{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T01:54:34Z","timestamp":1794275674824,"version":"4.9.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmology"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1016\/j.ophtha.2009.11.043","type":"journal-article","created":{"date-parts":[[2010,4,11]],"date-time":"2010-04-11T04:24:09Z","timestamp":1270959849000},"page":"1294-1299","source":"Crossref","is-referenced-by-count":52,"title":["Tailored Approach to the Treatment of Vernal Keratoconjunctivitis"],"prefix":"10.1016","volume":"117","author":[{"given":"Marta","family":"Sacchetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Lambiase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Mantelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Velika","family":"Deligianni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Leonardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Bonini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ophtha.2009.11.043_bib1","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/S0161-6420(00)00092-0","article-title":"Vernal keratoconjunctivitis revisited: a case series of 195 patients with long-term followup","volume":"107","author":"Bonini","year":"2000","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2009.11.043_bib2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S1350-9462(02)00006-X","article-title":"Vernal keratoconjunctivitis: pathogenesis and treatment","volume":"21","author":"Leonardi","year":"2002","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.ophtha.2009.11.043_bib3","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/sj.eye.6700675","article-title":"Vernal keratoconjunctivitis","volume":"18","author":"Bonini","year":"2004","journal-title":"Eye"},{"key":"10.1016\/j.ophtha.2009.11.043_bib4","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/j.1600-0420.2005.00622.x","article-title":"Case series of 406 vernal keratoconjunctivitis patients: a demographic and epidemiological study","volume":"84","author":"Leonardi","year":"2006","journal-title":"Acta Ophthalmol Scand"},{"key":"10.1016\/j.ophtha.2009.11.043_bib5","first-page":"88","article-title":"Ocular complications of vernal keratoconjunctivitis","volume":"34","author":"Tabbara","year":"1999","journal-title":"Can J Ophthalmol"},{"key":"10.1016\/j.ophtha.2009.11.043_bib6","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1080\/09286580802573177","article-title":"Prospective, multicenter demographic and epidemiological study on vernal keratoconjunctivitis: a glimpse of ocular surface in Italian population","volume":"16","author":"Lambiase","year":"2009","journal-title":"Ophthalmic Epidemiol"},{"key":"10.1016\/j.ophtha.2009.11.043_bib7","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.ajo.2007.06.028","article-title":"Development and testing of the quality of life in children with vernal keratoconjunctivitis questionnaire","volume":"144","author":"Sacchetti","year":"2007","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2009.11.043_bib8","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1136\/bjo.2007.122044","article-title":"Systematic review and meta-analysis of randomised clinical trials on topical treatments for vernal keratoconjunctivitis","volume":"91","author":"Mantelli","year":"2007","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2009.11.043_bib9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/00004397-200343010-00007","article-title":"Vernal keratoconjunctivitis","volume":"43","author":"Leonardi","year":"2003","journal-title":"Int Ophthalmol Clin"},{"key":"10.1016\/j.ophtha.2009.11.043_bib10","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1067\/mai.2000.111238","article-title":"Allergic and immunologic disorders of the eye","volume":"106","author":"Bielory","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ophtha.2009.11.043_bib11","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1097\/ACI.0b013e3282efb726","article-title":"Clinical grading of vernal keratoconjunctivitis","volume":"7","author":"Bonini","year":"2007","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.ophtha.2009.11.043_bib12","first-page":"18","article-title":"Classification and Regression Trees","author":"Breiman","year":"1984"},{"key":"10.1016\/j.ophtha.2009.11.043_bib13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0166-1280(02)00622-X","article-title":"The use of discriminant analysis, logistic regression and classification tree analysis in the development of classification models for human health effects","volume":"622","author":"Worth","year":"2003","journal-title":"Theochem"},{"key":"10.1016\/j.ophtha.2009.11.043_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cca.2008.04.007","article-title":"Logistic regression and CART in the analysis of multimarker studies","volume":"394","author":"Muller","year":"2008","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.ophtha.2009.11.043_bib15","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1023\/A:1016409317640","article-title":"Decision trees: an overview and their use in medicine","volume":"26","author":"Podgorelec","year":"2002","journal-title":"J Med Syst"},{"key":"10.1016\/j.ophtha.2009.11.043_bib16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2288-4-7","article-title":"Binary classification of dyslipidemia from the waist-to-hip ratio and body mass index: a comparison of linear, logistic, and CART models","volume":"4","author":"Costanza","year":"2004","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.ophtha.2009.11.043_bib17","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1177\/112067210101100203","article-title":"Comparison of lodoxamide 0.1% ophthalmic solution and levocabastine 0.05% ophthalmic suspension in vernal keratoconjunctivitis","volume":"11","author":"Verin","year":"2001","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.ophtha.2009.11.043_bib18","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/S0161-6420(00)00089-0","article-title":"Mechanisms and comparison of anti-allergic efficacy of topical lodoxamide and cromolyn sodium treatment in vernal keratoconjunctivitis","volume":"107","author":"Avunduk","year":"2000","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2009.11.043_bib19","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1046\/j.1365-2222.1999.00501.x","article-title":"Nedocromil sodium eye drops are more effective than sodium cromoglycate eye drops for the long-term management of vernal keratoconjunctivitis","volume":"29","author":"Verin","year":"1999","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.ophtha.2009.11.043_bib20","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1136\/bjo.2007.117515","article-title":"Clinical and biological efficacy of preservative-free NAAGA eye-drops versus levocabastine eye-drops in vernal keratoconjunctivitis patients","volume":"91","author":"Leonardi","year":"2007","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2009.11.043_bib21","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1177\/112067219500500417","article-title":"Levocabastine eye drops in vernal conjunctivitis","volume":"5","author":"Bonini","year":"1995","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.ophtha.2009.11.043_bib22","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.ajo.2004.12.009","article-title":"Improving the reporting of clinical case series","volume":"139","author":"Jabs","year":"2005","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2009.11.043_bib23","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1001\/archopht.121.11.1586","article-title":"Use of best and final visual acuity outcomes in ophthalmological research","volume":"121","author":"DiLoreto","year":"2003","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2009.11.043_bib24","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1167\/iovs.06-0018","article-title":"Serial measurements of higher-order aberrations after blinking in normal subjects","volume":"47","author":"Koh","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2009.11.043_bib25","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/eye.1992.139","article-title":"Effectiveness of nedocromil sodium 2% eyedrops on clinical symptoms and tear fluid cytology of patients with vernal conjunctivitis","volume":"6","author":"Bonini","year":"1992","journal-title":"Eye"},{"key":"10.1016\/j.ophtha.2009.11.043_bib26","first-page":"177","article-title":"Topical ketorolac 0.5% solution for the treatment of vernal keratoconjunctivitis","volume":"45","author":"Sharma","year":"1997","journal-title":"Indian J Ophthalmol"},{"key":"10.1016\/j.ophtha.2009.11.043_bib27","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/0002-9394(86)90819-6","article-title":"Cyclosporine eyedrops for the treatment of severe vernal keratoconjunctivitis","volume":"101","author":"BenEzra","year":"1986","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2009.11.043_bib28","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0002-9394(14)77061-8","article-title":"Topical use of cyclosporine in the treatment of vernal keratoconjunctivitis","volume":"110","author":"Secchi","year":"1990","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2009.11.043_bib29","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1016\/S0161-6420(91)32069-4","article-title":"Topical cyclosporine in vernal keratoconjunctivitis","volume":"98","author":"Bleik","year":"1991","journal-title":"Ophthalmology"}],"container-title":["Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642009014018?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642009014018?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T00:21:39Z","timestamp":1559002899000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161642009014018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S0161642009014018"],"URL":"https:\/\/doi.org\/10.1016\/j.ophtha.2009.11.043","relation":{},"ISSN":["0161-6420"],"issn-type":[{"value":"0161-6420","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}