{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T17:10:14Z","timestamp":1762535414097,"version":"build-2065373602"},"reference-count":14,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oooojournal.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.oooo.2025.08.003","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T16:59:30Z","timestamp":1755622770000},"page":"715-718","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Apremilast for refractory major recurrent aphthous stomatitis involving the posterior pharyngeal wall: a case report"],"prefix":"10.1016","volume":"140","author":[{"given":"Tinglan","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiankang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8518-8222","authenticated-orcid":false,"given":"Zhenlai","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.oooo.2025.08.003_bib0001","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.jfma.2018.10.023","article-title":"Recurrent aphthous stomatitis\u2014etiology, serum autoantibodies, anemia, hematinic deficiencies, and management","volume":"118","author":"Chiang","year":"2019","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.oooo.2025.08.003_bib0002","doi-asserted-by":"crossref","DOI":"10.1111\/dth.15500","article-title":"Recurrent aphthous stomatitis: a comprehensive review and recommendations on therapeutic options","volume":"35","author":"Lau","year":"2022","journal-title":"Dermatol Ther"},{"key":"10.1016\/j.oooo.2025.08.003_bib0003","first-page":"1554","article-title":"Pharyngeal reconstruction for severe pharyngeal stenosis in Behcet\u2019s disease: a retrospective case series","volume":"40","author":"Gu","year":"2022","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.oooo.2025.08.003_bib0004","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.jaad.2023.11.068","article-title":"Efficacy and safety of apremilast in pediatric patients with moderate-to-severe plaque psoriasis: 16-week results from SPROUT, a randomized controlled trial","volume":"90","author":"Fiorillo","year":"2024","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.oooo.2025.08.003_bib0005","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.jaad.2023.10.020","article-title":"Efficacy and safety of apremilast in patients with moderate-to-severe genital psoriasis: results from DISCREET, a phase 3 randomized, double-blind, placebo-controlled trial","volume":"90","author":"Merola","year":"2024","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.oooo.2025.08.003_bib0006","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s13555-022-00877-w","article-title":"Apremilast in palmoplantar psoriasis and palmoplantar pustulosis: a systematic review and meta-analysis","volume":"13","author":"Spencer","year":"2023","journal-title":"Dermatol Ther (Heidelb)"},{"key":"10.1016\/j.oooo.2025.08.003_bib0007","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1056\/NEJMc1901987","article-title":"Apremilast in treatment-refractory recurrent aphthous stomatitis","volume":"381","author":"Kolios","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.oooo.2025.08.003_bib0008","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.jaad.2022.05.063","article-title":"Apremilast for severe recurrent aphthous stomatitis: a prospective pilot study","volume":"88","author":"Pincelli","year":"2023","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.oooo.2025.08.003_bib0009","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/pde.15711","article-title":"Recurrent aphthous stomatitis in a child successfully treated with apremilast","volume":"42","author":"March-Rodriguez","year":"2025","journal-title":"Pediatr Dermatol"},{"key":"10.1016\/j.oooo.2025.08.003_bib0010","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.jdcr.2017.06.017","article-title":"Apremilast for treatment of recalcitrant aphthous stomatitis","volume":"3","author":"Schibler","year":"2017","journal-title":"JAAD Case Rep"},{"key":"10.1016\/j.oooo.2025.08.003_bib0011","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1080\/14712598.2021.1942832","article-title":"Interleukin-6 inhibition: a therapeutic strategy for the management of adult-onset Still\u2019s disease","volume":"22","author":"Kaneko","year":"2022","journal-title":"Expert Opin Biol Ther"},{"key":"10.1016\/j.oooo.2025.08.003_bib0012","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0305355","article-title":"Evaluation of cytokine expressions in patients with recurrent aphthous stomatitis: a systematic review and meta-analysis","volume":"19","author":"Teng","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.oooo.2025.08.003_bib0013","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1007\/s00403-025-04193-z","article-title":"Safety assessment of apremilast: real-world adverse event analysis from the FAERS database","volume":"317","author":"Ren","year":"2025","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.oooo.2025.08.003_bib0014","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ad.2020.08.007","article-title":"Multidisciplinary management of the adverse effects of apremilast","volume":"112","author":"Dauden Tello","year":"2021","journal-title":"Actas Dermosifiliogr (Engl Ed)"}],"container-title":["Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221244032501168X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221244032501168X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T17:06:41Z","timestamp":1762535201000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221244032501168X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S221244032501168X"],"URL":"https:\/\/doi.org\/10.1016\/j.oooo.2025.08.003","relation":{},"ISSN":["2212-4403"],"issn-type":[{"type":"print","value":"2212-4403"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Apremilast for refractory major recurrent aphthous stomatitis involving the posterior pharyngeal wall: a case report","name":"articletitle","label":"Article Title"},{"value":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oooo.2025.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}