{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:39:56Z","timestamp":1793947196996,"version":"4.8.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmology"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1016\/j.ophtha.2010.01.039","type":"journal-article","created":{"date-parts":[[2010,6,4]],"date-time":"2010-06-04T04:32:38Z","timestamp":1275625958000},"page":"1300-1305.e7","source":"Crossref","is-referenced-by-count":235,"title":["Corneal Neovascularization as a Risk Factor for Graft Failure and Rejection after Keratoplasty"],"prefix":"10.1016","volume":"117","author":[{"given":"Bjorn","family":"Bachmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rod S.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Cursiefen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ophtha.2010.01.039_bib1","first-page":"69","article-title":"The Australian Corneal Graft Registry 2007 Report","author":"Williams","year":"2007"},{"key":"10.1016\/j.ophtha.2010.01.039_bib2","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1001\/archopht.1992.01080220054021","article-title":"The Collaborative Corneal Transplantation Studies (CCTS): effectiveness of histocompatibility matching in high-risk corneal transplantation","volume":"110","year":"1992","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2010.01.039_bib3","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1167\/iovs.03-1380","article-title":"Inhibition of hemangiogenesis and lymphangiogenesis after normal-risk corneal transplantation by neutralizing VEGF promotes graft survival","volume":"45","author":"Cursiefen","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2010.01.039_bib4","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.ajo.2005.08.080","article-title":"Surgery-related factors influencing corneal neovascularization after low-risk keratoplasty","volume":"141","author":"Lam","year":"2006","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2010.01.039_bib5","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2353\/ajpath.2007.060896","article-title":"Inhibition of inflammatory lymphangiogenesis by integrin alpha5 blockade","volume":"171","author":"Dietrich","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ophtha.2010.01.039_bib6","doi-asserted-by":"crossref","first-page":"8868","DOI":"10.1073\/pnas.062040199","article-title":"Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea","volume":"99","author":"Kubo","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ophtha.2010.01.039_bib7","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00417-007-0683-5","article-title":"Blockade of VEGFR3-signalling specifically inhibits lymphangiogenesis in inflammatory corneal neovascularisation","volume":"246","author":"Bock","year":"2008","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.ophtha.2010.01.039_bib8","first-page":"626","article-title":"The chemokine receptor CCR7 mediates corneal antigen-presenting cell trafficking","volume":"13","author":"Jin","year":"2007","journal-title":"Mol Vis [serial online]"},{"key":"10.1016\/j.ophtha.2010.01.039_bib9","author":"Higgins"},{"key":"10.1016\/j.ophtha.2010.01.039_bib10","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S1470-2045(06)70800-2","article-title":"Response rate or time to progression as predictors of survival in trials of metastatic colorectal cancer or non-small-cell lung cancer: a meta-analysis","volume":"7","author":"Johnson","year":"2006","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ophtha.2010.01.039_bib11","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1093\/annonc\/mdl174","article-title":"Correlation between tumor response to first-line chemotherapy and prognosis in advanced gastric cancer patients","volume":"17","author":"Ichikawa","year":"2006","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ophtha.2010.01.039_bib12","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control Clin Trials"},{"key":"10.1016\/j.ophtha.2010.01.039_bib13","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/01.brs.0000149199.68381.fe","article-title":"Spinal cord stimulation for chronic back and leg pain and failed back surgery syndrome: a systematic review and analysis of prognostic factors","volume":"30","author":"Taylor","year":"2005","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.ophtha.2010.01.039_bib14","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1136\/bjo.81.8.631","article-title":"Conclusions of the Corneal Transplant Follow up Study","volume":"81","author":"Vail","year":"1997","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2010.01.039_bib15","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.ophtha.2007.08.049","article-title":"Penetrating keratoplasty in Asian eyes: the Singapore Corneal Transplant Study","volume":"115","author":"Tan","year":"2008","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2010.01.039_bib16","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1258\/1355819021927674","article-title":"Statistical heterogeneity in systematic reviews of clinical trials: a critical appraisal of guidelines and practice","volume":"7","author":"Higgins","year":"2002","journal-title":"J Health Serv Res Policy"},{"key":"10.1016\/j.ophtha.2010.01.039_bib17","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1001\/archopht.126.1.71","article-title":"Promotion of graft survival by vascular endothelial growth factor A neutralization after high-risk corneal transplantation","volume":"126","author":"Bachmann","year":"2008","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2010.01.039_bib18","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1136\/bjo.2008.145128","article-title":"Transient postoperative vascular endothelial growth factor (VEGF)-neutralisation improves graft survival in corneas with partly regressed inflammatory neovascularisation","volume":"93","author":"Bachmann","year":"2009","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2010.01.039_bib19","first-page":"2127","article-title":"Lymphatic vessels in vascularized human corneas: immunohistochemical investigation using LYVE-1 and podoplanin","volume":"43","author":"Cursiefen","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2010.01.039_bib20","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00417-007-0684-4","article-title":"Bevacizumab (Avastin) eye drops inhibit corneal neovascularization","volume":"246","author":"Bock","year":"2008","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.ophtha.2010.01.039_bib21","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1167\/iovs.06-0570","article-title":"Bevacizumab as a potent inhibitor of inflammatory corneal angiogenesis and lymphangiogenesis","volume":"48","author":"Bock","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2010.01.039_bib22","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1016\/j.ophtha.2008.02.013","article-title":"The effect of topical bevacizumab on corneal neovascularization [online report]","volume":"115","author":"Kim","year":"2008","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2010.01.039_bib23","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1016\/j.ophtha.2009.04.016","article-title":"GS-101 antisense oligonucleotide eye drops inhibit corneal neovascularization: interim results of a randomized phase II trial","volume":"116","author":"Cursiefen","year":"2009","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2010.01.039_bib24","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1001\/archopht.1981.03930010599002","article-title":"Clinical types of corneal transplant rejection: their manifestations, frequency, preoperative correlates, and treatment","volume":"99","author":"Alldredge","year":"1981","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2010.01.039_bib25","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1442-9071.1986.tb00024.x","article-title":"Corneal graft survival: a retrospective Australian study","volume":"14","author":"Bishop","year":"1986","journal-title":"Aust N Z J Ophthalmol"},{"key":"10.1016\/j.ophtha.2010.01.039_bib26","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/S0161-6420(93)31409-0","article-title":"Risk factors of corneal graft failure","volume":"100","author":"Boisjoly","year":"1993","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2010.01.039_bib27","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1136\/bjo.81.9.726","article-title":"Survival analysis and visual outcome in a large series of corneal transplants in India","volume":"81","author":"Dandona","year":"1997","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2010.01.039_bib28","first-page":"36","article-title":"The relative importance of risk factors used to define high-risk keratoplasty","volume":"5","author":"Hill","year":"1996","journal-title":"Ger J Ophthalmol"},{"key":"10.1016\/j.ophtha.2010.01.039_bib29","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1055\/s-2008-1045772","article-title":"The fate of corneal transplants from the Zurich eye bank [in German]","volume":"200","author":"Hoppeler","year":"1992","journal-title":"Klin Monbl Augenheilkd"},{"key":"10.1016\/j.ophtha.2010.01.039_bib30","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1034\/j.1600-0420.2001.790308.x","article-title":"Risk factors for corneal graft failure and rejection in penetrating keratoplasty","volume":"79","author":"Inoue","year":"2001","journal-title":"Acta Ophthalmol Scand"},{"key":"10.1016\/j.ophtha.2010.01.039_bib31","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/BF00154446","article-title":"Follow-up of corneal transplantations at the Academic Medical Center of Amsterdam","volume":"70","author":"Jager","year":"1988","journal-title":"Doc Ophthalmol"},{"key":"10.1016\/j.ophtha.2010.01.039_bib32","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0002-9394(01)01426-X","article-title":"Immunologic graft reactions after allogenic penetrating keratoplasty","volume":"133","author":"Jonas","year":"2002","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2010.01.039_bib33","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/S0161-6420(94)31138-9","article-title":"Risk factors for corneal graft failure and rejection in the Collaborative Corneal Transplantation Studies","volume":"101","author":"Maguire","year":"1994","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2010.01.039_bib34","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1001\/archopht.121.8.1087","article-title":"Risk factors for various causes of failure in initial corneal grafts","volume":"121","author":"Price","year":"2003","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2010.01.039_bib35","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1016\/j.transproceed.2007.08.020","article-title":"Epidemiology and risk factors for corneal graft rejection","volume":"39","author":"Sellami","year":"2007","journal-title":"Transplant Proc"},{"key":"10.1016\/j.ophtha.2010.01.039_bib36","first-page":"1221","article-title":"Multivariate analysis of factors affecting immunological rejection after penetrating keratoplasty","volume":"54","author":"Tachihara","year":"2000","journal-title":"Rinsho Ganka"},{"key":"10.1016\/j.ophtha.2010.01.039_bib37","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1442-9071.1987.tb00300.x","article-title":"Hierarchy of prognostic factors for corneal allograft survival","volume":"15","author":"Volker-Dieben","year":"1987","journal-title":"Aust N Z J Ophthalmol"},{"key":"10.1016\/j.ophtha.2010.01.039_bib38","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1097\/01.tp.0000185197.37824.35","article-title":"How effective is penetrating corneal transplantation?","volume":"81","author":"Williams","year":"2006","journal-title":"Transplantation"},{"key":"10.1016\/j.ophtha.2010.01.039_bib39","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/00003226-200205000-00014","article-title":"Draining lymph nodes play an essential role in alloimmunity generated in response to high-risk corneal transplantation","volume":"21","author":"Yamagami","year":"2002","journal-title":"Cornea"},{"key":"10.1016\/j.ophtha.2010.01.039_bib40","doi-asserted-by":"crossref","first-page":"249","DOI":"10.7888\/juoeh.9.249","article-title":"The factors necessary to achieve successful penetrating keratoplasty [in Japanese]","volume":"9","author":"Yano","year":"1987","journal-title":"J UOEH"}],"container-title":["Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642010001120?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642010001120?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T16:39:59Z","timestamp":1559147999000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161642010001120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S0161642010001120"],"URL":"https:\/\/doi.org\/10.1016\/j.ophtha.2010.01.039","relation":{},"ISSN":["0161-6420"],"issn-type":[{"value":"0161-6420","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}