{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T15:12:29Z","timestamp":1782745949053,"version":"3.54.5"},"reference-count":50,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmology"],"published-print":{"date-parts":[[2005,9]]},"DOI":"10.1016\/j.ophtha.2005.04.009","type":"journal-article","created":{"date-parts":[[2005,7,15]],"date-time":"2005-07-15T13:34:03Z","timestamp":1121434443000},"page":"1528.e1-1528.e8","source":"Crossref","is-referenced-by-count":70,"title":["Expression of Toll-like Receptors in Healthy and Allergic Conjunctiva"],"prefix":"10.1016","volume":"112","author":[{"given":"Stefano","family":"Bonini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Micera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Iovieno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Lambiase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Bonini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ophtha.2005.04.009_bib1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev.immunol.21.120601.141126","article-title":"Toll-like receptors","volume":"21","author":"Takeda","year":"2003","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.ophtha.2005.04.009_bib2","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/41131","article-title":"A human homologue of the Drosophila Toll protein signals activation of adaptive immunity","volume":"388","author":"Medzhitov","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.ophtha.2005.04.009_bib3","series-title":"Molecular Biology of the Cell","author":"Alberts","year":"2002"},{"key":"10.1016\/j.ophtha.2005.04.009_bib4","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/90609","article-title":"Toll-like receptors","volume":"2","author":"Akira","year":"2001","journal-title":"Nat Immunol"},{"key":"10.1016\/j.ophtha.2005.04.009_bib5","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1126\/science.1094351","article-title":"A toll-like receptor that prevents infection by uropathogenic bacteria","volume":"303","author":"Zhang","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.ophtha.2005.04.009_bib6","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1189\/jlb.0403160","article-title":"Biology of Toll receptors","volume":"75","author":"Imler","year":"2004","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.ophtha.2005.04.009_bib7","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.4049\/jimmunol.162.7.3749","article-title":"Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product","volume":"162","author":"Hoshino","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.ophtha.2005.04.009_bib8","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1126\/science.285.5428.732","article-title":"Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors","volume":"285","author":"Brightbill","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.ophtha.2005.04.009_bib9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smim.2003.10.003","article-title":"TLR signaling pathways","volume":"16","author":"Takeda","year":"2004","journal-title":"Semin Immunol"},{"key":"10.1016\/j.ophtha.2005.04.009_bib10","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1165\/rcmb.2003-0388OC","article-title":"Activation of airway epithelial cells by toll-like receptor agonists","volume":"31","author":"Sha","year":"2004","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.ophtha.2005.04.009_bib11","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1165\/rcmb.2004-0078OC","article-title":"Expression of functional toll-like receptor-2 and -4 on alveolar epithelial cells","volume":"31","author":"Armstrong","year":"2004","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.ophtha.2005.04.009_bib12","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1365-2567.2004.01946.x","article-title":"Histamine induces Toll-like receptor 2 and 4 expression in endothelial cells and enhances sensitivity to gram-positive and gram-negative bacterial cell wall components","volume":"113","author":"Talreja","year":"2004","journal-title":"Immunology"},{"key":"10.1016\/j.ophtha.2005.04.009_bib13","doi-asserted-by":"crossref","first-page":"5998","DOI":"10.4049\/jimmunol.164.11.5998","article-title":"Differential expression and regulation of toll-like receptors (TLR) in human leukocytes","volume":"164","author":"Muzio","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.ophtha.2005.04.009_bib14","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1182\/blood-2002-11-3355","article-title":"The toll-like receptor repertoire of human B lymphocytes","volume":"102","author":"Bourke","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.ophtha.2005.04.009_bib15","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1182\/blood.V95.4.1378.004k08_1378_1385","article-title":"Gene expressions of lipopolysaccharide receptors, toll-like receptors 2 and 4, are differently regulated in mouse T lymphocytes","volume":"95","author":"Matsuguchi","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.ophtha.2005.04.009_bib16","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1189\/jlb.70.6.977","article-title":"Toll-like receptor 4-mediated activation of murine mast cells","volume":"70","author":"McCurdy","year":"2001","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.ophtha.2005.04.009_bib17","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1182\/blood-2003-04-1078","article-title":"Toll-like receptors stimulate human neutrophil function","volume":"102","author":"Hayashi","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.ophtha.2005.04.009_bib18","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.4049\/jimmunol.171.8.3977","article-title":"Expression and function of Toll-like receptors in eosinophils","volume":"171","author":"Nagase","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.ophtha.2005.04.009_bib19","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1167\/iovs.03-1113","article-title":"Expression of toll-like receptor 4 and its associated lipopolysaccharide receptor complex by resident antigen-presenting cells in the human uvea","volume":"45","author":"Chang","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2005.04.009_bib20","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jneuroim.2004.04.018","article-title":"Innate immunity in the retina","volume":"153","author":"Kumar","year":"2004","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.ophtha.2005.04.009_bib21","first-page":"2867","article-title":"The expression of functional LPS receptor proteins CD14 and toll-like receptor 4 in human corneal cells","volume":"42","author":"Song","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2005.04.009_bib22","doi-asserted-by":"crossref","first-page":"4247","DOI":"10.1167\/iovs.03-0219","article-title":"Toll-like receptor 5-mediated corneal epithelial inflammatory responses to Pseudomonas aeruginosa flagellin","volume":"44","author":"Zhang","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2005.04.009_bib23","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.4049\/jimmunol.173.5.3337","article-title":"Intracellularly expressed TLR2s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium","volume":"173","author":"Ueta","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.ophtha.2005.04.009_bib24","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.smim.2003.10.006","article-title":"Toll-like receptors and acquired immunity","volume":"16","author":"Pasare","year":"2004","journal-title":"Semin Immunol"},{"key":"10.1016\/j.ophtha.2005.04.009_bib25","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/00001432-200306000-00003","article-title":"Toll-like receptors and T-helper-1\/T-helper-2 responses","volume":"16","author":"Dabbagh","year":"2003","journal-title":"Curr Opin Infect Dis"},{"key":"10.1016\/j.ophtha.2005.04.009_bib26","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/S0161-6420(00)00092-0","article-title":"Vernal keratoconjunctivitis revisited","volume":"107","author":"Bonini","year":"2000","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2005.04.009_bib27","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/00004397-200343010-00005","article-title":"Cytokines in ocular allergy","volume":"43","author":"Bonini","year":"2003","journal-title":"Int Ophthalmol Clin"},{"key":"10.1016\/j.ophtha.2005.04.009_bib28","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/00130832-200310000-00011","article-title":"Allergic chronic inflammation of the ocular surface in vernal keratoconjunctivitis","volume":"3","author":"Bonini","year":"2003","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.ophtha.2005.04.009_bib29","first-page":"4175","article-title":"Growth factors and collagen distribution in vernal keratoconjunctivitis","volume":"41","author":"Leonardi","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2005.04.009_bib30","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S1350-9462(02)00006-X","article-title":"Vernal keratoconjunctivitis","volume":"21","author":"Leonardi","year":"2002","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.ophtha.2005.04.009_bib31","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.4049\/jimmunol.146.4.1169","article-title":"Accumulation of Th2-like helper T cells in the conjunctiva of patients with vernal conjunctivitis","volume":"146","author":"Maggi","year":"1991","journal-title":"J Immunol"},{"key":"10.1016\/j.ophtha.2005.04.009_bib32","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1093\/nar\/30.9.e36","article-title":"Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR","volume":"30","author":"Pfaffl","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ophtha.2005.04.009_bib33","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.cell.2004.07.002","article-title":"Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis","volume":"118","author":"Rakoff-Nahoum","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.ophtha.2005.04.009_bib34","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1128\/IAI.72.5.2671-2678.2004","article-title":"Pattern of cytokine responses to gram-positive and gram-negative commensal bacteria is profoundly changed when monocytes differentiate into dendritic cells","volume":"72","author":"Karlsson","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.ophtha.2005.04.009_bib35","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1046\/j.1365-2222.1999.00560.x","article-title":"The intestinal microflora in allergic Estonian and Swedish 2-year-old children","volume":"29","author":"Bj\u00f6rksten","year":"1999","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.ophtha.2005.04.009_bib36","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1067\/mai.2001.118130","article-title":"Allergy development and the intestinal microflora during the first year of life","volume":"108","author":"Bj\u00f6rksten","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ophtha.2005.04.009_bib37","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1046\/j.1365-2222.2000.00982.x","article-title":"Microflora-associated characteristics in faeces from allergic and nonallergic infants","volume":"30","author":"B\u00f6ttcher","year":"2000","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.ophtha.2005.04.009_bib38","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1136\/bmj.320.7232.412","article-title":"Exposure to foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma","volume":"320","author":"Matricardi","year":"2000","journal-title":"BMJ"},{"key":"10.1016\/j.ophtha.2005.04.009_bib39","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1177\/09680519030090050901","article-title":"TLR signaling at the intestinal epithelial interface","volume":"9","author":"Abreu","year":"2003","journal-title":"J Endotoxin Res"},{"key":"10.1016\/j.ophtha.2005.04.009_bib40","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/intimm\/dxg068","article-title":"Expression and function of Toll-like receptors 2 and 4 in human keratinocytes","volume":"15","author":"Pivarcsi","year":"2003","journal-title":"Int Immunol"},{"key":"10.1016\/j.ophtha.2005.04.009_bib41","doi-asserted-by":"crossref","first-page":"4524","DOI":"10.4049\/jimmunol.168.9.4524","article-title":"Toll-like receptor 4 is required for optimal development of Th2 immune responses","volume":"168","author":"Dabbagh","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.ophtha.2005.04.009_bib42","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/S0960-9822(00)00700-4","article-title":"Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88","volume":"10","author":"Schnare","year":"2000","journal-title":"Curr Biol"},{"key":"10.1016\/j.ophtha.2005.04.009_bib43","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1084\/jem.194.6.863","article-title":"Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens","volume":"194","author":"Kadowaki","year":"2001","journal-title":"J Exp Med"},{"key":"10.1016\/j.ophtha.2005.04.009_bib44","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1146\/annurev.immunol.20.100301.064842","article-title":"CpG motifs in bacterial DNA and their immune effects","volume":"20","author":"Krieg","year":"2002","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.ophtha.2005.04.009_bib45","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.4049\/jimmunol.171.6.3119","article-title":"Toll-like receptor 4-mediated innate IL-10 activates antigen-specific regulatory T cells and confers resistance to Bordetella pertussis by inhibiting inflammatory pathology","volume":"171","author":"Higgins","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.ophtha.2005.04.009_bib46","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1084\/jem.20021340","article-title":"Lipopolysaccharide-enhanced, toll-like receptor 4\u2013dependent T helper cell type 2 responses to inhaled antigen","volume":"196","author":"Eisenbarth","year":"2002","journal-title":"J Exp Med"},{"key":"10.1016\/j.ophtha.2005.04.009_bib47","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000058808","article-title":"Mast cell-eosinophil-fibroblast crosstalk in allergic inflammation","volume":"78","author":"Smith","year":"2000","journal-title":"Chem Immunol"},{"key":"10.1016\/j.ophtha.2005.04.009_bib48","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/eji.200323830","article-title":"Toll-like receptor 2 (TLR2) and TLR4 differentially activate human mast cells","volume":"33","author":"Varadaradjalou","year":"2003","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.ophtha.2005.04.009_bib49","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1002\/1521-4141(200007)30:7<1841::AID-IMMU1841>3.0.CO;2-E","article-title":"Systemic or mucosal administration of immunostimulatory DNA inhibits early and late phases of murine allergic conjunctivitis","volume":"30","author":"Magone","year":"2000","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.ophtha.2005.04.009_bib50","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/S1367-5931(03)00077-2","article-title":"Novel therapeutic strategies based on toll-like receptor signaling","volume":"7","author":"Lawton","year":"2003","journal-title":"Curr Opin Chem Biol"}],"container-title":["Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642005006068?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642005006068?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T22:21:24Z","timestamp":1706394084000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161642005006068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":50,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["S0161642005006068"],"URL":"https:\/\/doi.org\/10.1016\/j.ophtha.2005.04.009","relation":{},"ISSN":["0161-6420"],"issn-type":[{"value":"0161-6420","type":"print"}],"subject":[],"published":{"date-parts":[[2005,9]]}}}