{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T19:23:06Z","timestamp":1789068186821,"version":"build-2803163510"},"reference-count":28,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002426","name":"Fondazione Telethon","doi-asserted-by":"publisher","award":["GGP06233"],"award-info":[{"award-number":["GGP06233"]}],"id":[{"id":"10.13039\/501100002426","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aaojournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.ophtha.2011.02.027","type":"journal-article","created":{"date-parts":[[2011,6,3]],"date-time":"2011-06-03T19:17:51Z","timestamp":1307128671000},"page":"2076-2080","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":79,"title":["Retinal Nerve Fiber Layer Thickness in Dominant Optic Atrophy"],"prefix":"10.1016","volume":"118","author":[{"given":"Piero","family":"Barboni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Savini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Parisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Carbonelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"La Morgia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Maresca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Sadun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"De Negri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Carta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo A.","family":"Sadun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Carelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"suppl","key":"10.1016\/j.ophtha.2011.02.027_bib1","first-page":"1","article-title":"Infantile optic atrophy with dominant mode of inheritance: a clinical and genetic study of 19 Danish families","volume":"164","author":"Kjer","year":"1959","journal-title":"Acta Ophthalmol Suppl"},{"key":"10.1016\/j.ophtha.2011.02.027_bib2","first-page":"465","article-title":"Hereditary optic neuropathies","volume":"vol 1","author":"Newman","year":"2005"},{"key":"10.1016\/j.ophtha.2011.02.027_bib3","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.ophtha.2009.12.038","article-title":"The prevalence and natural history of dominant optic atrophy due to OPA1 mutations","volume":"117","author":"Yu-Wai-Man","year":"2010","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2011.02.027_bib4","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1152\/physrev.00030.2008","article-title":"Mitochondrial dynamics in mammalian health and disease","volume":"89","author":"Liesa","year":"2009","journal-title":"Physiol Rev"},{"key":"10.1016\/j.ophtha.2011.02.027_bib5","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1093\/brain\/awm298","article-title":"OPA1 mutations induce mitochondrial DNA instability and optic atrophy \u2018plus\u2019 phenotypes","volume":"131","author":"Amati-Bonneau","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.ophtha.2011.02.027_bib6","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/brain\/awm272","article-title":"Mutation of OPA1 causes dominant optic atrophy with external ophthalmoplegia, ataxia, deafness and multiple mitochondrial DNA deletions: a novel disorder of mtDNA maintenance","volume":"131","author":"Hudson","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.ophtha.2011.02.027_bib7","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1093\/brain\/awq007","article-title":"Multi-system neurological disease is common in patients with OPA1 mutations","volume":"133","author":"Yu-Wai-Man","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.ophtha.2011.02.027_bib8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.preteyeres.2003.10.003","article-title":"Mitochondrial dysfunction as a cause of optic neuropathies","volume":"23","author":"Carelli","year":"2004","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.ophtha.2011.02.027_bib9","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ophtha.2004.06.034","article-title":"Retinal nerve fiber layer evaluation by optical coherence tomography in Leber's hereditary optic neuropathy","volume":"112","author":"Barboni","year":"2005","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2011.02.027_bib10","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ophtha.2004.09.033","article-title":"Retinal nerve fiber layer evaluation by optical coherence tomography in unaffected carriers with Leber's hereditary optic neuropathy mutations","volume":"112","author":"Savini","year":"2005","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2011.02.027_bib11","doi-asserted-by":"crossref","first-page":"5303","DOI":"10.1167\/iovs.06-0520","article-title":"Leber's hereditary optic neuropathy with childhood onset","volume":"47","author":"Barboni","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2011.02.027_bib12","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.ophtha.2009.07.026","article-title":"Natural history of Leber's hereditary optic neuropathy: longitudinal analysis of the retinal nerve fiber layer by optical coherence tomography","volume":"117","author":"Barboni","year":"2010","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2011.02.027_bib13","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1167\/iovs.08-2695","article-title":"Association of optic disc size with development and prognosis of Leber's hereditary optic neuropathy","volume":"50","author":"Ramos C do","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2011.02.027_bib14","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.ophtha.2009.12.042","article-title":"OPA1 mutations associated with dominant optic atrophy influence optic nerve head size","volume":"117","author":"Barboni","year":"2010","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2011.02.027_bib15","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1097\/IJG.0b013e31804d23aa","article-title":"Stratus OCT in dominant optic atrophy: features differentiating it from glaucoma","volume":"16","author":"Kim","year":"2007","journal-title":"J Glaucoma"},{"key":"10.1016\/j.ophtha.2011.02.027_bib16","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/j.1755-3768.2008.01469.x","article-title":"Axonal loss occurs early in dominant optic atrophy","volume":"88","author":"Milea","year":"2010","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.ophtha.2011.02.027_bib17","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.1167\/iovs.07-0024","article-title":"Reduction of inner retinal thickness in patients with autosomal dominant optic atrophy associated with OPA1 mutations","volume":"48","author":"Ito","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2011.02.027_bib18","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1136\/bjo.2004.052498","article-title":"Correlation between retinal nerve fibre layer thickness and optic nerve head size: an optical coherence tomography study","volume":"89","author":"Savini","year":"2005","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2011.02.027_bib19","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1001\/archopht.125.7.901","article-title":"The effect of scan diameter on retinal nerve fiber layer thickness measurement using Stratus optic coherence tomography","volume":"125","author":"Savini","year":"2007","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2011.02.027_bib20","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.ophtha.2007.01.023","article-title":"Normal age-related decay of retinal nerve fiber layer thickness","volume":"114","author":"Parikh","year":"2007","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2011.02.027_bib21","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.ophtha.2009.01.004","article-title":"Effects of age on optical coherence tomography measurements of healthy retinal nerve fiber layer, macula and optic nerve head","volume":"116","author":"Sung","year":"2009","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2011.02.027_bib22","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.ophtha.2006.08.046","article-title":"Determinants of normal retinal nerve fiber layer thickness measured by Stratus OCT","volume":"114","author":"Budenz","year":"2007","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2011.02.027_bib23","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/BF02431765","article-title":"Age-related decline of human optic nerve axon populations","volume":"10","author":"Johnson","year":"1987","journal-title":"Age"},{"key":"10.1016\/j.ophtha.2011.02.027_bib24","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1001\/archopht.123.6.785","article-title":"Delayed visual decline in patients with \u201cstable\u201d optic neuropathy","volume":"123","author":"Kim","year":"2005","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2011.02.027_bib25","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1167\/iovs.03-1093","article-title":"Developmental expression profile of the optic atrophy gene product: OPA1 is not localized exclusively in the mammalian retinal ganglion cell layer","volume":"45","author":"Aijaz","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2011.02.027_bib26","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.1167\/iovs.03-1261","article-title":"OPA1, the disease gene for autosomal dominant optic atrophy, is specifically expressed in ganglion cells and intrinsic neurons of the retina","volume":"45","author":"Pesch","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2011.02.027_bib27","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1093\/brain\/awm005","article-title":"A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy","volume":"130","author":"Alavi","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.ophtha.2011.02.027_bib28","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1093\/hmg\/ddm079","article-title":"Opa1 deficiency in a mouse model of autosomal dominant optic atrophy impairs mitochondrial morphology, optic nerve structure and visual function","volume":"16","author":"Davies","year":"2007","journal-title":"Hum Mol Genet"}],"container-title":["Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642011001862?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642011001862?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T14:00:51Z","timestamp":1758981651000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161642011001862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0161642011001862"],"URL":"https:\/\/doi.org\/10.1016\/j.ophtha.2011.02.027","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.11433956.12457054","asserted-by":"object"}]},"ISSN":["0161-6420"],"issn-type":[{"value":"0161-6420","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Retinal Nerve Fiber Layer Thickness in Dominant Optic Atrophy","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ophtha.2011.02.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}