{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:27:38Z","timestamp":1793662058173,"version":"4.5.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmology"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1016\/j.ophtha.2010.03.032","type":"journal-article","created":{"date-parts":[[2010,4,26]],"date-time":"2010-04-26T04:37:45Z","timestamp":1272256665000},"page":"1134-1146.e3","source":"Crossref","is-referenced-by-count":844,"title":["Randomized, Sham-Controlled Trial of Dexamethasone Intravitreal Implant in Patients with Macular Edema Due to Retinal Vein Occlusion"],"prefix":"10.1016","volume":"117","clinical-trial-number":[{"clinical-trial-number":"nct00168298","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct00168324","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Julia A.","family":"Haller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bandello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Rubens","family":"Belfort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Blumenkranz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Gillies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Heier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat","family":"Loewenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Hee","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Louise","family":"Jacques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott M.","family":"Whitcup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ophtha.2010.03.032_bib1","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1111\/j.1445-5994.2008.01720.x","article-title":"Retinal vein occlusion: an approach to diagnosis, systemic risk factors and management","volume":"38","author":"Yau","year":"2008","journal-title":"Intern Med J"},{"key":"10.1016\/j.ophtha.2010.03.032_bib2","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1001\/archopht.1996.01100140443012","article-title":"Prevalence and associations of retinal vein occlusion in Australia: the Blue Mountains Eye Study","volume":"114","author":"Mitchell","year":"1996","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2010.03.032_bib4","first-page":"133","article-title":"The epidemiology of retinal vein occlusion: the Beaver Dam Eye Study","volume":"98","author":"Klein","year":"2000","journal-title":"Trans Am Ophthalmol Soc"},{"key":"10.1016\/j.ophtha.2010.03.032_bib5","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1001\/archopht.1997.01100150488006","article-title":"Natural history and clinical management of central retinal vein occlusion","volume":"115","year":"1997","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2010.03.032_bib6","author":"Fonrose"},{"key":"10.1016\/j.ophtha.2010.03.032_bib7","author":"Hayreh"},{"key":"10.1016\/j.ophtha.2010.03.032_bib8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1080\/02713680701851902","article-title":"Branch retinal vein occlusion: pathogenesis, visual prognosis, and treatment modalities","volume":"33","author":"Rehak","year":"2008","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.ophtha.2010.03.032_bib9","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.2337\/diabetes.47.12.1953","article-title":"Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells","volume":"47","author":"Antonetti","year":"1998","journal-title":"Diabetes"},{"key":"10.1016\/j.ophtha.2010.03.032_bib10","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/mt.2008.10","article-title":"Ranibizumab for macular edema due to retinal vein occlusions: implication of VEGF as a critical stimulator","volume":"16","author":"Campochiaro","year":"2008","journal-title":"Mol Ther"},{"key":"10.1016\/j.ophtha.2010.03.032_bib11","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1001\/archophthalmol.2009.233","volume":"127","year":"2009","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2010.03.032_bib12","series-title":"Medical News Today","article-title":"Two phase III studies of Lucentis show early and sustained improvement in vision in patients with retinal vein occlusion","year":"2009"},{"key":"10.1016\/j.ophtha.2010.03.032_bib13","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1001\/archophthalmol.2009.234","volume":"127","year":"2009","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2010.03.032_bib14","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1007\/s00417-006-0348-9","article-title":"Intravitreal triamcinolone for acute central retinal vein occlusion: a randomized clinical trial","volume":"244","author":"Ramezani","year":"2006","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.ophtha.2010.03.032_bib15","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1001\/archopht.125.3.309","article-title":"Randomized controlled study of an intravitreous dexamethasone drug delivery system in patients with persistent macular edema","volume":"125","author":"Kuppermann","year":"2007","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2010.03.032_bib16","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1046\/j.0022-3042.2001.00740.x","article-title":"Hydrocortisone decreases retinal endothelial cell water and solute flux coincident with increased content and decreased phosphorylation of occludin","volume":"80","author":"Antonetti","year":"2002","journal-title":"J Neurochem"},{"key":"10.1016\/j.ophtha.2010.03.032_bib17","series-title":"Surgical Pharmacology of the Eye","first-page":"83","article-title":"Nonsteroidal and steroidal anti-inflammatory agents","author":"Leopold","year":"1985"},{"key":"10.1016\/j.ophtha.2010.03.032_bib18","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0014-2999(97)01464-7","article-title":"Corticosteroids inhibit the expression of the vascular endothelial growth factor gene in human vascular smooth muscle cells","volume":"341","author":"Nauck","year":"1998","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.ophtha.2010.03.032_bib19","series-title":"Current Concepts in Cataract Surgery: Selected Proceedings of the Fifth Biennial Cataract Surgical Congress. Section 3","first-page":"360","article-title":"Cystoid maculopathy: 125 prostaglandins in ophthalmology","author":"Tennant","year":"1978"},{"key":"10.1016\/j.ophtha.2010.03.032_bib20","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1001\/archopht.122.8.1131","article-title":"Intravitreal triamcinolone for the treatment of macular edema associated with central retinal vein occlusion","volume":"122","author":"Ip","year":"2004","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2010.03.032_bib21","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.ajo.2005.01.001","article-title":"Intravitreal triamcinolone acetonide for cystoid macular edema in nonischemic central retinal vein occlusion","volume":"139","author":"Williamson","year":"2005","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2010.03.032_bib22","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1600-0420.2005.00400.x","article-title":"Intravitreal triamcinolone acetonide in patients with macular oedema due to central retinal vein occlusion","volume":"83","author":"Krepler","year":"2005","journal-title":"Acta Ophthalmol Scand"},{"key":"10.1016\/j.ophtha.2010.03.032_bib23","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1177\/112067210501500615","article-title":"Intravitreal triamcinolone acetonide for treatment of central retinal vein occlusion","volume":"15","author":"Jonas","year":"2005","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.ophtha.2010.03.032_bib24","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/sj.eye.6701395","article-title":"Branch retinal vein occlusion treated by intravitreal triamcinolone acetonide","volume":"19","author":"Jonas","year":"2005","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.ophtha.2010.03.032_bib25","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1097\/00006982-200510000-00005","article-title":"Intravitreal triamcinolone treatment for macular edema associated with central retinal vein occlusion and hemiretinal vein occlusion","volume":"25","author":"Cekic","year":"2005","journal-title":"Retina"},{"key":"10.1016\/j.ophtha.2010.03.032_bib26","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.ajo.2005.12.011","article-title":"Intravitreal triamcinolone for the treatment of ischemic macular edema associated with branch retinal vein occlusion","volume":"141","author":"Chen","year":"2006","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2010.03.032_bib27","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S1607-551X(09)70318-3","article-title":"Intravitreal triamcinolone acetonide for patients with macular edema due to branch retinal vein occlusion","volume":"22","author":"Cheng","year":"2006","journal-title":"Kaohsiung J Med Sci"},{"key":"10.1016\/j.ophtha.2010.03.032_bib28","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3341\/kjo.2007.21.1.18","article-title":"Early versus late intravitreal triamcinolone acetonide for macular edema associated with branch retinal vein occlusion","volume":"21","author":"Oh","year":"2007","journal-title":"Korean J Ophthalmol"},{"key":"10.1016\/j.ophtha.2010.03.032_bib29","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1755-8794-2-58","article-title":"Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells","volume":"2","author":"Nehme","year":"2009","journal-title":"BMC Med Genomics [serial online]"},{"issue":"suppl","key":"10.1016\/j.ophtha.2010.03.032_bib30","first-page":"741","article-title":"Early Treatment Diabetic Retinopathy Study design and baseline patient characteristics","volume":"98","year":"1991","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2010.03.032_bib31","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ajo.2008.03.025","article-title":"Fluocinolone acetonide sustained drug delivery device for chronic central retinal vein occlusion: 12-month results","volume":"146","author":"Ramchandran","year":"2008","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2010.03.032_bib32","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1097\/00006982-200510000-00006","article-title":"Intravitreal triamcinolone injection for treatment of macular edema secondary to branch retinal vein occlusion","volume":"25","author":"Cekic","year":"2005","journal-title":"Retina"},{"key":"10.1016\/j.ophtha.2010.03.032_bib33","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.ophtha.2006.11.011","article-title":"Interventions for central retinal vein occlusion: an evidence-based systematic review","volume":"114","author":"Mohamed","year":"2007","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2010.03.032_bib34","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.ophtha.2007.01.010","article-title":"Interventions for branch retinal vein occlusion: an evidence-based systematic review","volume":"114","author":"McIntosh","year":"2007","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2010.03.032_bib35","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/S0161-6420(95)30848-2","article-title":"A randomized clinical trial of early panretinal photocoagulation for ischemic central vein occlusion: the Central Vein Occlusion Study Group N report","volume":"102","year":"1995","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2010.03.032_bib36","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0002-9394(84)90316-7","article-title":"Argon laser photocoagulation for macular edema in branch vein occlusion","volume":"98","year":"1984","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2010.03.032_bib37","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1001\/archopht.1992.01080220089028","article-title":"Ischemic macular edema: recognition and favorable natural history in branch vein occlusion","volume":"110","author":"Finkelstein","year":"1992","journal-title":"Arch Ophthalmol"}],"container-title":["Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642010003118?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642010003118?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T14:40:21Z","timestamp":1559054421000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161642010003118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S0161642010003118"],"URL":"https:\/\/doi.org\/10.1016\/j.ophtha.2010.03.032","relation":{},"ISSN":["0161-6420"],"issn-type":[{"value":"0161-6420","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6]]}}}