bioinformatics"},{"key":"10.1016\/j.oooo.2025.08.001_bib0039","doi-asserted-by":"crossref","first-page":"D672","DOI":"10.1093\/nar\/gkad1025","article-title":"The Reactome Pathway Knowledgebase 2024","volume":"52","author":"Milacic","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.oooo.2025.08.001_bib0040","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1002\/pro.3715","article-title":"Toward understanding the origin and evolution of cellular organisms","volume":"28","author":"Kanehisa","year":"2019","journal-title":"Protein Sci Publ Protein Soc"},{"key":"10.1016\/j.oooo.2025.08.001_bib0041","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.oooo.2025.08.001_bib0042","doi-asserted-by":"crossref","first-page":"D587","DOI":"10.1093\/nar\/gkac963","article-title":"KEGG for taxonomy-based analysis of pathways and genomes","volume":"51","author":"Kanehisa","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.oooo.2025.08.001_bib0043","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3390\/cells8040321","article-title":"Updates on the CDK4\/6 inhibitory strategy and combinations in breast cancer","volume":"8","author":"Sobhani","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.oooo.2025.08.001_bib0044","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/j.0022-0337.2009.73.2.tb04654.x","article-title":"Resident evaluation of orthodontic programs in Canada","volume":"73","author":"Noble","year":"2009","journal-title":"J Dent Educ"},{"key":"10.1016\/j.oooo.2025.08.001_bib0045","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1002\/j.0022-0337.2009.73.11.tb04820.x","article-title":"Resident Evaluation of Orthodontic Programs in the United States","volume":"73","author":"Noble","year":"2009","journal-title":"J Dent Educ"},{"key":"10.1016\/j.oooo.2025.08.001_bib0046","doi-asserted-by":"crossref","first-page":"228","DOI":"10.17796\/1053-4628-41.3.228","article-title":"Localized juvenile spongiotic gingival hyperplasia: report of two cases","volume":"41","author":"Kalogirou","year":"2017","journal-title":"J Clin Pediatr Dent"},{"key":"10.1016\/j.oooo.2025.08.001_bib0047","first-page":"1","article-title":"Targeting PI3K\/Akt signal transduction for cancer therapy","volume":"6","author":"He","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.oooo.2025.08.001_bib0048","first-page":"1","article-title":"Inflammation-related cytokines in oral lichen planus: an overview","volume":"44","author":"Lu","year":"2015","journal-title":"J Oral Pathol Med Off Publ Int Assoc Oral Pathol Am Acad Oral Pathol"},{"key":"10.1016\/j.oooo.2025.08.001_bib0049","doi-asserted-by":"crossref","first-page":"4614","DOI":"10.3390\/jcm12144614","article-title":"Expression of interleukin 17A and 17B in gingival tissue in patients with periodontitis","volume":"12","author":"Mazurek-Mochol","year":"2023","journal-title":"J Clin Med"},{"key":"10.1016\/j.oooo.2025.08.001_bib0050","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.cca.2008.06.003","article-title":"Elevated expression of IL-17 and IL-12 genes in chronic inflammatory periodontal disease","volume":"395","author":"Honda","year":"2008","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.oooo.2025.08.001_bib0051","doi-asserted-by":"crossref","first-page":"8051","DOI":"10.3390\/app12168051","article-title":"Levels of IL-23\/IL-17 axis in plasma and gingival tissue of periodontitis patients according to the new classification","volume":"12","author":"Rodr\u00edguez-Monta\u00f1o","year":"2022","journal-title":"Appl Sci"},{"key":"10.1016\/j.oooo.2025.08.001_bib0052","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1073\/pnas.1818812116","article-title":"Mutual interplay between IL-17\u2013producing \u03b3\u03b4T cells and microbiota orchestrates oral mucosal homeostasis","volume":"116","author":"Wilharm","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.oooo.2025.08.001_bib0053","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20190297","article-title":"The role of interleukin-17 in tumor development and progression","volume":"217","author":"Zhao","year":"2020","journal-title":"J Exp Med"},{"key":"10.1016\/j.oooo.2025.08.001_bib0054","series-title":"Stem Cell Biology and Tissue Engineering in Dental Sciences","first-page":"735","article-title":"Chapter 54 - Dental Implantology and Implants - Tissue Interface","author":"Gruber","year":"2015"},{"key":"10.1016\/j.oooo.2025.08.001_bib0055","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.oooo.2025.08.001_bib0056","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/BF03401664","article-title":"The CDKN2A (p16) gene and human cancer","volume":"3","author":"Foulkes","year":"1997","journal-title":"Mol Med"},{"key":"10.1016\/j.oooo.2025.08.001_bib0057","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S1535-6108(02)00102-2","article-title":"The RB and p53 pathways in cancer","volume":"2","author":"Sherr","year":"2002","journal-title":"Cancer Cell"},{"key":"10.1016\/j.oooo.2025.08.001_bib0058","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/s41418-022-00988-z","article-title":"Cell cycle regulation: p53-p21-RB signaling","volume":"29","author":"Engeland","year":"2022","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.oooo.2025.08.001_bib0059","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12943-023-01827-6","article-title":"PI3K\/AKT\/mTOR signaling transduction pathway and targeted therapies in cancer","volume":"22","author":"Glaviano","year":"2023","journal-title":"Mol Cancer"}],"container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440325011629?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212440325011629?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T15:45:56Z","timestamp":1772898356000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212440325011629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S2212440325011629"],"URL":"https:\/\/doi.org\/10.1016\/j.oooo.2025.08.001","relation":{},"ISSN":["2212-4403"],"issn-type":[{"value":"2212-4403","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spongiotic gingival hyperplasia: identifying new mechanisms and a survey of clinical approach","name":"articletitle","label":"Article Title"},{"value":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oooo.2025.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}