{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:41:23Z","timestamp":1768869683985,"version":"3.49.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmology"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1016\/j.ophtha.2010.06.035","type":"journal-article","created":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T04:53:39Z","timestamp":1285908819000},"page":"265-271","source":"Crossref","is-referenced-by-count":71,"title":["Ocular Features and Histopathologic Changes during Follow-up of Toxic Epidermal Necrolysis"],"prefix":"10.1016","volume":"118","author":[{"given":"Jose Santiago","family":"L\u00f3pez-Garc\u00eda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Rivas Jara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen Isabel","family":"Garc\u00eda-Lozano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Conesa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel Elosua","family":"de Juan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Murube del Castillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ophtha.2010.06.035_bib1","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1016\/S0161-6420(95)30811-1","article-title":"Analysis of the acute ophthalmic manifestations of the erythema multiforme\/Stevens-Johnson syndrome\/toxic epidermal necrolysis disease spectrum","volume":"102","author":"Power","year":"1995","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2010.06.035_bib2","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1056\/NEJM199411103311906","article-title":"Severe adverse cutaneous reactions to drugs","volume":"331","author":"Roujeau","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ophtha.2010.06.035_bib3","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1001\/archderm.1987.01660330071012","article-title":"Toxic epidermal necrolysis: clinical findings and prognosis factors in 87 patients","volume":"123","author":"Revuz","year":"1987","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.ophtha.2010.06.035_bib4","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/FPC.0b013e3282f3ef9c","article-title":"A European study of HLA-B in Stevens-Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs","volume":"18","author":"Lonjou","year":"2008","journal-title":"Pharmacogenet Genomics"},{"key":"10.1016\/j.ophtha.2010.06.035_bib5","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/S0002-9440(10)64284-8","article-title":"Toxic epidermal necrolysis and Stevens-Johnson syndrome are induced by soluble Fas ligand","volume":"162","author":"Abe","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ophtha.2010.06.035_bib6","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/0895-4356(96)00035-2","article-title":"Epidemiology of erythema exsudativum multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrolysis in Germany (1990\u20131992): structure and results of a population-based registry","volume":"49","author":"Rzany","year":"1996","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.ophtha.2010.06.035_bib7","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1097\/00003226-199111000-00013","article-title":"Ocular complications of Stevens-Johnson syndrome and toxic epidermal necrolysis in patients with AIDS","volume":"10","author":"Belfort","year":"1991","journal-title":"Cornea"},{"key":"10.1016\/j.ophtha.2010.06.035_bib8","first-page":"366","article-title":"Clinical characteristics of childhood erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis in Taiwanese children","volume":"37","author":"Lam","year":"2004","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.ophtha.2010.06.035_bib9","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.ophtha.2005.09.001","article-title":"Amniotic membrane transplantation in acute phase of toxic epidermal necrolysis with severe corneal involvement","volume":"113","author":"Kobayashi","year":"2006","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2010.06.035_bib10","doi-asserted-by":"crossref","first-page":"965","DOI":"10.2165\/00002018-200225130-00006","article-title":"Erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis in children: a review of 10 years' experience","volume":"25","author":"Forman","year":"2002","journal-title":"Drug Saf"},{"key":"10.1016\/j.ophtha.2010.06.035_bib11","first-page":"169","article-title":"A study of lacunar folds in relation to the etiology and severity of dry eye [in Spanish]","volume":"79","author":"Lopez Garcia","year":"2004","journal-title":"Arch Soc Esp Oftalmol"},{"key":"10.1016\/j.ophtha.2010.06.035_bib12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0039-6257(98)00005-8","article-title":"Management of conjunctival cicatrizing diseases and severe ocular surface dysfunction","volume":"43","author":"Chiou","year":"1998","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.ophtha.2010.06.035_bib13","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1177\/112067210301300302","article-title":"Biopsy of the conjunctiva in dry eye patients establishes a correlation between squamous metaplasia and dry eye clinical severity","volume":"13","author":"Murube","year":"2003","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.ophtha.2010.06.035_bib14","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1097\/00003226-200308000-00009","article-title":"Analysis of limbal stem cell deficiency by corneal impression cytology","volume":"22","author":"Donisi","year":"2003","journal-title":"Cornea"},{"key":"10.1016\/j.ophtha.2010.06.035_bib15","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1097\/00125480-200311000-00003","article-title":"Ocular surface impression cytology","volume":"10","author":"McKelvie","year":"2003","journal-title":"Adv Anat Pathol"},{"key":"10.1016\/j.ophtha.2010.06.035_bib16","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ophtha.2007.03.087","article-title":"Autologous serum eyedrops in the treatment of aniridic keratopathy","volume":"115","author":"L\u00f3pez-Garc\u00eda","year":"2008","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2010.06.035_bib17","doi-asserted-by":"crossref","first-page":"28S","DOI":"10.1111\/1523-1747.ep12388434","article-title":"The spectrum of Stevens-Johnson syndrome and toxic epidermal necrolysis: a clinical classification","volume":"102","author":"Roujeau","year":"1994","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ophtha.2010.06.035_bib18","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1177\/112067210101100303","article-title":"Measuring the lacunar sulci as a new indicator of shrinkage of the ocular surface","volume":"11","author":"Murube","year":"2001","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.ophtha.2010.06.035_bib19","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1755-3768.1991.tb04830.x","article-title":"Topographical distribution of ocular surface cells by the use of impression cytology","volume":"69","author":"Rivas","year":"1991","journal-title":"Acta Ophthalmol (Copenh)"},{"key":"10.1016\/j.ophtha.2010.06.035_bib20","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1177\/112067210301300201","article-title":"Impression cytology on conjunctiva and cornea in dry eye patients establishes a correlation between squamous metaplasia and dry eye clinical severity","volume":"13","author":"Murube","year":"2003","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.ophtha.2010.06.035_bib21","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/ICO.0b013e31802eb264","article-title":"Erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis: acute ocular manifestations, causes and management","volume":"26","author":"Chang","year":"2007","journal-title":"Cornea"},{"key":"10.1016\/j.ophtha.2010.06.035_bib22","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1056\/NEJM199512143332404","article-title":"Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis","volume":"333","author":"Roujeau","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ophtha.2010.06.035_bib23","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1046\/j.1440-0960.1999.00342.x","article-title":"Clinical manifestation and outcomes in 17 cases of Stevens-Johnson syndrome and toxic epidermal necrolysis","volume":"40","author":"Wong","year":"1999","journal-title":"Australas J Dermatol"},{"key":"10.1016\/j.ophtha.2010.06.035_bib24","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1001\/jama.283.2.175","article-title":"Recent therapeutic advances in dermatology","volume":"283","author":"Lipper","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.ophtha.2010.06.035_bib25","first-page":"157","article-title":"Risk factors for the development of ocular complications of Stevens-Johnson syndrome and toxic epidermal necrolysis","volume":"145","author":"Gueudry","year":"2009","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.ophtha.2010.06.035_bib26","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0161-6420(01)00900-9","article-title":"Amniotic membrane in the surgical management of acute toxic epidermal necrolysis","volume":"109","author":"John","year":"2002","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2010.06.035_bib27","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.ophtha.2004.11.035","article-title":"Correlation of corneal complications with eyelid cicatricial pathologies in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis syndrome","volume":"112","author":"Di Pascuale","year":"2005","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2010.06.035_bib28","first-page":"21","article-title":"Lacunar folds study in dry eye diagnosis [in Spanish]","volume":"78","author":"L\u00f3pez-Garc\u00eda","year":"2003","journal-title":"Arch Soc Esp Oftalmol"},{"key":"10.1016\/j.ophtha.2010.06.035_bib29","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1136\/pgmj.67.784.195","article-title":"Sj\u00f6gren-like pluriglandular exocrine insufficiency after drug-induced toxic epidermal necrolysis","volume":"67","author":"Saban","year":"1991","journal-title":"Postgrad Med J"},{"key":"10.1016\/j.ophtha.2010.06.035_bib30","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/ICO.0b013e31818cd299","article-title":"In vivo confocal microscopic evaluation of corneal changes in chronic Stevens-Johnson syndrome and toxic epidermal necrolysis","volume":"28","author":"Vera","year":"2009","journal-title":"Cornea"},{"key":"10.1016\/j.ophtha.2010.06.035_bib31","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1136\/bjo.2006.113241","article-title":"Early pathological features of the cornea in toxic epidermal necrolysis","volume":"91","author":"Williams","year":"2007","journal-title":"Br J Ophthalmol"}],"container-title":["Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642010007074?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642010007074?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T01:06:17Z","timestamp":1559696777000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161642010007074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["S0161642010007074"],"URL":"https:\/\/doi.org\/10.1016\/j.ophtha.2010.06.035","relation":{},"ISSN":["0161-6420"],"issn-type":[{"value":"0161-6420","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2]]}}}